Indazole N-oxide derivatives as antiprotozoal agents: Synthesis, biological evaluation and mechanism of action studies

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 10, 2006, Pages 3467-3480

  Gerpe, Alejandra ^a   Aguirre, Gabriela ^a   Boiani, Lucía ^a   Cerecetto, Hugo ^a   González, Mercedes ^a   Olea Azar, Claudio ^b   Rigol, Carolina ^b   Maya, Juan D ^c   Morello, Antonio ^c   Piro, Oscar E ^d   Arán, Vicente J ^e   Azqueta, Amaia ^f   de Ceráin, Adela López ^f   Monge, Antonio ^f   Rojas, María Antonieta ^g   Yaluff, Gloria ^g  

^a UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

^b UNIVERSITY OF CHILE   (Chile)

^c UNIVERSITY OF CHILE   (Chile)

^d FACULTAD DE CIENCIAS EXACTAS   (Argentina)

^e INSTITUTO DE QUÍMICA MÉDICA   (Spain)

^f UNIVERSITY OF NAVARRA   (Spain)

^g Instituto de Investigaciones en Ciencias de la Salud Universidad Nacional de Asuncion   (Paraguay)

Author keywords

Antichagasic activity; Indazole N oxide; Leishmanocidal activity

Indexed keywords

2 (4 CHLOROPHENYL) 3 CYANO 2H INDAZOLE N OXIDE; 2 BUTYL 3 CYANO 2H INDAZOLE N OXIDE; 2 CHLOROETHYL 3 CYANO 2H INDAZOLE N OXIDE; 3 CYANO 2 (2 FURYLMETHYL) 2H INDAZOLE N OXIDE; 3 CYANO 2 (2 NAPHTHYL) 2H INDAZOLE N OXIDE; 3 CYANO 2 (3 NITROPHENYL) 2H INDAZOLE N OXIDE; 3 CYANO 2 (4 HYDROXYPHENYL) 2H INDAZOLE; 3 CYANO 2 (4 HYDROXYPHENYL) 2H INDAZOLE N OXIDE; 3 CYANO 2 (4 IODOPHENYL) 2H INDAZOLE; 3 CYANO 2 (4 IODOPHENYL) 2H INDAZOLE N OXIDE; 3 CYANO 2 (4 NITROPHENYL) 2H INDAZOLE; 3 CYANO 2 (4 NITROPHENYL) 2H INDAZOLE N OXIDE; 3 CYANO 2 (4 TOLYL) 2H INDAZOLE N OXIDE; 3 CYANO 2 PHENETHYL 2H INDAZOLE N OXIDE; 3 CYANO 2 PHENYL 2H INDAZOLE N OXIDE; ANTIPROTOZOAL AGENT; ANTITRYPANOSOMAL AGENT; INDAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIPROTOZOAL ACTIVITY; ARTICLE; BIOLOGICAL MONITORING; DRUG ACTIVITY; DRUG SYNTHESIS; ELECTROCHEMICAL ANALYSIS; ELECTRON SPIN RESONANCE; PARASITE; PARASITE DEVELOPMENT; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTIPROTOZOAL AGENTS; CELL LINE, TUMOR; CELLS, CULTURED; CRYSTALLOGRAPHY, X-RAY; ELECTROCHEMISTRY; INDAZOLES; LEISHMANIA; MODELS, MOLECULAR; PARASITIC SENSITIVITY TESTS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOSOMA CRUZI;

EID: 33646476539     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.01.007     Document Type: Article

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