메뉴 건너뛰기




Volumn 15, Issue 6, 2011, Pages 677-693

Targeting p27Kip1 protein: Its relevance in the therapy of human cancer

Author keywords

cancer therapy; cyclin dependent kinases; p 27Kip1 metabolism; p27Kip1

Indexed keywords

ANASTROZOLE; BORTEZOMIB; CYCLIN DEPENDENT KINASE INHIBITOR 1B; IMATINIB; PROTEIN KINASE P60; RETINOIC ACID; S PHASE KINASE ASSOCIATED PROTEIN 2; SALINOSPORAMIDE A; TAMOXIFEN; VORINOSTAT; ANTINEOPLASTIC AGENT; CDKN1B PROTEIN, HUMAN;

EID: 79955859448     PISSN: 14728222     EISSN: None     Source Type: Journal    
DOI: 10.1517/14728222.2011.561318     Document Type: Review
Times cited : (55)

References (131)
  • 1
    • 0028176483 scopus 로고
    • Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals
    • Polyak K, Lee MH, Erdjument-Bromage H, et al. Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell 1994;15:59-66
    • (1994) Cell , vol.15 , pp. 59-66
    • Polyak, K.1    Lee, M.H.2    Erdjument-Bromage, H.3
  • 2
    • 0028363519 scopus 로고
    • P27, A novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21
    • DOI 10.1016/0092-8674(94)90573-8
    • Toyoshima H, Hunter T. p27, a novel inhibitor of G1 cyclin-cdk protein kinase activity, is related to p21. Cell 1994;78:67-74 (Pubitemid 24228301)
    • (1994) Cell , vol.78 , Issue.1 , pp. 67-74
    • Toyoshima, H.1    Hunter, T.2
  • 5
    • 0027496935 scopus 로고
    • The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin- dependent kinases
    • DOI 10.1016/0092-8674(93)90499-G
    • Harper JW, Adami GR, Wei N, et al. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 1993;75:805-16 (Pubitemid 23346377)
    • (1993) Cell , vol.75 , Issue.4 , pp. 805-816
    • Harper, J.W.1    Adami, G.R.2    Wei, N.3    Keyomarsi, K.4    Elledge, S.J.5
  • 6
    • 0028988158 scopus 로고
    • Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution
    • Lee MH, Reynisdottir I, Massague J. Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution. Genes Dev 1995;9:639-49
    • (1995) Genes Dev , vol.9 , pp. 639-49
    • Lee, M.H.1    Reynisdottir, I.2    Massague, J.3
  • 7
    • 0033564697 scopus 로고    scopus 로고
    • 1-phase progression
    • Sherr CJ, Roberts JM. Cdk inhibitors: positive and negative regulators of G1-phase progression. Genes Dev 1999;13:1501-12 (Pubitemid 29297917)
    • (1999) Genes and Development , vol.13 , Issue.12 , pp. 1501-1512
    • Sherr, C.J.1    Roberts, J.M.2
  • 10
    • 27144528728 scopus 로고    scopus 로고
    • Kip1 exhibits intrinsic structure resembling the Cdk2/cyclin A-bound conformation
    • DOI 10.1016/j.jmb.2005.08.074, PII S0022283605010545
    • Sivakolundu SG, Bashford D, Kriwacki RW. Disordered p27Kip1 exhibits intrinsic structure resembling the Cdk2/Cyclin A-bound conformation. J Mol Biol 2005;353:1118-28 (Pubitemid 41503276)
    • (2005) Journal of Molecular Biology , vol.353 , Issue.5 , pp. 1118-1128
    • Sivakolundu, S.G.1    Bashford, D.2    Kriwacki, R.W.3
  • 11
    • 0032749078 scopus 로고    scopus 로고
    • Intrinsically unstructured proteins: Re-assessing the protein structure-function paradigm
    • DOI 10.1006/jmbi.1999.3110
    • Wright PE, Dyson HJ. Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm. J Mol Biol 1999;293:321-31 (Pubitemid 29516173)
