Regional suppression of tumor growth by in vivo transfer of a cDNA encoding a secreted form of the extracellular domain of the flt-1 vascular endothelial growth factor receptor

Human Gene Therapy

Volumn 9, Issue 6, 1998, Pages 823-833

  Kong, Hwai Loong ^a   Hecht, Dalit ^b   Song, Wenru ^a   Kovesdi, Imre ^c   Hackett, Neil R ^a   Yayon, Avner ^b   Crystal, Ronald G ^a  

^a WEILL CORNELL MEDICAL CENTER   (United States)

^b WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^c GENVEC INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; VASCULOTROPIN RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; LIVER METASTASIS; LUNG METASTASIS; MOUSE; NONHUMAN; SPLEEN TUMOR; TUMOR CELL LINE; TUMOR GROWTH; TUMOR MODEL;

ADENOVIRIDAE; ANIMALIA; MURINAE;

EID: 0032502843     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.1998.9.6-823     Document Type: Article

References (4)

1. AIELLO, L.P., AVERY, R.L., ARRIGG, P.G., KEYT, B.A., JAMPEL, H.D., SHAH, S.T., PASQUALE, L.R., THIEME, H., IWAMOTO, M.A., PARK, J.E., NGUYEN, H.V., AIELLO, M., FERRARA, N., and KING, G.L. (1994). Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N. Engl. J. Med. 331, 1480-1487.
2. AIELLO, L.P., PIERCE, E.A., FOLEY, E.D., TAKAGI, H., CHEN, H., RIDDLE, L., FERRARA, N., KING, G.L., and SMITH, L.E. (1995). Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins. Proc. Natl. Acad. Sci. U.S.A. 92, 10457-10461.
3. ALLEY, M.C., SCUDIERO, D.A., MONKS, A., HURSEY, M.L., CZERWINSKI, M.J., FINE, D.L., ABBOTT, B.J., MAYO, J.G., SHOEMAKER, R.H., and BOYD, M.R. (1988). Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay. Cancer. Res. 48, 589-601.
4. YUAN, F., CHEN, Y., DELLIAN, M., SAFABAKHSH, N., FERRARA, N., and JAIN, R.K. (1996). Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody. Proc. Natl. Acad. Sci. U.S.A. 93, 14765-14770.