-
1
-
-
85071339760
-
-
Accessed May 5, 2009
-
TAACF: http://www.taacf.org/about-TB-background.htm. Accessed May 5, 2009.
-
-
-
-
2
-
-
85071293992
-
-
Accessed May 5, 2009
-
NIAID: http://www3.niaid.nih.gov/topics/tuberculosis/. Accessed May 5, 2009.
-
-
-
-
3
-
-
15444370985
-
Synthesis of new quinoxaline-2-carboxylate 1,4-dioxide derivatives as anti-Mycobacterium tuberculosis agents
-
Jaso, A.; Zarranz, B.; Aldana, I.; Monge, A. Synthesis of new quinoxaline-2-carboxylate 1,4-dioxide derivatives as anti-Mycobacterium tuberculosis agents. J. Med. Chem. 2005, 48, 2019-2025.
-
(2005)
J. Med. Chem.
, vol.48
, pp. 2019-2025
-
-
Jaso, A.1
Zarranz, B.2
Aldana, I.3
Monge, A.4
-
4
-
-
4744373628
-
Synthesis and evaluation of nitrofuranylamides as novel antituberculosis agents
-
Tangallapally, R.P.; Yendapally, R.; Lee, R.E.; Hevener, K.; Jones, V.C.; Lenaerts, A.J.; McNeil, M.R.; Wang, Y.; Franzblau, S.; Lee, R.E. Synthesis and evaluation of nitrofuranylamides as novel antituberculosis agents. J. Med. Chem. 2004, 47, 5276-5283.
-
(2004)
J. Med. Chem.
, vol.47
, pp. 5276-5283
-
-
Tangallapally, R.P.1
Yendapally, R.2
Lee, R.E.3
Hevener, K.4
Jones, V.C.5
Lenaerts, A.J.6
McNeil, M.R.7
Wang, Y.8
Franzblau, S.9
Lee, R.E.10
-
5
-
-
85071311404
-
-
Accessed June 14, 2009
-
WHO: http://www.who.int/neglected_diseases/diseases/chagas/en/index.html. Accessed June 14, 2009.
-
-
-
-
6
-
-
0036835130
-
Chemotherapy of Chagas´ disease: Status and new developments
-
Cerecetto, H.; González, M. Chemotherapy of Chagas´ disease: Status and new developments. Curr. Top. Med. Chem. 2002. 2, 1187-1213.
-
(2002)
Curr. Top. Med. Chem.
, vol.2
, pp. 1187-1213
-
-
Cerecetto, H.1
González, M.2
-
7
-
-
77951204325
-
Quinoxaline 1,4-dioxide and Phenazine 5,10-dioxide. Chemistry and biology
-
Heterocycles Khan, M.T.H., Ed.; Springer: Berlin, Germany
-
González, M.; Cerecetto, H.; Monge, A. Quinoxaline 1,4-dioxide and Phenazine 5,10-dioxide. Chemistry and Biology. In Topics in Heterocyclic Chemistry. Bioactive Heterocycles V; Khan, M.T.H., Ed.; Springer: Berlin, Germany, 2007; Volume 11, p. 179-211.
-
(2007)
Topics in Heterocyclic Chemistry. Bioactive
, vol.11
, pp. 179-211
-
-
González, M.1
Cerecetto, H.2
Monge, A.3
-
8
-
-
0032920188
-
Synthesis and antituberculosis activity of new 2-quinoxalinecarbonitrile 1,4-di-N-oxides
-
Ortega, M.A.; Sainz, Y.; Montoya, M.E.; López de Ceráin, A.; Monge, A. Synthesis and antituberculosis activity of new 2-quinoxalinecarbonitrile 1,4-di-N-oxides. Pharmazie 1999, 54, 24-25.
