-
1
-
-
0030754050
-
Multiple endocrine abnormalities of the growth hormone and insulin-like growth factor axis in prepubertal children with exogenous obesity: Effect of short- And long-term weight reduction
-
DOI 10.1210/jc.82.7.2076
-
Argente J, Caballo N, Barrios V, Pozo J, Muñoz MT, Chowen JA, Hernández M 1997 Multiple endocrine abnormalities of the growth hormone and insulin-like growth factor axis in prepubertal children with exogenous obesity: effect of short- and long-term weight reduction. J Clin Endocrinol Metab 82:2076-2083 (Pubitemid 27287564)
-
(1997)
Journal of Clinical Endocrinology and Metabolism
, vol.82
, Issue.7
, pp. 2076-2083
-
-
Argente, J.1
Caballo, N.2
Barrios, V.3
Pozo, J.4
Munoz, M.T.5
Chowen, J.A.6
Hernandez, M.7
-
2
-
-
0034611732
-
Central nervous system control of food intake
-
Schwartz MW, Woods SC, Porte Jr D, Seeley RJ, Baskin DG 2000 Central nervous system control of food intake. Nature 404:661-671
-
(2000)
Nature
, vol.404
, pp. 661-671
-
-
Schwartz, M.W.1
Woods, S.C.2
Porte Jr., D.3
Seeley, R.J.4
Baskin, D.G.5
-
4
-
-
0036800760
-
Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency
-
Farooqi IS, Matarese G, Lord GM, Keogh JM, Lawrence E, Agwu C, Sanna V, Jebb SA, Perna F, Fontana S, Lechler RI, DePaoli AM, O'Rahilly S 2002 Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J Clin Invest 110:1093-1103
-
(2002)
J Clin Invest
, vol.110
, pp. 1093-1103
-
-
Farooqi, I.S.1
Matarese, G.2
Lord, G.M.3
Keogh, J.M.4
Lawrence, E.5
Agwu, C.6
Sanna, V.7
Jebb, S.A.8
Perna, F.9
Fontana, S.10
Lechler, R.I.11
DePaoli, A.M.12
O'Rahilly, S.13
-
5
-
-
33846409122
-
Clinical and molecular genetic spectrum of congenital deficiency of the leptin receptor
-
Farooqi IS, Wangensteen T, Collins S, Kimber W, Matarese G, Keogh JM, Lank E, Bottomley B, Lopez-Fernandez J, Ferraz-Amaro I, Dattani MT, Ercan O, Myhre AG, Retterstol L, Stanhope R, Edge JA, McKenzie S, Lessan N, Ghodsi M, De Rosa V, Perna F, Fontana S, Barroso I, Undlien DE, O'Rahilly S 2007 Clinical and molecular genetic spectrum of congenital deficiency of the leptin receptor. N Engl J Med 356:237-247
-
(2007)
N Engl J Med
, vol.356
, pp. 237-247
-
-
Farooqi, I.S.1
Wangensteen, T.2
Collins, S.3
Kimber, W.4
Matarese, G.5
Keogh, J.M.6
Lank, E.7
Bottomley, B.8
Lopez-Fernandez, J.9
Ferraz-Amaro, I.10
Dattani, M.T.11
Ercan, O.12
Myhre, A.G.13
Retterstol, L.14
Stanhope, R.15
Edge, J.A.16
McKenzie, S.17
Lessan, N.18
Ghodsi, M.19
De Rosa, V.20
Perna, F.21
Fontana, S.22
Barroso, I.23
Undlien, D.E.24
O'Rahilly, S.25
more..
