Liver X receptor alpha associates with human life span

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 62, Issue 4, 2007, Pages 343-349

  Mooijaart, Simon P ^a   Kuningas, Maris ^a,b   Westendorp, Rudi G J ^a   Houwing Duistermaat, Jeanine J ^a   Slagboom, P Eline ^a   Rensen, Patrick C N ^a   Van Heemst, Diana ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF TARTU   (Estonia)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E; HORMONE RECEPTOR; LIVER X RECEPTOR ALPHA; PROTEIN DAF 12; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; CELL RECEPTOR; DNA BINDING PROTEIN; LIVER X RECEPTOR;

AGED; AMINO ACID SEQUENCE; ARTICLE; CAENORHABDITIS ELEGANS; DIAPAUSE; DNA POLYMORPHISM; FEMALE; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; LIFESPAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; TRIACYLGLYCEROL BLOOD LEVEL; BLOOD; CAUSE OF DEATH; COHORT ANALYSIS; FOLLOW UP; GENETIC POLYMORPHISM; GENETICS; INFECTION; LONGEVITY; MORTALITY; PROPORTIONAL HAZARDS MODEL; PROSPECTIVE STUDY;

CAENORHABDITIS ELEGANS;

AGED, 80 AND OVER; APOLIPOPROTEINS E; CAUSE OF DEATH; COHORT STUDIES; DNA-BINDING PROTEINS; FEMALE; FOLLOW-UP STUDIES; HAPLOTYPES; HUMANS; INFECTION; LONGEVITY; MALE; POLYMORPHISM, GENETIC; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRIGLYCERIDES; VARIATION (GENETICS);

EID: 34250364575     PISSN: 10795006     EISSN: None     Source Type: Journal    
DOI: 10.1093/gerona/62.4.343     Document Type: Article

References (42)

