-
1
-
-
77349088003
-
Unraveling the functions of plasmacytoid dendritic cells during viral infections, autoimmunity, and tolerance
-
Swiecki, M. & M. Colonna: Unraveling the functions of plasmacytoid dendritic cells during viral infections, autoimmunity, and tolerance. Immunol Rev, 234, 142-62 (2010)
-
(2010)
Immunol Rev
, vol.234
, pp. 142-162
-
-
Swiecki, M.1
Colonna, M.2
-
2
-
-
77954128990
-
Immune cell crosstalk in type 1 diabetes
-
Lehuen, A., J. Diana, P. Zaccone & A. Cooke: Immune cell crosstalk in type 1 diabetes. Nat Rev Immunol, 10, 501-13 (2010)
-
(2010)
Nat Rev Immunol
, vol.10
, pp. 501-513
-
-
Lehuen, A.1
Diana, J.2
Zaccone, P.3
Cooke, A.4
-
3
-
-
77649152255
-
Autoimmunity and the clearance of dead cells
-
Nagata, S., R. Hanayama & K. Kawane: Autoimmunity and the clearance of dead cells. Cell, 140, 619-30 (2002)
-
(2002)
Cell
, vol.140
, pp. 619-630
-
-
Nagata, S.1
Hanayama, R.2
Kawane, K.3
-
4
-
-
0037066502
-
Decoding the patterns of self and nonself by the innate immune system
-
DOI 10.1126/science.1068883
-
Medzhitov, R. & C. A. Janeway, Jr.: Decoding the patterns of self and nonself by the innate immune system. Science, 296, 298-300 (2002) (Pubitemid 34303673)
-
(2002)
Science
, vol.296
, Issue.5566
, pp. 298-300
-
-
Medzhitov, R.1
Janeway Jr., C.A.2
-
6
-
-
1542317578
-
Species-Specific Recognition of Single-Stranded RNA via Till-like Receptor 7 and 8
-
DOI 10.1126/science.1093620
-
Heil, F., H. Hemmi, H. Hochrein, F. Ampenberger, C. Kirschning, S. Akira, G. Lipford, H. Wagner & S. Bauer: Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science, 303, 1526-9 (2004) (Pubitemid 38314424)
-
(2004)
Science
, vol.303
, Issue.5663
, pp. 1526-1529
-
-
Heil, F.1
Hemmi, H.2
Hochrein, H.3
Ampenberger, F.4
Kirschning, C.5
Akira, S.6
Lipford, G.7
Wagner, H.8
Bauer, S.9
-
7
-
-
0034619794
-
A Toll-like receptor recognizes bacterial DNA
-
DOI 10.1038/35047123
-
Hemmi, H., O. Takeuchi, T. Kawai, T. Kaisho, S. Sato, H. Sanjo, M. Matsumoto, K. Hoshino, H. Wagner, K. Takeda & S. Akira: A Toll-like receptor recognizes bacterial DNA. Nature, 408, 740-5 (2000) (Pubitemid 32015992)
-
(2000)
Nature
, vol.408
, Issue.6813
, pp. 740-745
-
-
Hemmi, H.1
Takeuchi, O.2
Kawai, T.3
Kaisho, T.4
Sato, S.5
Sanjo, H.6
Matsumoto, M.7
Hoshino, K.8
Wagner, H.9
Takeda, K.10
Akira, S.11
-
8
-
-
0035909372
-
Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
-
DOI 10.1038/35099560
-
Alexopoulou, L., A. C. Holt, R. Medzhitov & R. A. Flavell: Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature, 413, 732-8 (2001) (Pubitemid 33009951)
-
(2001)
Nature
, vol.413
, Issue.6857
, pp. 732-738
-
-
Alexopoulou, L.1
Holt, A.C.2
Medzhitov, R.3
Flavell, R.A.4
-
9
-
-
1542317550
-
Innate Antiviral Responses by Means of TLR7-Mediated Recognition of Single-Stranded RNA
-
DOI 10.1126/science.1093616
-
Diebold, S. S., T. Kaisho, H. Hemmi, S. Akira & C. Reise Sousa: Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science, 303, 1529-31 (2004) (Pubitemid 38314425)
-
(2004)
Science
, vol.303
, Issue.5663
, pp. 1529-1531
-
-
Diebold, S.S.1
Kaisho, T.2
Hemmi, H.3
Akira, S.4
Reis E Sousa, C.5
-
10
-
-
0036088492
-
Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848 [1]
-
DOI 10.1038/ni0602-499
-
Jurk, M., F. Heil, J. Vollmer, C. Schetter, A. M. Krieg, H. Wagner, G. Lipford & S. Bauer: Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848. Nat Immunol, 3, 499 (2002) (Pubitemid 34669818)
-
(2002)
Nature Immunology
, vol.3
, Issue.6
, pp. 499
-
-
Jurk, M.1
Heil, F.2
Vollmer, J.3
Schetter, C.4
