Energy intake and energy expenditure among children with polymorphisms of the melanocortin-3 receptor

American Journal of Clinical Nutrition

Volumn 90, Issue 4, 2009, Pages 912-920

  Savastano, David M ^a   Tanofsky Kraff, Marian ^a,b   Han, Joan C ^a   Ning, Cong ^a   Sorg, Rachael A ^a   Roza, Caroline A ^a   Wolkoff, Laura E ^a,b   Anandalingam, Kavitha ^a   Jefferson George, Kyra S ^a   Figueroa, Roberto E ^a   Sanford, Ethan L ^a   Brady, Sheila ^a   Kozlosky, Merel ^c   Schoeller, Dale A ^d   Yanovski, Jack A ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^b Uniformed Services University of the Health Sciences and the Walter Reed National Military Medical Center   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MELANOCORTIN 3 RECEPTOR;

ADOLESCENT; ADULT; ALLELE; ARTICLE; BODY COMPOSITION; BODY MASS; CALORIC INTAKE; CALORIMETRY; CHILD; CLINICAL TRIAL; CONTROLLED STUDY; DNA POLYMORPHISM; ENERGY BALANCE; ENERGY EXPENDITURE; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENETIC LINKAGE; GENOTYPE; HAPLOTYPE; HARDY WEINBERG DISTRIBUTION LAW; HOMOZYGOSITY; HUMAN; MALE; PRESCHOOL CHILD; SCHOOL CHILD; ADIPOSE TISSUE; BASAL METABOLIC RATE; BODY WEIGHT; ENERGY METABOLISM; GENE FREQUENCY; GENETIC VARIABILITY; GENETICS; HOMOZYGOTE; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL MODEL;

ADIPOSE TISSUE; ADOLESCENT; BASAL METABOLISM; BODY MASS INDEX; BODY WEIGHT; CHILD; ENERGY INTAKE; ENERGY METABOLISM; FEMALE; GENE FREQUENCY; GENETIC VARIATION; GENOTYPE; HOMOZYGOTE; HUMANS; LINEAR MODELS; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTOR, MELANOCORTIN, TYPE 3; YOUNG ADULT;

EID: 70349785440     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.3945/ajcn.2009.27537     Document Type: Article

References (38)

