POMC gene-derived peptides activate melanocortin type 3 receptor on murine macrophages, suppress cytokine release, and inhibit neutrophil migration in acute experimental inflammation

Journal of Immunology

Volumn 162, Issue 12, 1999, Pages 7446-7453

  Getting, Stephen J ^a   Gibbs, Linda ^a   Clark, Adrian J L ^b   Flower, Roderick J ^a   Perretti, Mauro ^a,b  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN; MELANOCORTIN RECEPTOR;

AMINO ACID SEQUENCE; ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLOOD CELL COUNT; CELL MIGRATION; CELL REGENERATION; CYTOKINE PRODUCTION; GENE EXPRESSION REGULATION; HORMONE RELEASE; INFLAMMATION; MACROPHAGE ACTIVATION; MOUSE; NEUTROPHIL; NONHUMAN; PEPTIDE SYNTHESIS; PHAGOCYTOSIS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ACUTE DISEASE; ADRENOCORTICOTROPIC HORMONE; AMINO ACID SEQUENCE; ANIMALS; ARTHRITIS, GOUTY; CELL MIGRATION INHIBITION; CYTOKINES; IMMUNOSUPPRESSIVE AGENTS; MACROPHAGE ACTIVATION; MACROPHAGES, PERITONEAL; MALE; MELANOCYTE-STIMULATING HORMONES; MICE; MOLECULAR SEQUENCE DATA; NEUTROPHILS; PEPTIDE FRAGMENTS; PRO-OPIOMELANOCORTIN; RECEPTOR, MELANOCORTIN, TYPE 3; RECEPTORS, CORTICOTROPIN;