Krieg, A.M.5
Wagner, H.6
Lipford, G.7
Bauer, S.8
-
11
-
-
77950883727
-
Toll-like receptor 8-mediated activation of murine plasmacytoid dendritic cells by vaccinia viral DNA
-
Martinez, J., X. Huang & Y. Yang: Toll-like receptor 8-mediated activation of murine plasmacytoid dendritic cells by vaccinia viral DNA. Proc Natl Acad Sci U S A, 107, 6442-7 (2010)
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 6442-6447
-
-
Martinez, J.1
Huang, X.2
Yang, Y.3
-
12
-
-
69949108452
-
RIG-I-like receptors: Sensing and responding to RNA virus infection
-
Nakhaei, P., P. Genin, A. Civas & J. Hiscott: RIG-I-like receptors: sensing and responding to RNA virus infection. Semin Immunol, 21, 215-22 (2009)
-
(2009)
Semin Immunol
, vol.21
, pp. 215-222
-
-
Nakhaei, P.1
Genin, P.2
Civas, A.3
Hiscott, J.4
-
13
-
-
77249118801
-
The inflammasomes: Mechanisms of activation and function
-
Latz, E.: The inflammasomes: mechanisms of activation and function. Curr Opin Immunol, 22, 28-33 (2010)
-
(2010)
Curr Opin Immunol
, vol.22
, pp. 28-33
-
-
Latz, E.1
-
14
-
-
3142724031
-
Toll-like receptor signalling
-
Akira, S. & K. Takeda: Toll-like receptor signalling. Nat Rev Immunol, 4, 499-511 (2004) (Pubitemid 38931765)
-
(2004)
Nature Reviews Immunology
, vol.4
, Issue.7
, pp. 499-511
-
-
Akira, S.1
Takeda, K.2
-
15
-
-
0038393016
-
IKKE and TBKI are essential components of the IRF3 signalling pathway
-
DOI 10.1038/ni921
-
Fitzgerald, K. A., S. M. McWhirter, K. L. Faia, D. C. Rowe, E. Latz, D. T. Golenbock, A. J. Coyle, S. M. Liao & T. Maniatis: IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. Nat Immunol, 4, 491-6 (2003) (Pubitemid 36592443)
-
(2003)
Nature Immunology
, vol.4
, Issue.5
, pp. 491-496
-
-
Fitzgerald, K.A.1
McWhirter, S.M.2
Faia, K.L.3
Rowe, D.C.4
Latz, E.5
Golenbock, D.T.6
Coyle, A.J.7
Liao, S.-M.8
Maniatis, T.9
-
16
-
-
0141923690
-
Toll/IL-1 receptor domain-containing adaptor inducing IFN-β (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-κB and IFN-regulatory factor-3, in the toll-like receptor signaling
-
Sato, S., M. Sugiyama, M. Yamamoto, Y. Watanabe, T. Kawai, K. Takeda & S. Akira: Toll/IL-1 receptor domaincontaining adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling. J Immunol, 171, 4304-10 (2003) (Pubitemid 37238709)
-
(2003)
Journal of Immunology
, vol.171
, Issue.8
, pp. 4304-4310
-
-
Sato, S.1
Sugiyama, M.2
Yamamoto, M.3
Watanabe, Y.4
Kawai, T.5
Takeda, K.6
Akira, S.7
-
17
-
-
2442642691
-
RIP1 is an essential mediator of Toll-like receptor 3-induced NF κB activation
-
DOI 10.1038/ni1061
-
Meylan, E., K. Burns, K. Hofmann, V. Blancheteau, F. Martinon, M. Kelliher & J. Tschopp: RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation. Nat Immunol, 5, 503-7 (2004) (Pubitemid 38660462)
-
(2004)
Nature Immunology
, vol.5
, Issue.5
, pp. 503-507
-
-
Meylan, E.1
Burns, K.2
Hofmann, K.3
Blancheteau, V.4
Martinon, F.5
Kelliher, M.6
Tschopp, J.7
-
18
-
-
34247566510
-
The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling
-
DOI 10.1038/nri2079, PII NRI2079
-
O'Neill, L. A. & A. G. Bowie: The family of five: TIRdomain-containing adaptors in Toll-like receptor signalling. Nat Rev Immunol, 7, 353-64 (2007) (Pubitemid 46674493)
-
(2007)
Nature Reviews Immunology
, vol.7
, Issue.5
, pp. 353-364
-
-
O'Neill, L.A.J.1
Bowie, A.G.2
-
19
-
-
5444274514
-
Interferon-α induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6
-
DOI 10.1038/ni1118
-