    • (1999) Journal of Molecular Biology , vol.293 , Issue.2 , pp. 321-331
    • Wright, P.E.1    Dyson, H.J.2
  • 12
    • 0034894258 scopus 로고    scopus 로고
    • Kip1
    • DOI 10.1021/bm015502z
    • Flaugh SL, Lumb KJ. Effects of macromolecular crowding on the intrinsically disordered proteins c-Fos and p27Kip1. Biomacromolecules 2001;2:538-40 (Pubitemid 32707535)
    • (2001) Biomacromolecules , vol.2 , Issue.2 , pp. 538-540
    • Flaugh, S.L.1    Lumb, K.J.2
  • 13
    • 34248208651 scopus 로고    scopus 로고
    • P27Kip1 metabolism: A fascinating labyrinth
    • Borriello A, Cucciolla V, Oliva A, et al. p27Kip1 metabolism: a fascinating labyrinth. Cell Cycle 2007;9:1053-61
    • (2007) Cell Cycle , vol.9 , pp. 1053-61
    • Borriello, A.1    Cucciolla, V.2    Oliva, A.3
  • 14
    • 1942466518 scopus 로고    scopus 로고
    • Kip1 modulates cell migration through the regulation of RhoA activation
    • DOI 10.1101/gad.1185504
    • Besson A, Gurian-West M, Schmidt A, et al. p27Kip1 modulates cell migration through the regulation of RhoA activation. Genes Dev 2004;15:862-76 (Pubitemid 38529656)
    • (2004) Genes and Development , vol.18 , Issue.8 , pp. 862-876
    • Besson, A.1    Gurian-West, M.2    Schmidt, A.3    Hall, A.4    Roberts, J.M.5
  • 16
    • 0035853813 scopus 로고    scopus 로고
    • Direct binding of the signal-transducing adaptor Grb2 facilitates down-regulation of the cyclin-dependent kinase inhibitor p27Kip1
    • Sugiyama Y, Tomoda K, Tanaka T, et al. Direct binding of the signal-transducing adaptor Grb2 facilitates down-regulation of the cyclin-dependent kinase inhibitor p27Kip1. J Biol Chem 2001;276:12084-90
    • (2001) J Biol Chem , vol.276 , pp. 12084-90
    • Sugiyama, Y.1    Tomoda, K.2    Tanaka, T.3
  • 17
    • 0037047268 scopus 로고    scopus 로고
    • Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization
    • Fujita N, Sato S, Katayama K, Tsuruo T. Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization. J Biol Chem 2002;277:28706-13
    • (2002) J Biol Chem , vol.277 , pp. 28706-13
    • Fujita, N.1    Sato, S.2    Katayama, K.3    Tsuruo, T.4
  • 18
    • 3142512358 scopus 로고    scopus 로고
    • Kip1
    • DOI 10.1038/sj.emboj.7600198
    • Sekimoto T, Fukumoto M, Yoneda Y. 14-3-3 suppresses the nuclear localization of threonine 157-phosphorylated p27. EMBO J 2004;23:1934-42 (Pubitemid 38902071)
    • (2004) EMBO Journal , vol.23 , Issue.9 , pp. 1934-1942
    • Sekimoto, T.1    Fukumoto, M.2    Yoneda, Y.3
  • 20
    • 0028179669 scopus 로고
    • P27kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest
    • Polyak K, Kato JY, Solomon MJ, et al. p27kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest. Genes Dev 1994;8:9-22
    • (1994) Genes Dev , vol.8 , pp. 9-22
    • Polyak, K.1    Kato, J.Y.2    Solomon, M.J.3
  • 21
    • 0029894515 scopus 로고    scopus 로고
    • Transforming growth factor-β and p27 expression in pituitary cells
    • DOI 10.1210/en.137.7.3051
    • Qian X, Jin L, Grande JP, Lloyd RV. Transforming growth factor-beta and p27 expression in pituitary cells. Endocrinology 1996;137:3051-60 (Pubitemid 26192204)
    • (1996) Endocrinology , vol.137 , Issue.7 , pp. 3051-3060
