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Volumn 121, Issue 6, 2011, Pages 2080-2086

Genetic approaches to understanding human obesity

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN; LEPTIN RECEPTOR; MELANOCORTIN; MELANOCORTIN RECEPTOR AGONIST;

EID: 79957925582     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI46044     Document Type: Review
Times cited : (149)

References (112)
  • 1
    • 0034611675 scopus 로고    scopus 로고
    • Obesity in the new millennium
    • Friedman JM. Obesity in the new millennium. Nature. 2000;404(6778):632- 634. (Pubitemid 30205067)
    • (2000) Nature , vol.404 , Issue.6778 , pp. 632-634
    • Friedman, J.M.1
  • 2
    • 38949187953 scopus 로고    scopus 로고
    • Evidence for a strong genetic influence on childhood adiposity despite the force of the obesogenic environment
    • Wardle J, Carnell S, Haworth CM, Plomin R. Evidence for a strong genetic influence on childhood adiposity despite the force of the obesogenic environment. Am J Clin Nutr. 2008;87(2):398-404. (Pubitemid 351226077)
    • (2008) American Journal of Clinical Nutrition , vol.87 , Issue.2 , pp. 398-404
    • Wardle, J.1    Carnell, S.2    Haworth, C.M.A.3    Plomin, R.4
  • 3
    • 0034611681 scopus 로고    scopus 로고
    • Genetics of bodyweight regulation
    • Barsh GS, Farooqi IS, O'Rahilly S. Genetics of bodyweight regulation. Nature. 2000;404(6778):644-651.
    • (2000) Nature , vol.404 , Issue.6778 , pp. 644-651
    • Barsh, G.S.1    Farooqi, I.S.2    O'Rahilly, S.3
  • 7
    • 46249128314 scopus 로고    scopus 로고
    • Childhood obesity: Genetic and environmental overlap with normal-range BMI
    • DOI 10.1038/oby.2008.240, PII OBY2008240
    • Haworth CM, Plomin R, Carnell S, Wardle J. Childhood obesity: genetic and environmental overlap with normal-range BMI. Obesity (Silver Spring). 2008;16(7):1585-1590. (Pubitemid 351915111)
    • (2008) Obesity , vol.16 , Issue.7 , pp. 1585-1590
    • Haworth, C.M.A.1    Plomin, R.2    Carnell, S.3    Wardle, J.4
  • 11
    • 84958689411 scopus 로고
    • The role of depot fat in the hypothalamic control of food intake in the rat
    • Kennedy GC. The role of depot fat in the hypothalamic control of food intake in the rat. Proc R Soc Lond B Biol Sci. 1953;140(901)578-596.
    • (1953) Proc R Soc Lond B Biol Sci , vol.140 , Issue.901 , pp. 578-596
    • Kennedy, G.C.1
  • 12
    • 76949125582 scopus 로고
    • Hypothalamic control of food intake in rats and cats
    • Anand BK, Brobeck JR. Hypothalamic control of food intake in rats and cats. Yale J Biol Med. 1951;24(2):123-146.
    • (1951) Yale J Biol Med , vol.24 , Issue.2 , pp. 123-146
    • Anand, B.K.1    Brobeck, J.R.2
  • 13
    • 70449255388 scopus 로고
    • The effects of lesions in the hypothalamus in parabiotic rats
    • Hervey GR. The effects of lesions in the hypothalamus in parabiotic rats. J Physiol London. 1959;145(2):336.
    • (1959) J Physiol London , vol.145 , Issue.2 , pp. 336
    • Hervey, G.R.1
  • 14
    • 0014608866 scopus 로고
    • Effects of parabiosis of normal with genetically diabetic mice
    • Coleman DL, Hummel KP. Effects of parabiosis of normal with genetically diabetic mice. Am J Physiol. 1969;217(5):1298-1304.