Kawai, T., S. Sato, K. J. Ishii, C. Coban, H. Hemmi, M. Yamamoto, K. Terai, M. Matsuda, J. Inoue, S. Uematsu, O. Takeuchi & S. Akira: Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. Nat Immunol, 5, 1061-8 (2004) (Pubitemid 41057726)
-
(2004)
Nature Immunology
, vol.5
, Issue.10
, pp. 1061-1068
-
-
Kawai, T.1
Sato, S.2
Ishii, K.J.3
Coban, C.4
Hemmi, H.5
Yamamoto, M.6
Terai, K.7
Matsuda, M.8
Inoue, J.-I.9
Uematsu, S.10
Takeuchi, O.11
Akira, S.12
-
20
-
-
5444262511
-
Toll-like receptor control of the adaptive immune responses
-
DOI 10.1038/ni1112
-
Iwasaki, A. & R. Medzhitov: Toll-like receptor control of the adaptive immune responses. Nat Immunol, 5, 987-95 (2004) (Pubitemid 41057715)
-
(2004)
Nature Immunology
, vol.5
, Issue.10
, pp. 987-995
-
-
Iwasaki, A.1
Medzhitov, R.2
-
21
-
-
33947668943
-
Viral recognition by Toll-like receptors
-
DOI 10.1016/j.smim.2007.01.003, PII S104453230700005X, TLR-Mediated Innate Immune Recognition
-
Barton, G. M.: Viral recognition by Toll-like receptors. Semin Immunol, 19, 33-40 (2007) (Pubitemid 46498754)
-
(2007)
Seminars in Immunology
, vol.19
, Issue.1
, pp. 33-40
-
-
Barton, G.M.1
-
22
-
-
0036219195
-
CpG motifs in bacterial DNA and their immune effects
-
DOI 10.1146/annurev.immunol.20.100301.064842
-
Krieg, A. M.: CpG motifs in bacterial DNA and their immune effects. Annu Rev Immunol, 20, 709-60 (2002) (Pubitemid 34293438)
-
(2002)
Annual Review of Immunology
, vol.20
, pp. 709-760
-
-
Krieg, A.M.1
-
23
-
-
75749143405
-
Regulation of autoreactive B cell responses to endogenous TLR ligands
-
Avalos, A. M., L. Busconi & A. Marshak-Rothstein: Regulation of autoreactive B cell responses to endogenous TLR ligands. Autoimmunity, 43, 76-83 (2010)
-
(2010)
Autoimmunity
, vol.43
, pp. 76-83
-
-
Avalos, A.M.1
Busconi, L.2
Marshak-Rothstein, A.3
-
24
-
-
77953641046
-
Spatiotemporal regulation of heat shock protein 90-chaperoned self-DNA and CpGoligodeoxynucleotide for type i IFN induction via targeting to static early endosome
-
Okuya, K., Y. Tamura, K. Saito, G. Kutomi, T. Torigoe, K. Hirata & N. Sato: Spatiotemporal regulation of heat shock protein 90-chaperoned self-DNA and CpGoligodeoxynucleotide for type I IFN induction via targeting to static early endosome. J Immunol, 184, 7092-9 (2010)
-
(2010)
J Immunol
, vol.184
, pp. 7092-7099
-
-
Okuya, K.1
Tamura, Y.2
Saito, K.3
Kutomi, G.4
Torigoe, T.5
Hirata, K.6
Sato, N.7
-
25
-
-
69549135324
-
Self-RNA-antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8
-
Ganguly, D., G. Chamilos, R. Lande, J. Gregorio, S. Meller, V. Facchinetti, B. Homey, F. J. Barrat, T. Zal & M. Gilliet: Self-RNA-antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8. J Exp Med, 206, 1983-94 (2009)
-
(2009)
J Exp Med
, vol.206
, pp. 1983-1994
-
-
Ganguly, D.1
Chamilos, G.2
Lande, R.3
Gregorio, J.4
Meller, S.5
Facchinetti, V.6
Homey, B.7
Barrat, F.J.8
Zal, T.9
Gilliet, M.10
-
26
-
-
0032476602
-
CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation
-
DOI 10.1093/emboj/17.21.6230
-
Hacker, H., H. Mischak, T. Miethke, S. Liptay, R. Schmid, T. Sparwasser, K. Heeg, G. B. Lipford & H. Wagner: CpG-DNA-specific activation of antigenpresenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation. Embo J, 17, 6230-40 (1998) (Pubitemid 28497796)
-
(1998)
EMBO Journal
, vol.17
, Issue.21
, pp. 6230-6240
-
-
Hacker, H.1
Mischak, H.2
Miethke, T.3
Liptay, S.4
Schmid, R.5
Sparwasser, T.6
Heeg, K.7
Lipford, G.B.8
Wagner, H.9
-
27
-
-
3142697714
-
TLR9 is localized in the endoplasmic reticulum prior to stimulation
-
Leifer, C. A., M. N. Kennedy, A. Mazzoni, C. Lee, M. J. Kruhlak & D. M. Segal: TLR9 is localized in the endoplasmic reticulum prior to stimulation. J Immunol, 173, 1179-83 (2004) (Pubitemid 38924294)