    • Qian, X.1    Jin, L.2    Grande, J.P.3    Lloyd, R.V.4
  • 22
    • 21844431711 scopus 로고    scopus 로고
    • The regulation of S phase initiation by p27Kip1 in NIH3T3 cells
    • Sa G, Guo Y, Stacey DW. The regulation of S phase initiation by p27Kip1 in NIH3T3 cells. Cell Cycle 2005;4:618-27 (Pubitemid 41359792)
    • (2005) Cell Cycle , vol.4 , Issue.4 , pp. 618-627
    • Sa, G.1    Guo, Y.2    Stacey, D.W.3
  • 23
    • 33749591900 scopus 로고    scopus 로고
    • P27Kip1 and cyclin dependent kinase 2 regulate passage through the restriction point
    • Hitomi M, Yang K, Guo Y, et al. p27Kip1 and cyclin dependent kinase 2 regulate passage through the restriction point. Cell Cycle 2006;5:2281-9 (Pubitemid 44546566)
    • (2006) Cell Cycle , vol.5 , Issue.19 , pp. 2281-2289
    • Hitomi, M.1    Yang, K.2    Guo, Y.3    Fretthold, J.4    Harwalkar, J.5    Stacey, D.W.6
  • 24
    • 25444526687 scopus 로고    scopus 로고
    • Using kinetic studies to uncover new Rb functions in inhibiting cell cycle progression
    • Ji P, Zhu L. Using kinetic studies to uncover new Rb functions in inhibiting cell cycle progression. Cell Cycle 2005;4:373-5 (Pubitemid 41359718)
    • (2005) Cell Cycle , vol.4 , Issue.3 , pp. 373-375
    • Ji, P.1    Zhu, L.2
  • 25
    • 53549126089 scopus 로고    scopus 로고
    • Phosphorylation of p27Kip1 regulates assembly and activation of cyclin D1-Cdk4
    • Larrea MD, Liang J, Da Silva T, et al. Phosphorylation of p27Kip1 regulates assembly and activation of cyclin D1-Cdk4. Mol Cell Biol 2008;28:6462-72
    • (2008) Mol Cell Biol , vol.28 , pp. 6462-72
    • Larrea, M.D.1    Liang, J.2    Da Silva, T.3
  • 26
    • 15844384256 scopus 로고    scopus 로고
    • A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice
    • Fero ML, Rivkin M, Tasch M, et al. A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice. Cell 1996;85:733-44
    • (1996) Cell , vol.85 , pp. 733-44
    • Fero, M.L.1    Rivkin, M.2    Tasch, M.3
  • 27
    • 15844415946 scopus 로고    scopus 로고
    • Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27Kip1
    • Kiyokawa H, Kineman RD, Manova-Todorova KO, et al. Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27Kip1. Cell 1996;85:721-32
    • (1996) Cell , vol.85 , pp. 721-32
    • Kiyokawa, H.1    Kineman, R.D.2    Manova-Todorova, K.O.3
  • 28
    • 0030010591 scopus 로고    scopus 로고
    • Mice lacking p27Kip1 display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors
    • Nakayama K, Ishida N, Shirane M, et al. Mice lacking p27Kip1 display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors. Cell 1996;85:707-20
    • (1996) Cell , vol.85 , pp. 707-20
    • Nakayama, K.1    Ishida, N.2    Shirane, M.3
  • 29
    • 23144451917 scopus 로고    scopus 로고
    • Cdc2-cyclin E complexes regulate the G1/S phase transition
    • DOI 10.1038/ncb1284
    • Aleem E, Kiyokawa H, Kaldis P. Cdc2-cyclin E complexes regulate the G1/S phase transition. Nat Cell Biol 2005;7:831-6 (Pubitemid 41079056)
    • (2005) Nature Cell Biology , vol.7 , Issue.8 , pp. 831-836
    • Aleem, E.1    Kiyokawa, H.2    Kaldis, P.3
  • 30
    • 0032511848 scopus 로고    scopus 로고
