Biology of the Mi-2/NuRD complex in SLAC (Stemness, Lonagevity/Ageing, and Cancer)

Gene Regulation and Systems Biology

Volumn 2011, Issue 5, 2011, Pages 1-26

  Zhang, Yue ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

4 2 1 SLAC; Ageing; Caenorhabditis elegans; Cancer; Longevity; Mammals; Mi 2 NuRD; Stemness

Indexed keywords

GLUCAGON LIKE PEPTIDE 1; HEAT SHOCK PROTEIN; HISTONE DEACETYLASE; LAMIN A; MAMMALIAN TARGET OF RAPAMYCIN; RNA;

AGING; CAENORHABDITIS ELEGANS; CANCER PREVENTION; CANCER STEM CELL; CELL COUNT; CELL METABOLISM; COMPLEX FORMATION; CONTROLLED STUDY; DEACETYLATION; DNA REPAIR; EMBRYONIC STEM CELL; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; GENE FUNCTION; GENOMIC INSTABILITY; LIFESPAN; LONGEVITY; NONHUMAN; PLURIPOTENT STEM CELL; PROTEIN TARGETING; REVIEW; RNA SPLICING; SIGNAL TRANSDUCTION;

CAENORHABDITIS ELEGANS; MAMMALIA;

EID: 79958806259     PISSN: 11776250     EISSN: None     Source Type: Journal    
DOI: 10.4137/GRSB.S6510     Document Type: Review

References (163)

1. Rosch PJ. Stress and cancer: Disorders of communication, control, and civilization. In: Handbook of Stress, Medicine, and Health. Boca Raton, FL: CRC Press Inc; 1996.
2. Cao L, Liu X, Lin EJ, Wang C, et al. Environmental and genetic activation of a brain-adipocyte BDNF/leptin axis causes cancer remission and inhibition. Cell. 2010;142:52-64.
3. Blagosklonny MV. Why human lifespan is rapidly increasing: Solving "longevity riddle" with "revealed-slow-aging" hypothesis. Aging (Albany NY). 2010;2:177-82.
4. David AR, Zimmerman MR. Cancer: An old disease, a new disease or something in between? Nature Reviews Cancer. 2010;10:728-33.
5. Ho L, Crabtree GR. Chromatin remodelling during development. Nature. 2010;463:474-84.
6. Zhang Y, Li Y. The expanding Mi-2/NuRD complexes: A schematic glance. Proteomics Insights. 2010;3:79-109.
7. Denslow SA, Wade PA. The human Mi-2/NuRD complex and gene regulation. Oncogene. 2007;26:5433-8.
8. Ramírez J, Hagman J. The Mi-2/NuRD complex: A critical epigenetic regulator of hematopoietic development, differentiation and cancer. Epigenetics. 2009;4:532-6.
9. Peric-Hupkes D, Meuleman W, Pagie L, et al. Molecular maps of the reorganization of genome-nuclear lamina interactions during differentiation. Mol Cell. 2010;38:603-13.
10. Ng HH, Bird A. Histone deacetylases: Silencers for hire. Trends Biochem Sci. 2000;25:121-6.
11. Struhl K. Histone acetylation and transcriptional regulatory mechanisms. Genes Dev. 1998;12:599-606.
12. Wang Y, Zhang H, Chen Y, et al. LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer. Cell. 2009;138:660-72.
13. Curran SP, Wu X, Riedel CG, Ruvkun G. A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants. Nature. 2009;459: 1079-84.
14. Scaffidi P, Misteli T. Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing. Nat Cell Biol. 2008;10:452-9.
15. Yamanaka S. Elite and stochastic models for induced pluripotent stem cell generation. Nature. 2009;460:49-52.
16. Lendahl U, Orrenius S, Brenner S, Horvitz R, Sulston J. Genetic regulation of organ development and programmed cell death. Lakartidningen. 2002;99:4026-32. Swedish.