-
(2004)
Journal of Immunology
, vol.173
, Issue.2
, pp. 1179-1183
-
-
Leifer, C.A.1
Kennedy, M.N.2
Mazzoni, A.3
Lee, C.4
Kruhlak, M.J.5
Segal, D.M.6
-
28
-
-
10744219675
-
TLR9 signals after translocating from the ER to CpG DNA in the lysosome
-
DOI 10.1038/ni1028
-
Latz, E., A. Schoenemeyer, A. Visintin, K. A. Fitzgerald, B. G. Monks, C. F. Knetter, E. Lien, N. J. Nilsen, T. Espevik & D. T. Golenbock: TLR9 signals after translocating from the ER to CpG DNA in the lysosome. Nat Immunol, 5, 190-8 (2004) (Pubitemid 38208361)
-
(2004)
Nature Immunology
, vol.5
, Issue.2
, pp. 190-198
-
-
Latz, E.1
Schoenemeyer, A.2
Visintin, A.3
Fitzgerald, K.A.4
Monks, B.G.5
Knetter, C.F.6
Lien, E.7
Nilsen, N.J.8
Espevik, T.9
Golenbock, D.T.10
-
29
-
-
0036318851
-
Bacterial CpG-DNA and lipopolysaccharides activate toll-like receptors at distinct cellular compartments
-
DOI 10.1002/1521-4141(200207)32:7<1958::AID-IMMU1958>3.0.CO;2-U
-
Ahmad-Nejad, P., H. Hacker, M. Rutz, S. Bauer, R. M. Vabulas & H. Wagner: Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments. Eur J Immunol, 32, 1958-68 (2002) (Pubitemid 34814552)
-
(2002)
European Journal of Immunology
, vol.32
, Issue.7
, pp. 1958-1968
-
-
Ahmad-Nejad, P.1
Hacker, H.2
Rutz, M.3
Bauer, S.4
Vabulas, R.M.5
Wagner, H.6
-
30
-
-
62849109129
-
TLR9 traffics through the Golgi complex to localize to endolysosomes and respond to CpG DNA
-
Chockalingam, A., J. C. Brooks, J. L. Cameron, L. K. Blum & C. A. Leifer: TLR9 traffics through the Golgi complex to localize to endolysosomes and respond to CpG DNA. Immunol Cell Biol, 87, 209-17 (2009)
-
(2009)
Immunol Cell Biol
, vol.87
, pp. 209-217
-
-
Chockalingam, A.1
Brooks, J.C.2
Cameron, J.L.3
Blum, L.K.4
Leifer, C.A.5
-
31
-
-
57349191215
-
The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor
-
Ewald, S. E., B. L. Lee, L. Lau, K. E. Wickliffe, G. P. Shi, H. A. Chapman & G. M. Barton: The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor. Nature, 456, 658-62 (2008)
-
(2008)
Nature
, vol.456
, pp. 658-662
-
-
Ewald, S.E.1
Lee, B.L.2
Lau, L.3
Wickliffe, K.E.4
Shi, G.P.5
Chapman, H.A.6
Barton, G.M.7
-
32
-
-
2442565738
-
Ligand-regulated Chimeric Receptor Approach Reveals Distinctive Subcellular Localization and Signaling Properties of the Toll-like Receptors
-
DOI 10.1074/jbc.M311618200
-
Nishiya, T. & A. L. DeFranco: Ligand-regulated chimeric receptor approach reveals distinctive subcellular localization and signaling properties of the Toll-like receptors. J Biol Chem, 279, 19008-17 (2004) (Pubitemid 38623331)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.18
, pp. 19008-19017
-
-
Nishiya, T.1
DeFranco, A.L.2
-
33
-
-
27744526784
-
TLR3 and TLR7 are targeted to the same intracellular compartments by distinct regulatory elements
-
DOI 10.1074/jbc.M504951200
-
Nishiya, T., E. Kajita, S. Miwa & A. L. Defranco: TLR3 and TLR7 are targeted to the same intracellular compartments by distinct regulatory elements. J Biol Chem, 280, 37107-17 (2005) (Pubitemid 41587795)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.44
, pp. 37107-37117
-
-
Nishiya, T.1
Kajita, E.2
Miwa, S.3
DeFranco, A.L.4
-
34
-
-
2942679083
-
The immunobiology of the TLR9 subfamily
-
DOI 10.1016/j.it.2004.04.011, PII S1471490604001504
-
Wagner, H.: The immunobiology of the TLR9 subfamily. Trends Immunol, 25, 381-6 (2004) (Pubitemid 38780955)
-
(2004)
Trends in Immunology
, vol.25
, Issue.7
, pp. 381-386
-
-
Wagner, H.1
-
35
-
-
