3-trifluoromethylquinoxaline N, N′-dioxides as anti-Trypanosomatid agents. Identification of optimal anti- T. cruzi agents and mechanism of action studies

Journal of Medicinal Chemistry

Volumn 54, Issue 10, 2011, Pages 3624-3636

  Benitez, Diego ^a   Cabrera, Mauricio ^a   Hernández, Paola ^a   Boiani, Lucía ^a   Lavaggi, María L ^a   Di Maio, Rossanna ^a   Yaluff, Gloria ^b   Serna, Elva ^b   Torres, Susana ^b   Ferreira, María E ^b   Vera De Bilbao, Ninfa ^b   Torres, Enrique ^c   Pérez Silanes, Silvia ^c   Solano, Beatriz ^c   Moreno, Elsa ^c   Aldana, Ignacio ^c   López De Ceráin, Adela ^c   Cerecetto, Hugo ^a   González, Mercedes ^a   Monge, Antonio ^c  

^a UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

^b UNIVERSIDAD NACIONAL DE ASUNCIÓN   (Paraguay)

^c UNIVERSITY OF NAVARRA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITRYPANOSOMAL AGENT; QUINOXALINE DERIVATIVE;

ANTIPROTOZOAL ACTIVITY; ARTICLE; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG SYNTHESIS; MUTAGENICITY; NONHUMAN; TRYPANOSOMA CRUZI;

ANIMALS; CHEMISTRY, PHARMACEUTICAL; CYCLIC N-OXIDES; DRUG DESIGN; ELECTRONS; HUMANS; INHIBITORY CONCENTRATION 50; MICE; MODELS, CHEMICAL; MUTAGENICITY TESTS; PARASITEMIA; QUINOXALINES; TOXICITY TESTS; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

EID: 79957775904     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm2002469     Document Type: Article

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