17. Bernards R. The Nobel Prize in Physiology or Medicine for 2006 for the discovery of RNA interference. Ned Tijdschr Geneeskd. 2006;150:2849-53. Dutch.
18. Chalfie M. The 2009 Lindau Nobel Laureate meeting: Martin Chalfie, Chemistry 2008. J Vis Exp. 2010;36:1570.
19. Ruvkun G. The perfect storm of tiny RNAs. Nat Med. 2008;14:1041-5.
20. Johnson TE. For the special issue: The nematode Caenorhabditis elegans in aging research. Exp Gerontol. 2006;41:887-9.
21. Kenyon C. My adventures with genes from the fountain of youth. Harvey Lect. 2004-2005;100:29-70.
22. Pinkston-Gosse J, Kenyon C. DAF-16/FOXO targets genes that regulate tumor growth in Caenorhabditis elegans. Nat Genet. 2007;39:1403-9.
23. Kirienko NV, Mani K, Fay DS. Cancer models in Caenorhabditis elegans. Dev Dyn. 2010;239:1413-48.
24. Nimmo RA, Slack FJ. An elegant miRror: MicroRNAs in stem cells, developmental timing and cancer. Chromosoma. 2009;118:405-18.
25. Liang J, Wan M, Zhang Y, et al. Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells. Nat Cell Biol. 2008;10:731-9.
26. Koch HB, Zhang R, Verdoodt B, et al. Large-scale identification of c-MYCassociated proteins using a combined TAP/MudPIT approach. Cell Cycle. 2007;6:205-17.
27. Feng B, Jiang J, Kraus P, et al. Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb. Nat Cell Biol. 2009;11:197-203.
28. Van den Berg DL, Snoek T, Mullin NP, et al. An Oct4-centered protein interaction network in embryonic stem cells. Cell Stem Cell. 2010;6:369-81.
29. Pardo M, Lang B, Yu L, et al. An expanded Oct4 interaction network: Implications for stem cell biology, development, and disease. Cell Stem Cell. 2010;6:382-95.
30. Tai MH, Chang CC, Kiupel M, et al. Oct4 expression in adult human stem cells: Evidence in support of the stem cell theory of carcinogenesis. Carcinogenesis. 2005;26:495-502.
31. Jaenisch R, Young R. Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming. Cell. 2008;132:567-82K.
32. Okita K, Ichisaka T, Yamanaka S. Generation of germline-competent induced pluripotent stem cells. Nature. 2007;448:313-7.
33. Lauberth SM, Rauchman M. A conserved 12-amino acid motif in Sall1 recruits the nucleosome remodeling and deacetylase corepressor complex. J Biol Chem. 2006;281:23922-31.
34. Kanga J, Shakyaa A, Tantina D. Stem cells, stress, metabolism and cancer: A drama in two Octs. Trends Biochem Sci. 2009;34:491-9.
35. Bultman S, Gebuhr T, Yee D, et al. A Brg1 null mutation in the mouse reveals functional differences among mammalian SWI/SNF complexes. Mol Cell. 2000;6:1287-95.
36. Yan Z, Wang Z, Sharova L, et al. BAF250B-associated SWI/SNF chromatinremodeling complex is required to maintain undifferentiated mouse embryonic stem cells. Stem Cells. 2008;26:1155-65.
37. Ho L, Jothi R, Ronan JL, Cui K, Zhao K, Crabtree GR. An embryonic stem cell chromatin remodeling complex, esBAF, is an essential component of the core pluripotency transcriptional network. Proc Natl Acad Sci U S A. 2009;106:5187-91.
38. Singhal N, Graumann J, Wu G, Araúzo-Bravo MJ, et al. Chromatin-remodeling components of the BAF complex facilitate reprogramming. Cell. 2010;141:943-55.