    • The murine gene p27(Kip 1) is haplo-insufficient for tumour suppression
    • DOI 10.1038/24179
    • Fero M, Randel E, Gurley K, et al. The murine gene p27Kip1 is haplo-insufficient for tumour suppression. Nature 1998;396:177-80 (Pubitemid 28523620)
    • (1998) Nature , vol.396 , Issue.6707 , pp. 177-180
    • Fero, M.L.1    Randel, E.2    Gurley, K.E.3    Roberts, J.M.4    Kemp, C.J.5
  • 31
    • 77952463207 scopus 로고    scopus 로고
    • Characterization of a naturally-occurring p27 mutation predisposing to multiple endocrine tumors
    • Molatore S, Kiermaier E, Jung C, et al. Characterization of a naturally-occurring p27 mutation predisposing to multiple endocrine tumors. Mol Cancer 2010;9:116
    • (2010) Mol Cancer , vol.9 , pp. 116
    • Molatore, S.1    Kiermaier, E.2    Jung, C.3
  • 33
    • 67249107699 scopus 로고    scopus 로고
    • RSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility
    • Larrea MD, Hong F, Wander SA, et al. RSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility. Proc Natl Acad Sci USA 2009;106:9268-73
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 9268-73
    • Larrea, M.D.1    Hong, F.2    Wander, S.A.3
  • 34
    • 0037216528 scopus 로고    scopus 로고
    • kip1 C-terminal scatter domain mediates Rac-dependent cell migration independent of cell cycle arrest functions
    • DOI 10.1128/MCB.23.1.216-228.2003
    • McAllister SS, Becker-Hapak M, Pintucci G, et al. Novel p27kip1 C-terminal scatter domain mediates Rac-dependent cell migration independent of cell cycle arrest functions. Mol Cell Biol 2003;23:216-28 (Pubitemid 36008515)
    • (2003) Molecular and Cellular Biology , vol.23 , Issue.1 , pp. 216-228
    • McAllister, S.S.1    Becker-Hapak, M.2    Pintucci, G.3    Pagano, M.4    Dowdy, S.F.5
  • 36
    • 33644509197 scopus 로고    scopus 로고
    • Reduction of cytosolic p27Kip1 inhibits cancer cell motility, survival, and tumorigenicity
    • Wu FY, Wang SE, Sanders ME, et al. Reduction of cytosolic p27Kip1 inhibits cancer cell motility, survival, and tumorigenicity. Cancer Res 2006;66:2162-72
    • (2006) Cancer Res , vol.66 , pp. 2162-72
    • Wu, F.Y.1    Wang, S.E.2    Sanders, M.E.3
  • 37
    • 35148901042 scopus 로고    scopus 로고
    • Kip1 tumor suppressor functions as a cytoplasmic metastatic oncogene in melanoma
    • DOI 10.1158/0008-5472.CAN-07-1375
    • Denicourt C, Saenz CC, Datnow B, et al. Relocalized p27Kip1 tumor suppressor functions as a cytoplasmic metastatic oncogene in melanoma. Cancer Res 2007;67:9238-43 (Pubitemid 47535911)
    • (2007) Cancer Research , vol.67 , Issue.19 , pp. 9238-9243
    • Denicourt, C.1    Saenz, C.C.2    Datnow, B.3    Cui, X.-S.4    Dowdy, S.F.5
  • 38
    • 0034842489 scopus 로고    scopus 로고
    • Kip1 by doxycycline-regulated adenoviral vectors inhibits endothelial cell proliferation and migration and impairs angiogenesis
    • DOI 10.1096/fj.01-0065com
    • Goukassian D, Diez-Juan A, Asahara T, et al. Overexpression of p27Kip1 by doxycycline-regulated adenoviral vectors inhibits endothelial cell proliferation and migration and impairs angiogenesis. FASEB J 2001;11:1877-85 (Pubitemid 32848791)
    • (2001) FASEB Journal , vol.15 , Issue.11 , pp. 1877-1885