    • (1969) Am J Physiol , vol.217 , Issue.5 , pp. 1298-1304
    • Coleman, D.L.1    Hummel, K.P.2
  • 15
    • 0028139089 scopus 로고
    • Positional cloning of the mouse obese gene and its human homologue
    • DOI 10.1038/372425a0
    • Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue [published erratum appears in Nature 1995 Mar 30;374(6521):479] [see comments]. Nature. 1994;372(6505):425-432. (Pubitemid 24365442)
    • (1994) Nature , vol.372 , Issue.6505 , pp. 425-432
    • Zhang, Y.1    Proenca, R.2    Maffei, M.3    Barone, M.4    Leopold, L.5    Friedman, J.M.6
  • 16
    • 0028845877 scopus 로고
    • Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects
    • Maffei M, et al. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med. 1995;1(11):1155-1161.
    • (1995) Nat Med , vol.1 , Issue.11 , pp. 1155-1161
    • Maffei, M.1
  • 18
    • 0029896530 scopus 로고    scopus 로고
    • Role of leptin in the neuroendocrine response to fasting
    • Ahima RS, et al. Role of leptin in the neuroendocrine response to fasting. Nature. 1996;382(6588):250-252.
    • (1996) Nature , vol.382 , Issue.6588 , pp. 250-252
    • Ahima, R.S.1
  • 20
    • 0032527071 scopus 로고    scopus 로고
    • Distributions of leptin receptor mRNA isoforms in the rat brain
    • DOI 10.1002/(SICI)1096-9861(19980615)395:4<535::AID-CNE9>3.0.CO;2-2
    • Elmquist JK, Bjorbaek C, Ahima RS, Flier JS, Saper CB. Distributions of leptin receptor mRNA isoforms in the rat brain. J Comp Neurol. 1998;395(4):535-547. (Pubitemid 28226097)
    • (1998) Journal of Comparative Neurology , vol.395 , Issue.4 , pp. 535-547
    • Elmquist, J.K.1    Bjorbaek, C.2    Ahima, R.S.3    Flier, J.S.4    Saper, C.B.5
  • 21
    • 17844401704 scopus 로고    scopus 로고
    • Anatomy and regulation of the central melanocortin system
    • DOI 10.1038/nn1455
    • Cone RD. Anatomy and regulation of the central melanocortin system. Nat Neurosci. 2005;8(5):571-578. (Pubitemid 40594196)
    • (2005) Nature Neuroscience , vol.8 , Issue.5 , pp. 571-578
    • Cone, R.D.1
  • 26
    • 0032014836 scopus 로고    scopus 로고
    • A leptin missense mutation associated with hypogonadism and morbid obesity
    • Strobel A, Issad T, Camoin L, Ozata M, Strosberg AD. A leptin missense mutation associated with hypogonadism and morbid obesity. Nat Genet. 1998;18(3):213-215.
    • (1998) Nat Genet , vol.18 , Issue.3 , pp. 213-215
    • Strobel, A.1    Issad, T.2    Camoin, L.3    Ozata, M.4    Strosberg, A.D.5
  • 28
    • 0036800760 scopus 로고    scopus 로고
    • Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency
    • Farooqi IS, et al. Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J Clin Invest. 2002;110(8):1093-1103.
    • (2002) J Clin Invest , vol.110 , Issue.8 , pp. 1093-1103
    • Farooqi, I.S.1
  • 32
    • 34548675339 scopus 로고    scopus 로고
    • Leptin regulates striatal regions and human eating behavior
    • DOI 10.1126/science.1144599
    • Farooqi IS, Bullmore E, Keogh J, Gillard J, O'Rahilly S, Fletcher PC. Leptin regulates striatal regions and human eating behavior. Science. 2007;317(5843):1355. (Pubitemid 47417470)
    • (2007) Science , vol.317 , Issue.5843 , pp. 1355
    • Sadaf, F.I.1    Bullmore, E.2    Keogh, J.3    Gillard, J.4    O'Rahilly, S.5    Fletcher, P.C.6
  • 33
    • 46749099010 scopus 로고    scopus 로고
    • Leptin reverses weight loss-induced changes in regional neural activity responses to visual food stimuli
    • DOI 10.1172/JC135055
    • Rosenbaum M, Sy M, Pavlovich K, Leibel RL, Hirsch J. Leptin reverses weight loss-induced changes in regional neural activity responses to visual food stimuli. J Clin Invest. 2008;118(7):2583-2591. (Pubitemid 351949785)
    • (2008) Journal of Clinical Investigation , vol.118 , Issue.7 , pp. 2583-2591
    • Rosenbaum, M.1    Sy, M.2    Pavlovich, K.3    Leibel, R.L.4    Hirsch, J.5
  • 36
    • 76149128662 scopus 로고    scopus 로고
    • Leptin replacement prevents weight loss-induced metabolic adaptation in congenital leptin-deficient patients
    • Galgani JE, Greenway FL, Caglayan S, Wong ML, Licinio J, Ravussin E. Leptin replacement prevents weight loss-induced metabolic adaptation in congenital leptin-deficient patients. J Clin Endocrinol Metab. 2010;95(2):851-855.