39. Ng SY, Yoshida T, Georgopoulos K. Ikaros and chromatin regulation in early hematopoiesis. Curr Opin Immunol. 2007;19:116-22.
40. Laslo P, Spooner CJ, Warmflash A, et al. Multilineage transcriptional priming and determination of alternate hematopoietic cell fates. Cell. 2006;126: 755-66.
41. Yoshida T, Hazan I, Zhang J, et al. The role of the chromatin remodeler Mi-2beta in hematopoietic stem cell self-renewal and multilineage differentiation. Genes Dev. 2008;22:1174-89.
42. Unhavaithaya Y, Shin TH, Miliaras N, Lee J, Oyama T, Mello CC. MEP-1 and a homolog of the NURD complex component Mi-2 act together to maintain germline-soma distinctions in C. elegans. Cell. 2002;111:991-1002.
43. Wang J, Rao S, Chu J, et al. A protein interaction network for pluripotency of embryonic stem cells. Nature. 2006;444:364-8.
44. Cui M, Kim EB, Han M. Diverse chromatin remodeling genes antagonize the Rb-involved SynMuv pathways in C. elegans. PLoS Genet. 2006;2:e74.
45. Takasaki T, Liu Z, Habara Y, et al. MRG-1, an autosome-associated protein, silences X-linked genes and protects germline immortality in Caenorhabditis elegans. Development. 2007;134:757-67.
46. Wang D, Kennedy S, Conte D Jr, et al. Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants. Nature. 2005;436:593-7.
47. Sun G, Alzayady K, Stewart R, et al. Histone demethylase LSD1 regulates neural stem cell proliferation. Mol Cell Biol. 2010;30:1997-2005.
48. Aguirre A, Rubio ME, Gallo V. Notch and EGFR pathway interaction regulates neural stem cell number and self-renewal. Nature. 2010;467: 323-7.
49. Yoo AS, Bais C, Greenwald I. Crosstalk between the EGFR and LIN-12/Notch pathways in C. elegans vulval development. Science. 2004;303:663-6.
50. Sternberg PW. Developmental biology. A pattern of precision. Science. 2004;303:637-8.
51. Dufourcq P, Victor M, Gay F, Calvo D, Hodgkin J, Shi Y. Functional requirement for histone deacetylase 1 in Caenorhabditis elegans gonadogenesis. Mol Cell Biol. 2002;22:3024-34.
52. Poulin G, Dong Y, Fraser AG, Hopper NA, Ahringer J. Chromatin regulation and sumoylation in the inhibition of Ras-induced vulval development in Caenorhabditis elegans. EMBO J. 2005;24:2613-23.
53. Kaji K, Caballero IM, MacLeod R, Nichols J, Wilson VA, Hendrich B. The NuRD component MBD3 is required for pluripotency of embryonic stem cells. Nat Cell Biol. 2006;8:285-92.
54. Kaji K, Nichols J, Hendrich B. MBD3, a component of the NuRD co-repressor complex, is required for development of pluripotent cells. Development. 2007;134:1123-32.
55. Zhu D, Fang J, Li Y, Zhang J. MBD3, a component of NuRD/Mi-2 complex, helps maintain pluripotency of mouse embryonic stem cells by repressing trophectoderm differentiation. PLoS One. 2009;4:e7684.
56. Prokocimer M, Davidovich M, Nissim-Rafinia M, et al. Nuclear lamins: Key regulators of nuclear structure and activities. J Cell Mol Med. 2009;13: 1059-85.
57. Kumaran RI, Muralikrishna B, Parnaik VK. Lamin A/C speckles mediate spatial organization of splicing factor compartments and RNA polymerase II transcription. J Cell Biol. 2002;159:783-93.
58. Spann TP, Goldman AE, Wang C, Huang S, Goldman RD. Alteration of nuclear lamin organization inhibits RNA polymerase II-dependent transcription. J Cell Biol. 2002;156:603-8.