-
(1999)
Pharmazie
, vol.54
, pp. 24-25
-
-
Ortega, M.A.1
Sainz, Y.2
Montoya, M.E.3
López de Ceráin, A.4
Monge, A.5
-
9
-
-
0002818310
-
New quinoxaline 1,4-di-N-oxides for treatment of tuberculosis
-
Sainz, Y.; Montoya, M.E.; Martínez-Crespo, F.J.; Ortega, M.A.; López de Ceráin, A.; Monge, A. New quinoxaline 1,4-di-N-oxides for treatment of tuberculosis. Arzneimittelforschung 1999, 49, 55-59.
-
(1999)
Arzneimittelforschung
, vol.49
, pp. 55-59
-
-
Sainz, Y.1
Montoya, M.E.2
Martínez-Crespo, F.J.3
Ortega, M.A.4
López de Ceráin, A.5
Monge, A.6
-
10
-
-
0035093384
-
Antimycobacterial activity of new quinoxaline-2-carbonitrile and quinoxaline-2-carbonitrile 1,4-di-N-oxide derivatives
-
Ortega, M.A.; Montoya, M.E.; Jaso, A.; Zarranz, B.; Tirapu, I.; Aldana, I.; Monge, A. Antimycobacterial activity of new quinoxaline-2-carbonitrile and quinoxaline-2-carbonitrile 1,4-di-N-oxide derivatives. Pharmazie 2001, 56, 205-207.
-
(2001)
Pharmazie
, vol.56
, pp. 205-207
-
-
Ortega, M.A.1
Montoya, M.E.2
Jaso, A.3
Zarranz, B.4
Tirapu, I.5
Aldana, I.6
Monge, A.7
-
11
-
-
0036170226
-
Anti-Mycobacterium tuberculosis agents derived from quinoxaline-2-carbonitrile and quinoxaline-2carbonitrile 1,4-di-N-oxide
-
Ortega, M.A.; Sainz, Y.; Montoya, M.E.; Jaso, A.; Zarranz, B.; Aldana, I.; Monge, A. Anti-Mycobacterium tuberculosis agents derived from quinoxaline-2-carbonitrile and quinoxaline-2carbonitrile 1,4-di-N-oxide. Arzneimittelforschung 2002, 52, 113-119.
-
(2002)
Arzneimittelforschung
, vol.52
, pp. 113-119
-
-
Ortega, M.A.1
Sainz, Y.2
Montoya, M.E.3
Jaso, A.4
Zarranz, B.5
Aldana, I.6
Monge, A.7
-
12
-
-
0037447952
-
Synthesis and antimycobacterial activity of new quinoxaline-2-carboxamide 1,4-di-N-oxide derivatives
-
Zarranz, B.; Jaso, A.; Aldana, I.; Monge, A. Synthesis and antimycobacterial activity of new quinoxaline-2-carboxamide 1,4-di-N-oxide derivatives. Bioorg. Med. Chem. 2003, 11, 2149-2156.
-
(2003)
Bioorg. Med. Chem.
, vol.11
, pp. 2149-2156
-
-
Zarranz, B.1
Jaso, A.2
Aldana, I.3
Monge, A.4
-
13
-
-
0141953265
-
Synthesis of new 2-acetyl and 2-benzoyl quinoxaline 1,4-di-N-oxide derivatives as anti-Mycobacterium tuberculosis agents
-
Jaso, A.; Zarranz, B.; Aldana, I.; Monge, A. Synthesis of new 2-acetyl and 2-benzoyl quinoxaline 1,4-di-N-oxide derivatives as anti-Mycobacterium tuberculosis agents. Eur. J. Med. Chem. 2003, 38, 791-800.
-
(2003)
Eur. J. Med. Chem.
, vol.38
, pp. 791-800
-
-
Jaso, A.1
Zarranz, B.2
Aldana, I.3
Monge, A.4
-
14
-
-
49649096677
-
In vitro and in vivo antimycobacterial activities of ketone and amide derivatives of quinoxaline 1,4-di-N-oxide
-
Villar, R.; Vicente, E.; Solano, B.; Pérez-Silanes, S.; Aldana, I.; Maddry, J.A.; Lenaerts, A.J.; Franzblau, S.G.; Cho, S.H.; Monge, A.; Goldman, R.C. In vitro and in vivo antimycobacterial activities of ketone and amide derivatives of quinoxaline 1,4-di-N-oxide. J. Antimicrob. Chemother. 2008, 62, 547-554.