    • (2010) J Clin Endocrinol Metab , vol.95 , Issue.2 , pp. 851-855
    • Galgani, J.E.1    Greenway, F.L.2    Caglayan, S.3    Wong, M.L.4    Licinio, J.5    Ravussin, E.6
  • 39
    • 0033304576 scopus 로고    scopus 로고
    • Human leptin deficiency caused by a missense mutation: Multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin, and spontaneous correction of leptin-mediated defects
    • Ozata M, Ozdemir IC, Licinio J. Human leptin deficiency caused by a missense mutation: multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin, and spontaneous correction of leptin-mediated defects. J Clin Endocrinol Metab. 1999;84(10):3686-3695. (Pubitemid 30645226)
    • (1999) Journal of Clinical Endocrinology and Metabolism , vol.84 , Issue.10 , pp. 3686-3695
    • Ozata, M.1    Ozdemir, I.C.2    Licinio, J.3
  • 40
    • 0036093071 scopus 로고    scopus 로고
    • Low dose leptin administration reverses effects of sustained weight-reduction on energy expenditure and circulating concentrations of thyroid hormones
    • DOI 10.1210/jc.87.5.2391
    • Rosenbaum M, Murphy EM, Heymsfield SB, Matthews DE, Leibel RL. Low dose leptin administration reverses effects of sustained weight-reduction on energy expenditure and circulating concentrations of thyroid hormones. J Clin Endocrinol Metab. 2002;87(5):2391-2394. (Pubitemid 34521535)
    • (2002) Journal of Clinical Endocrinology and Metabolism , vol.87 , Issue.5 , pp. 2391-2394
    • Rosenbaum, M.1    Murphy, E.M.2    Heymsfield, S.B.3    Matthews, D.E.4    Leibel, R.L.5
  • 41
    • 57849127113 scopus 로고    scopus 로고
    • Reproductive functions of kisspeptin and Gpr54 across the life cycle of mice and men
    • Chan YM, Broder-Fingert S, Seminara SB. Reproductive functions of kisspeptin and Gpr54 across the life cycle of mice and men. Peptides. 2009;30(1):42-48.
    • (2009) Peptides , vol.30 , Issue.1 , pp. 42-48
    • Chan, Y.M.1    Broder-Fingert, S.2    Seminara, S.B.3
  • 42
    • 78650956096 scopus 로고    scopus 로고
    • Leptin's effect on puberty in mice is relayed by the ventral premammillary nucleus and does not require signaling in Kiss1 neurons
    • Donato J Jr, et al. Leptin's effect on puberty in mice is relayed by the ventral premammillary nucleus and does not require signaling in Kiss1 neurons. J Clin Invest. 2011;121(1):355-368.
    • (2011) J Clin Invest , vol.121 , Issue.1 , pp. 355-368
    • Donato Jr., J.1
  • 43
    • 77951663638 scopus 로고    scopus 로고
    • CNS leptin action modulates immune response and survival in sepsis
    • Tschop J, et al. CNS leptin action modulates immune response and survival in sepsis. J Neurosci. 2010;30(17):6036-6047.