59. Mancini MA, Shan B, Nickerson JA, Penman S, Lee WH. The retinoblastoma gene product is a cell cycle-dependent, nuclear matrix-associated protein. Proc Natl Acad Sci U S A. 1994;91:418-22.
60. Jagatheesan G, Thanumalayan S, Muralikrishna B, Rangaraj N, Karande AA, Parnaik VK. Colocalization of intranuclear lamin foci with RNA splicing factors. J Cell Sci. 1999;112:4651-61.
61. Constantinescu D, Gray HL, Sammak PJ, Schatten GP, Csoka AB. Lamin A expression is a marker of mouse and human embryonic stem cell differentiation. Stem Cells. 2006;24:177-85.
62. Maherali N, Sridharan R, Xie W, et al. Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution. Cell Stem Cell. 2007;1:55-70.
63. Takahashi K, Tanabe K, Ohnuki M, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 2007;131:861-72.
64. Kim JB, Zaehres H, Wu G, et al. Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors. Nature. 2008;454: 646-50.
65. Yu J, Vodyanik MA, Smuga-Otto K, et al. Induced pluripotent stem cell lines derived from human somatic cells. Science. 2007;318:1917-20.
66. Bru T, Clarke C, McGrew MJ, Sang HM, Wilmut I, Blow JJ. Rapid induction of pluripotency genes after exposure of human somatic cells to mouse ES cell extracts. Exp Cell Res. 2008;314:2634-42.
67. Paradisi M, McClintock D, Boguslavsky RL, Pedicelli C, Worman HJ, Djabali K. Dermal fibroblasts in Hutchinson-Gilford progeria syndrome with the lamin A G608G mutation have dysmorphic nuclei and are hypersensitive to heat stress. BMC Cell Biol. 2005;6:27.
68. Andrés V, González JM. Role of A-type lamins in signaling, transcription, and chromatin organization. J Cell Biol. 2009;187:945-57.
69. Halaschek-Wiener J, Brooks-Wilson A. Progeria of stem cells: Stem cell exhaustion in Hutchinson-Gilford progeria syndrome. J Gerontol A Biol Sci Med Sci. 2007;62:3-8.
70. Csoka AB, English SB, Simkevich CP, et al. Genome-scale expression profiling of Hutchinson-Gilford progeria syndrome reveals widespread transcriptional misregulation leading to mesodermal/mesenchymal defects and accelerated atherosclerosis. Aging Cell. 2004;3:235-43.
71. Whetstine JR, Ceron J, Ladd B, Dufourcq P, Reinke V, Shi Y. Regulation of tissue-specific and extracellular matrix-related genes by a class I histone deacetylase. Mol Cell. 2005;18:483-90.
72. Arantes-Oliveira N, Apfeld J, Dillin A, Kenyon C. Regulation of life-span by germ-line stem cells in Caenorhabditis elegans. Science. 2002;295:502-5.
73. Warner HR, Sierra F. Models of accelerated ageing can be informative about the molecular mechanisms of ageing and/or age-related pathology. Mech Ageing Dev. 2003 May;124:581-7.
74. Von Zelewsky T, Palladino F, Brunschwig K, Tobler H, Hajnal A, Müller F. The C. elegans Mi-2 chromatin-remodelling proteins function in vulval cell fate determination. Development. 2000;127:5277-84.
75. Guerry F, Marti CO, Zhang Y, Moroni PS, Jaquiéry E, Müller F. The Mi-2 nucleosome-remodeling protein LET-418 is targeted via LIN-1/ETS to the promoter of lin-39/Hox during vulval development in C. elegans. Dev Biol. 2007;306:469-79.
76. Zhang Y. Identification of differentially expressed target genes of human nucleosome remodelling Mi-2 orthologue LET-418 in C. elegans. University of Fribourg, PhD Thesis; 2006.
77. Khaleque MA, Bharti A, Gong J, et al. Heat shock factor 1 represses estrogen-dependent transcription through association with MTA1. Oncogene. 2008;27:1886-93.