38449098414
-
Spatiotemporal mobilization of Toll/IL-1 receptor domain-containing adaptor molecule-1 in response to dsRNA
-
Funami, K., M. Sasai, Y. Ohba, H. Oshiumi, T. Seya & M. Matsumoto: Spatiotemporal mobilization of Toll/IL-1 receptor domain-containing adaptor molecule-1 in response to dsRNA. J Immunol, 179, 6867-72 (2007)
-
(2007)
J Immunol
, vol.179
, pp. 6867-6872
-
-
Funami, K.1
Sasai, M.2
Ohba, Y.3
Oshiumi, H.4
Seya, T.5
Matsumoto, M.6
-
36
-
-
4344620814
-
The cytoplasmic 'linker region' in Toll-like receptor 3 controls receptor localization and signaling
-
DOI 10.1093/intimm/dxh115
-
Funami, K., M. Matsumoto, H. Oshiumi, T. Akazawa, A. Yamamoto & T. Seya: The cytoplasmic 'linker region' in Toll-like receptor 3 controls receptor localization and signaling. Int Immunol, 16, 1143-54 (2004) (Pubitemid 39136731)
-
(2004)
International Immunology
, vol.16
, Issue.8
, pp. 1143-1154
-
-
Funami, K.1
Matsumoto, M.2
Oshiumi, H.3
Akazawa, T.4
Yamamoto, A.5
Seya, T.6
-
37
-
-
0036076593
-
Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling
-
DOI 10.1016/S0006-291X(02)00380-7, PII S0006291X02003807
-
Matsumoto, M., S. Kikkawa, M. Kohase, K. Miyake & T. Seya: Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling. Biochem Biophys Res Commun, 293, 1364-9 (2002) (Pubitemid 34681026)
-
(2002)
Biochemical and Biophysical Research Communications
, vol.293
, Issue.5
, pp. 1364-1369
-
-
Matsumoto, M.1
Kikkawa, S.2
Kohase, M.3
Miyake, K.4
Seya, T.5
-
38
-
-
0041331693
-
Subcellular localization of toll-like receptor 3 in human dendritic cells
-
Matsumoto, M., K. Funami, M. Tanabe, H. Oshiumi, M. Shingai, Y. Seto, A. Yamamoto & T. Seya: Subcellular localization of Toll-like receptor 3 in human dendritic cells. J Immunol, 171, 3154-62 (2003) (Pubitemid 37093540)
-
(2003)
Journal of Immunology
, vol.171
, Issue.6
, pp. 3154-3162
-
-
Matsumoto, M.1
Funami, K.2
Tanabe, M.3
Oshiumi, H.4
Shingai, M.5
Seto, Y.6
Yamamoto, A.7
Seya, T.8
-
39
-
-
33645111302
-
The transmembrane domain directs TLR9 to intracellular compartments that contain TLR3
-
Kajita, E., T. Nishiya & S. Miwa: The transmembrane domain directs TLR9 to intracellular compartments that contain TLR3. Biochem Biophys Res Commun, 343, 578-84 (2006)
-
(2006)
Biochem Biophys Res Commun
, vol.343
, pp. 578-574
-
-
Kajita, E.1
Nishiya, T.2
Miwa, S.3
-
40
-
-
33746545577
-
Toll-like receptor 3 associates with c-Src tyrosine kinase on endosomes to initiate antiviral signaling
-
DOI 10.1038/sj.emboj.7601222, PII 7601222
-
Johnsen, I. B., T. T. Nguyen, M. Ringdal, A. M. Tryggestad, O. Bakke, E. Lien, T. Espevik & M. W. Anthonsen: Toll-like receptor 3 associates with c-Src tyrosine kinase on endosomes to initiate antiviral signaling. Embo J, 25, 3335-46 (2006) (Pubitemid 44141791)
-
(2006)
EMBO Journal
, vol.25
, Issue.14
, pp. 3335-3346
-
-
Johnsen, I.B.1
Nguyen, T.T.2
Ringdal, M.3
Tryggestad, A.M.4
Bakke, O.5
Lien, E.6
Espevik, T.7
Anthonsen, M.W.8
-
41
-
-
29244450802
-
Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA
-
DOI 10.1038/ni1280, PII N1280
-
Barton, G. M., J. C. Kagan & R. Medzhitov: Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA. Nat Immunol, 7, 49-56 (2006) (Pubitemid 41823868)
-
(2006)
Nature Immunology
, vol.7
, Issue.1
, pp. 49-56
-
-
Barton, G.M.1
Kagan, J.C.2
Medzhitov, R.3
-
42
-
-
0034114882
-
Features of systemic lupus erythematosus in Dnase1-deficient mice
-
DOI 10.1038/76032
-
Napirei, M., H. Karsunky, B. Zevnik, H. Stephan, H. G. Mannherz & T. Moroy: Features of systemic lupus erythematosus in Dnase1-deficient mice. Nat Genet, 25, 177-81 (2000) (Pubitemid 30394988)