-
(2008)
J. Antimicrob. Chemother.
, vol.62
, pp. 547-554
-
-
Villar, R.1
Vicente, E.2
Solano, B.3
Pérez-Silanes, S.4
Aldana, I.5
Maddry, J.A.6
Lenaerts, A.J.7
Franzblau, S.G.8
Cho, S.H.9
Monge, A.10
Goldman, R.C.11
-
15
-
-
50949110277
-
Efficacy of quinoxaline-2carboxylate 1,4-di-N-oxide derivatives in experimental tuberculosis
-
Vicente, E.; Villar, R.; Burguete, A.; Solano, B.; Pérez-Silanes, S.; Aldana, I.; Maddry, J.A.; Lenaerts, A.J.; Franzblau, S.G.; Cho, S.H.; Monge, A.; Goldman, R.C. Efficacy of quinoxaline-2carboxylate 1,4-di-N-oxide derivatives in experimental tuberculosis. Antimicrob. Agents Chemother. 2008, 52, 3321-3326.
-
(2008)
Antimicrob. Agents Chemother.
, vol.52
, pp. 3321-3326
-
-
Vicente, E.1
Villar, R.2
Burguete, A.3
Solano, B.4
Pérez-Silanes, S.5
Aldana, I.6
Maddry, J.A.7
Lenaerts, A.J.8
Franzblau, S.G.9
Cho, S.H.10
Monge, A.11
Goldman, R.C.12
-
16
-
-
57649196329
-
Selective activity against Mycobacterium tuberculosis of new quinoxaline 1,4-di-N-oxides
-
Vicente, E.; Pérez-Silanes, S.; Lima, L.M.; Ancizu, S.; Burguete, A.; Solano, B.; Villar, R.; Aldana, I.; Monge, A. Selective activity against Mycobacterium tuberculosis of new quinoxaline 1,4-di-N-oxides. Bioorg. Med. Chem. 2009, 17, 385-389.
-
(2009)
Bioorg. Med. Chem.
, vol.17
, pp. 385-389
-
-
Vicente, E.1
Pérez-Silanes, S.2
Lima, L.M.3
Ancizu, S.4
Burguete, A.5
Solano, B.6
Villar, R.7
Aldana, I.8
Monge, A.9
-
17
-
-
2942532638
-
Quinoxaline N,N'-dioxide derivatives and related compounds as growth inhibitors of Trypanosoma cruzi. Structure-activity relationships
-
Aguirre, G.; Cerecetto, H.; Di Maio, R.; González, M.; Montoya Alfaro, M.E.; Jaso, A.; Zarranz, B.; Ortega, M.A.; Aldana, I.; Monge-Vega, A. Quinoxaline N,N'-dioxide derivatives and related compounds as growth inhibitors of Trypanosoma cruzi. Structure-activity relationships. Bioorg. Med. Chem. Lett. 2004, 14, 3835-3839.
-
(2004)
Bioorg. Med. Chem. Lett.
, vol.14
, pp. 3835-3839
-
-
Aguirre, G.1
Cerecetto, H.2
Di Maio, R.3
González, M.4
Montoya Alfaro, M.E.5
Jaso, A.6
Zarranz, B.7
Ortega, M.A.8
Aldana, I.9
Monge-Vega, A.10
-
18
-
-
47949115310
-
Pyrimido[1,2-a]quinoxaline 6-oxide and phenazine 5,10-dioxide derivatives and related compounds as growth inhibitors of Trypanosoma cruzi
-
Lavaggi, M.L.; Aguirre, G.; Boiani, L.; Orelli, L.; García, B.; Cerecetto, H.; González, M. Pyrimido[1,2-a]quinoxaline 6-oxide and phenazine 5,10-dioxide derivatives and related compounds as growth inhibitors of Trypanosoma cruzi. Eur. J. Med. Chem. 2008 43, 1737-1741.
