New potent 5-substituted benzofuroxans as inhibitors of Trypanosoma cruzi growth: Quantitative structure-activity relationship studies

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 23, 2005, Pages 6336-6346

  Aguirre, Gabriela ^a   Boiani, Lucía ^a   Boiani, Mariana ^a   Cerecetto, Hugo ^a   Di Maio, Rossanna ^a   González, Mercedes ^a   Porcal, Williams ^a   Denicola, Ana ^b   Piro, Oscar E ^c   Castellano, Eduardo E ^d   Sant'Anna, Carlos Mauricio R ^e   Barreiro, Eliezer J ^f  

^a UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

^b UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

^c UNIVERSIDAD NACIONAL DE LA PLATA   (Argentina)

^d UNIVERSITY OF SÃO PAULO   (Brazil)

^e FEDERAL RURAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^f FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

5 (ETHENYL) N 1 OXOBENZ[1,2 C] 1,2,5 OXADIAZOLE; 5 [2 (4 CHLOROPHENYL)ETHENYL] N 1 OXOBENZ[1,2 C] 1,2,5 OXADIAZOLE; 5 [2 (4 NITROPHENYL)ETHENYL] N 1 OXOBENZ[1,2 C] 1,2,5 OXADIAZOLE; 5 [2 (4 NITROPHENYL)ETHENYL]BENZ[1,2 C] 1,2,5 OXADIAZOLE; 5 [2 (4 TRIFLUOROMETHYLPHENYL)ETHENYL] N 1 OXOBENZ[1,2 C] 1,2,5 OXADIAZOLE; ANTITRYPANOSOMAL AGENT; BENZOFURAN DERIVATIVE; N 1 OXOPYRIDO[2,3 C] 1,2,5 OXADIAZOLE; OXIDE; UNCLASSIFIED DRUG;

ARTICLE; ATOM; COMPARATIVE MOLECULAR FIELD ANALYSIS; CONTROLLED STUDY; DENSITY FUNCTIONAL THEORY; DRUG SYNTHESIS; LOW TEMPERATURE; MULTIPLE REGRESSION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PARAMETER; PHYSICAL CHEMISTRY; QUANTITATIVE STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; TRYPANOSOMA CRUZI;

ANIMALS; BENZOXAZOLES; ELECTRONS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; NIFURTIMOX; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; TEMPERATURE; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

TRYPANOSOMA CRUZI;

EID: 27544437500     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.07.072     Document Type: Article

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