    • (2010) J Neurosci , vol.30 , Issue.17 , pp. 6036-6047
    • Tschop, J.1
  • 44
    • 77956903809 scopus 로고    scopus 로고
    • Crucial role of the central leptin receptor in murine Trypanosoma cruzi (Brazil strain) infection
    • Nagajyothi F, et al. Crucial role of the central leptin receptor in murine Trypanosoma cruzi (Brazil strain) infection. J Infect Dis. 2010;202(7):1104-1113.
    • (2010) J Infect Dis , vol.202 , Issue.7 , pp. 1104-1113
    • Nagajyothi, F.1
  • 46
    • 0031838353 scopus 로고    scopus 로고
    • Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans
    • DOI 10.1038/509
    • Krude H, Biebermann H, Luck W, Horn R, Brabant G, Gruters A. Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nat Genet. 1998;19(2):155-157. (Pubitemid 28248796)
    • (1998) Nature Genetics , vol.19 , Issue.2 , pp. 155-157
    • Krude, H.1    Biebermann, H.2    Luck, W.3    Horn, R.4    Brabant, G.5    Gruters, A.6
  • 49
    • 33645048441 scopus 로고    scopus 로고
    • A POMC variant implicates beta-melanocyte-stimulating hormone in the control of human energy balance
    • Lee YS, et al. A POMC variant implicates beta-melanocyte-stimulating hormone in the control of human energy balance. Cell Metab. 2006;3(2):135-140.
    • (2006) Cell Metab , vol.3 , Issue.2 , pp. 135-140
    • Lee, Y.S.1
  • 50
    • 33645089926 scopus 로고    scopus 로고
    • A role for beta-melanocyte-stimulating hormone in human body-weight regulation
    • Biebermann H, et al. A role for beta-melanocyte-stimulating hormone in human body-weight regulation. Cell Metab. 2006;3(2):141-146.
    • (2006) Cell Metab , vol.3 , Issue.2 , pp. 141-146
    • Biebermann, H.1
  • 56
    • 33847186636 scopus 로고    scopus 로고
    • Prevalence and functionality of paucimorphic and private MC4R mutations in a large, unselected European British population, scanned by meltMADGE
    • Alharbi KK, et al. Prevalence and functionality of paucimorphic and private MC4R mutations in a large, unselected European British population, scanned by meltMADGE. Hum Mutat. 2007;28(3):294-302.
    • (2007) Hum Mutat , vol.28 , Issue.3 , pp. 294-302
    • Alharbi, K.K.1
  • 59
    • 52749092130 scopus 로고    scopus 로고
    • Prevalence of MC4R deficiency in European population and their age-dependant penetrance in multi-generational pedigrees
    • Stutzmann F, et al. Prevalence of MC4R deficiency in European population and their age-dependant penetrance in multi-generational pedigrees. Diabetes. 2008;57(9):2511-2518.
    • (2008) Diabetes , vol.57 , Issue.9 , pp. 2511-2518
    • Stutzmann, F.1
  • 60
    • 33646404622 scopus 로고    scopus 로고
    • Melanocortin 4 receptor mutations in a large cohort of severely obese adults: Prevalence, functional classification, genotype-phenotype relationship, and lack of association with binge eating
    • Lubrano-Berthelier C, et al. Melanocortin 4 receptor mutations in a large cohort of severely obese adults: prevalence, functional classification, genotype-phenotype relationship, and lack of association with binge eating. J Clin Endocrinol Metab. 2006;91(5):1811-1818.
    • (2006) J Clin Endocrinol Metab , vol.91 , Issue.5 , pp. 1811-1818
    • Lubrano-Berthelier, C.1
  • 61
    • 33645280903 scopus 로고    scopus 로고
    • The severely obese patient - A genetic work-up
    • Farooqi IS. The severely obese patient - a genetic work-up. Nat Clin Pract Endocrinol Metab. 2006;2(3):172-177.
    • (2006) Nat Clin Pract Endocrinol Metab , vol.2 , Issue.3 , pp. 172-177
    • Farooqi, I.S.1
  • 62
    • 78649594776 scopus 로고    scopus 로고
    • Pharmacological chaperones restore function to MC4R mutants responsible for severe early-onset obesity
    • Rene P, et al. Pharmacological chaperones restore function to MC4R mutants responsible for severe early-onset obesity. J Pharmacol Exp Ther. 2010;335(3):520-532.