EID: 0033564575     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Besedovsky, H., A. Del Rey, E. Sorkin, and C. A. Dinarello. 1986. Immuno-regulatory feedback between interleukin-1 and glucocorticoid hormones. Science 233:652.
2. Munck, A., P. M. Guyre, and N. J. Holbrook. 1984. Physiological functions of glucocorticoids in stress and their relation to pharmacological actions. Endocr. Rev. 5:25.
3. Blalock, J. E. 1985. Proopiomelanocortin-derived peptides in the immune system. Clin. Endocrinol. 22:823.
4. Lyons, P. D., and J. E. Blalock. 1997. Pro-opiomelanocortin gene expression and protein processing in rat mononuclear leukocytes. J. Neuroimmunol. 78:47.
5. Slominski, A., G. Ermak, J. Hwang, J. Mazurkiewicz, D. Corliss, and A. Eastman. 1996. The expression of proopiomelanocortin (POMC) and of corticotropin releasing hormone receptor (CRH-R) genes in mouse skin. Biochim. Biophys. Acta 1289:247.
6. Brandt, K. D., and H. R. Schumaker. 1995. Osteoarthritis and crystal deposition diseases. Curr. Opin. Rheumatol. 7:343.
7. Ritter, J., L. D. Kerr, J. Valeriano-Marcet, and H. Spiera. 1994. ACTH revisited: effective treatment for acute crystal induced synovitis in patients with multiple medical problems. J. Rheumatol. 21:696.
8. Getting, S. J., R. J. Flower, L. Parente, R. de Médicis, A. Lussier, B. A. Wolitzky, M. A. Martins, and M. Perretti. 1997. Molecular determinants of monosodium urate crystal-induced murine peritonitis: a role for endogenous mast cells and a distinct requirement for endothelial-derived selectins. J. Pharmacol. Exp. Ther. 283:123.
9. Gecse, A., A. Ottlecz, M. Faragó, T. Forster, and G. Telegdy. 1980. Effect of ACTH on prostaglandin induced vascular permeability. Acta Physiol. Acad. Scient. Hung. 55:305.
10. Harris, J. G., R. J. Flower, and M. Perretti. 1995. Endogenous corticosteroids mediate neutrophilia caused by platelet-activating factor in the mouse. Eur. J. Pharmacol. 283:9.
11. Fan, W., B. A. Boston, R. A. Kesterson, V. J. Hruby, and R. D. Cone. 1997. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature 385:165.
12. Quillan, J. M., and W. Sadee. 1997. Dynorphin peptides: antagonists of melanocortin receptors. Pharm. Res. 14:713.
13. Getting, S. J., R. J. Flower, and M. Perretti. 1997. Inhibition of neutrophil and monocyte recruitment by endogenous and exogenous lipocortin 1. Br. J. Pharmacol. 120:1075.
14. Ajuebor, M. N., R. J. Flower, R. Hannon, M. Christie, K. Bowers, A. Verity, and M. Perretti. 1998. Endogenous monocyte chemoattractant protein-1 recruits monocytes in the zymosan peritonitis model. J. Leukocyte Biol. 63:108.
15. Berry, D. A., and B. W. Lindgren. 1990. Statistics: Theory and Methods. Brooks/ Cole Publishing Company, Pacific Grove, CA.
16. Luster, A. D. 1998. Chemokines: chemotactic cytokines that mediate inflammation. New Eng. J. Med. 338:436.
17. Terkeltaub, R., S. Baird, P. Sears, R. Santiago, and W. Boisvert. 1998. The murine homolog of the interleukin-8-receptor CXCR-2 is essential for the occurrence of neutrophilic inflammation in the air pouch model of acute urate crystal-induced gouty arthritis. Arthritis Rheum. 41:900.
18. Matsukawa, A., T. Yoshimura, T. Maeda, T. Takahashi, S. Ohkawara, and M. Yoshinaga. 1998. Analysis of the cytokine network among tumor necrosis factor α, interleukin-1β, interleukin-8, and interleukin-1 receptor antagonist in monosodium urate crystal-induced rabbit arthritis. Lab. Invest. 78:559.
19. Hachica, M., P. H. Naccache, and S. R. McColl. 1995. Inflammatory microcrystals differentially regulate the secretion of macrophage inflammatory protein 1 and interleukin 8 by human neutrophils: a possible mechanism of neutrophil recruitment to sites of inflammation in synovitis. J. Exp. Med. 182:2019.
20. di Giovine, F. S., S. E. Malawista, E. Thornton, and G. W. Duff. 1991. Urate crystals stimulate production of tumor necrosis factor α from human blood monocytes and synovial cells. J. Clin. Invest. 87:1375.
21. Lipton, J. M., and A. Catania. 1997. Anti-inflammatory actions of the neuroimmunomodulalor α-MSH. Immunol. Today 18:140.
22. Delgado, R., A. Carlin, L. Airaghi, M. T. Demitri, L. Meda, D. Galimberti, P. Baron, J. M. Lipton, and A. Catania. 1998. Melanocortin peptides inhibit production of proinflammatory cytokines and nitric oxide by activated microglia. J. Leukocyte Biol. 63:740.
23. 4, PAF, and rIL-8. Cytokine 4:320.
24. Ichinose, M., M. Sawada, and T. Maeno. 1994. Suppression of phagocytosis by adrenocorticotrophic hormone in murine peritoneal macrophages. Immunol. Lett. 42:161.
25. Haugen, S. E., and P. Wiik. 1997. Glucocorticoid and ACTH regulation of rat peritoneal phagocyte chemiluminescence and nitric oxide production in culture. Acta Physiol. Scand. 161:93.
26. Mechanick, J. I., N. Levin, J. L. Roberts, and D. J. Autelitano. 1992. Proopiomelanocortin gene expression in a distinct population of rat spleen and lung leukocytes. Endocrinology 131:518.
27. Lolait, S. J., J. A. Clements, A. J. Markwick, C. Cheng, M. McNally, A. I. Smith, and J. W. Funder. 1986. Pro-opiomelanocortin messenger ribonucleic acid and posttranslational processing of β endorphin in spleen macrophages. J. Clin. Invest. 77:1776.
28. Larsson, L. I., P. Blume-Jensen, T. Skovsgaard, and L. Scopsi. 1988. Pro-opiomelanocortin producing cells of spleen: increase after transplantation with opioid-peptide producing Ehlrich ascites tumor cells. Eur. J. Cell Biol. 47:373.
29. Koff, W. C., and M. A. Dunegan. 1985. Modulation of macrophage-mediated tumoricidal activity by neuropeptides and neurohormones. J. Immunol. 135:350.
30. Chiao, H., S. Foster, R. Thomas, J. Lipton and R. A. Star. 1996 α-Melanocyte-stimulating hormone reduces endotoxin-induced liver inflammation J. Clin Invest. 97:2038.
31. Cone, R. D., and K. G. Mountjoy. 1993. Molecular genetics of the ACTH and melanocyte-stimulating hormone receptors. Trends Endocrinol. Metab. 4:242.
32. Tatro, J. B. 1996. Receptor biology of the melanocortins, a family of immunomodulatory peptides. Neuroimmunomodulation 3:259.
33. Labbé, O., F. Desaenaud, D. Eggerickx, G. Vassart, and M. Parmentier. 1994. Molecular cloning of a mouse melanocortin 5 receptor gene widely expressed in peripheral tissue. Biochemistry 33:4543.
34. Gantz, I., Y. Konda, T. Tashiro, Y. Shimoto, H. Miwa, G. Munzert, S. J. Watson, J. Del Valle, and T. Yamada. 1993. Molecular cloning of a novel melanocortin receptor. J. Biol. Chem. 268:8246.
35. Gantz, I., H. Miwa, Y. Konda, Y. Shimoto, T. Tashiro, S. J. Watson, J. Del Valle, and T. Yamada. 1993. Molecular cloning, expression, and gene localization of a fourth melanocortin receptor. J. Biol. Chem. 268:15174.
36. Schiöth, H. B., R. Muceniece, M. Larsson, F. Mutulis, M. Szardenings, P. Prusis, G. Lindeberg, and J. E. S. Wikberg. 1997. Binding of cyclic and linear MSH core peptides to the melanocortin receptor subtypes. Eur. J. Pharmacol. 319:369.
37. Schiöth, H. B., F. Mutulis, R. Muceniece, P. Prusis, and J. E. S. Wikberg. 1998. Discovery of novel melanocortin 4 receptor selective MSH analogues. Br. J. Pharmacol. 124:75.
38. Desamaud, F., O. Labbe, D. Eggerickx, G. Vassart, and M. Parmentier. 1994. Molecular cloning, functional expression and pharmacological characterization of a mouse melanocortin receptor gene. Biochem. J. 299:367.
39. Johnson, E. W., J. E. Blalock, and E. M. Smith. 1988. ACTH receptor-mediated induction of leukocyte cyclic AMP Biochem. Biophys. Res. Commun. 157:1205.
40. Blalock, J. E. 1997. Natural painkillers. Nat. Med. 3:1302.
41. Lyons, P. D., and J. E. Blalock. 1995. The kinetics of ACTH expression in rat leukocyte subpopulations. J. Neurimmunol. 63:103.
42. Stephanou, A., P. Fitzharris, R. A. Knight, and S. L. Lightman. 1991. Characteristics and kinetics of proopiomelanocortin mRNA expression by human leukocytes. Brain Behav. Immun. 5:319.
43. Buzzetti, R., L. McLoughlin, P. M. Lavender, A. J. L. Clark, and L. H. Rees. 1988. Expression of pro-opiomelanocortin gene and quantification of adrenocorticotrophic hormone-like immunoreactivity in human normal peripheral mononuclear cells and lymphoid and myeloid malignancies. J. Clin. Invest. 83:733.