    • Goukassian, D.1    Diez-Juan, A.2    Asahara, T.3    Schratzberger, P.4    Silver, M.5    Murayama, T.6    Isner, J.M.7    Andres, V.8
  • 40
    • 0037423864 scopus 로고    scopus 로고
    • Kip1/cyclin-dependent kinase/retinoblastoma pathway in vascular smooth muscle cells and fibroblasts
    • DOI 10.1161/01.RES.0000059306.71961.ED
    • Diez-Juan A, Andres V. Coordinate control of proliferation and migration by the p27Kip1cyclin-dependent kinase/Retinoblastoma pathway in vascular smooth muscle cells and fibroblasts. Circ Res 2003;92:402-10 (Pubitemid 36298200)
    • (2003) Circulation Research , vol.92 , Issue.4 , pp. 402-410
    • Diez-Juan, A.1    Andres, V.2
  • 41
    • 0642375769 scopus 로고    scopus 로고
    • Effect of p27Kip1 on the ability of invasion and metastasis of an oral cancer cell line
    • Supriatno, Harada K, Kawaguchi S, et al. Effect of p27Kip1 on the ability of invasion and metastasis of an oral cancer cell line. Oncol Rep 2003;10:527-32
    • (2003) Oncol Rep , vol.10 , pp. 527-32
    • Supriatno Harada, K.1    Kawaguchi, S.2
  • 42
    • 33751255370 scopus 로고    scopus 로고
    • Coupling cell cycle exit, neuronal differentiation and migration in cortical neurogenesis
    • Nguyen L, Besson A, Roberts JM, Guillemot F. Coupling cell cycle exit, neuronal differentiation and migration in cortical neurogenesis. Cell Cycle 2006;5:2314-18 (Pubitemid 44785839)
    • (2006) Cell Cycle , vol.5 , Issue.20 , pp. 2314-2318
    • Nguyen, L.1    Besson, A.2    Roberts, J.M.3    Guillemot, F.4
  • 43
    • 49849088123 scopus 로고    scopus 로고
    • P27Kip1 expression inhibits glioblastoma growth, invasion, and tumor-induced neoangiogenesis
    • Schiappacassi M, Lovat F, Canzonieri V, et al. p27Kip1 expression inhibits glioblastoma growth, invasion, and tumor-induced neoangiogenesis. Mol Canc Ther 2008;7:1164-75
    • (2008) Mol Canc Ther , vol.7 , pp. 1164-75
    • Schiappacassi, M.1    Lovat, F.2    Canzonieri, V.3
  • 44
    • 77950676582 scopus 로고    scopus 로고
    • P27kip1 controls cell morphology and motility by regulating microtubule-dependent lipid raft recycling
    • Belletti B, Pellizzari I, Berton S, et al. p27kip1 controls cell morphology and motility by regulating microtubule-dependent lipid raft recycling. Mol Cell Biol 2010;30:2229-40
    • (2010) Mol Cell Biol , vol.30 , pp. 2229-40
    • Belletti, B.1    Pellizzari, I.2    Berton, S.3
  • 45
    • 0031439355 scopus 로고    scopus 로고
    • Promoting apoptosis: A novel activity associated with the cyclin- dependent kinase inhibitor p27
    • Katayose Y, Kim M, Rakkar AN, et al. Promoting apoptosis: a novel activity associated with the cyclin-dependent kinase inhibitor p27. Cancer Res 1997;57:5441-5 (Pubitemid 28006743)
    • (1997) Cancer Research , vol.57 , Issue.24 , pp. 5441-5445
    • Katayose, Y.1    Kim, M.2    Rakkar, A.N.S.3    Li, Z.4    Cowan, K.H.5    Seth, P.6
  • 46
    • 0032429122 scopus 로고    scopus 로고
    • Novel dipeptidyl proteasome inhibitors overcome Bcl-2 protective function and selectively accumulate the cyclin-dependent kinase inhibitor p27 and induce apoptosis in transformed, but not normal, human fibroblasts