78. Valgardsdottir R, Chiodi I, Giordano M, et al. Transcription of Satellite III non-coding RNAs is a general stress response in human cells. Nucleic Acids Res. 2008;36:423-34.
79. Shumaker DK, Dechat T, Kohlmaier A, et al. Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging. Proc Natl Acad Sci U S A. 2006;103:8703-8.
80. Enukashvily NI, Donev R, Waisertreiger IS, Podgornaya OI. Human chromosome 1 satellite 3 DNA is decondensed, demethylated and transcribed in senescent cells and in A431 epithelial carcinoma cells. Cytogenet Genome Res. 2007;118:42-54.
81. Eymery A, Calllanan M and Vourch C. The secret message of heterochromatin new insights into the mechanisms and function of centromeric and pericentric repeat sequence transcription. Int. J. Dev. Biol. 2009;53:259-268.
82. Faulkner J, Keirstead HS. Human embryonic stem cell-derived oligodendrocyte progenitors for the treatment of spinal cord injury. Transpl Immunol. 2005;15:131-42.
83. Volpe TA, Kidner C, Hall IM, Teng G, Grewal SI, Martienssen RA. Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi. Science. 2002;297:1833-7.
84. Thyagarajan B, Blaszczak AG, Chandler KJ, Watts JL, Johnson WE, Graves BJ. ETS-4 is a transcriptional regulator of life span in Caenorhabditis elegans. PLoS Genet. 2010;6:e1001125.
85. Lapointe J, Hekimi S. When a theory of aging ages badly. Cell Mol Life Sci. 2010;67:1-8.
86. Apfeld J, O'Connor G, McDonagh T, DiStefano PS, Curtis R. The AMPactivated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans. Genes Dev. 2004;18:3004-9.
87. Lithgow GJ, White TM, Melov S, Johnson TE. Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress. Proc Natl Acad Sci U S A. 1995;92:7540-4.
88. Hsu AL, Murphy CT, Kenyon C. Regulation of aging and age-related disease by DAF-16 and heat-shock factor. Science. 2003;300:1142-5.
89. Houthoofd K, Braeckman BP, Johnson TE, Vanfleteren JR. Extending lifespan in C. elegans. Science. 2004;305:1238-9.
90. Alcedo J, Kenyon C. Regulation of C. elegans longevity by specific gustatory and olfactory neurons. Neuron. 2004;41:45-55.
91. Haithcock E, Dayani Y, Neufeld E, et al. Age-related changes of nuclear architecture in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2005;102: 16690-5.
92. Lammerding J, Hsiao J, Schulze PC, Kozlov S, Stewart CL, Lee RT. Abnormal nuclear shape and impaired mechanotransduction in emerindeficient cells. J Cell Biol. 2005;170:781-91.
93. McKenna NJ, O'Malley BW. Nuclear receptors I. Cell. 2010;142:822.
94. Mooijaart SP, Kuningas M, Westendorp RG, et al. Liver X receptor alpha associates with human life span. J Gerontol A Biol Sci Med Sci. 2007;62: 343-9.
95. Li X, Zhang S, Blander G, Tse JG, Krieger M, Guarente L. SIRT1 deacetylates and positively regulates the nuclear receptor LXR. Mol Cell. 2007;28: 91-106.
96. Vellai T, Takacs-Vellai K, Zhang Y, Kovacs AL, Orosz L, Müller F. Genetics: Influence of TOR kinase on lifespan in C. elegans. Nature. 2003; 426:620.
97. Kapahi P, Chen D, Rogers, et al. With TOR, less is more: A key role for the conserved nutrient-sensing TOR pathway in aging. Cell Metab. 2010;11: 453-65.
98. Burtner CR, Kennedy BK. Progeria syndromes and ageing: What is the connection? Nat Rev Mol Cell Biol. 2010;11:567-78.