-
6
-
-
0037456768
-
Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene
-
DOI 10.1056/NEJMoa022050
-
Farooqi IS, Keogh JM, Yeo GS, Lank EJ, Cheetham T, O'Rahilly S 2003 Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene. N Engl J Med 348:1085-1095 (Pubitemid 36337319)
-
(2003)
New England Journal of Medicine
, vol.348
, Issue.12
, pp. 1085-1095
-
-
Farooqi, I.S.1
Keogh, J.M.2
Yeo, G.S.H.3
Lank, E.J.4
Cheetham, T.5
O'Rahilly, S.6
-
7
-
-
0242320429
-
Obesity due to proopiomelanocortin deficiency: Three new cases and treatment trials with thyroid hormone and ACTH4-10
-
Krude H, Biebermann H, Schnabel D, Tansek MZ, Theunissen P, Mullis PE, Grüters A 2003 Obesity due to proopiomelanocortin deficiency: three new cases and treatment trials with thyroid hormone and ACTH4-10. J Clin Endocrinol Metab 88:4633-4640
-
(2003)
J Clin Endocrinol Metab
, vol.88
, pp. 4633-4640
-
-
Krude, H.1
Biebermann, H.2
Schnabel, D.3
Tansek, M.Z.4
Mullis, P.E.5
Grüters, A.6
-
8
-
-
0030889192
-
Targeted disruption of the melanocortin-4 receptor results in obesity in mice
-
Huszar D, Lynch CA, Fairchild-Huntress V, Dunmore JH, Fang Q, Berkemeier LR, Gu W, Kesterson RA, Boston BA, Cone RD, Smith FJ, Campfield LA, Burn P, Lee F 1997 Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 88:131-141
-
(1997)
Cell
, vol.88
, pp. 131-141
-
-
Huszar, D.1
Lynch, C.A.2
Fairchild-Huntress, V.3
Dunmore, J.H.4
Fang, Q.5
Berkemeier, L.R.6
Gu, W.7
Kesterson, R.A.8
Boston, B.A.9
Cone, R.D.10
Smith, F.J.11
Campfield, L.A.12
Burn, P.13
Lee, F.14
-
9
-
-
0031436635
-
The molecular genetics of rodent single gene obesities
-
DOI 10.1074/jbc.272.51.31937
-
Leibel RL, Chung WK, Chua Jr SC 1997 The molecular genetics of rodent single gene obesities. J Biol Chem 272:31937-31940 (Pubitemid 28011856)
-
(1997)
Journal of Biological Chemistry
, vol.272
, Issue.51
, pp. 31937-31940
-
-
Leibel, R.L.1
Chung, W.K.2
Chua Jr., S.C.3
-
10
-
-
0037341511
-
Mutations in the human melanocortin-4 receptor gene associated with severe familial obesity disrupts receptor function through multiple molecular mechanisms
-
DOI 10.1093/hmg/ddg057
-
Yeo GS, Lank EJ, Farooqi IS, Keogh J, Challis BG, O'Rahilly S 2003 Mutations in the human melanocortin-4 receptor gene associated with severe familial obesity disrupts receptor function through multiple molecular mechanisms. Hum Mol Genet 12:561-574 (Pubitemid 36305594)
-
(2003)
Human Molecular Genetics
, vol.12
, Issue.5
, pp. 561-574
-
-
Yeo, G.S.H.1
Lank, E.J.2
Farooqi, I.S.3
Keogh, J.4
Challis, B.G.5
O'Rahilly, S.6
-
11
-
-
0033927916
-
Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity
-
Vaisse C, Clement K, Durand E, Hercberg S, Guy-Grand B, Froguel P 2000 Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity. J Clin Invest 106:253-262
-
(2000)
J Clin Invest
, vol.106
, pp. 253-262
-
-
Vaisse, C.1
Clement, K.2
Durand, E.3
Hercberg, S.4
Guy-Grand, B.5
Froguel, P.6
-
12
-
-
0033343736
-
Several mutations in the melanocortin- 4 receptor gene including a nonsense and a frameshift mutation associated with dominantly inherited obesity in humans
-
Hinney A, Schmidt A, Nottebom K, Heibült O, Becker I, Ziegler A, Gerber G, Sina M, Görg T, Mayer H, Siegfried W, Fichter M, Remschmidt H, Hebebrand J 1999 Several mutations in the melanocortin- 4 receptor gene including a nonsense and a frameshift mutation associated with dominantly inherited obesity in humans. J Clin Endocrinol Metab 84:1483-1486