    • An B, Goldfarb RH, Siman R, Dou QP. Novel dipeptidyl proteasome inhibitors overcome Bcl-2 protective function and selectively accumulate the cyclin-dependent kinase inhibitor p27 and induce apoptosis in transformed, but not normal, human fibroblasts. Cell Death Differ 1998;12:1062-75 (Pubitemid 29008220)
    • (1998) Cell Death and Differentiation , vol.5 , Issue.12 , pp. 1062-1075
    • An, B.1    Goldfarb, R.H.2    Siman, R.3    Ping Dou, Q.4
  • 47
    • 2342598475 scopus 로고    scopus 로고
    • The role of l. p27Kip1 in proteasome inhibitor induced apoptosis
    • Drexler HCA. The role of l. p27Kip1 in proteasome inhibitor induced apoptosis. Cell Cycle 2003;2:438-41
    • (2003) Cell Cycle , vol.2 , pp. 438-41
    • Drexler, H.C.A.1
  • 50
    • 0031875095 scopus 로고    scopus 로고
    • Contribution of the cyclin-dependent kinase inhibitor p27(KIP1) to the confluence-dependent resistance of HT29 human colon carcinoma cells
    • DOI 10.1002/(SICI)1097-0215(19980831)77:5<796::AID-IJC20>3.0.CO;2-Z
    • Dimanche-Boitrel M, Micheau O, Hammann A, et al. Contribution of the cyclin-dependent kinase inhibitor p27KIP1 to the confluence-dependent resistance of colon carcinoma HT29 cells. Int J Cancer 1998;77:796-802 (Pubitemid 28341399)
    • (1998) International Journal of Cancer , vol.77 , Issue.5 , pp. 796-802
    • Dimanche-Boitrel, M.-T.1    Micheau, O.2    Hammann, A.3    Haugg, M.4    Eymin, B.5    Chauffert, B.6    Solary, E.7
  • 52
    • 77955380286 scopus 로고    scopus 로고
    • Increased expression of p27 is associated with the cisplatin resistance in gastric cancer cell line YCC-3
    • Le TVT, Seo Y, Ryu CJ, et al. Increased expression of p27 is associated with the cisplatin resistance in gastric cancer cell line YCC-3. Arch Pharm Res 2010;33:1127-32
    • (2010) Arch Pharm Res , vol.33 , pp. 1127-32
    • Le Tvt Seo, Y.1    Ryu, C.J.2
  • 58
    • 52949127316 scopus 로고    scopus 로고
    • MiR-221 controls CDKN1C/p57 and CDKN1B/p27 expression in human hepatocellular carcinoma
    • Fornari F, Gramantieri L, Ferracin M, et al. MiR-221 controls CDKN1C/p57 and CDKN1B/p27 expression in human hepatocellular carcinoma. Oncogene 2008;27:5651-61
    • (2008) Oncogene , vol.27 , pp. 5651-61
    • Fornari, F.1    Gramantieri, L.2    Ferracin, M.3
  • 59
    • 56449092072 scopus 로고    scopus 로고
    • MicroRNA-221/222 confers tamoxifen resistance in breast cancer by targeting p27Kip1
    • Miller TE, Ghoshal K, Ramaswamy B, et al. MicroRNA-221/222 confers tamoxifen resistance in breast cancer by targeting p27Kip1. J Biol Chem 2008;283:29897-903
    • (2008) J Biol Chem , vol.283 , pp. 29897-903
    • Miller, T.E.1    Ghoshal, K.2    Ramaswamy, B.3
  • 60
    • 80052433665 scopus 로고    scopus 로고
    • Clinical significance of miR-221 and its inverse correlation with p27Kip1 in hepatocellular carcinoma
    • published online 10 February 2010, doi: 10.1007/s11033-010-9969-5
    • Fu X, Wang Q, Chen J, et al. Clinical significance of miR-221 and its inverse correlation with p27Kip1 in hepatocellular carcinoma. Mol Biol Rep 2010: published online 10 February 2010, doi: 10.1007/s11033-010-9969-5
    • (2010) Mol Biol Rep
    • Fu, X.1    Wang, Q.2    Chen, J.3
  • 61
    • 77953004738 scopus 로고    scopus 로고