-
(2000)
Nature Genetics
, vol.25
, Issue.2
, pp. 177-181
-
-
Napirei, M.1
Karsunky, H.2
Zevnik, B.3
Stephan, H.4
Mannherz, H.G.5
Moroy, T.6
-
44
-
-
56349114913
-
Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9
-
Park, B., M. M. Brinkmann, E. Spooner, C. C. Lee, Y. M. Kim & H. L. Ploegh: Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9. Nat Immunol, 9, 1407-14 (2008)
-
(2008)
Nat Immunol
, vol.9
, pp. 1407-1414
-
-
Park, B.1
Brinkmann, M.M.2
Spooner, E.3
Lee, C.C.4
Kim, Y.M.5
Ploegh, H.L.6
-
45
-
-
38649126557
-
Cathepsins are required for Toll-like receptor 9 responses
-
Matsumoto, F., S. Saitoh, R. Fukui, T. Kobayashi, N. Tanimura, K. Konno, Y. Kusumoto, S. Akashi-Takamura & K. Miyake: Cathepsins are required for Toll-like receptor 9 responses. Biochem Biophys Res Commun, 367, 693-9 (2008)
-
(2008)
Biochem Biophys Res Commun
, vol.367
, pp. 693-699
-
-
Matsumoto, F.1
Saitoh, S.2
Fukui, R.3
Kobayashi, T.4
Tanimura, N.5
Konno, K.6
Kusumoto, Y.7
Akashi-Takamura, S.8
Miyake, K.9
-
46
-
-
38849127573
-
Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis
-
DOI 10.1126/science.1150110
-
Asagiri, M., T. Hirai, T. Kunigami, S. Kamano, H. J. Gober, K. Okamoto, K. Nishikawa, E. Latz, D. T. Golenbock, K. Aoki, K. Ohya, Y. Imai, Y. Morishita, K. Miyazono, S. Kato, P. Saftig & H. Takayanagi: Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis. Science, 319, 624-7 (2008) (Pubitemid 351197065)
-
(2008)
Science
, vol.319
, Issue.5863
, pp. 624-627
-
-
Asagiri, M.1
Hirai, T.2
Kunigami, T.3
Kamano, S.4
Gober, H.-J.5
Okamoto, K.6
Nishikawa, K.7
Latz, E.8
Golenbock, D.T.9
Aoki, K.10
Ohya, K.11
Imai, Y.12
Morishita, Y.13
Miyazono, K.14
Kato, S.15
Saftig, P.16
Takayanagi, H.17
-
47
-
-
77954381441
-
TRIF modulates TLR5-dependent responses by inducing proteolytic degradation of TLR5
-
Choi, Y. J., E. Im, C. Pothoulakis & S. H. Rhee: TRIF modulates TLR5-dependent responses by inducing proteolytic degradation of TLR5. J Biol Chem, 285, 21382-90 (2010)
-
(2010)
J Biol Chem
, vol.285
, pp. 21382-21390
-
-
Choi, Y.J.1
Im, E.2
Pothoulakis, C.3
Rhee, S.H.4
-
48
-
-
34147116078
-
Biochemical and functional analyses of the human Toll-like receptor 3 ectodomain
-
DOI 10.1074/jbc.M610946200
-
Ranjith-Kumar, C. T., W. Miller, J. Xiong, W. K. Russell, R. Lamb, J. Santos, K. E. Duffy, L. Cleveland, M. Park, K. Bhardwaj, Z. Wu, D. H. Russell, R. T. Sarisky, M. L. Mbow & C. C. Kao: Biochemical and functional analyses of the human Toll-like receptor 3 ectodomain. J Biol Chem, 282, 7668-78 (2007) (Pubitemid 47093703)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.10
, pp. 7668-7678
-
-
Ranjith-Kumar, C.T.1
Miller, W.2
Xiong, J.3
Russell, W.K.4
Lamb, R.5
Santos, J.6
Duffy, K.E.7
Cleveland, L.8
Park, M.9
Bhardwaj, K.10
Wu, Z.11
Russell, D.H.12
Sarisky, R.T.13
Mbow, M.L.14
Kao, C.C.15
-
49
-
-
33745048928
-
The dsRNA binding site of human Toll-like receptor 3
-
DOI 10.1073/pnas.0603245103
-
Bell, J. K., J. Askins, P. R. Hall, D. R. Davies & D. M. Segal: The dsRNA binding site of human Toll-like receptor 3. Proc Natl Acad Sci U S A, 103, 8792-7 (2006) (Pubitemid 43878098)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.23
, pp. 8792-8797
-
-
Bell, J.K.1
Askins, J.2
Hall, P.R.3
Davies, D.R.4
Segal, D.M.5
-
50
-
-
31344466165
-
The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9
-
DOI 10.1038/ni1297, PII N1297
-