-
(1999)
J Clin Endocrinol Metab
, vol.84
, pp. 1483-1486
-
-
Hinney, A.1
Schmidt, A.2
Nottebom, K.3
Heibült, O.4
Becker, I.5
Ziegler, A.6
Gerber, G.7
Sina, M.8
Görg, T.9
Mayer, H.10
Siegfried, W.11
Fichter, M.12
Remschmidt, H.13
Hebebrand, J.14
-
14
-
-
0022447036
-
Cluster analysis: A simple, versatile, and robust algorithm for endocrine pulse detection
-
Veldhuis JD, Johnson ML 1986 Cluster analysis: a simple, versatile, and robust algorithm for endocrine pulse detection. Am J Physiol 250:E486-E493
-
(1986)
Am J Physiol
, vol.250
-
-
Veldhuis, J.D.1
Johnson, M.L.2
-
15
-
-
0026724547
-
Deconvolution analysis of hormone data
-
Veldhuis JD, Johnson ML 1992 Deconvolution analysis of hormone data. Methods Enzymol 210:539-575
-
(1992)
Methods Enzymol
, vol.210
, pp. 539-575
-
-
Veldhuis, J.D.1
Johnson, M.L.2
-
16
-
-
0026780669
-
Quantification of hormone pulsatility via an approximate entropy algorithm
-
Pincus SM, Keefe DL 1992 Quantification of hormone pulsatility via an approximate entropy algorithm. Am J Physiol 262:E741-E754
-
(1992)
Am J Physiol
, vol.262
-
-
Pincus, S.M.1
Keefe, D.L.2
-
17
-
-
0343953074
-
Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency
-
Farooqi IS, Yeo GS, Keogh JM, Aminian S, Jebb SA, Butler G, Cheetham T, O'Rahilly S 2000 Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency. J Clin Invest 106:271-279
-
(2000)
J Clin Invest
, vol.106
, pp. 271-279
-
-
Farooqi, I.S.1
Yeo, G.S.2
Keogh, J.M.3
Aminian, S.4
Jebb, S.A.5
Butler, G.6
Cheetham, T.7
O'Rahilly, S.8
-
18
-
-
0023250788
-
Reduced growth hormone response to growth hormone-releasing hormone in children with simple obesity: Evidence for somatomedin-C mediated inhibition
-
Loche S, Cappa M, Borrelli P, Faedda A, Crino A, Cella SG, Corda R, Muller EE, Pintor C 1987 Reduced growth hormone response to growth hormone-releasing hormone in children with simple obesity: evidence for somatomedin-C mediated inhibition. Clin Endocrinol (Oxf) 27:145-153 (Pubitemid 17093746)
-
(1987)
Clinical Endocrinology
, vol.27
, Issue.2
, pp. 145-153
-
-
Loche, S.1
Cappa, M.2
Borrelli, P.3
-
19
-
-
0026694055
-
Insulin regulation of insulin-like growth factor binding protein-1 in obese and nonobese humans
-
Conover CA, Lee PD, Kanaley JA, Clarkson JT, Jensen MD 1992 Insulin regulation of insulin-like growth factor binding protein-1 in obese and nonobese humans. J Clin Endocrinol Metab 74:1355-1360
-
(1992)
J Clin Endocrinol Metab
, vol.74
, pp. 1355-1360
-
-
Conover, C.A.1
Lee, P.D.2
Kanaley, J.A.3
Clarkson, J.T.4
Jensen, M.D.5
-
20
-
-
3142690729
-
Differential impact of simple childhood obesity on the components of the growth hormone-insulin-like growth factor (IGF)-IGF binding proteins axis
-
Ballerini MG, Ropelato MG, Domené HM, Pennisi P, Heinrich JJ, Jasper HG 2004 Differential impact of simple childhood obesity on the components of the growth hormone-insulin-like growth factor (IGF)-IGF binding proteins axis. J Pediatr Endocrinol Metab 17: 749-757
-
(2004)
J Pediatr Endocrinol Metab
, vol.17
, pp. 749-757
-
-
Ballerini, M.G.1
Ropelato, M.G.2
Domené, H.M.3
Pennisi, P.4
Heinrich, J.J.5
Jasper, H.G.6
-
21
-
-
0026619132
-
Clinical pathophysiology of the somatotropic (GH) axis in adults
-
Iranmanesh A, Veldhuis JD 1992 Clinical pathophysiology of the somatotropic (GH) axis in adults. Endocrinol Metab Clin North Am 21:783-816
-
(1992)
Endocrinol Metab Clin North Am
, vol.21
, pp. 783-816
-
-