    • MicroRNA and proliferation control in chronic lymphocytic leukemia: Functional relationship between miR-221/222 cluster and p27
    • Frenquelli M, Muzio M, Scielzo C, et al. MicroRNA and proliferation control in chronic lymphocytic leukemia: functional relationship between miR-221/222 cluster and p27. Blood 2010;115:3949-59
    • (2010) Blood , vol.115 , pp. 3949-59
    • Frenquelli, M.1    Muzio, M.2    Scielzo, C.3
  • 62
    • 77953213140 scopus 로고    scopus 로고
    • MiR-221 and MiR-222 alterations in sporadic ovarian carcinoma: Relationship to CDKN1B, CDKNIC and overall survival
    • Wurz K, Garcia RL, Goff BA, et al. MiR-221 and MiR-222 alterations in sporadic ovarian carcinoma: relationship to CDKN1B, CDKNIC and overall survival. Genes Chromosomes Cancer 2010;49:577-84
    • (2010) Genes Chromosomes Cancer , vol.49 , pp. 577-84
    • Wurz, K.1    Garcia, R.L.2    Goff, B.A.3
  • 63
    • 77957564277 scopus 로고    scopus 로고
    • A Pumilio-induced RNA structure switch in p27-3¢?UTR controls miR-221 and miR-222 accessibility
    • Kedde M, van Kouwenhove M, Zwart W, et al. A Pumilio-induced RNA structure switch in p27-3¢?UTR controls miR-221 and miR-222 accessibility. Nat Cell Biol 2010;12:1014-20
    • (2010) Nat Cell Biol , vol.12 , pp. 1014-20
    • Kedde, M.1    Van Kouwenhove, M.2    Zwart, W.3
  • 64
    • 77954152739 scopus 로고    scopus 로고
    • Ubiquitylation and proteasomal degradation of the p21Cip1, p27Kip1 and p57Kip2 CDK inhibitors
    • Lu Z, Hunter T. Ubiquitylation and proteasomal degradation of the p21Cip1, p27Kip1 and p57Kip2 CDK inhibitors. Cell Cycle 2010;12:1-11
    • (2010) Cell Cycle , vol.12 , pp. 1-11
    • Lu, Z.1    Hunter, T.2
  • 65
    • 0030847760 scopus 로고    scopus 로고
    • Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27(Kip1)
    • DOI 10.1093/emboj/16.17.5334
    • Vlach J, Hennecke S, Amati B. Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27. EMBO J 1997;16:5334-44 (Pubitemid 27380141)
    • (1997) EMBO Journal , vol.16 , Issue.17 , pp. 5334-5344
    • Vlach, J.1    Hennecke, S.2    Amati, B.3
  • 67
    • 0033176887 scopus 로고    scopus 로고
    • SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27
    • Carrano AC, Eytan E, Hershko A, Pagano M. SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27. Nat Cell Biol 1999;1:193-9 (Pubitemid 129500937)
    • (1999) Nature Cell Biology , vol.1 , Issue.4 , pp. 193-199
    • Carrano, A.C.1    Eytan, E.2    Hershko, A.3    Pagano, M.4
  • 69
    • 69949134410 scopus 로고    scopus 로고
    • Pin1 catalyzes conformational changes of Thr-187 in p27Kip1 and mediates its stability through a polyubiquitination process
    • Zhou W, Yang Q, Low CB, et al. Pin1 catalyzes conformational changes of Thr-187 in p27Kip1 and mediates its stability through a polyubiquitination process. J Biol Chem 2009;284:23980-8
    • (2009) J Biol Chem , vol.284 , pp. 23980-8
    • Zhou, W.1    Yang, Q.2    Low, C.B.3
  • 70
    • 33845939310 scopus 로고    scopus 로고
    • The COP9 signalosome regulates Skp2 levels and proliferation of human cells
    • DOI 10.1074/jbc.M604746200