Tabeta, K., K. Hoebe, E. M. Janssen, X. Du, P. Georgel, K. Crozat, S. Mudd, N. Mann, S. Sovath, J. Goode, L. Shamel, A. A. Herskovits, D. A. Portnoy, M. Cooke, L. M. Tarantino, T. Wiltshire, B. E. Steinberg, S. Grinstein & B. Beutler: The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9. Nat Immunol, 7, 156-64 (2006) (Pubitemid 43135881)
-
(2006)
Nature Immunology
, vol.7
, Issue.2
, pp. 156-164
-
-
Tabeta, K.1
Hoebe, K.2
Janssen, E.M.3
Du, X.4
Georgel, P.5
Crozat, K.6
Mudd, S.7
Mann, N.8
Sovath, S.9
Goode, J.10
Shamel, L.11
Herskovits, A.A.12
Portnoy, D.A.13
Cooke, M.14
Tarantino, L.M.15
Wiltshire, T.16
Steinberg, B.E.17
Grinstein, S.18
Beutler, B.19
-
51
-
-
34247484007
-
The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling
-
DOI 10.1083/jcb.200612056
-
Brinkmann, M. M., E. Spooner, K. Hoebe, B. Beutler, H. L. Ploegh & Y. M. Kim: The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling. J Cell Biol, 177, 265-75 (2007) (Pubitemid 46658638)
-
(2007)
Journal of Cell Biology
, vol.177
, Issue.2
, pp. 265-275
-
-
Brinkmann, M.M.1
Spooner, E.2
Hoebe, K.3
Beutler, B.4
Ploegh, H.L.5
Kim, Y.-M.6
-
52
-
-
40749098665
-
UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes
-
DOI 10.1038/nature06726, PII NATURE06726
-
Kim, Y. M., M. M. Brinkmann, M. E. Paquet & H. L. Ploegh: UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes. Nature, 452, 234-8 (2008) (Pubitemid 351380247)
-
(2008)
Nature
, vol.452
, Issue.7184
, pp. 234-238
-
-
Kim, Y.-M.1
Brinkmann, M.M.2
Paquet, M.-E.3
Ploegh, H.L.4
-
53
-
-
68949143231
-
Transcriptional regulation of the novel Toll-like receptor Tlr13
-
Shi, Z., Z. Cai, S. Wen, C. Chen, C. Gendron, A. Sanchez, K. Patterson, S. Fu, J. Yang, D. Wildman, R. H. Finnell & D. Zhang: Transcriptional regulation of the novel Toll-like receptor Tlr13. J Biol Chem, 284, 20540-7 (2009)
-
(2009)
J Biol Chem
, vol.284
, pp. 20540-20547
-
-
Shi, Z.1
Cai, Z.2
Wen, S.3
Chen, C.4
Gendron, C.5
Sanchez, A.6
Patterson, K.7
Fu, S.8
Yang, J.9
Wildman, D.10
Finnell, R.H.11
Zhang, D.12
-
54
-
-
23744483354
-
TLR3 in antiviral immunity: Key player or bystander?
-
DOI 10.1016/j.it.2005.07.002, PII S147149060500181X
-
Schroder, M. & A. G. Bowie: TLR3 in antiviral immunity: key player or bystander? Trends Immunol, 26, 462-8 (2005) (Pubitemid 41139255)
-
(2005)
Trends in Immunology
, vol.26
, Issue.9
, pp. 462-468
-
-
Schroder, M.1
Bowie, A.G.2
-
55
-
-
36549072863
-
A protein associated with Toll-like receptor (TLR) 4 (PRAT4A) is required for TLR-dependent immune responses
-
DOI 10.1084/jem.20071132
-
Takahashi, K., T. Shibata, S. Akashi-Takamura, T. Kiyokawa, Y. Wakabayashi, N. Tanimura, T. Kobayashi, F. Matsumoto, R. Fukui, T. Kouro, Y. Nagai, K. Takatsu, S. Saitoh & K. Miyake: A protein associated with Toll-like receptor (TLR) 4 (PRAT4A) is required for TLRdependent immune responses. J Exp Med, 204, 2963-76 (2007) (Pubitemid 350179564)
-
(2007)
Journal of Experimental Medicine
, vol.204
, Issue.12
, pp. 2963-2976
-
-
Takahashi, K.1
Shibata, T.2
Akashi-Takamura, S.3
Kiyokawa, T.4
Wakabayashi, Y.5
Tanimura, N.6
Kobayashi, T.7
Matsumoto, F.8
Fukui, R.9
Kouro, T.10
Nagai, Y.11
Takatsu, K.12
Saitoh, S.-I.13
Miyake, K.14
-
56
-
-
33847260278
-
Heat Shock Protein gp96 Is a Master Chaperone for Toll-like Receptors and Is Important in the Innate Function of Macrophages
-
DOI 10.1016/j.immuni.2006.12.005, PII S1074761307001161
-
Yang, Y., B. Liu, J. Dai, P. K. Srivastava, D. J. Zammit, L. Lefrancois & Z. Li: Heat shock protein gp96 is a master chaperone for toll-like receptors and is important in the innate function of macrophages. Immunity, 26, 215-26 (2007) (Pubitemid 46329432)