99. Carver BS, Tran J, Chen Z, et al. ETS rearrangements and prostate cancer initiation. Nature. 2009;457:E1.
100. Nardella C, Carracedo A, Alimonti A, et al. Differential requirement of mTOR in postmitotic tissues and tumorigenesis. Sci Signal. 2009; 27:2ra2.
101. Angelo G, Van Gilst MR. Starvation protects germline stem cells and extends reproductive longevity in C. elegans. Science. 2009;326:954-8.
102. McColl G, Killilea DW, Hubbard AE, Vantipalli MC, Melov S, Lithgow GJ. Pharmacogenetic analysis of lithium-induced delayed aging in Caenorhabditis elegans. J Biol Chem. 2008;283:350-7.
103. Li DQ, Kumar R. Mi-2/NuRD complex making inroads into DNA-damage response pathway. Cell Cycle. 2010:9(11). [Epub ahead of print].
104. Larsen DH, Poinsignon C, Gudjonsson T, et al. The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage. J Cell Biol. 2010;190:731-40.
105. Smeenk G, Wiegant WW, Vrolijk H, Solari AP, Pastink A, van Attikum H. The NuRD chromatin-remodeling complex regulates signaling and repair of DNA damage. J Cell Biol. 2010;190:741-9.
106. Polo SE, Kaidi A, Baskcomb L, Galanty Y, Jackson SP. Regulation of DNA-damage responses and cell-cycle progression by the chromatin remodelling factor CHD4. EMBO J. 2010;29:3130-9.
107. Gurdon JB. Adult frogs derived from the nuclei of single somatic cells. Dev Biol. 1962;4:256-73.
108. Zhang Y, Zhu X. Progress of fish gene technology research in China. Aquaculture Asia. 2002;7:15-6.
109. Yu L, Zuo W, et al. Cell-engineering grass carp produced by the combination of electric fusion and nuclear transplantation. J Fishery China. 1996;20:314-8.
110. Hochedlinger K, Jaenisch R. Monoclonal mice generated by nuclear transfer from mature B and T donor cells. Nature. 2002;415:1035-8.
111. Campbell KH, McWhir J, Ritchie WA, Wilmut I. Sheep cloned by nuclear transfer from a cultured cell line. Nature. 1996;380:64-6.
112. Weimann JM, Johansson CB, Trejo A, Blau HM. Stable reprogrammed heterokaryons form spontaneously in Purkinje neurons after bone marrow transplant. Nat Cell Biol. 2003;5:959-66.
113. Yamanaka S. Strategies and new developments in the generation of patientspecific pluripotent stem cells. Cell Stem Cell. 2007;1(1):39-49.
114. Schambach A, Cantz T, Baum C, Cathomen T. Generation and genetic modification of induced pluripotent stem cells. Expert Opin Biol Ther. 2010;10:1089-103.
115. Ding S, Schultz PG. A role for chemistry in stem cell biology. Nat Biotechnol. 2004;22:833-40.
116. Kaji K, Norrby K, Paca A, Mileikovsky M, Mohseni P, Woltjen K. Virus- free induction of pluripotency and subsequent excision of reprogramming factors. Nature. 2009;458:771-5.
117. Zhao R, Daley GQ. From fibroblasts to iPS cells: Induced pluripotency by defined factors. J Cell Biochem. 2008;105:949-55.
118. Warren L, Manos PD, Ahfeldt T, et al. Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. Cell Stem Cell. 2010;7:618-30.
119. Mikkelsen TS, Hanna J, Zhang X, et al. Dissecting direct reprogramming through integrative genomic analysis. Nature. 2008;454:49-55.
120. Feng B, Ng JH, Heng JC, Ng HH. Molecules that promote or enhance reprogramming of somatic cells to induced pluripotent stem cells. Cell Stem Cell. 2009;4:301-12.
