The cap'n'collar transcription factor Nrf2 mediates both intrinsic resistance to environmental stressors and an adaptive response elicited by chemopreventive agents that determines susceptibility to electrophilic xenobiotics

Chemico-Biological Interactions

Volumn 192, Issue 1-2, 2011, Pages 37-45

  Higgins, Larry G ^a   Hayes, John D ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Adaptive response; Chemoprevention; Cytotoxicity; Drug metabolism; Gene induction; Glutathione; Glutathione S transferase; NAD(P)H:quinone oxidoreductase 1; Sulforaphane

Indexed keywords

ACROLEIN; ANTINEOPLASTIC AGENT; ANTIOXIDANT; BUTHIONINE SULFOXIMINE; CARBONYL DERIVATIVE; CARRIER PROTEIN; CHLORAMBUCIL; CHLORMETHINE; CISPLATIN; CYTOTOXIC AGENT; DRUG METABOLIZING ENZYME; EPOXIDE; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; HYDROQUINONE DERIVATIVE; ISOTHIOCYANIC ACID; MENADIONE; MESSENGER RNA; MUTAGENIC AGENT; PEROXIDE; PEROXIREDOXIN; PROPIOLACTONE; QUINONE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); SULFORAPHANE; THIOREDOXIN; TRANSCRIPTION FACTOR NRF2; UNINDEXED DRUG; XENOBIOTIC AGENT;

ADAPTIVE IMMUNITY; CELL ACTIVITY; CELL STRESS; CHEMICAL STRESS; CHEMICAL STRUCTURE; CONFERENCE PAPER; CYTOTOXICITY; DRUG MECHANISM; ELECTROPHILIC STRESS; EMBRYO CELL; ENVIRONMENTAL STRESS; ENZYME ACTIVITY; FIBROBLAST; HUMAN; LOW DRUG DOSE; NONHUMAN; NRF2 GENE; OXIDATION REDUCTION REACTION; PROTEIN DEPLETION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; TRANSCRIPTION INITIATION; WILD TYPE;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; ANTICARCINOGENIC AGENTS; CELLS, CULTURED; MICE; NF-E2-RELATED FACTOR 2; XENOBIOTICS;

MUS;

EID: 79958023999     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2010.09.025     Document Type: Conference Paper

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