-
1
-
-
0034456398
-
A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouse
-
Butler AA, Kesterson RA, Khong K, Cullen MJ, Pelleymounter MA, Dekoning J, Baetscher M, Cone RD: A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouse. Endocrinology 141:3518-3521, 2000
-
(2000)
Endocrinology
, vol.141
, pp. 3518-3521
-
-
Butler, A.A.1
Kesterson, R.A.2
Khong, K.3
Cullen, M.J.4
Pelleymounter, M.A.5
Dekoning, J.6
Baetscher, M.7
Cone, R.D.8
-
2
-
-
0033818103
-
Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass
-
Chen AS, Marsh DJ, Trumbauer ME, Frazier EG, Guan XM, Yu H, Rosenblum CI, Vongs A, Feng Y, Cao L, Metzger JM, Strack AM, Camacho RE, Mellin TN, Nunes CN, Min W, Fisher J, Gopal-Truter S, MacIntyre DE, Chen HY, Van der Ploeg LHT: Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass. Nat Genet 26:97-102, 2000
-
(2000)
Nat Genet
, vol.26
, pp. 97-102
-
-
Chen, A.S.1
Marsh, D.J.2
Trumbauer, M.E.3
Frazier, E.G.4
Guan, X.M.5
Yu, H.6
Rosenblum, C.I.7
Vongs, A.8
Feng, Y.9
Cao, L.10
Metzger, J.M.11
Strack, A.M.12
Camacho, R.E.13
Mellin, T.N.14
Nunes, C.N.15
Min, W.16
Fisher, J.17
Gopal-Truter, S.18
MacIntyre, D.E.19
Chen, H.Y.20
Van der Ploeg, L.H.T.21
more..
-
3
-
-
0030889192
-
Targeted disruption of the melanocortin-4 receptor results in obesity in mice
-
Huszar D, Lynch CA, Fairchild-Huntress V, Dunmore JH, Fang Q, Berkemeier LR, Gu W, Kesterson RA, Boston BA, Cone RD, Smith FJ, Campfield LA, Burn P, Lee F: Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 88:131-141, 1997
-
(1997)
Cell
, vol.88
, pp. 131-141
-
-
Huszar, D.1
Lynch, C.A.2
Fairchild-Huntress, V.3
Dunmore, J.H.4
Fang, Q.5
Berkemeier, L.R.6
Gu, W.7
Kesterson, R.A.8
Boston, B.A.9
Cone, R.D.10
Smith, F.J.11
Campfield, L.A.12
Burn, P.13
Lee, F.14
-
4
-
-
0027456619
-
Molecular cloning of a novel melanocortin receptor
-
Gantz I, Konda Y, Tashiro T, Shimoto Y, Miwa H, Munzert G, Watson SJ, DelValle J, Yamada T: Molecular cloning of a novel melanocortin receptor. J Biol Chem 268:8246-8250, 1993
-
(1993)
J Biol Chem
, vol.268
, pp. 8246-8250
-
-
Gantz, I.1
Konda, Y.2
Tashiro, T.3
Shimoto, Y.4
Miwa, H.5
Munzert, G.6
Watson, S.J.7
DelValle, J.8
Yamada, T.9
-
5
-
-
0027436690
-
Identification of a receptor for gamma melanotropin and other proopiomelanocortin peptides in the hypothalamus and limbic system
-
Roselli-Rehfuss L, Mountjoy KG, Robbins LS, Mortrud MT, Low MJ, Tatro JB, Entwistle ML, Simerly RB, Cone RD: Identification of a receptor for gamma melanotropin and other proopiomelanocortin peptides in the hypothalamus and limbic system. Proc Natl Acad Sci U S A 90:8856-8860, 1993
-
(1993)
Proc Natl Acad Sci U S A
, vol.90
, pp. 8856-8860
-
-
Roselli-Rehfuss, L.1
Mountjoy, K.G.2
Robbins, L.S.3
Mortrud, M.T.4
Low, M.J.5
Tatro, J.B.6
Entwistle, M.L.7
Simerly, R.B.8
Cone, R.D.9
-
6
-
-
0033927916
-
Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity
-
Vaisse C, Clement K, Durand E, Hercberg S, Guy-Grand B, Frogeul P: Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity. J Clin Invest 106:253-262, 2000
-
(2000)
J Clin Invest
, vol.106
, pp. 253-262
-
-
Vaisse, C.1
Clement, K.2
Durand, E.3
Hercberg, S.4
Guy-Grand, B.5
Frogeul, P.6
-
7
-
-
0343953074
-
Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency
-
Farooqi IS, Yeo GSH, Keogh JM, Aminian S, Jebb SA, Butler G, Cheetham T, O'Rahilly S: Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency. J Clin Invest 106:271-279, 2000
-
(2000)
J Clin Invest
, vol.106
, pp. 271-279
-
-
Farooqi, I.S.1
Yeo, G.S.H.2
Keogh, J.M.3
Aminian, S.4
Jebb, S.A.5
Butler, G.6
Cheetham, T.7
O'Rahilly, S.8
