Redundancy of a functional melanocortin 1 receptor in the anti-inflammatory actions of melanocortin peptides: Studies in the recessive yellow (e/e) mouse suggest an important role for melanocortin 3 receptor

Journal of Immunology

Volumn 170, Issue 6, 2003, Pages 3323-3330

  Getting, Stephen J ^a   Christian, Helen C ^b   Lam, Connie W ^a   Gavins, Felicity N E ^a   Flower, Roderick J ^a   Schiöth, Helgi B ^c   Perretti, Mauro ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; GAMMA INTERMEDIN; HORMONE RECEPTOR BLOCKING AGENT; HORMONE RECEPTOR STIMULATING AGENT; HP 228; HS 024; MELANOCORTIN; MELANOCORTIN 1 RECEPTOR; MESSENGER RNA; MS 05; N ACETYL ALPHA INTERMEDIN[4-10]CYCLO[4 NORLEUCINE 5 ASPARTIC ACID 7 [3 (2 NAPHTHYL)ALANINE] 10 LYSINAMIDE]; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL ULTRASTRUCTURE; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG RECEPTOR BINDING; IMMUNOPHARMACOLOGY; IN VITRO STUDY; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; PERITONEUM MACROPHAGE; PERITONITIS; PRIORITY JOURNAL; RECEPTOR BINDING; RECEPTOR BLOCKING; RECESSIVE INHERITANCE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WILD TYPE;

EID: 0347927272     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.170.6.3323     Document Type: Article

References (37)

