Synthesis and structure-activity relationship of 3-phenylquinoxaline 1,4-di-N-oxide derivatives as antimalarial agents

European Journal of Medicinal Chemistry

Volumn 43, Issue 9, 2008, Pages 1903-1910

  Vicente, Esther ^a,b   Lima, Lidia M ^a   Bongard, Emily ^b   Charnaud, Sarah ^b   Villar, Raquel ^a   Solano, Beatriz ^a   Burguete, Asunción ^a   Perez Silanes, Silvia ^a   Aldana, Ignacio ^a   Vivas, Livia ^b   Monge, Antonio ^a  

^a UNIVERSITY OF NAVARRA   (Spain)

^b LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

Antiplasmodial; Beirut reaction; Malaria; N Oxide; Plasmodium falciparum; Quinoxaline

Indexed keywords

3 PHENYLQUINOXALINE 1,4 DI N OXIDE; 3 PHENYLQUINOXALINE 2 CARBOXYLIC ACID 1,4 DI N OXIDE; CHLOROQUINE; ETHYL 3 PHENYLQUINOXALINE 2 CARBOXYLATE 1,4 DI N OXIDE; HYPOXANTHINE; QUINOXALINE 2 CARBONITRILE 1,4 DI N OXIDE; QUINOXALINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; BEIRUT REACTION; CELL STRAIN KB; CHEMICAL REACTION; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; PLASMODIUM FALCIPARUM; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIMALARIALS; CATTLE; CELL SURVIVAL; DRUG DESIGN; HUMANS; KB CELLS; PLASMODIUM FALCIPARUM; QUINOXALINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 50949128431     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2007.11.024     Document Type: Article

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