1. Hjelmborg JV, Iachine I, Skytthe A, et al. Genetic influence on human lifespan and longevity. Hum Genet. 2006;119:312-321.
2. Schoenmaker M, de Craen AJ, de Meijer PH, et al. Evidence of genetic enrichment for exceptional survival using a family approach: the Leiden Longevity Study. Eur J Hum Genet. 2006;14:79-84.
3. Antebi A, Culotti JG, Hedgecock EM. Daf-12 regulates developmental age and the dauer alternative in Caenorhabditis elegans. Development. 1998;125:1191-1205.
4. Klass M, Hirsh D. Non-ageing developmental variant of Caenorhabditis elegans. Nature. 1976;260:523-525.
5. Antebi A, Yeh WH, Tait D, Hedgecock EM, Riddle DL. Daf-12 encodes a nuclear receptor that regulates the dauer diapause and developmental age in C. elegans. Genes Dev. 2000;14:1512-1527.
6. Fisher AL, Lithgow GJ. The nuclear hormone receptor DAF-12 has opposing effects on Caenorhabditis elegans lifespan and regulates genes repressed in multiple long-lived worms. Aging Cell. 2006;5:127-138.
7. Mooijaart SP, Brandt BW, Baldal EA, et al. C. elegans DAF-12, nuclear hormone receptors and human longevity and disease at old age. Ageing Res Rev. 2005;4:351-371.
8. Peet DJ, Turley SD, Ma W, et al. Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha. Cell. 1998;93:693-704.
9. Janowski BA, Grogan MJ, Jones SA, et al. Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta. Proc Natl Acad Sci U S A. 1999;96:266-271.
10. Lu TT, Repa JJ, Mangelsdorf DJ. Orphan nuclear receptors as ELiXiRs and FiXeRs of sterol metabolism. J Biol Chem. 2001;276:37735-37738.
11. Repa JJ, Turley SD, Lobaccaro JA, et al. Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers. Science. 2000;289:1524-1529.
12. Weverling-Rijnsburger AW, Blauw GJ, Lagaay AM, Knook DL, Meinders AE, Westendorp RG. Total cholesterol and risk of mortality in the oldest old. Lancet. 1997;350:1119-1123.
13. Joseph SB, Castrillo A, Laffitte BA, Mangelsdorf DJ, Tontonoz P. Reciprocal regulation of inflammation and lipid metabolism by liver X receptors. Nat Med. 2003;9:213-219.
14. de Craen AJ, Posthuma D, Remarque EJ, van den Biggelaar AH, Westendorp RG, Boomsma DI. Heritability estimates of innate immunity: an extended twin study. Genes Immunol. 2005;6:167-170.
15. van den Biggelaar AH, de Craen AJ, Gussekloo J, et al. Inflammation underlying cardiovascular mortality is a late consequence of evolutionary programming. FASEB J. 2004;18:1022-1024.
16. Bootsma van der Wiel A, van Exel E, de Craen AJ, Gussekloo J, Lagaay AM, Knook DL, Westendorp RG. A high response is not essential to prevent selection bias: results from the Leiden 85-Plus Study. J Clin Epidemiol. 2002;55:1119-1125.
17. van Vlijmen BJ, van den Maagdenberg AM, Gijbels MJ, et al. Diet-induced hyperlipoproteinemia and atherosclerosis in apolipoprotein E3-Leiden transgenic mice. J Clin Invest. 1994;93:1403-1410.
18. Mooijaart SP, Berbee JFP, van Heemst D, et al. ApoE plasma levels and risk of cardiovascular mortality in old age. PLoS Med. 2006; 3:e176.
19. van der Linden MW, Huizinga TW, Stoeken DJ, Sturk A, Westendorp RG. Determination of tumour necrosis factor-alpha and interleukin-10 production in a whole blood stimulation system: assessment of laboratory error and individual variation. J Immunol Methods. 1998;218:63-71.
20. van den Biggelaar AH, Huizinga TW, de Craen AJ, et al. Impaired innate immunity predicts frailty in old age. The Leiden 85-Plus Study. Exp Gerontol. 2004;39:1407-1414.
21. Barrett JC, Fry B, Mailer J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics. 2005;21: 263-265.
22. Joseph SB, Bradley MN, Castrillo A, et al. LXR-dependent gene expression is important for macrophage survival and the innate immune response. Cell. 2004;119:299-309.
23. Grefhorst A, Elzinga BM, Voshol PJ, et al. Stimulation of lipogenesis by pharmacological activation of the liver X receptor leads to production of large, triglyceride-rich very low density lipoprotein particles. J Biol Chem. 2002;277:34182-34190.
24. Barcia AM, Harris HW. Triglyceride-rich lipoproteins as agents of innate immunity. Clin Infect Dis. 2005;41(Suppl 7):S498-S503.
25. Rensen PC, Oosten M, Bilt E, Eck M, Kuiper J, Berkel TJ. Human recombinant apolipoprotein E redirects lipopolysaccharide from Kupffer cells to liver parenchymal cells in rats in vivo. J Clin Invest. 1997;99:2438-2445.
26. van den Elzen P, Garg S, Leon L, et al. Apolipoprotein-mediated pathways of lipid antigen presentation. Nature. 2005;437:906-910.
27. Haukim N, Bidwell JL, Smith AJ, et al. Cytokine gene polymorphism in human disease: on-line databases, supplement 2. Genes Immunol. 2002;3:313-330.
28. Landis MS, Patel HV, Capone JP. Oxysterol activators of liver X receptor and 9-cis-retinoic acid promote sequential steps in the synthesis and secretion of tumor necrosis factor-alpha from human monocytes. J Biol Chem. 2002;277:4713-4721.
29. Joseph SB, McKilligin E, Pei L, et al. Synthetic LXR ligand inhibits the development of atherosclerosis in mice. Proc Natl Acad Sci U S A. 2002;99:7604-7609.
30. Tangirala RK, Bischoff ED, Joseph SB, et al. Identification of macrophage liver X receptors as inhibitors of atherosclerosis. Proc Natl Acad Sci U S A. 2002;99:11896-11901.
31. Repa JJ, Mangelsdorf DJ. The liver X receptor gene team: potential new players in atherosclerosis. Nat Med. 2002;8:1243-1248.
32. Levin N, Bischoff ED, Daige CL, et al. Macrophage liver X receptor is required for antiatherogenic activity of LXR agonists. Arterioscler Thromb Vasc Biol. 2005;25:135-142.
33. Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang RA C. elegans mutant that lives twice as long as wild type. Nature. 1993;366: 461-464.
34. Kimura KD, Tissenbaum HA, Liu Y, Ruvkun G. Daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science. 1997;277:942-946.
35. Tatar M, Kopelman A, Epstein D, Tu MP, Yin CM, Garofalo RS. A mutant Drosophila insulin receptor homolog that extends lifespan and impairs neuroendocrine function. Science. 2001;292: 107-110.
36. Bluher M, Kahn BB, Kahn CR. Extended longevity in mice lacking the insulin receptor in adipose tissue. Science. 2003;299:572-574.
37. Holzenberger M, Dupont J, Ducos B, et al. IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature. 2003;421: 182-187.
38. van Heemst D, Beekman M, Mooijaart SP, et al. Reduced insulin/IGF-1 signalling and human longevity. Aging Cell. 2005;4:79-85.
39. Motola DL, Cummins CL, Rottiers V, et al. Identification of ligands for DAF-12 that govern Dauer formation and reproduction in C. elegans. Cell. 2006;124:1209-1223.
40. Rottiers V, Motola DL, Gerisch B, et al. Hormonal control of C. elegans Dauer formation and life span by a Rieske-like oxygenase. Dev Cell. 2006;10:473-482.
41. Held JM, White MP, Fisher AL, Gibson BW, Lithgow GJ, Gill MS. DAF-12-dependent rescue of Dauer formation in Caenorhabditis elegans by (25S)-cholestenoic acid. Aging Cell. 2006;5:283-291.
42. Jonsson EG, Cichon S, Gustavsson JP, et al. Association between a promoter dopamine D2 receptor gene variant and the personality trait detachment. Biol Psychiatry. 2003;53:577-584.