2H-benzimidazole 1,3-dioxide derivatives: A new family of water-soluble anti-trypanosomatid agents

Journal of Medicinal Chemistry

Volumn 49, Issue 11, 2006, Pages 3215-3224

  Boiani, Mariana ^a   Boiani, Lucía ^a   Denicola, Ana ^a   Torres De Ortiz, Susana ^b   Serna, Elva ^b   Vera De Bilbao, Ninfa ^b   Sanabria, Luis ^b   Yaluff, Gloria ^b   Nakayama, Héctor ^b   Rojas De Arias, Antonieta ^b   Vega, Celeste ^c   Rolan, Miriam ^c   Gómez Barrio, Alicia ^c   Cerecetto, Hugo ^a,d   González, Mercedes ^a,d  

^a UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

^b Instituto de Investigaciones en Ciencias de la Salud Universidad Nacional de Asuncion   (Paraguay)

^c UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^d Facultad de Ciencias   (Uruguay)

Author keywords

[No Author keywords available]

Indexed keywords

2,2 DIMETHYL 2H BENZIMIDAZOLE 1,3 DIOXIDE; 2,2 DIMETHYL 5 (1,3 DIOXOLAN 2 YL) 2H BENZIMIDAZOLE 1,3 DIOXIDE; 2,2 DIMETHYL 5 (2 PHENYLETHENYL) 2H BENZIMIDAZOLE 1,3 DIOXIDE; 2,2 DIMETHYL 5 (HYDROXYIMINO)METHYL 2H BENZIMIDAZOLE 1,3 DIOXIDE; 2,2,5 TRIMETHYL 2H BENZIMIDAZOLE 1,3 DIOXIDE; AMPHOTERICIN B LIPID COMPLEX; ANTITRYPANOSOMAL AGENT; BENZIMIDAZOLE DERIVATIVE; BENZNIDAZOLE; MEGLUMINE ANTIMONATE; NIFURTIMOX; PENTAMIDINE; STIBOGLUCONATE SODIUM; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPROTOZOAL ACTIVITY; AQUEOUS SOLUTION; ARTICLE; CHAGAS DISEASE; CONTROLLED STUDY; CYTOTOXICITY; DRUG SELECTIVITY; DRUG SYNTHESIS; EPIMASTIGOTE; IC 50; LEISHMANIA; MACROPHAGE; MALE; MOUSE; NONHUMAN; PROMASTIGOTE; REDUCTION; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA CRUZI; TRYPANOSOMIASIS;

ACUTE DISEASE; ANIMALS; BENZIMIDAZOLES; CELL LINE; CHAGAS DISEASE; CYCLIC N-OXIDES; LEISHMANIA; MACROPHAGES; MICE; MICE, INBRED BALB C; MODELS, MOLECULAR; OXIDATION-REDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

EID: 33744802230     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0600343     Document Type: Article

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