Melanocortin 3 receptors control crystal-induced inflammation

FASEB Journal

Volumn 20, Issue 13, 2006, Pages 2234-2241

  Getting, Stephen J ^a   Lam, Connie W ^a   Chen, Airu S ^b   Grieco, Paolo ^c   Perretti, Mauro ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b MERCK RESEARCH LABORATORIES   (United States)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Anti inflammation; Drug discovery; Macrophage activation; Neutrophil trafficking

Indexed keywords

ANTIINFLAMMATORY AGENT; CYCLIC AMP; GAMMA INTERMEDIN; HORMONE RECEPTOR BLOCKING AGENT; HORMONE RECEPTOR STIMULATING AGENT; HS 024; INTERLEUKIN 1; MELANOCORTIN 3 RECEPTOR; MELANOCORTIN 3 RECEPTOR AGONIST; MELANOCORTIN 3 RECEPTOR ANTAGONIST; MELANOCORTIN 4 RECEPTOR ANTAGONIST; N ACETYL ALPHA INTERMEDIN[4-10]CYCLO[4 NORLEUCINE 5 ASPARTIC ACID 7 [3 (2 NAPHTHYL)ALANINE] 10 LYSINAMIDE];

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CRYSTAL; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DRUG ACTIVITY; DRUG ANTAGONISM; DRUG BINDING; DRUG EFFECT; DRUG EFFICACY; GOUT; HORMONAL REGULATION; LEUKOCYTE; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PERITONITIS; PRIORITY JOURNAL; RAT;

ANIMALS; ARTHRITIS, EXPERIMENTAL; ARTHRITIS, GOUTY; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; INFLAMMATION; MACROPHAGE ACTIVATION; MACROPHAGES, PERITONEAL; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, MELANOCORTIN, TYPE 3; RECEPTORS, MELANOCORTIN; URIC ACID;

EID: 33845664425     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.06-6339com     Document Type: Article

References (43)

