Monoclonal mice generated by nuclear transfer from mature B and T donor cells

Nature

Volumn 415, Issue 6875, 2002, Pages 1035-1038

  Hochedlinger, Konrad ^a   Jaenisch, Rudolf ^a  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCATALYSTS; BIODIVERSITY; CLONING; IMMUNOLOGY; TISSUE;

LYMPHOCYTES;

CELLS;

DNA; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; RNA; T LYMPHOCYTE RECEPTOR;

GENE; GENETIC ENGINEERING; TRANSFER FUNCTION;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE; BLASTOCYST; CELL NUCLEUS; CELL NUCLEUS TRANSPLANTATION; CELL TRANSFORMATION; CONTROLLED STUDY; EMBRYO; EMBRYO CELL; FEMALE; FLOW CYTOMETRY; GENE REARRANGEMENT; LYMPHOCYTE CLONE; LYMPHOCYTE DIFFERENTIATION; MALE; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SOMATIC CELL; STEM CELL; T LYMPHOCYTE;

ANIMALS; B-LYMPHOCYTES; BLASTOCYST; CELL DIFFERENTIATION; CELL LINE; CLONING, ORGANISM; CULTURE TECHNIQUES; EMBRYO; FEMALE; GENE REARRANGEMENT, B-LYMPHOCYTE; GENE REARRANGEMENT, BETA-CHAIN T-CELL ANTIGEN RECEPTOR; LEUKOPOIESIS; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; NUCLEAR TRANSFER TECHNIQUES; STEM CELLS; T-LYMPHOCYTES;

ANIMALIA;

EID: 0037186519     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature718     Document Type: Article

References (30)

1. Nuclear cloning and epigenetic reprogramming of the genome
2. Mammalian cloning: Advances and limitations
3. Mice cloned from embryonic stem cells
4. Generation of mice from wild-type and targeted ES cells by nuclear cloning
5. Epigenetic instability in ES cells and cloned mice
6. Hybrid vigor, fetal overgrowth, and viability of mice derived by nuclear cloning and tetraploid embryo complementation
7. Mouse cloning with nucleus donor cells of different age and type
8. Stem cells: Units of development, units of regeneration, and units in evolution
9. Cloning efficiency and differentiation
10. The developmental capacity of nuclei transplanted from keratinized skin cells of adult frogs
11. Genetic stability and modulation of metazoan nuclei transplanted into eggs and oocytes
12. Changes in the nuclei of differentiating endoderm cells as revealed by nuclear transplantation
13. Production of gene-targeted sheep by nuclear transfer from cultured somatic cells
14. Lymphocytes of the toad Xenopus laevis have the gene set for promoting tadpole development
15. Full-term development of mice from enucleated oocytes injected with cumulus cell nuclei
16. Mammalian leukocytes contain all the genetic information necessary for the development of a new individual
17. Clonal selection and learning in the antibody system
18. Development and selection of T cells: Facts and puzzles
19. Derivation of completely cell culture-derived mice from early-passage embryonic stem cells
20. Mouse embryonic stem (ES) cell lines established from neuronal cell-derived cloned blastocysts
21. Isolation of pluripotent embryonic stem cells from reprogrammed adult mouse somatic cell nuclei
22. Differentiation of embryonic stem cell lines generated from adult somatic cells by nuclear transfer
23. Role of receptor editing and revision in shaping the B and T lymphocyte repertoire
24. RAG-2-deficient blastocyst complementation: An assay of gene function in lymphocyte development
25. A quasi-monoclonal mouse
26. Production of cloned calves following nuclear transfer with cultured adult mural granulosa cells
27. Allelic inactivation regulates olfactory receptor gene expression
28. In-frame TCRδ gene rearrangements play a critical role in the αβ/γδ T cell lineage decision
29. Control of V(D)J recombinational accessibility of the Dβ1 gene segment at the TCRβ locus by a germline promoter
30. Rearrangement and expression of immunoglobulin light chain genes can precede heavy chain expression during normal B cell development in mice