-
(2007)
Immunity
, vol.26
, Issue.2
, pp. 215-226
-
-
Yang, Y.1
Liu, B.2
Dai, J.3
Srivastava, P.K.4
Zammit, D.J.5
Lefrancois, L.6
Li, Z.7
-
57
-
-
33744791510
-
Essential role of mda-5 in type I IFN responses to polyriboinosinic: Polyribocytidylic acid and encephalomyocarditis picornavirus
-
DOI 10.1073/pnas.0603082103
-
Gitlin, L., W. Barchet, S. Gilfillan, M. Cella, B. Beutler, R. A. Flavell, M. S. Diamond & M. Colonna: Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus. Proc Natl Acad Sci U S A, 103, 8459-64 (2006) (Pubitemid 43838477)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.22
, pp. 8459-8464
-
-
Gitlin, L.1
Barchet, W.2
Gilfillan, S.3
Cella, M.4
Beutler, B.5
Flavell, R.A.6
Diamond, M.S.7
Colonna, M.8
-
58
-
-
33646342149
-
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
-
Kato, H., O. Takeuchi, S. Sato, M. Yoneyama, M. Yamamoto, K. Matsui, S. Uematsu, A. Jung, T. Kawai, K. J. Ishii, O. Yamaguchi, K. Otsu, T. Tsujimura, C. S. Koh, C. Reis e Sousa, Y. Matsuura, T. Fujita & S. Akira: Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature, 441, 101-5 (2006)
-
(2006)
Nature
, vol.441
, pp. 101-105
-
-
Kato, H.1
Takeuchi, O.2
Sato, S.3
Yoneyama, M.4
Yamamoto, M.5
Matsui, K.6
Uematsu, S.7
Jung, A.8
Kawai, T.9
Ishii, K.J.10
Yamaguchi, O.11
Otsu, K.12
Tsujimura, T.13
Koh, C.S.14
Reis Sousa, E.C.15
Matsuura, Y.16
Fujita, T.17
Akira, S.18
-
59
-
-
34547953017
-
Lysosome-associated small Rab GTPase Rab7b negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4
-
DOI 10.1182/blood-2007-01-066027
-
Wang, Y., T. Chen, C. Han, D. He, H. Liu, H. An, Z. Cai & X. Cao: Lysosome-associated small Rab GTPase Rab7b negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Blood, 110, 962-71 (2007) (Pubitemid 47267435)
-
(2007)
Blood
, vol.110
, Issue.3
, pp. 962-971
-
-
Wang, Y.1
Chen, T.2
Han, C.3
He, D.4
Liu, H.5
An, H.6
Cai, Z.7
Cao, X.8
-
60
-
-
68149132205
-
Late endosome/lysosome-localized Rab7b suppresses TLR9-initiated proinflammatory cytokine and type i IFN production in macrophages
-
Yao, M., X. Liu, D. Li, T. Chen, Z. Cai & X. Cao: Late endosome/lysosome-localized Rab7b suppresses TLR9-initiated proinflammatory cytokine and type I IFN production in macrophages. J Immunol, 183, 1751-8 (2009)
-
(2009)
J Immunol
, vol.183
, pp. 1751-1758
-
-
Yao, M.1
Liu, X.2
Li, D.3
Chen, T.4
Cai, Z.5
Cao, X.6
-
61
-
-
2442643942
-
Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors
-
DOI 10.1038/ni1066
-
Chuang, T. H. & R. J. Ulevitch: Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors. Nat Immunol, 5, 495-502 (2004) (Pubitemid 38660461)
-
(2004)
Nature Immunology
, vol.5
, Issue.5
, pp. 495-502
-
-
Chuang, T.-H.1
Ulevitch, R.J.2
-
62
-
-
75649113377
-
Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21
-
Sheedy, F. J., E. Palsson-McDermott, E. J. Hennessy, C. Martin, J. J. O'Leary, Q. Ruan, D. S. Johnson, Y. Chen & L. A. O'Neill: Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21. Nat Immunol, 11, 141-7 (2010)
-
(2010)
Nat Immunol
, vol.11
, pp. 141-147
-
-
Sheedy, F.J.1
Palsson-Mcdermott, E.2
Hennessy, E.J.3
Martin, C.4
O'Leary, J.J.5
Ruan, Q.6
Johnson, D.S.7
Chen, Y.8
O'Neill, L.A.9
-
64
-
-
68849085894
-
A cell biological view of Toll-like receptor function: Regulation through compartmentalization
-
Barton, G. M. & J. C. Kagan: A cell biological view of Toll-like receptor function: regulation through compartmentalization. Nat Rev Immunol, 9, 535-42 (2009)
-
(2009)
Nat Rev Immunol
, vol.9
, pp. 535-542
-
-
Barton, G.M.1
Kagan, J.C.2
|