    • (2010) J Pharmacol Exp Ther , vol.335 , Issue.3 , pp. 520-532
    • Rene, P.1
  • 64
    • 23244451186 scopus 로고    scopus 로고
    • Melanocortin-4 receptor-deficient mice are not hypertensive or salt-sensitive despite obesity, hyperinsulinemia, and hyperleptinemia
    • DOI 10.1161/01.HYP.0000175474.99326.bf
    • Tallam LS, Stec DE, Willis MA, da Silva AA, Hall JE. Melanocortin-4 receptor-deficient mice are not hypertensive or salt-sensitive despite obesity, hyperinsulinemia, and hyperleptinemia. Hypertension. 2005;46(2):326-332. (Pubitemid 41099165)
    • (2005) Hypertension , vol.46 , Issue.2 , pp. 326-332
    • Tallam, L.S.1    Stec, D.E.2    Willis, M.A.3    Da, S.A.A.4    Hall, J.E.5
  • 65
    • 58249087146 scopus 로고    scopus 로고
    • Modulation of blood pressure by central melanocortinergic pathways
    • Greenfield JR, et al. Modulation of blood pressure by central melanocortinergic pathways. N Engl J Med. 2009;360(1):44-52.
    • (2009) N Engl J Med , vol.360 , Issue.1 , pp. 44-52
    • Greenfield, J.R.1
  • 66
    • 78651099871 scopus 로고    scopus 로고
    • Melanocortin signalling and the regulation of blood pressure in human obesity
    • Greenfield JR. Melanocortin signalling and the regulation of blood pressure in human obesity. J Neuroendocrinol. 2011;23(2):186-193.
    • (2011) J Neuroendocrinol , vol.23 , Issue.2 , pp. 186-193
    • Greenfield, J.R.1
  • 67
    • 78650912045 scopus 로고    scopus 로고
    • Obesity due to Melanocortin 4 receptor (MC4R) deficiency is associated with increased linear growth and final height, fasting hyperinsulinemia, and incompletely suppressed growth hormone secretion
    • Martinelli CE, et al. Obesity due to Melanocortin 4 receptor (MC4R) deficiency is associated with increased linear growth and final height, fasting hyperinsulinemia, and incompletely suppressed growth hormone secretion. J Clin Endocrinol Metab. 2011;96(1):E181-E188.
    • (2011) J Clin Endocrinol Metab , vol.96 , Issue.1
    • Martinelli, C.E.1
  • 68
    • 33644615796 scopus 로고    scopus 로고
    • Abnormalities of the somatotrophic axis in the obese agouti mouse
    • Martin NM, et al. Abnormalities of the somatotrophic axis in the obese agouti mouse. Int J Obes (Lond). 2006;30(3):430-438.
    • (2006) Int J Obes (Lond) , vol.30 , Issue.3 , pp. 430-438
    • Martin, N.M.1
  • 72
    • 50449091665 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor and obesity in the WAGR syndrome
    • Han JC, et al. Brain-derived neurotrophic factor and obesity in the WAGR syndrome. N Engl J Med. 2008;359(9):918-927.
    • (2008) N Engl J Med , vol.359 , Issue.9 , pp. 918-927
    • Han, J.C.1
  • 73
    • 0034016043 scopus 로고    scopus 로고
    • Profound obesity associated with a balanced translocation that disrupts the SIM1 gene
    • Holder JL Jr, Butte NF, Zinn AR. Profound obesity associated with a balanced translocation that disrupts the SIM1 gene. Hum Mol Genet. 2000;9(1):101-108. (Pubitemid 30145294)
    • (2000) Human Molecular Genetics , vol.9 , Issue.1 , pp. 101-108
    • Holder Jr., J.L.1    Butte, N.F.2    Zinn, A.R.3
  • 74
    • 33847257845 scopus 로고    scopus 로고
    • Studies of the SIM1 gene in relation to human obesity and obesity-related traits
    • Hung CC, et al. Studies of the SIM1 gene in relation to human obesity and obesity-related traits. Int J Obes (Lond). 2007;31(3):429-434.
