Mode of action of Nifurtimox and N-oxide-containing heterocycles against Trypanosoma cruzi: Is oxidative stress involved?

Biochemical Pharmacology

Volumn 79, Issue 12, 2010, Pages 1736-1745

  Boiani, Mariana ^a   Piacenza, Lucia ^b,c   Hernández, Paola ^a   Boiani, Lucia ^a   Cerecetto, Hugo ^a   González, Mercedes ^a   Denicola, Ana ^c  

^a UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

^b DEPARTAMENTO DE BIOQUÍMICA   (Uruguay)

^c UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

Author keywords

N Oxide containing heterocycles; Nifurtimox; Oxidative stress; Trypanosoma cruzi

Indexed keywords

2,2 DIMETHYL 5 (HYDROXYIMINO)METHYL 2H BENZIMIDAZOLE 1,3 DIOXIDE; 2,2 DIMETHYL 5 PHENYLETHENYL 2H BENZIMIDAZOLE 1,3 DIOXIDE; 3 CYANO 2 (4 IODOPHENYL) 2H INDAZOLE N OXIDE; 5 BROMOMETHYLBENZO[1,2 C][1,2,5]OXADIAZOLE N OXIDE; 5 PHENYLETHENYLBENZO[1,2 C][1,2,5]OXADIAZOLE N OXIDE; BENZNIDAZOLE; BENZOFURAN DERIVATIVE; MENADIONE; NIFURTIMOX; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; CELL GROWTH; CELL PROLIFERATION; CELL VIABILITY; CHAGAS DISEASE; DRUG STRUCTURE; DRUG UPTAKE; ELECTRON SPIN RESONANCE; ENZYME ACTIVITY; EPIMASTIGOTE; HUMAN; IC 50; MITOCHONDRIAL MEMBRANE POTENTIAL; MOLECULAR WEIGHT; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PRIORITY JOURNAL; TRYPANOSOMA CRUZI;

BENZOXAZOLES; CELLS, CULTURED; CYCLIC N-OXIDES; MEMBRANE POTENTIALS; MITOCHONDRIA; MOLECULAR STRUCTURE; NIFURTIMOX; OXIDATION-REDUCTION; OXIDATIVE STRESS; OXIDOREDUCTASES; OXYGEN; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

EID: 77951623379     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2010.02.009     Document Type: Article

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