-
8
-
-
0037255271
-
Melanocortin-3-receptor gene variants in morbid obesity
-
Schalin-Jantti C, Valli-Jaakola K, Oksanen L, Martelin E, Laitinen K, Krusius T, Mustajoki P, Heikinheimo M, Kontula K: Melanocortin-3-receptor gene variants in morbid obesity. Int J Obes Relat Metab Disord 27:70-74, 2003
-
(2003)
Int J Obes Relat Metab Disord
, vol.27
, pp. 70-74
-
-
Schalin-Jantti, C.1
Valli-Jaakola, K.2
Oksanen, L.3
Martelin, E.4
Laitinen, K.5
Krusius, T.6
Mustajoki, P.7
Heikinheimo, M.8
Kontula, K.9
-
9
-
-
0033977437
-
Melanocortin 3 receptor (MC3R) gene variants in extremely obese women
-
Li WD, Joo EJ, Furlong EB, Galvin M, Abel K, Bell CJ, Price RA: Melanocortin 3 receptor (MC3R) gene variants in extremely obese women. Int J Obes Relat Metab Disord 24:206-210, 2000
-
(2000)
Int J Obes Relat Metab Disord
, vol.24
, pp. 206-210
-
-
Li, W.D.1
Joo, E.J.2
Furlong, E.B.3
Galvin, M.4
Abel, K.5
Bell, C.J.6
Price, R.A.7
-
10
-
-
0035380668
-
Naturally occurring mutations in the melanocortin receptor 3 gene are not associated with type 2 diabetes mellitus in French Caucasians
-
Hani EH, Dupont S, Durand E, Dina C, Gallina S, Gantz I, Froguel P: Naturally occurring mutations in the melanocortin receptor 3 gene are not associated with type 2 diabetes mellitus in French Caucasians. J Clin Endocrinol Metab 86:2895-2898, 2001
-
(2001)
J Clin Endocrinol Metab
, vol.86
, pp. 2895-2898
-
-
Hani, E.H.1
Dupont, S.2
Durand, E.3
Dina, C.4
Gallina, S.5
Gantz, I.6
Froguel, P.7
-
11
-
-
10244226787
-
The Val81 missense mutation of the melanocortin 3 receptor gene, but not the 1908c/T nucleotide polymorphism in lamin A/C gene, is associated with hyperleptinemia and hyperinsulinemia in obese Greek Caucasians
-
Yiannakouris N, Melistas L, Kontogianni M, Heist K, Mantzoros CS: The Val81 missense mutation of the melanocortin 3 receptor gene, but not the 1908c/T nucleotide polymorphism in lamin A/C gene, is associated with hyperleptinemia and hyperinsulinemia in obese Greek Caucasians. J Endocrinol Invest 27:714-720, 2004
-
(2004)
J Endocrinol Invest
, vol.27
, pp. 714-720
-
-
Yiannakouris, N.1
Melistas, L.2
Kontogianni, M.3
Heist, K.4
Mantzoros, C.S.5
-
12
-
-
24144443764
-
Co-occurrence of two partially inactivating polymorphisms of MC3R is associated with pediatric-onset obesity
-
Feng N, Young SF, Aguilera G, Puricelli E, Adler-Wailes DC, Sebring NG, Yanovski JA: Co-occurrence of two partially inactivating polymorphisms of MC3R is associated with pediatric-onset obesity. Diabetes 54:2663-2667, 2005
-
(2005)
Diabetes
, vol.54
, pp. 2663-2667
-
-
Feng, N.1
Young, S.F.2
Aguilera, G.3
Puricelli, E.4
Adler-Wailes, D.C.5
Sebring, N.G.6
Yanovski, J.A.7
-
13
-
-
0036963510
-
A novel melanocortin 3 receptor gene (MC3R) mutation associated with severe obesity
-
Lee YS, Poh LKS, Loke KY: A novel melanocortin 3 receptor gene (MC3R) mutation associated with severe obesity. J Clin Endocrinol Metab 87:1423-1426, 2002
-
(2002)
J Clin Endocrinol Metab
, vol.87
, pp. 1423-1426
-
-
Lee, Y.S.1
Poh, L.K.S.2
Loke, K.Y.3
-
14
-
-
0021813187
-
Homeostasis model assessment: Insulin resistance and beta cell function from fasting plasma glucose and insulin concentrations in man
-
Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC: Homeostasis model assessment: insulin resistance and beta cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412-419, 1985
-
(1985)
Diabetologia
, vol.28
, pp. 412-419
-
-
Matthews, D.R.1
Hosker, J.P.2
Rudenski, A.S.3
Naylor, B.A.4
Treacher, D.F.5
Turner, R.C.6
-
15
-
-
0034456568
-