    • (2007) Int J Obes (Lond) , vol.31 , Issue.3 , pp. 429-434
    • Hung, C.C.1
  • 76
    • 77949416159 scopus 로고    scopus 로고
    • Postnatal Sim1 deficiency causes hyperphagic obesity and reduced Mc4r and oxytocin expression
    • Tolson KP, Gemelli T, Gautron L, Elmquist JK, Zinn AR, Kublaoui BM. Postnatal Sim1 deficiency causes hyperphagic obesity and reduced Mc4r and oxytocin expression. J Neurosci. 2010;30(10):3803-3812.
    • (2010) J Neurosci , vol.30 , Issue.10 , pp. 3803-3812
    • Tolson, K.P.1    Gemelli, T.2    Gautron, L.3    Elmquist, J.K.4    Zinn, A.R.5    Kublaoui, B.M.6
  • 77
    • 33748742610 scopus 로고    scopus 로고
    • Sim1 haploinsufficiency impairs melanocortin-mediated anorexia and activation of paraventricular nucleus neurons
    • DOI 10.1210/me.2005-0483
    • Kublaoui BM, Holder JL Jr, Gemelli T, Zinn AR. Sim1 haploinsufficiency impairs melanocortin-mediated anorexia and activation of paraventricular nucleus neurons. Mol Endocrinol. 2006;20(10):2483-2492. (Pubitemid 44496416)
    • (2006) Molecular Endocrinology , vol.20 , Issue.10 , pp. 2483-2492
    • Kublaoui, B.M.1    Holder Jr., J.L.2    Gemelli, T.3    Zinn, A.R.4
  • 78
    • 46349095132 scopus 로고    scopus 로고
    • Oxytocin deficiency mediates hyperphagic obesity of Sim1 haploinsufficient mice
    • DOI 10.1210/me.2008-0067
    • Kublaoui BM, Gemelli T, Tolson KP, Wang Y, Zinn AR. Oxytocin deficiency mediates hyperphagic obesity of Sim1 haploinsufficient mice. Mol Endocrinol. 2008;22(7):1723-1734. (Pubitemid 351920403)
    • (2008) Molecular Endocrinology , vol.22 , Issue.7 , pp. 1723-1734
    • Kublaoui, B.M.1    Gemelli, T.2    Tolson, K.P.3    Wang, Y.4    Zinn, A.R.5
  • 79
    • 34249978500 scopus 로고    scopus 로고
    • Bardet-Biedl syndrome: Beyond the cilium
    • DOI 10.1007/s00467-007-0435-0
    • Tobin JL, Beales PL. Bardet-Biedl syndrome: beyond the cilium. Pediatr Nephrol. 2007;22(7):926-936. (Pubitemid 46881909)
    • (2007) Pediatric Nephrology , vol.22 , Issue.7 , pp. 926-936
    • Tobin, J.L.1    Beales, P.L.2
  • 81
    • 34547758426 scopus 로고    scopus 로고
    • Cilia: Tails of the unexpected
    • DOI 10.1038/448638a, PII 448638A
    • Ainsworth C. Cilia: tails of the unexpected. Nature. 2007;448(7154):638- 641. (Pubitemid 47236838)
    • (2007) Nature , vol.448 , Issue.7154 , pp. 638-641
    • Ainsworth, C.1
  • 82
    • 63149175815 scopus 로고    scopus 로고
    • Requirement of Bardet-Biedl syndrome proteins for leptin receptor signaling
    • Seo S, Guo DF, Bugge K, Morgan DA, Rahmouni K, Sheffield VC. Requirement of Bardet-Biedl syndrome proteins for leptin receptor signaling. Hum Mol Genet. 2009;18(7):1323-1331.