Iranmanesh, A.1
Veldhuis, J.D.2
-
22
-
-
0029057791
-
Pulsatile growth hormone secretion in normal-weight and obese men: Differential metabolic regulation during energy restriction
-
Riedel M, Hoeft B, Blum WF, von zur Mühlen A, Brabant G 1995 Pulsatile growth hormone secretion in normal-weight and obese men: differential metabolic regulation during energy restriction. Metabolism 44:605-610
-
(1995)
Metabolism
, vol.44
, pp. 605-610
-
-
Riedel, M.1
Hoeft, B.2
Blum, W.F.3
Von Zur Mühlen, A.4
Brabant, G.5
-
23
-
-
0035115801
-
The somato-medin hypothesis: 2001
-
Le Roith D, Bondy C, Yakar S, Liu JL, Butler A 2001 The somato-medin hypothesis: 2001. Endocr Rev 22:53-74
-
(2001)
Endocr Rev
, vol.22
, pp. 53-74
-
-
Le Roith, D.1
Bondy, C.2
Yakar, S.3
Liu, J.L.4
Butler, A.5
-
24
-
-
0028112970
-
Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor
-
Lu D, Willard D, Patel IR, Kadwell S, Overton L, Kost T, Luther M, Chen W, Woychik RP, Wilkison WO, et al. 1994 Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor. Nature 371:799-802
-
(1994)
Nature
, vol.371
, pp. 799-802
-
-
Lu, D.1
Willard, D.2
Patel, I.R.3
Kadwell, S.4
Overton, L.5
Kost, T.6
Luther, M.7
Chen, W.8
Woychik, R.P.9
Wilkison, W.O.10
-
25
-
-
33644615796
-
Abnormalities of the somatotrophic axis in the obese agouti
-
Lond
-
Martin NM, Houston PA, Patterson M, Sajedi A, Carmignac DF, Ghatei MA, Bloom SR, Small CJ 2006 Abnormalities of the somatotrophic axis in the obese agouti. Int J Obes (Lond) 30:430-438
-
(2006)
Int J Obes
, vol.30
, pp. 430-438
-
-
Martin, N.M.1
Houston, P.A.2
Patterson, M.3
Sajedi, A.4
Carmignac, D.F.5
Ghatei, M.A.6
Bloom, S.R.7
Small, C.J.8
-
26
-
-
0028134706
-
Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain
-
Mountjoy KG, Mortrud MT, Low MJ, Simerly RB, Cone RD 1994 Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain. Mol Endocrinol 8:1298-1308
-
(1994)
Mol Endocrinol
, vol.8
, pp. 1298-1308
-
-
Mountjoy, K.G.1
Mortrud, M.T.2
Low, M.J.3
Simerly, R.B.4
Cone, R.D.5
-
27
-
-
0034802108
-
Minireview: Ghrelin and the regulation of energy balance-a hypothalamic perspective
-
Horvath TL, Diano S, Sotonyi P, Heiman M, Tschöp M 2001 Minireview: ghrelin and the regulation of energy balance-a hypothalamic perspective. Endocrinology 142:4163-4169
-
(2001)
Endocrinology
, vol.142
, pp. 4163-4169
-
-
Horvath, T.L.1
Diano, S.2
Sotonyi, P.3
Heiman, M.4
Tschöp, M.5
-
28
-
-
0033711116
-
The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion
-
Wren AM, Small CJ, Ward HL, Murphy KG, Dakin CL, Taheri S, Kennedy AR, Roberts GH, Morgan DG, Ghatei MA, Bloom SR 2000 The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. Endocrinology 141:4325-4328
-
(2000)
Endocrinology
, vol.141
, pp. 4325-4328
-
-
Wren, A.M.1
Small, C.J.2
Ward, H.L.3
Murphy, K.G.4
Dakin, C.L.5
Taheri, S.6
Kennedy, A.R.7
Roberts, G.H.8
Morgan, D.G.9
Ghatei, M.A.10
Bloom, S.R.11
-
29
-
-
0035216623
-
Ghrelin enhances appetite and increases food intake in humans
-
Wren AM, Seal LJ, Cohen MA, Brynes AE, Frost GS, Murphy KG, Dhillo WS, Ghatei MA, Bloom SR 2001 Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab 86: 5992
-
(2001)
J Clin Endocrinol Metab
, vol.86
, pp. 5992
-
-
Wren, A.M.1
Seal, L.J.2
Cohen, M.A.3
Brynes, A.E.4
Frost, G.S.5
Murphy, K.G.6
Dhillo, W.S.7
Ghatei, M.A.8
Bloom, S.R.9
-
30
-
-
0035082265
-
Circulating ghrelin levels are decreased in human obesity
-
