ETS rearrangements and prostate cancer initiation

Nature

Volumn 457, Issue 7231, 2009, Pages

  Carver, Brett S ^a   Tran, Jennifer ^a   Chen, Zhenbang ^a,c   Carracedo Perez, Arkaitz ^a   Alimonti, Andrea ^a,c   Nardella, Caterina ^a,c   Gopalan, Anuradha ^a   Scardino, Peter T ^a   Cordon Cardo, Carlos ^b   Gerald, William ^a   Pandolfi, Pier Paolo ^a,c  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CANCER GROWTH; CARCINOGENESIS; CELL PROLIFERATION; CONTROLLED STUDY; GENE REARRANGEMENT; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; NOTE; PHENOTYPE; PRIORITY JOURNAL; PROSTATE CANCER; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; DISEASE PROGRESSION; DNA-BINDING PROTEINS; GENE EXPRESSION; MALE; MICE; MICE, TRANSGENIC; ONCOGENE PROTEINS; PROSTATIC NEOPLASMS; TRANSCRIPTION FACTORS; TRANSLOCATION, GENETIC;

EID: 60149091983     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature07738     Document Type: Note

References (4)

1. Tomlins, S. A. et al. Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer. Science 310, 644-648 (2005).
2. Tu J. J., Rohan S., Kao J., Kitabayashi N., Mathew S. & Chen Y.T.. Gene fusions between TMPRSS2 and ETS family genes in prostate cancer: frequency and transcript variant analysis by RT-PCR and FISH on paraffin-embedded tissues. Mod. Pathol. 20, 921-928 (2007).
3. Perner, S. et al. TMPRSS2-ERG fusion prostate cancer: an early molecular event associated with invasion. Am. J. Surg. Pathol. 31, 882-888 (2007).
4. Tomlins, S. A. et al. Distinct classes of chromosomal rearrangements create oncogenic ETS gene fusions in prostate cancer. Nature 448, 595-599 (2007).