121. Judson RL, Babiarz JE, Venere M, Blelloch R. Embryonic stem cell- specific microRNAs promote induced pluripotency. Nat Biotechnol. 2009; 27:459-61.
122. Ieda M, Fu JD, Delgado-Olguin P, et al. Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell. 2010;142: 375-86.
123. Roche AE, Bassett BJ, Samant SA, Hong W, Blobel GA, Svensson EC. The zinc finger and C-terminal domains of MTA proteins are required for FOG-2-mediated transcriptional repression via the NuRD complex. J Mol Cell Cardiol. 2008;44:352-60.
124. Kim K, Doi A, Wen B, et al. Epigenetic memory in induced pluripotent stem cells. Nature. 2010;467:285-90.
125. Chin MH, Mason MJ, Xie W, et al. Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures. Cell Stem Cell. 2009;5:111-23.
126. Marchetto MCN, Yeo GW, Kainohana O, Marsala M, Gage FH, Muotri AR. Transcriptional signature and memory retention of human-induced pluripotent stem cells. PLoS ONE. 2009;4:e7076.
127. Dolgin E. Gene flaw found in induced stem cells. Nature. 2010;464:663.
128. Gutierrez-Aranda I, Ramos-Mejia V, Bueno C, et al. Human induced pluripotent stem cells develop teratoma more efficiently and faster than human embryonic stem cells regardless the site of injection. Stem Cells. 2010;28: 1568-70.
129. Hu Q, Friedrich AM, Johnson LV, Clegg DO. Memory in induced pluripotent stem cells: Reprogrammed human retinal pigmented epithelial cells show tendency for spontaneous redifferentiation. Stem Cells. 2010;28: 1981-91.
130. Guenther MG, Frampton GM, Soldner F, et al. Chromatin structure and gene expression programs of human embryonic and induced pluripotent stem cells. Cell Stem Cell. 2010;7:249-57.
131. Newman AM, Cooper JB. Lab-specific gene expression signatures in pluripotent stem cells. Cell Stem Cell. 2010;7:258-62.
132. Xu N, Papagiannakopoulos T, Pan G, Thomson JA, Kosik KS. MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells. Cell. 2009;137:647-58.
133. Liu Y, Clem B, Zuba-Surma EK, et al. Mouse fibroblasts lacking RB1 function form spheres and undergo reprogramming to a cancer stem cell phenotype. Cell Stem Cell. 2009;4:336-47.
134. Yu F, Yao H, Zhu P, et al. let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell. 2007;131:1109-23.
135. Hammond SM, Sharpless NE. HMGA2, microRNAs, and stem cell aging. Cell. 2008;135:1013-6.
136. Shamovsky I, Ivannikov M, Kandel ES, Gershon D, Nudler E. RNA-mediated response to heat shock in mammalian cells. Nature. 2006;440: 556-60.
137. Caretti G, Lei EP, Sartorelli V. The DEAD-box p68/p72 proteins and the noncoding RNA steroid receptor activator SRA: Eclectic regulators of disparate biological functions. Cell Cycle. 2007;6:1172-6.
138. Carter CL, Lin C, Liu CY, Yang L, Liu ZR. Phosphorylated p68 RNA helicase activates Snail1 transcription by promoting HDAC1 dissociation from the Snail1 promoter. Oncogene. 2010;29:5427-36.
139. DeBerardinis RJ, Lum JJ, Hatzivassiliou G, Thompson CB. The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation. Cell Metab. 2008;7:11-20.
140. Finkel T, Serrano M, Blasco MA. The common biology of cancer and ageing. Nature. 2007;448:767-74.
141. Fisher AL, Page KE, Lithgow GJ, Nash L. The Caenorhabditis elegans K10C2.4 gene encodes a member of the fumarylacetoacetate hydrolase family: A Caenorhabditis elegans model of type I tyrosinemia. J Biol Chem. 2008;283:9127-35.