    • (2009) Hum Mol Genet , vol.18 , Issue.7 , pp. 1323-1331
    • Seo, S.1    Guo, D.F.2    Bugge, K.3    Morgan, D.A.4    Rahmouni, K.5    Sheffield, V.C.6
  • 85
    • 68749097161 scopus 로고    scopus 로고
    • A deletion of the HBII-85 class of small nucleolar RNAs (snoRNAs) is associated with hyperphagia, obesity and hypogonadism
    • de Smith AJ, et al. A deletion of the HBII-85 class of small nucleolar RNAs (snoRNAs) is associated with hyperphagia, obesity and hypogonadism. Hum Mol Genet. 2009;18(17):3257-3265.
    • (2009) Hum Mol Genet , vol.18 , Issue.17 , pp. 3257-3265
    • De Smith, A.J.1
  • 88
    • 0028852641 scopus 로고
    • Alterations in the hypothalamic paraventricular nucleus and its oxytocin neurons (putative satiety cells) in Prader-Willi syndrome: A study of five cases
    • Swaab DF, Purba JS, Hofman MA. Alterations in the hypothalamic paraventricular nucleus and its oxytocin neurons (putative satiety cells) in Prader-Willi syndrome: a study of five cases. J Clin Endocrinol Metab. 1995;80(2):573-579.
    • (1995) J Clin Endocrinol Metab , vol.80 , Issue.2 , pp. 573-579
    • Swaab, D.F.1    Purba, J.S.2    Hofman, M.A.3
  • 90
    • 66049136160 scopus 로고    scopus 로고
    • Central nervous system imprinting of the G protein G(s)alpha and its role in metabolic regulation
    • Chen M, et al. Central nervous system imprinting of the G protein G(s)alpha and its role in metabolic regulation. Cell Metab. 2009;9(6):548-555.
    • (2009) Cell Metab , vol.9 , Issue.6 , pp. 548-555
    • Chen, M.1
  • 91
    • 76349083132 scopus 로고    scopus 로고
    • Large, rare chromosomal deletions associated with severe early-onset obesity
    • Bochukova EG, et al. Large, rare chromosomal deletions associated with severe early-onset obesity. Nature. 2010;463(7281):666-670.
    • (2010) Nature , vol.463 , Issue.7281 , pp. 666-670
    • Bochukova, E.G.1
  • 92
    • 76249116215 scopus 로고    scopus 로고
    • A new highly penetrant form of obesity due to deletions on chromosome 16p11.2
    • Walters RG, et al. A new highly penetrant form of obesity due to deletions on chromosome 16p11.2. Nature. 2010;463(7281):671-675.
    • (2010) Nature , vol.463 , Issue.7281 , pp. 671-675
    • Walters, R.G.1
  • 93
    • 25144523930 scopus 로고    scopus 로고
    • Identification of SH2-B as a key regulator of leptin sensitivity, energy balance, and body weight in mice
    • Ren D, Li M, Duan C, Rui L. Identification of SH2-B as a key regulator of leptin sensitivity, energy balance, and body weight in mice. Cell Metab. 2005;2(2):95-104.
    • (2005) Cell Metab , vol.2 , Issue.2 , pp. 95-104
    • Ren, D.1    Li, M.2    Duan, C.3    Rui, L.4
  • 97
    • 78049337953 scopus 로고    scopus 로고
    • Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
    • Speliotes EK, et al. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet. 2010;42(11):937-948.
    • (2010) Nat Genet , vol.42 , Issue.11 , pp. 937-948
    • Speliotes, E.K.1
  • 99
    • 57749121512 scopus 로고    scopus 로고
    • An obesity-associated FTO gene variant and increased energy intake in children
    • Cecil JE, Tavendale R, Watt P, Hetherington MM, Palmer CN. An obesity-associated FTO gene variant and increased energy intake in children. N Engl J Med. 2008;359(24):2558-2566.
    • (2008) N Engl J Med , vol.359 , Issue.24 , pp. 2558-2566
    • Cecil, J.E.1    Tavendale, R.2    Watt, P.3    Hetherington, M.M.4    Palmer, C.N.5
  • 102
    • 67349211789 scopus 로고    scopus 로고
    • Inactivation of the Fto gene protects from obesity
    • Fischer J, et al. Inactivation of the Fto gene protects from obesity. Nature. 2009;458(7240):894-898.
