DNA strand cleaving properties and hypoxia-selective cytotoxicity of 7-chloro-2-thienylcarbonyl-3-trifluoromethylquinoxaline 1,4-dioxide

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 9, 2010, Pages 3125-3132

  Junnotula, Venkatraman ^a   Rajapakse, Anuruddha ^a   Arbillaga, Leire ^b   López de Cerain, Adela ^b   Solano, Beatriz ^c   Villar, Raquel ^c   Monge, Antonio ^c   Gates, Kent S ^a  

^a UNIVERSITY OF MISSOURI   (United States)

^b Aplicada (CIFA)   (Spain)

^c UNIVERSITY OF NAVARRA   (Spain)

Author keywords

Antitumor agent; DNA damaging agent; Tumor hypoxia

Indexed keywords

7 CHLORO 2 THIENYLCARBONYL 3 TRIFLUOROMETHYLQUINOXALINE 1,4 DIOXIDE; CATALASE; DIMETHYL SULFOXIDE; DNA; QUINOXALINE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE FERRIHEMOPROTEIN REDUCTASE; SUPEROXIDE DISMUTASE; TIRAPAZAMINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL STRAIN V 79; CONTROLLED STUDY; CYTOTOXICITY; DNA CLEAVAGE; DNA STRAND; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; HUMAN; HUMAN CELL; HYPOXIA; LIQUID CHROMATOGRAPHY; NONHUMAN; OXIDATION; OXIDATION REDUCTION STATE; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

ANOXIA; ANTINEOPLASTIC AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; DNA; DNA CLEAVAGE; HUMANS; MOLECULAR STRUCTURE; NADP; OXIDATION-REDUCTION; QUINOXALINES; TRIAZINES;

EID: 77951204822     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.03.042     Document Type: Article

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