Tschöp M, Weyer C, Tataranni PA, Devanarayan V, Ravussin E, Heiman ML 2001 Circulating ghrelin levels are decreased in human obesity. Diabetes 50:707-709
-
(2001)
Diabetes
, vol.50
, pp. 707-709
-
-
Tschöp, M.1
Weyer, C.2
Tataranni, P.A.3
Devanarayan, V.4
Ravussin, E.5
Heiman, M.L.6
-
31
-
-
0037240916
-
Serum ghrelin levels are inversely correlated with body mass index, age, and insulin concentrations in normal children and are markedly increased in Prader-Willi Syndrome
-
DOI 10.1210/jc.2002-021052
-
Haqq AM, Farooqi IS, O'Rahilly S, Stadler DD, Rosenfeld RG, Pratt KL, LaFranchi SH, Purnell JQ 2003 Serum ghrelin levels are inversely correlated with body mass index, age, and insulin concentrations in normal children and are markedly increased in Prader- Willi syndrome. J Clin Endocrinol Metab 88:174-178 (Pubitemid 36115161)
-
(2003)
Journal of Clinical Endocrinology and Metabolism
, vol.88
, Issue.1
, pp. 174-178
-
-
Haqq, A.M.1
Sadaf Farooqi, I.2
O'Rahilly, S.3
Stadler, D.D.4
Rosenfeld, R.G.5
Pratt, K.L.6
LaFranchi, S.H.7
Purnell, J.Q.8
-
32
-
-
1642365834
-
Acipimox enhances spontaneous growth hormone secretion in obese women
-
Kok P, Buijs MM, Kok SW, van Ierssel IH, Frölich M, Roelfsema F, Voshol PJ, Meinders AE, Pijl H 2004 Acipimox enhances spontaneous growth hormone secretion in obese women. Am J Physiol Regul Integr Comp Physiol 286:R693-R698
-
(2004)
Am J Physiol Regul Integr Comp Physiol
, vol.286
-
-
Kok, P.1
Buijs, M.M.2
Kok, S.W.3
Van Ierssel, I.H.4
Frölich, M.5
Roelfsema, F.6
Voshol, P.J.7
Meinders, A.E.8
Pijl, H.9
-
33
-
-
0034456475
-
The central melanocortin system can directly regulate serum insulin levels
-
Fan W, Dinulescu DM, Butler AA, Zhou J, Marks DL, Cone RD 2000 The central melanocortin system can directly regulate serum insulin levels. Endocrinology 141:3072-3079
-
(2000)
Endocrinology
, vol.141
, pp. 3072-3079
-
-
Fan, W.1
Dinulescu, D.M.2
Butler, A.A.3
Zhou, J.4
Marks, D.L.5
Cone, R.D.6
-
34
-
-
0025873043
-
Insulin-like growth factor (IGF) binding proteins: The role of serum IGFBPs in regulating IGF availability
-
discussion 115
-
Baxter RC 1991 Insulin-like growth factor (IGF) binding proteins: the role of serum IGFBPs in regulating IGF availability. Acta Paediatr Scand Suppl 372:107-114; discussion 115
-
(1991)
Acta Paediatr Scand Suppl
, vol.372
, pp. 107-114
-
-
Baxter, R.C.1
-
35
-
-
0030853530
-
Cafeteria diet-induced obese rats have an increased somatostatin protein content and gene expression in the periventricular nucleus
-
Zhou X, De Schepper J, Vergeylen A, Luis O, Delhase M, Hooghe- Peters EL 1997 Cafeteria diet-induced obese rats have an increased somatostatin protein content and gene expression in the periventricular nucleus. J Endocrinol Invest 20:264-269
-
(1997)
J Endocrinol Invest
, vol.20
, pp. 264-269
-
-
Zhou, X.1
De Schepper, J.2
Vergeylen, A.3
Luis, O.4
Delhase, M.5
Hooghe-Peters, E.L.6
-
36
-
-
0026554057
-
Endogenous growth hormone secretion and clearance rates in normal boys, as determined by deconvolution analysis: Relationship to age, pubertal status, and body mass
-
Martha Jr PM, Gorman KM, Blizzard RM, Rogol AD, Veldhuis JD 1992 Endogenous growth hormone secretion and clearance rates in normal boys, as determined by deconvolution analysis: relationship to age, pubertal status, and body mass. J Clin Endocrinol Metab 74:336-344
-
(1992)
J Clin Endocrinol Metab
, vol.74
, pp. 336-344
-
-
Martha Jr., P.M.1
Gorman, K.M.2
Blizzard, R.M.3
Rogol, A.D.4
Veldhuis, J.D.5
|