1. Richard, D. B., and J. M. Lipton. 1984. Effect of α-MSH11-13 on fever in rabbits. Peptides 5:815.
2. Ceriani, G., J. Diaz, S. Murphree, A. Catania and J. M. Lipton. 1994. The neuropeptide α-melanocyte stimulating hormone inhibits experimental arthritis in rats. Neuroimmunomodulation 1:28.
3. Wikberg, J. E. S., R. Muceniece, I. Mandrika, P. Prusis, J. Lindblom, C. Post and A. Skottner. 2000. New aspects on the melanocortins and their receptors. Pharmacol. Res. 42:393.
4. 1 receptors are constitutively expressed on leukocyte subpopulations with antigen presenting and cytotoxic functions. Clin. Exp. Immunol. 126:441.
5. Becher, E., K. Mahnke, T. Brzoska, D. H. Kalden, S. Grabbe and T. A. Luger. 1999. Human peripheral blood-derived dendritic cells express functional melanocortin receptor MC1-R. Ann. NY Acad. Sci. 885:188.
6. Adachi, S., T. Nakano, H. Vliagoftis and D. D. Metcalfe. 1999. Receptor-mediated modulation of murine mast cell function by α-melanocyte stimulating hormone. J. Immunol. 163:3363.
7. Manna, S. K., and B. B. Aggarwal. 1998. α-Melanocyte stimulating hormone inhibits the nuclear transcription factor NF-κB activation by various inflammatory agents. J. Immunol. 161:2873.
8. Kalden, D. H., T. Scholzen, T. Brzoska and T. A. Luger. 1999. Mechanisms of the anti-inflammatory effects of α-MSH: role of transcription factor NF-κB and adhesion molecule expression. Ann. NY Acad. Sci. 885:254.
9. Ichiyama, T., T. Sakai, A. Catania, G. S. Barsh, S. Furukawa and J. M. Lipton. 1999. Inhibition of peripheral NF-κB activation by central action of α-melanocyte-stimulating hormone. J. Neuroimmunol. 99:211.
10. Mason, M. J., and D. Van Epps. 1989. Modulation of IL-1, tumour necrosis factor, and C5A-mediated murine neutrophil migration by α-melanocyte stimulating hormone. J. Immunol. 142:1646.
11. Hiltz, M. E., and J. M. Lipton. 1989. Anti-inflammatory activity of a COOH-terminal fragment of the neuropeptide α-MSH. FASEB J. 11:2282.
12. Lipton, J. M., and A. Catania. 1998. Mechanisms of antiinflammatory action of the neuroimmunomodulatory peptide α-MSH. Ann. NY Acad. Sci. 840:373.
13. Getting, S. J., L. Gibbs, A. J. L. Clark, R. J. Flower and M. Perretti. 1999. POMC gene derived peptides activate melanocortin type 3 receptor on murine macrophages, suppress cytokine release and inhibit neutrophil migration in acute experimental inflammation. J. Immunol. 162:7446.
14. Roselli-Rehfuss, L., K. G. Mountjoy, L. S. Robbins, M. T. Mortrud, M. J. Low, J. B. Tatro, M. L. Entwistle, R. B. Simerly and R. D. Cone. 1993. Identification of a receptor for γ melanotropin and other proopiomelanocortin peptides in the hypothalalmus and limbic system. Proc. Natl. Acad. Sci. USA 90:8856.
15. Fan, W., B. A. Boston, R. A. Kesterson, V. J. Hruby and R. D. Cone. 1997. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature 385:165.
16. Getting, S. J., G. H. Allcock, R. Flower and M. Perretti. 2001. Natural and synthetic agonists of the melanocortin type 3 possess anti-inflammatory properties. J. Leukocyte Biol. 69:98.
17. Getting, S. J., H. C. Christian, R. J. Flower and M. Perretti. 2002. Activation of melanocortin type 3 receptor as a molecular mechanism for adrenocorticotrophic hormone in gouty arthritis. Arthritis Rheum. 46:2765.
18. Robbins L. S., J. H. Nadeau, K. R. Johnson, M. A. Kelly, L. Roselli-Rehfuss, E. Baack, K. G. Mountjoy and R. D. Cone. 1993. Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function. Cell 72:827.
19. Abdel-Malek, Z. A., M. C. Scott, M. Furumura, M. L. Lamoreux, M. Ollmann, G. S. Barsh and V. J. Hearing. 2001. The melanocortin 1 receptor is the principle mediator of the effects of agouti signalling protein on mammalian melanocytes. J. Cell. Sci. 114:1019.
20. Schioth H. B., S. R. Phillips, R. Rudzish, M. A. Birch-Machin, J. E. Wikberg and J. L. Rees. 1999. Loss of function mutations of the human melanocortin I receptor are common and are associated with red hair. Biochem. Biophys. Res. Commun. 260:488.
21. Getting, S. J., R. J. Flower, L. Parente, R. de Medicis, A. Lussier, B. A. Wolitztky, M. A. Martins and M. Perretti. 1997. Molecular determinants of monosodium urate crystal-induced murine peritonitis: a role for endogenous mast cells and a distinct requirement for endothelial-derived selectins. J. Pharmacol. Exp. Ther. 283:123.
22. Abou-Mohamed, G., D. Papapetropoulos, J. D. Ulreich, J. D. Catravas, R. R. Tuttle and R. W. Caldwell. 1995. HP-228, a novel synthetic peptide inhibits the induction of nitric oxide synthase in vivo but not in vitro. J. Pharmacol. Exp. Ther. 275:584.
23. Szardenings, M., R. Muceniece, I. Mutule, F. Mutulis and J. E. Wikberg. 2000. New highly specific agonistic peptides for human melanocortin MC(1) receptor. Peptides 21:239.
24. Berry, D. A., and B. W. Lindgren. 1990. Statistics: Theory and Methods. Brooks/Cole Publishing Company, Pacific Grove, CA.
25. Lipton, J. M., and A. Catania. 1997. Anti-inflammatory actions of the neuroimmunomodulator α-MSH. Immunol. Today 18:140.
26. Cannon, J. G., J. B. Tatro, S. Reichli and C. A. Dinarello. 1986. α-Melanocyte stimulating inhibits immunostimulatory actions of interleukin-1. J. Immunol. 137:2232.
27. 4, PAF, and IL-8. Cytokine 4:320.
28. Delgado, R., A. Carlin, L. Airaghi, M. T. Demitri, L. Meda, D. Galimberti, P. Baron, J. M. Lipton and A. Catania. 1998. Melanocortin peptides inhibit production of proinflammatory cytokines and nitric oxide by activated microglia. J. Leukocyte Biol. 63:740.
29. Parry, G. C. N., and N. Mackman. 1997. Role of cyclic AMP response element-binding protein in cyclic AMP inhibition of NF-κB-mediated transcription. J. Immunol. 159:5450.
30. 2-Melanocyte-stimulating hormone suppression of systemic inflammatory responses to endotoxin is associated with modulation of central autonomic and neuroendocrine activities. J. Neuroimmunol. 120:67.
31. Chiao, H., S. Foster, R. Thomas, J. Lipton and R. A. Star. 1996. α-Melanocyte-stimulating hormone reduces endotoxin-induced liver inflammation. J. Clin. Invest. 97:2038.
32. Brzoka, T., D. H. Kalden, M. Fastrich, M. Moller, H. B. Schioth, J. E. S. Wikberg and T. Luger. 1999. Two new a-melanocyte stimulating (α-MSH) analogues (MS05 and MS09) are potent immunomodulators in vivo and in vitro. J. Invest. Dermatol. 113:482.
33. Guarini, S., Schioth, H. B., Mioni, C., Cainazzo, M., Ferrazza, G., Giuliani, D., Wikberg, J. E., Bertolini, A. and C. Bazzani. 2002. MC(3) receptors are involved in the protective effect of melanocortins in myocardial ischemia/reperfusion-induced arrhythmias. Naunyn. Schrniedebergs. Arch. Pharmacol. 366:177.
34. Box N. F., J. R. Wyeth, L. E. O'Gorman, N. G. Martin and R. A. Sturm. 1997. Characterization of melanocyte stimulating hormone receptor variant alleles in twins with red hair. Hum. Mol. Genet. 6:1891.
35. Smith R, E. Healy, S. Siddiqui, N. Flanagan, P. M. Steijlen, I. Rosdahl, J. P. Jacques, S. Rogers, R. Turner, I. J. Jackson, et al. 1998. Melanocortin 1 receptor variants in an Irish population. J. Invest. Dermatol. 111:119.
36. Chen, A. S., D. J. Marsh, M. E. Trumbauer, E. G. Frazier, X. M. Guan, H. Yu, C. I. Rosenblum, A. Vongs, Y. Feng, L. Cao, et al. 2000. Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass. Nat. Genet. 26:97.
37. Butler, A. A., R. A. Kesterson, K. Khong, M. J. Cullen, M. A. Pelleymounter, J. Dekoning, M. Baetscher and R. D. Cone. 2000. A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouse. Endocrinology 141:3518.