    • (2009) Nature , vol.458 , Issue.7240 , pp. 894-898
    • Fischer, J.1
  • 103
    • 78649459183 scopus 로고    scopus 로고
    • Overexpression of Fto leads to increased food intake and results in obesity
    • Church C, et al. Overexpression of Fto leads to increased food intake and results in obesity. Nat Genet. 2010;42(12):1086-1092.
    • (2010) Nat Genet , vol.42 , Issue.12 , pp. 1086-1092
    • Church, C.1
  • 104
    • 58149163142 scopus 로고    scopus 로고
    • Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
    • Willer CJ, et al. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet. 2009;41(1):25-34.
    • (2009) Nat Genet , vol.41 , Issue.1 , pp. 25-34
    • Willer, C.J.1
  • 105
    • 58149163141 scopus 로고    scopus 로고
    • Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
    • Thorleifsson G, et al. Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat Genet. 2009;41(1):18-24.
    • (2009) Nat Genet , vol.41 , Issue.1 , pp. 18-24
    • Thorleifsson, G.1
  • 106
    • 70249111091 scopus 로고    scopus 로고
    • Targeted capture and massively parallel sequencing of 12 human exomes
    • Ng SB, et al. Targeted capture and massively parallel sequencing of 12 human exomes. Nature. 2009;461(7261):272-276.
    • (2009) Nature , vol.461 , Issue.7261 , pp. 272-276
    • Ng, S.B.1
  • 107
    • 77951799158 scopus 로고    scopus 로고
    • Analysis of genetic inheritance in a family quartet by whole-genome sequencing
    • Roach JC, et al. Analysis of genetic inheritance in a family quartet by whole-genome sequencing. Science. 2010;328(5978):636-639.
    • (2010) Science , vol.328 , Issue.5978 , pp. 636-639
    • Roach, J.C.1
  • 108
    • 77953121877 scopus 로고    scopus 로고
    • Pooled association tests for rare variants in exon-resequencing studies
    • Price AL, et al. Pooled association tests for rare variants in exon-resequencing studies. Am J Hum Genet. 2010;86(6):832-838.
    • (2010) Am J Hum Genet , vol.86 , Issue.6 , pp. 832-838
    • Price, A.L.1
  • 109
    • 0035342146 scopus 로고    scopus 로고
    • The genetic epidemiology of thinness
    • Bulik CM, Allison DB. The genetic epidemiology of thinness. Obes Rev. 2001;2(2):107-115. (Pubitemid 33755920)
    • (2001) Obesity Reviews , vol.2 , Issue.2 , pp. 107-115
    • Bulik, C.M.1    Allison, D.B.2
  • 110
    • 73349110071 scopus 로고    scopus 로고
    • Exome sequencing identifies the cause of a mendelian disorder
    • Ng SB, et al. Exome sequencing identifies the cause of a mendelian disorder. Nat Genet. 2010;42(1):30-35.
    • (2010) Nat Genet , vol.42 , Issue.1 , pp. 30-35
    • Ng, S.B.1
  • 111
    • 61749094289 scopus 로고    scopus 로고
    • Maternal high-fat diet triggers lipotoxicity in the fetal livers of nonhuman primates
    • McCurdy CE, et al. Maternal high-fat diet triggers lipotoxicity in the fetal livers of nonhuman primates. J Clin Invest. 2009;119(2):323-335.
    • (2009) J Clin Invest , vol.119 , Issue.2 , pp. 323-335
    • McCurdy, C.E.1
  • 112
    • 77956913463 scopus 로고    scopus 로고
    • Personalized epigenomic signatures that are stable over time and covary with body mass index
    • Feinberg AP, et al. Personalized epigenomic signatures that are stable over time and covary with body mass index. Sci Transl Med. 2010;2(49):49ra67.
    • (2010) Sci Transl Med , vol.2 , Issue.49
    • Feinberg, A.P.1


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