-
(2008)
Eur. J. Med. Chem.
, vol.43
, pp. 1737-1741
-
-
Lavaggi, M.L.1
Aguirre, G.2
Boiani, L.3
Orelli, L.4
García, B.5
Cerecetto, H.6
González, M.7
-
19
-
-
69249229903
-
QSAR analysis for quinoxaline-2carboxylate 1,4-di-N-oxides as anti-mycobacterial agents
-
Vicente, E.; Duchowicz, P.R.; Castro, E.A.; Monge, A. QSAR analysis for quinoxaline-2carboxylate 1,4-di-N-oxides as anti-mycobacterial agents. J. Mol. Graph. Model. 2009, doi:10.1016/j.jmgm.2009.03.004.
-
(2009)
J. Mol. Graph. Model.
-
-
Vicente, E.1
Duchowicz, P.R.2
Castro, E.A.3
Monge, A.4
-
20
-
-
38949155327
-
Substitutions of fluorine atoms and phenoxy groups in the synthesis of quinoxaline 1,4-di-N-oxide derivatives
-
Vicente, E.; Villar, R.; Burguete, A.; Solano, B.; Ancizu, S.; Pérez-Silanes, S.; Aldana, I.; Monge, A. Substitutions of fluorine atoms and phenoxy groups in the synthesis of quinoxaline 1,4-di-N-oxide derivatives. Molecules 2008, 13, 86-95.
-
(2008)
Molecules
, vol.13
, pp. 86-95
-
-
Vicente, E.1
Villar, R.2
Burguete, A.3
Solano, B.4
Ancizu, S.5
Pérez-Silanes, S.6
Aldana, I.7
Monge, A.8
-
21
-
-
58149377783
-
Anti-T. Cruzi agents: Our experience in the evaluation of more than five hundred compounds
-
Cerecetto, H.; González, M. Anti-T. cruzi agents: our experience in the evaluation of more than five hundred compounds. Mini Rev. Med. Chem. 2008, 8, 1355-1383.
-
(2008)
Mini Rev. Med. Chem.
, vol.8
, pp. 1355-1383
-
-
Cerecetto, H.1
González, M.2
-
22
-
-
56249126152
-
Benzofuroxan and furoxan. Chemistry and biology
-
Khan, M.T.H, Ed.; Springer: Berlin, Germany
-
González, M.; Cerecetto, H. Benzofuroxan and Furoxan. Chemistry and Biology. In Topics in Heterocyclic Chemistry. Bioactive Heterocycles V.; Khan, M.T.H, Ed.; Springer: Berlin, Germany, 2007; Volume 10, pp. 265-308.
-
(2007)
Topics in Heterocyclic Chemistry. Bioactive Heterocycles
, vol.10
, pp. 265-308
-
-
González, M.1
Cerecetto, H.2
-
23
-
-
84993582130
-
Synthesis unter verwendung von benzofuroxan
-
Ley, K.; Seng. F. Synthesis unter verwendung von benzofuroxan. Synthesis 1975, 415-422.
-
(1975)
Synthesis
, pp. 415-422
-
-
Ley, K.1
Seng, F.2
-
24
-
-
0027465474
-
Synthesis of new amide-linked N-hydroxyurea 5-lipoxygenase inhibitors by an intramolecular oxygen to nitrogen acyl transfer
-
Dellaria, J.F.; Sallin K.J.; Rodriques, K. Synthesis of new amide-linked N-hydroxyurea 5-lipoxygenase inhibitors by an intramolecular oxygen to nitrogen acyl transfer. Bioorg. Med. Chem. Lett. 1993, 3, 305-308.
-
(1993)
Bioorg. Med. Chem. Lett.
