Pregnane X receptor- and CYP3A4-humanized mouse models and their applications

British Journal of Pharmacology

Volumn 163, Issue 3, 2011, Pages 461-468

  Cheng, Jie ^a   Ma, Xiaochao ^b   Gonzalez, Frank J ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

CYP3A4; mouse model; PXR

Indexed keywords

ALDOSTERONE SYNTHASE; BILIRUBIN; CD36 ANTIGEN; CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); CONSTITUTIVE ANDROSTANE RECEPTOR; COUMESTROL; CYCLOSPORIN A; CYTOCHROME P450 3A4; CYTOCHROME P450 3A5; CYTOCHROME P450 3A7; DOCETAXEL; FARNESOID X RECEPTOR; FATTY ACID BINDING PROTEIN; GLUCURONOSYLTRANSFERASE 1A1; HYPERFORIN; KETOCONAZOLE; LIVER X RECEPTOR; MIDAZOLAM; ORGANIC ANION TRANSPORTER 2; PARACETAMOL; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PREGNANE X RECEPTOR; RIFAMPICIN; RIFAXIMIN; VITAMIN K GROUP;

AREA UNDER THE CURVE; BACTERIAL ARTIFICIAL CHROMOSOME; BILE ACID METABOLISM; CATALYSIS; DRUG BIOAVAILABILITY; DRUG DETOXIFICATION; DRUG ELIMINATION; DRUG HYDROXYLATION; DRUG METABOLISM; DRUG RECEPTOR BINDING; DRUG SCREENING; ENTERITIS; ENZYME INDUCTION; ENZYME REGULATION; ENZYME SUBSTRATE COMPLEX; FATTY LIVER; GENE CLUSTER; HEPATIC ENCEPHALOPATHY; HUMAN; LIGAND BINDING; LIPID METABOLISM; LIVER TOXICITY; NONHUMAN; OSTEOPOROSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; SIGNAL TRANSDUCTION; STEROID METABOLISM; TRANSCRIPTION INITIATION; TRAVELLER DIARRHEA; XENOBIOTIC METABOLISM;

ANIMALS; CYTOCHROME P-450 CYP3A; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; DRUG TOXICITY; HUMANS; INFLAMMATORY BOWEL DISEASES; INTESTINES; LIVER; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; ORGAN SPECIFICITY; PHARMACEUTICAL PREPARATIONS; RECEPTORS, STEROID; SPECIES SPECIFICITY; XENOBIOTICS;

EID: 79955882480     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2010.01129.x     Document Type: Review

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