142. Krizhanovsky V, Lowe SW. Stem cells: The promises and perils of p53. Nature. 2009;460:1085-6.
143. Nicklin P, Bergman P, Zhang B, et al. Bidirectional transport of amino acids regulates mTOR and autophagy. Cell. 2009;136:521-34.
144. Hanna J, Saha K, Pando B, et al. Direct cell reprogramming is a stochastic process amenable to acceleration. Nature. 2009;462:595-601.
145. Yamagoe S, Kanno T, Kanno Y, et al. Interaction of histone acetylases and deacetylases in vivo. Mol Cell Biol. 2003;23:1025-33.
146. Sharma SV, Lee DY, Li B, et al. A chromatin-mediated reversible drugtolerant state in cancer cell subpopulations. Cell. 2010;141:69-80.
147. Vilaboa NE, Galán A, Troyano A, de Blas E, Aller P. MDR1 regulation of multidrug resistance 1 (MDR1)/P-glycoprotein gene expression and activity by heat-shock transcription factor 1 (HSF1). J Biol Chem. 2000;275: 24970-6.
148. Magdinier F, Wolffe AP. Selective association of the methyl-CpG binding protein MBD2 with the silent p14/p16 locus in human neoplasia. Proc Natl Acad Sci U S A. 2001;98:4990-5.
149. Lemos Taíla A, Passos Dario O, Nery Flávia C, Kobarg. Characterization of a new family of proteins that interact with the C-terminal region of the chromatin-remodeling factor CHD-3. FEBS Lett. 2003;533:14-20.
150. Akhtar A, Zink D, Becker PB. Chromodomains are protein-RNA interaction modules. Nature. 2000;407(6802):405-9.
151. Vesuna F, Lisok A, Kimble B, Raman V. Twist modulates breast cancer stem cells by transcriptional regulation of CD24 expression. Neoplasia. 2009;11:1318-28.
152. Dang CV. MYC, microRNAs and glutamine addiction in cancers. Cell Cycle. 2009;8:3243-5.
153. Rothenberg ME, Clarke MF, Diehn M. The Myc connection: ES cells and cancer. Cell. 2010;143:184-6.
154. Helbling Chadwick L, Chadwick BP, Jaye DL, Wade PA. The Mi-2/ NuRD complex associates with pericentromeric heterochromatin during S phase in rapidly proliferating lymphoid cells. Chromosoma. 2009;118: 445-57.
155. Wu SC, Zhang Y. Active DNA demethylation: many roads lead to Rome. Nat Rev Mol Cell Biol. 2010 Sep;11(9):607-20. Epub 2010 Aug 4.
156. Karberg S. Switching on Epigenetic Therapy. 2009;139(6):1029-31.
157. Lanz RB, O'Malley BW, Qin J. Streamlined analysis schema for highthroughput identification of endogenous protein complexes. Proc Natl Acad Sci U S A. 2010;107:2431-6.
158. Deshpande AM, Dai YS, Kim Y, et al. Cdk2ap1 is required for epigenetic silencing of Oct4 during murine embryonic stem cell differentiation. J Biol Chem. 2009;284:6043-7.
159. Zhang Y. ETS-Fusions networking, triggering and beyond. Genetics and Epigenetics. 2010:31-4.
160. Zhao J, Ohsumi TK, Kung JT, et al. Genome-wide Identification of Polycomb-Associated RNAs by RIP-seq. Molecular Cell. 2010;40(960): 939-53.
161. Zhang Y. Rough set soft computing cancer classification and network: One stone, two birds. Cancer Inform. 2010;9:139-45.
162. Shahrestani P, Mueller LD, Rose MR. Does aging stop? Curr Aging Sci. 2009;2:3-11.
163. Ayyadevara S, Alla R, Thaden JJ, Shmookler Reis RJ. Remarkable longevity and stress resistance of nematode PI3K-null mutants. Aging Cell. 2008; 7:13-22.