, vol.3
, pp. 305-308
-
-
Dellaria, J.F.1
Sallin, K.J.2
Rodriques, K.3
-
26
-
-
85071289092
-
-
Accessed 5 May, 2009
-
TAACF: http://www.taacf.org/Process-text.htm#assays. Accessed 5 May, 2009.
-
-
-
-
27
-
-
0030903133
-
Microplate Alamar Blue Assay versus BACTEC 460 System for High-Throughput Screening of Compounds against Mycobacterium tuberculosis and Mycobacterium avium
-
Collins, L.A.; Franzblau, S.G. Microplate Alamar Blue Assay versus BACTEC 460 System for High-Throughput Screening of Compounds against Mycobacterium tuberculosis and Mycobacterium avium. Antimicrob. Antimicrob. Agents Chemother. 1997, 41, 1004-1009.
-
(1997)
Antimicrob. Antimicrob. Agents Chemother.
, vol.41
, pp. 1004-1009
-
-
Collins, L.A.1
Franzblau, S.G.2
-
28
-
-
37849011377
-
In vivo anti-Chagas vinylthio-, vinylsulfinyl-, and vinylsulfonylbenzofuroxan derivatives
-
Porcal, W.; Hernández, P.; Boiani, M.; Aguirre, G.; Boiani, L.; Chidichimo, A.; Cazzulo, J.J.; Campillo, N.E.; Paez, J.A.; Castro, A.; Krauth-Siegel, R.L.; Davies, C.; Basombrío, M.A.; González, M.; Cerecetto, H. In vivo anti-Chagas vinylthio-, vinylsulfinyl-, and vinylsulfonylbenzofuroxan derivatives. J. Med. Chem. 2007, 50, 6004-6015.
-
(2007)
J. Med. Chem.
, vol.50
, pp. 6004-6015
-
-
Porcal, W.1
Hernández, P.2
Boiani, M.3
Aguirre, G.4
Boiani, L.5
Chidichimo, A.6
Cazzulo, J.J.7
Campillo, N.E.8
Paez, J.A.9
Castro, A.10
Krauth-Siegel, R.L.11
Davies, C.12
Basombrío, M.A.13
González, M.14
Cerecetto, H.15
-
29
-
-
61349109395
-
Study of 5-nitroindazoles' anti-Trypanosoma cruzi mode of action: Electrochemical behaviour and ESR spectroscopic studies
-
Rodríguez, J.; Gerpe, A.; Aguirre, G.; Kemmerling, U.; Piro, O.E.; Arán, V.J.; Maya, J.D.; Olea-Azar, C.; González, M.; Cerecetto, H. Study of 5-nitroindazoles' anti-Trypanosoma cruzi mode of action: electrochemical behaviour and ESR spectroscopic studies. Eur. J. Med. Chem. 2009, 44, 1545-1553.
-
(2009)
Eur. J. Med. Chem.
, vol.44
, pp. 1545-1553
-
-
Rodríguez, J.1
Gerpe, A.2
Aguirre, G.3
Kemmerling, U.4
Piro, O.E.5
Arán, V.J.6
Maya, J.D.7
Olea-Azar, C.8
González, M.9
Cerecetto, H.10
-
30
-
-
60049087260
-
New potent imidazoisoquinolinone derivatives as anti-Trypanosoma cruzi agents: Biological evaluation and structure-activity relationships
-
Bollini, M.; Casal, J.J.; Alvarez, D.E.; Boiani, L.; González, M.; Cerecetto, H.; Bruno, A.M. New potent imidazoisoquinolinone derivatives as anti-Trypanosoma cruzi agents: biological evaluation and structure-activity relationships. Bioorg. Med. Chem. 2009, 17, 1437-1444.
-
(2009)
Bioorg. Med. Chem.
, vol.17
, pp. 1437-1444
-
-
Bollini, M.1
Casal, J.J.2
Alvarez, D.E.3
Boiani, L.4
González, M.5
Cerecetto, H.6
Bruno, A.M.7
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