1. Lipton, J. M., and Catania, A. (1997) Anti-inflammatory actions of the neuroimmunomodulator α-MSH. Immunol. Today 18, 140-145
2. Wikberg, J. E., Muceniece, R., Mandrika, I., Prusis, P., Lindblom, J., Post, C., and Skottner, A. (2000) New aspects on the melanocortins and their receptors. Pharmacol. Res. 42, 393-420
3. Catania, A., Gatti, S., Colombo, G., and Lipton, J. M. (2004) Targeting melanocortin receptors as a novel strategy to control inflammation. Pharmacol. Rev. 56, 1-29
4. Abdel-Malek, Z. A., Scott, M. C., Furumura, M., Lamoreux, M. L., Ollmann, M., Barsh, G. S., and Hearing, V. J. (2001) The melanocortin 1 receptor is the principal mediator of the effects of agouti signaling protein on mammalian melanocytes. J. Cell Sci. 114, 1019-1024
5. Penhoat, A., Jaillard, C., and Saez, J. M. (1989) Corticotropin positively regulates its own receptors and cAMP response in cultured bovine adrenal cells. Proc. Natl. Acad. Sci. U. S. A. 86, 4978-4981
6. Ellacott, K. L., and Cone, R. D. (2004) The central melanocortin system and the integration of short- and long-term regulators of energy homeostasis. Recent Prog. Horm. Res. 59, 395-408
7. Martin, W. J., and MacIntyre, D. E. (2004) Melanocortin receptors and erectile function. Eur. Urol. 45, 706-713
8. Getting, S. J. (2002) Melanocortin peptides and their receptors: new targets for anti-inflammatory therapy. Trends Pharmacol. Sci. 23, 447-449
9. Getting, S. J., Christian, H. C., Flower, R. J., and Perretti, M. (2002) Activation of melanocortin type 3 receptor as a molecular mechanism for adrenocorticotropic hormone efficacy in gouty arthritis. Arthritis Rheum. 46, 2765-2775
10. Ceriani, G., Diaz, J., Murphree, S., Catania, A., and Lipton, J. M. (1994) The neuropeptide alpha-melanocyte-stimulating hormone inhibits experimental arthritis in rats. Neuroimmunomodulation 1, 28-32
11. Rajora, N., Boccoli, G., Catania, A., and Lipton, J. M. (1997) alpha-MSH modulates experimental inflammatory bowel disease. Peptides 18, 381-385
12. Raap, U., Brzoska, T., Sohl, S., Path, G., Emmel, J., Herz, U., Braun, A., Luger, T., and Renz, H. (2003) alpha-Melanocyte-stimulating hormone inhibits allergic airway inflammation. J. Immunol. 171, 353-359
13. Manna, S. K., and Aggarwal, B. B. (1998) Alpha-melanocyte-stimulating hormone inhibits the nuclear transcription factor NF-kappa B activation induced by various inflammatory agents. J. Immunol. 161, 2873-2880
14. Kalden, D. H., Scholzen, T., Brzoska, T., and Luger, T. A. (1999) Mechanisms of the antiinflammatory effects of alpha-MSH. Role of transcription factor NF-kappa B and adhesion molecule expression. Ann. N. Y. Acad. Sci. 885, 254-261
15. Lam, C. W., Getting, S. J., and Perretti, M. (2005) In vitro and in vivo induction of heme oxygenase 1 in mouse macrophages following melanocortin receptor activation. J. Immunol. 174, 2297-2304
16. Lam, C. W., Perretti, M., and Getting, S. J. (2006) Melanocortin receptor signaling in RAW264.7 macrophage cell line. Peptides 27, 404-412
17. Schiller, M., Brzoska, T., Bohm, M., Metze, D., Scholzen, T. E., Rougier, A., and Luger, T. A. (2004) Solar-simulated ultraviolet radiation-induced upregulation of the melanocortin-1 receptor, proopiomelanocortin, and alpha-melanocyte-stimulating hormone in human epidermis in vivo. J. Invest. Dermatol. 122, 468-476
18. Guarini, S., Schioth, H. B., Mioni, C., Cainazzo, M., Ferrazza, G., Giuliani, D., Wikberg, J. E., Bertolini, A., and Bazzani, C. (2002) MC(3) receptors are involved in the protective effect of melanocortins in myocardial ischemia/reperfusion-induced arrhythmias. Naun. Schm. Arch. Pharmacol. 366, 177-182
19. Mioni, C., Giuliani, D., Cainazzo, M. M., Leone, S., Iannone, C., Bazzani, C., Grieco, P., Novellino, E., Tomasi, A., Bertolini, A., and Guarini, S. (2003) Further evidence that melanocortins prevent myocardial reperfusion injury by activating melanocortin MC(3) receptors. Eur. J. Pharmacol. 477, 227-234
20. Getting, S. J., Christian, H. C., Lam, C. W., Gavins, F. N., Flower, R. J., Schioth, H. B., and Perretti, M. (2003) Redundancy of a functional melanocortin 1 receptor in the anti-inflammatory actions of melanocortin peptides: studies in the recessive yellow (e/e) mouse suggest an important role for melanocortin 3 receptor. J. Immunol. 170, 3323-3330
21. Grieco, P., Balse, P. M., Weinberg, D., MacNeil, T., and Hruby, V. J. (2000) D-Amino acid scan of gamma-melanocyte-stimulating hormone: importance of Trp(8) on human MC3 receptor selectivity. J. Med. Chem. 43, 4998-5002