Quantitative insulin sensitivity check index: A simple, accurate method for assessing insulin sensitivity in humans
-
Katz A, Nambi SS, Mather K, Baron AD, Follmann DA, Sullivan G, Quon MJ: Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab 85:2402-2410, 2000
-
(2000)
J Clin Endocrinol Metab
, vol.85
, pp. 2402-2410
-
-
Katz, A.1
Nambi, S.S.2
Mather, K.3
Baron, A.D.4
Follmann, D.A.5
Sullivan, G.6
Quon, M.J.7
-
16
-
-
0021989139
-
The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger
-
Stunkard AJ, Messick S: The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger. J Psychosom Res 29:71-83, 1985
-
(1985)
J Psychosom Res
, vol.29
, pp. 71-83
-
-
Stunkard, A.J.1
Messick, S.2
-
17
-
-
0029043105
-
Reproducibility and validity of an epidemiologic questionnaire to assess past year physical activity in adolescents
-
Aaron DJ, Kriska AM, Dearwater SR, Cauley JA, Metz KF, LaPorte RE: Reproducibility and validity of an epidemiologic questionnaire to assess past year physical activity in adolescents. Am J Epidemiol 142:191-201, 1995
-
(1995)
Am J Epidemiol
, vol.142
, pp. 191-201
-
-
Aaron, D.J.1
Kriska, A.M.2
Dearwater, S.R.3
Cauley, J.A.4
Metz, K.F.5
LaPorte, R.E.6
-
19
-
-
0015861774
-
Relationship between the inhibition constant (Ki) and the concentration of inhibitor which causes 50 percent inhibition (IC50) of an enzymatic reaction
-
Cheng Y, Prusoff WH: Relationship between the inhibition constant (Ki) and the concentration of inhibitor which causes 50 percent inhibition (IC50) of an enzymatic reaction. Biochem Pharm 55:3099-3108, 1973
-
(1973)
Biochem Pharm
, vol.55
, pp. 3099-3108
-
-
Cheng, Y.1
Prusoff, W.H.2
-
20
-
-
0032863468
-
Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin
-
Yaswen L, Diehl N, Brennan MB, Hochgeschwender U: Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin. Nat Med 5:1066-1070, 1999
-
(1999)
Nat Med
, vol.5
, pp. 1066-1070
-
-
Yaswen, L.1
Diehl, N.2
Brennan, M.B.3
Hochgeschwender, U.4
-
21
-
-
12144291698
-
Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY(3-36)
-
Challis BG, Coll AP, Yeo GS, Pinnock SB, Dickson SL, Thresher RR, Dixon J, Zahn D, Rochford JJ, White A, Oliver RL, Millington G, Aparicio SA, Colledge WH, Russ AP, Carlton MB, O'Rahilly S: Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY(3-36). Proc Natl Acad Sci U S A 101:4695-4700, 2004
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 4695-4700
-
-
Challis, B.G.1
Coll, A.P.2
Yeo, G.S.3
Pinnock, S.B.4
Dickson, S.L.5
Thresher, R.R.6
Dixon, J.7
Zahn, D.8
Rochford, J.J.9
White, A.10
Oliver, R.L.11
Millington, G.12
Aparicio, S.A.13
Colledge, W.H.14
Russ, A.P.15
Carlton, M.B.16
O'Rahilly, S.17
-
22
-
-
0242320429
-
Obesity due to proopiomelanocortin deficiency: Three new cases and treatment trials with thyroid hormone and ACTH4-10
-
Krude H, Biebermann H, Schnabel D, Tansek MZ, Theunissen P, Mullis PE, Gruters A: Obesity due to proopiomelanocortin deficiency: three new cases and treatment trials with thyroid hormone and ACTH4-10. J Clin Endocrinol Metab 88:4633-4640, 2003
-
(2003)
J Clin Endocrinol Metab
, vol.88
, pp. 4633-4640
-
-
Krude, H.1
Biebermann, H.2
Schnabel, D.3
Tansek, M.Z.4
Theunissen, P.5
Mullis, P.E.6
Gruters, A.7
-
23
-
-
33750592655
-
Heterozygosity for a POMC-null mutation and increased obesity risk in humans
-
Farooqi IS, Drop S, Clements A, Keogh JM, Biernacka J, Lowenbein S, Challis BG, O'Rahilly S: Heterozygosity for a POMC-null mutation and increased obesity risk in humans. Diabetes 55:2549-2553, 2006
-
(2006)
Diabetes
, vol.55
, pp. 2549-2553
-
-
Farooqi, I.S.1
Drop, S.2
Clements, A.3
Keogh, J.M.4
