The Mi-2/NuRD complex: A critical epigenetic regulator of hematopoietic development, differentiation and cancer

Epigenetics

Volumn 4, Issue 8, 2009, Pages 532-536

  Ramírez, Julita ^a   Hagman, James ^a  

^a DEPARTMENT OF MEDICINE   (United States)

Author keywords

B cell; Chromatin remodeling; Histone deacetylation; Histone demethylation; Leukemogenesis; Mi 2 ; Oncogenesis; T cell; Transcription

Indexed keywords

ADENOSINE TRIPHOSPHATASE; HISTONE; MULTIPROTEIN COMPLEX; PROTEIN MI 2 NURD; PROTEIN SUBUNIT; PROTEIN SWI; TRANSCRIPTION FACTOR SNF; UNCLASSIFIED DRUG;

CARCINOGENESIS; CELL DIFFERENTIATION; CELL LINEAGE; CHROMATIN ASSEMBLY AND DISASSEMBLY; DEACETYLATION; DEMETHYLATION; EPIGENETICS; GENETIC REGULATION; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HUMAN; NONHUMAN; NUCLEOSOME; PROTEIN FUNCTION; REVIEW; TRANSCRIPTION REGULATION;

METAZOA; PYRONIA TITHONUS;

EID: 74549137552     PISSN: 15592294     EISSN: 15592308     Source Type: Journal    
DOI: 10.4161/epi.4.8.10108     Document Type: Review

References (30)

1. Cairns BR. The logic of chromatin architecture and remodelling at promoters. Nature 2009; 461:193-8.
2. Zhang Y, LeRoy G, Seelig HP, Lane W, Reinberg D. The dermatomyositis- specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities. Cell 1998; 95:279-89.
3. Tong JK, Hassig CA, Schnitzler GR, Kingston RE, Schreiber SL. Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex. Nature 1998; 395:917-21.
4. Xue Y, Wong J, Moreno TG, Young MK, Côté J, Wang W. NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities. Mol Cell 1998; 2:851-61.
5. Bowen NJ, Fujita N, Kajita M, Wade P. Mi-2/NuRD: multiple complexes for many purposes. Biochim Biophys Acta 2004; 1677:52-7.
6. Kim J, Sif S, Jones B, Jackson A, Koipally J, Heller E, et al. Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes. Immunity 1999; 10:345-55.
7. Koipally J, Renold A, Kim J, Georgopoulos K. Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes. EMBO J 1999; 18:3090-100.
8. Sridharan R, Smale ST. Predominant interaction of both Ikaros and Helios with the NuRD complex in immature thymocytes. J Biol Chem 2007; 282:30227-38.
9. Gao H, Lukin K, Ramírez J, Fields S, Lopez D, Hagman J. Opposing effects of SWI/SNF and Mi-2/NuRD chromatin remodeling complexes on epigenetic reprogramming by EBF and Pax5. Proc Natl Acad Sci USA 2009; 106:11258-63.
10. Maier H, Colbert J, Fitzsimmons D, Clark DR, Hagman J. Activation of the early B-cell-specific mb-1 (Igα) gene by Pax-5 is dependent on an unmethylated Ets binding site. Mol Cell Biol 2003; 23:1946-60.
11. Sigvardsson M, Clark DR, Fitzsimmons D, Doyle M, Akerblad P, Breslin T, et al. Early B-cell factor, E2A and Pax-5 cooperate to activate the early B cell-specific mb-1 promoter. Mol Cell Biol 2002; 22:8539-51.
12. Ramirez-Carrozzi V, Nazarian A, Li C, Gore S, Sridharan R, Imbalzano A, Smale S. Selective and antagonistic functions of SWI/SNF and Mi-2β nucleosome remodeling complexes during an inflammatory response. Genes Dev 2006; 20:282-9.
13. Williams C, Naito T, Gomex-del Arco P, Seavitt J, Cashman S, De Souza B, et al. The chromatin remodeler Mi-2β is required for CD4 gene expression and T cell development. Immunity 2004; 20:719-33.
14. Naito T, Gómez-del Arco P, Williams CJ, Georgopoulos K. Antagonistic interactions between Ikaros and the chromatin remodeler Mi-2β determine silencer activity and Cd4 gene expression. Immunity 2007; 27:723-34.
15. Fujita N, Jaye D, Geigerman C, Akyildiz A, Mooney M, Boss J, Wade P. MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation. Cell 2004; 119:75-86.
16. Fujita N, Jaye DL, Kajita M, Geigerman C, Moreno CS, Wade PA. MTA3, a Mi-2/NuRD complex sub-unit, regulates an invasive growth pathway in breast cancer. Cell 2003; 113:207-19.
17. Yoshida T, Hazan I, Zhang J, Ng SY, Naito T, Snippert HJ, et al. The role of the chromatin remodeler Mi-2β in hematopoietic stem cell self-renewal and multilineage differentiation. Genes Dev 2008; 22:1174-89.
18. Hong W, Nakazawa M, Chen YY, Kori R, Vakoc CR, Rakowski C, Blobel GA. FOG-1 recruits the NuRD repressor complex to mediate transcriptional repression by GATA-1. EMBO J 2005 24:2367-78.
19. Harju-Baker S, Costa FC, Fedosyuk H, Neades R, Peterson KR. Silencing of Aγ-globin gene expression during adult definitive erythropoiesis mediated by GATA-1-FOG-1-Mi2 complex binding at the -566 GATA site. Mol Cell Biol 2008; 28:3101-13.
20. Sigurgeirsson S, Lindelöf B, Edhag O, Allander E. Risk of cancer in patients with dermatomyositis or polymyositis. A population-based study. N Engl J Med 1992; 326:363-7.
21. Callen JP, Wortmann RL. Dermatomyositis. Clin Dermatol 2006; 24:363-73.
22. Hill CL, Zhang Y, Sigurgeirsson B, Pukkala E, Mellemkjaer L, Airio A, et al. Frequency of specific cancer types in dermatomyositis and polymyositis: a population-based study. Lancet 2001; 357:96-100.
23. Luo J, Su F, Chen D, Shiloh A, Gu W. Deacetylation of p53 modulated its effect on cell growth and apoptosis. Nature 2000; 408:377-81.
24. Moon HE, Cheon H, Lee MS. Metastasis-associated protein 1 inhibits p53-induced apoptosis. Oncol Rep 2007; 18:1311-4.
25. Kumar R, Wang RA, Bagheri-Yarmand R. Emerging roles of MTA family members in human cancers. Semin Oncol 2003; 30:30-7.
26. Morey L, Brenner C, Fazi F, Villa R, Gutierrez A, Bushbeck M, et al. MBD3, a component of the NuRD complex, facilitates chromatin alteration and deposition of epigenetic marks. Mol Cell Biol 2008; 28:5912-23.
27. Wang Y, Zhang H, Chen Y, Sun Y, Yang F, Yu W, et al. LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer. Cell 2009; 138:660-72.
28. Shi Y, Lan F, Matson C, Mulligan P, Whetstine JR, Cole PA, Casero RA. Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell 2004; 119:941-53.
29. Su ST, Ying HY, Chiu YK, Lin FR, Chen MY, Lin KI. Involvement of histone demethylase LSD1 in Blimp-1-mediated gene repression during plasma cell differentiation. Mol Cell Biol 2009; 29:1421-31.
30. Chau CM, Deng Z, Kang H, Lieberman PM. Cell cycle association of the retinoblastoma protein Rb and the histone demethylase LSD1 with the Epstein-Barr virus latency promoter Cp. J Virol 2008; 82:3428-37.