22. Gantz, I., and Fong, T. M. (2003) The melanocortin system. Am. J. Physiol. 284, E468-E474
23. Chen, A. S., Marsh, D. J., Trumbauer, M. E., Frazier, E. G., Guan, X. M., Yu, H., Rosenblum, C. I., Vongs, A., Feng, Y., Cao, L., et al. (2000) Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass. Nat. Genet. 26, 97-102
24. Yang, Y., Leech, M., Hutchinson, P., Holdsworth, S. R., and Morand, E. F. (1997) Antiinflammatory effect of lipocortin 1 in experimental arthritis. Inflammation 21, 583-596
25. Fan, W., Boston, B. A., Kesterson, R. A., Hruby, V. J., and Cone, R. D. (1997) Role of melanocortinergic neurones in feeding and the agouti obesity syndrome. Nature 385, 165-168
26. Hruby, V. J., Lu, D., Sharma, S. D., Castrucci, A. L., Kesterson, R. A., al-Obeidi, F. A., Hadley, M. E., and Cone, R. D. (1995) Cyclic lactam alpha-melanotropin analogues of Ac-Nle4-cyclo[Asp5, D-Phe7, Lys10] alpha-melanocyte-stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin receptors. J. Med. Chem. 38, 3454-3461
27. 4 receptor selective MSH analogues. Br. J. Pharmacol. 124, 75-82
28. Getting, S. J., Flower, R. J., Parente, L., de Médicis, R., Lussier, A., Wolitzky, B. A., Martins, M. A., and Perretti, M. (1997) Molecular determinants of monosodium urate crystal-induced murine peritonitis: a role for endogenous mast cells and a distinct requirement for endothelial-derived selectins. J. Pharmacol. Exp. Ther. 283, 123-130
29. Butler, A. A., Kesterson, R. A., Khong, K., Cullen, M. J., Pelleymounter, M. A., Dekoning, J., Baetscher, M., and Cone, R. D. (2000) A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouse. Endocrinology 141, 3518-3521
30. Catania, A., Airaghi, L., Colombo, G., and Lipton, J. M. (2000) Alpha-melanocyte-stimulating hormone in normal human physiology and disease states. Trends Endocrinol. Metab. 11, 304-308
31. Hench, P. S., Kendall, E. C., Slocumb, C. H., and Polley, H. E. (1949) The effect of the adrenal cortex (17-hydroxy-11-dehydrocortisone: compound E) and of pituitary adrenocorticotropic hormone on rheumatoid arthritis; preliminary report. Proc. Staff Meet. Mayo Clin. 24, 181-197
32. Catania, A., Rajora, N., Capsoni, F., Minonzio, F., Star, R. A., and Lipton, J. M. (1996) The neuropeptide alpha-MSH has specific receptors on neutrophils and reduces chemotaxis in vitro. Peptides 17, 675-679
33. Taherzadeh, S., Sharma, S., Chhajlani, V., Gantz, I., Rajora, N., Demitri, M. T., Kelly, L., Zhao, H., Ichiyama, T., Catania, A., and Lipton, J. M. (1999) alpha-MSH and its receptors in regulation of tumor necrosis factor-alpha production by human monocyte/macrophages. Am. J. Physiol. 276, R1289-R1294
34. Adachi, S., Nakano, T., Vliagoftis, H., and Metcalfe, D. D. (1999) Receptor-mediated modulation of murine mast cell function by alpha-melanocyte stimulating hormone. J. Immunol. 163, 3363-3368
35. Scholzen, T. E., Koenig, S., Fastrich, M., Bohm, M., and Luger, T. A. (2005) Production and processing of POMC peptides by dermal microvascular endothelial cells (EC): modulation of EC biologic functions and implication for skin inflammation. Exp. Dermatol. 14, 158
36. Getting, S. J., Gibbs, L., Clark, A. J., Flower, R. J., and Perretti, M. (1999) POMC gene-derived peptides activate melanocortin type 3 receptor on murine macrophages, suppress cytokine release, and inhibit neutrophil migration in acute experimental inflammation. J. Immunol. 162, 7446-7453
37. Getting, S. J., Allcock, G. H., Flower, R., and Perretti, M. (2001) Natural and synthetic agonists of the melanocortin receptor type 3 possess anti-inflammatory properties. J. Leukoc. Biol. 69, 98-104
38. Getting, S. J., Di Filippo, C., Christian, H. C., Lam, C. W., Rossi, F., D'Amico, M., and Perretti, M. (2004) MC-3 receptor and the inflammatory mechanisms activated in acute myocardial infarct. J. Leukoc. Biol. 76, 845-853
39. Gutman, A. B., and Yu, T. F. (1950) Effects of ACTH in gout. Am. J. Med. 9, 24-30
40. Ritter, J., Kerr, L. D., Valeriano-Marcet, J., and Spiera, H. (1994) ACTH revisited: effective treatment for acute crystal induced synovitis in patients with multiple medical problems. J. Rheumatol. 21, 696-699
41. Brandt, K. D., and Schumaker, H. R. (1995) Osteoarthritis and crystal deposition diseases. Curr. Op. Rheumatol. 7, 343-345
42. Kirwan, J. R. (1995) The effect of glucocorticoids on joint destruction in rheumatoid arthritis. N. Engl. J. Med. 333, 142-146
43. Geborek, P., Mansson, B., Wollheim, F. A., and Moritz, U. (1990) Intraarticular corticosteroid injection into rheumatoid arthritis knees improves extensor muscles strength. Rheumatol. Int. 9, 265-270