Biernacka, J.5
Lowenbein, S.6
Challis, B.G.7
O'Rahilly, S.8
-
24
-
-
0037101841
-
A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism
-
Challis BG, Pritchard LE, Creemers JW, Delplanque J, Keogh JM, Luan J, Wareham NJ, Yeo GS, Bhattacharyya S, Froguel P, White A, Farooqi IS, O'Rahilly S: A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism. Hum Mol Genet 11:1997-2004, 2002
-
(2002)
Hum Mol Genet
, vol.11
, pp. 1997-2004
-
-
Challis, B.G.1
Pritchard, L.E.2
Creemers, J.W.3
Delplanque, J.4
Keogh, J.M.5
Luan, J.6
Wareham, N.J.7
Yeo, G.S.8
Bhattacharyya, S.9
Froguel, P.10
White, A.11
Farooqi, I.S.12
O'Rahilly, S.13
-
25
-
-
33645048441
-
A POMC variant implicates beta-melanocyte-stimulating hormone in the control of human energy balance
-
Lee YS, Challis BG, Thompson DA, Yeo GS, Keogh JM, Madonna ME, Wraight V, Sims M, Vatin V, Meyre D, Shield J, Burren C, Ibrahim Z, Cheetham T, Swift P, Blackwood A, Hung CC, Wareham NJ, Froguel P, Millhauser GL, O'Rahilly S, Farooqi IS: A POMC variant implicates beta-melanocyte-stimulating hormone in the control of human energy balance. Cell Metab 3:135-140, 2006
-
(2006)
Cell Metab
, vol.3
, pp. 135-140
-
-
Lee, Y.S.1
Challis, B.G.2
Thompson, D.A.3
Yeo, G.S.4
Keogh, J.M.5
Madonna, M.E.6
Wraight, V.7
Sims, M.8
Vatin, V.9
Meyre, D.10
Shield, J.11
Burren, C.12
Ibrahim, Z.13
Cheetham, T.14
Swift, P.15
Blackwood, A.16
Hung, C.C.17
Wareham, N.J.18
Froguel, P.19
Millhauser, G.L.20
O'Rahilly, S.21
Farooqi, I.S.22
more..
-
26
-
-
1842292786
-
Identification of an obesity quantitative trait locus on mouse chromosome 2 and evidence of linkage to body fat and insulin on the human homologous region 20q
-
Lembertas AV, Perusse L, Chagnon YC, Fisler JS, Warden CH, Purcell-Huynh DA, Dionne FT, Gagnon J, Nadeau A, Lusis AJ, Bouchard C: Identification of an obesity quantitative trait locus on mouse chromosome 2 and evidence of linkage to body fat and insulin on the human homologous region 20q. J Clin Invest 100:1240-1247, 1997
-
(1997)
J Clin Invest
, vol.100
, pp. 1240-1247
-
-
Lembertas, A.V.1
Perusse, L.2
Chagnon, Y.C.3
Fisler, J.S.4
Warden, C.H.5
Purcell-Huynh, D.A.6
Dionne, F.T.7
Gagnon, J.8
Nadeau, A.9
Lusis, A.J.10
Bouchard, C.11
-
27
-
-
4043093705
-
Functional characterization of melanocortin-3 receptor variants identify a loss-of-function mutation involving an amino acid critical for G protein-coupled receptor activation
-
Tao YX, Segaloff DL: Functional characterization of melanocortin-3 receptor variants identify a loss-of-function mutation involving an amino acid critical for G protein-coupled receptor activation. J Clin Endocrinol Metab 89:3936-3942, 2004
-
(2004)
J Clin Endocrinol Metab
, vol.89
, pp. 3936-3942
-
-
Tao, Y.X.1
Segaloff, D.L.2
-
28
-
-
3242795783
-
Inactivation and intracellular retention of the human I183N mutated melanocortin 3 receptor associated with obesity
-
Rached M, Buronfosse A, Begeot M, Penhoat A: Inactivation and intracellular retention of the human I183N mutated melanocortin 3 receptor associated with obesity. Biochim Biophys Acta 1689:229-234, 2004
-
(2004)
Biochim Biophys Acta
, vol.1689
, pp. 229-234
-
-
Rached, M.1
Buronfosse, A.2
Begeot, M.3
Penhoat, A.4
-
29
-
-
0039531811
-
Deletions of the N-terminal regions of the human melanocortin receptors
-
Schioth HB, Petersson S, Muceniece R, Szardenings M, Wikberg JE: Deletions of the N-terminal regions of the human melanocortin receptors. FEBS Lett 410:223-228, 1997
-
(1997)
FEBS Lett
, vol.410
, pp. 223-228
-
-
Schioth, H.B.1
Petersson, S.2
Muceniece, R.3
Szardenings, M.4
Wikberg, J.E.5
|