Starvation protects germline stem cells and extends reproductive longevity in C. elegans

Science

Volumn 326, Issue 5955, 2009, Pages 954-958

  Angelo, Giana ^a   Van Gilst, Marc R ^a  

^a Fred Hutchinson Cancer Research Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGING; APOPTOSIS; BIOASSAY; FEEDING; GENETIC ANALYSIS; LONGEVITY; NEMATODE; POPULATION DYNAMICS; REPRODUCTION; STARVATION; SURVIVAL;

ADULT; ARTICLE; CAENORHABDITIS ELEGANS; DIAPAUSE; EMBRYO; GERM CELL; GERMLINE STEM CELL; HUMAN; LARVAL DEVELOPMENT; LIFESPAN; NONHUMAN; PRIORITY JOURNAL; PROGENY; REPRODUCTION; STARVATION; STEM CELL;

AGING; ANIMALS; APOPTOSIS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CASPASES; EMBRYONIC DEVELOPMENT; GERM CELLS; LARVA; LONGEVITY; MUTATION; RECEPTORS, CYTOPLASMIC AND NUCLEAR; REPRODUCTION; SIGNAL TRANSDUCTION; STARVATION; STEM CELLS; STRESS, PHYSIOLOGICAL;

ANIMALIA; CAENORHABDITIS ELEGANS;

EID: 72449170138     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1178343     Document Type: Article

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30. We thank J. Priess and B. Edgar for critical reading of the manuscript; J. Kimble and L Jones for helpful suggestions; the Priess lab for materials and equipment; and the Van Gilst, Priess, and Roth laboratories for helpful discussions and feedback. G.A. is funded by a Ruth Kirchstein postdoctoral fellowship from NIH (GM080895-02). This work was also funded by an American Diabetes Association Junior Investigator Award (ADA 1-07-JF-72) and by a grant from NIH (RDK079273A).