1. Butler AA. The melanocortin system and energy balance. Peptides 2006;27:281-290
2. Lembertas AV, Perusse L, Chagnon YC, et al. Identification of an obesity quantitative trait locus on mouse chromosome 2 and evidence of linkage to body fat and insulin on the human homologous region 20q. J Clin Invest 1997;100:1240-1247 (Pubitemid 27386310)
3. Marks DL, Hruby V, Brookhart G, Cone RD. The regulation of food intake by selective stimulation of the type 3 melanocortin receptor (MC3R). Peptides 2006;27:259-264 (Pubitemid 43162897)
4. Lee JH, Reed DR, Li WD, et al. Genome scan for human obesity and linkage to markers in 20q13. Am J Hum Genet 1999;64:196-209. (Pubitemid 30428973)
5. Chen AS, Marsh DJ, Trumbauer ME, et al. Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass. Nat Genet 2000;26:97-102.
6. Schalin-Jantti C, Valli-Jaakola K, Oksanen L, et al.Melanocortin-3- receptor gene variants in morbid obesity. Int J Obes Relat Metab Disord 2003;27:70-74
7. Wong J, Love DR, Kyle C, et al. Melanocortin-3 receptor gene variants in a Maori kindred with obesity and early onset type 2 diabetes. Diabetes Res Clin Pract 2002;58:61-71. (Pubitemid 34823626)
8. Hani EH, Dupont S, Durand E, et al. Naturally occurring mutations in the melanocortin receptor 3 gene are not associated with type 2 diabetes mellitus in French Caucasians. J Clin Endocrinol Metab 2001;86:2895-2898 (Pubitemid 32545758)
9. Li WD, Joo EJ, Furlong EB, et al. Melanocortin 3 receptor (MC3R) gene variants in extremely obese women. Int J Obes Relat Metab Disord 2000;24:206-210
10. Boucher N, Lanouette CM, Larose M, Perusse L, Bouchard C, Chagnon YCA. +2138InsCAGACC polymorphism of the melanocortin receptor 3 gene is associated in human with fat level and partitioning in interaction with body corpulence. Mol Med 2002;8:158-165 (Pubitemid 35015262)
11. Feng N, Young SF, Aguilera G, et al. Co-occurrence of two partially inactivating polymorphisms of MC3R is associated with pediatric-onset obesity. Diabetes 2005;54:2663-2667 (Pubitemid 41233588)
12. Lee YS, Poh LK, Loke KY. A novel melanocortin 3 receptor gene (MC3R) mutation associated with severe obesity. J Clin Endocrinol Metab 2002;87:1423-1426 (Pubitemid 36121119)
13. Rutanen J, Pihlajamaki J, Vanttinen M, et al. Single nucleotide polymorphisms of the melanocortin-3 receptor gene are associated with substrate oxidation and first-phase insulin secretion in offspring of type 2 diabetic subjects. J Clin Endocrinol Metab 2007;92:1112-1117 (Pubitemid 46465690)
14. Yiannakouris N, Melistas L, Kontogianni M, Heist K, Mantzoros CS. The Val81 missense mutation of the melanocortin 3 receptor gene, but not the 1908c/T nucleotide polymorphism in lamin A/C gene, is associated with hyperleptinemia and hyperinsulinemia in obese Greek caucasians. J Endocrinol Invest 2004;27:714-720
15. Matsuoka N, Patki A, Tiwari HK, et al. Association of MC3R with body mass index in African Americans. Int J Body Compos Res 2007;5:123-129
16. Lee YS, Poh LK, Kek BL, Loke KY. The role of melanocortin 3 receptor gene in childhood obesity. Diabetes 2007;56:2622-2630 (Pubitemid 47523271)
17. Santoro N, Perrone L, Cirillo G, et al. Effect of the melanocortin-3 receptor C17A and G241A variants on weight loss in childhood obesity. Am J Clin Nutr 2007;85:950-953 (Pubitemid 46557907)
18. Ogden CL, Flegal KM, Carroll MD, Johnson CL. Prevalence and trends in overweight among US children and adolescents, 1999-2000. JAMA 2002;288:1728-1732
19. McDuffie JR, Calis KA, Uwaifo GI, et al. Three-month tolerability of orlistat in adolescents with obesity-related comorbid conditions. Obes Res 2002;10:642-650
20. Mirch MC, McDuffie JR, Yanovski SZ, et al. Effects of binge eating on satiation, satiety, and energy intake of overweight children. Am J Clin Nutr 2006;84:732-738
21. Nicholson JC, McDuffie JR, Bonat SH, et al. Estimation of body fatness by air displacement plethysmography in African American and white children. Pediatr Res 2001;50:467-473
22. Kuczmarski RJ, Ogden CL, Grummer-Strawn LM, et al. CDC growth charts: United States. Adv Data 2000:1-27.
23. Robotham DR, Schoeller DA, Mercado AB, et al. Estimates of body fat in children by Hologic QDR-2000 and QDR-4500A dual-energy X-ray absorptiometers compared with deuterium dilution. J Pediatr Gastroenterol Nutr 2006;42:331-335
24. McDuffie JR, Adler-Wailes DC, Elberg J, et al. Prediction equations for resting energy expenditure in overweight and normal-weight black and white children. Am J Clin Nutr 2004;80:365-373 (Pubitemid 41080010)
25. Schoeller DA, Hnilicka JM. Reliability of the doubly labeled water method for the measurement of total daily energy expenditure in free-living subjects. J Nutr 1996;126(suppl):348S-54S.
26. Schoeller DA, Taylor PB, Shay K. Analytic requirements for the doubly labeled water method. Obes Res 1995;3(suppl 1):15-20.
27. Trabulsi J, Troiano RP, Subar AF, et al. Precision of the doubly labeled water method in a large-scale application: evaluation of a streamlined-dosing protocol in the Observing Protein and Energy Nutrition (OPEN) study. Eur J Clin Nutr 2003;57:1370-1377 (Pubitemid 37407131)
28. DeLany JP, Bray GA, Harsha DW, Volaufova J. Energy expenditure in preadolescent African American and white boys and girls: the Baton Rouge Children's Study. Am J Clin Nutr 2002;75:705-713 (Pubitemid 34250684)
29. Maffeis C, Schutz Y, Grezzani A, Provera S, Piacentini G, Tato L. Meal-induced thermogenesis and obesity: is a fat meal a risk factor for fat gain in children? J Clin Endocrinol Metab 2001;86:214-219
30. Energy and protein requirements. Report of a joint FAO/WHO/UNU Expert Consultation.World Health Organ Tech Rep Ser 1985;724:1-206.
31. Gaunt TR, Rodriguez S, Day IN. Cubic exact solutions for the estimation of pairwise haplotype frequencies: implications for linkage disequilibrium analyses and a web tool 'CubeX'. BMC Bioinformatics 2007;8:428.
32. Carter KW, McCaskie PA, Palmer LJ. SimHap GUI: an intuitive graphical user interface for genetic association analysis. BMC Bioinformatics 2008;9:557.
33. Butler AA, Cone RD. Knockout studies defining different roles for melanocortin receptors in energy homeostasis. Ann N Y Acad Sci 2003;994:240-245
34. Butler AA, Kesterson RA, Khong K, et al. A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouse. Endocrinology 2000;141:3518-3521 (Pubitemid 32269044)
35. Zhang Y, Kilroy GE, Henagan TM, et al. Targeted deletion of melanocortin receptor subtypes 3 and 4, but not CART, alters nutrient partitioning and compromises behavioral and metabolic responses to leptin. FASEB J 2005;19:1482-1491 (Pubitemid 41279007)
36. Sutton GM, Trevaskis JL, Hulver MW, et al. Diet-genotype interactions in the development of the obese, insulin-resistant phenotype of C57BL/6J mice lacking melanocortin-3 or -4 receptors. Endocrinology 2006;147:2183-2196
37. Rolls BJ, Shide DJ. Both naturalistic and laboratory-based studies contribute to the understanding of human eating behavior. Appetite 1992;19:76-77 (discussion 84-6).
38. Tanofsky-Kraff M, Haynos AF, Kotler LA, Yanovski SZ, Yanovski JA. Laboratory-based studies of eating among children and adolescents. Curr Nutr Food Sci 2007;3:55-74. (Pubitemid 46267950)