    • Denti S, Fernandez-Sanchez ME, Rogge L, Bianchi E. The COP9 signalosome regulates Skp2 levels and proliferation of human cells. J Biol Chem 2006;281:32188-96 (Pubitemid 46036773)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.43 , pp. 32188-32196
    • Denti, S.1    Fernandez-Sanchez, M.E.2    Rogge, L.3    Bianchi, E.4
  • 71
    • 33744457243 scopus 로고    scopus 로고
    • Cul4A targets p27 for degradation and regulates proliferation, cell cycle exit, and differentiation during erythropoiesis
    • DOI 10.1182/blood-2005-08-3349
    • Li B, Jia N, Kapur R, Chun KT. Cul4A targets p27 for degradation and regulates proliferation, cell cycle exit, and differentiation during erythropoiesis. Blood 2006;107:4291-9 (Pubitemid 43801353)
    • (2006) Blood , vol.107 , Issue.11 , pp. 4291-4299
    • Li, B.1    Jia, N.2    Kapur, R.3    Chun, K.T.4
  • 73
    • 24044555556 scopus 로고    scopus 로고
    • 1 phase
    • DOI 10.1074/jbc.M500866200
    • Kotoshiba S, Kamura T, Hara T, et al. Molecular dissection of the interaction between p27 and Kip1 ubiquitylation-promoting complex, the ubiquitin ligase that regulates proteolysis of p27 in G1 phase. J Biol Chem 2005;280:17694-700 (Pubitemid 41389006)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.18 , pp. 17694-17700
    • Kotoshibai, S.1    Kamura, T.2    Hara, T.3    Ishida, N.4    Nakayama, K.I.5
  • 74
    • 0035803593 scopus 로고    scopus 로고
    • P27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis
    • DOI 10.1093/emboj/20.23.6672
    • Rodier G, Montagnoli A, Di Marcotullio L, et al. p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis. EMBO J 2001;20:6672-82 (Pubitemid 33134197)
    • (2001) EMBO Journal , vol.20 , Issue.23 , pp. 6672-6682
    • Rodier, G.1    Montagnoli, A.2    Di Marcotullio, L.3    Coulombe, P.4    Draetta, G.F.5    Pagano, M.6    Meloche, S.7
  • 77
    • 33750080428 scopus 로고    scopus 로고
    • Calpain activation is required for glutamate-induced p27 down-regulation in cultured cortical neurons
    • DOI 10.1111/j.1471-4159.2006.04100.x
    • Akashiba H, Matsuki N, Nishiyama N. Calpain activation is required for glutamate-induced p27 down-regulation in cultured cortical neurons. J Neurochem 2006;99:733-44 (Pubitemid 44583433)
    • (2006) Journal of Neurochemistry , vol.99 , Issue.3 , pp. 733-744
    • Akashiba, H.1    Matsuki, N.2    Nishiyama, N.3
  • 78
    • 77955795702 scopus 로고    scopus 로고
    • Tumor suppressor p27Kip1 undergoes endolysosomal degradation through its interaction with sorting nexin 6
    • Fuster JJ, Gonzalez JM, Edo MD, et al. Tumor suppressor p27Kip1 undergoes endolysosomal degradation through its interaction with sorting nexin 6. FASEB J 2010;24:2998-3009
    • (2010) FASEB J , vol.24 , pp. 2998-3009
    • Fuster, J.J.1    Gonzalez, J.M.2    Edo, M.D.3
  • 79
    • 12544259437 scopus 로고    scopus 로고
    • Role of serine 10 phosphorylation in p27 stabilization revealed by analysis of p27 knock-in mice harboring a serine 10 mutation
    • Kotake Y, Nakayama K, Ishida N, Nakayama KI. Role of serine 10 phosphorylation in p27 stabilization revealed by analysis of p27 knock-in mice harboring a serine 10 mutation. J Biol Chem 2005;280:1095-102
    • (2005) J Biol Chem , vol.280 , pp. 1095-102
    • Kotake, Y.1    Nakayama, K.2    Ishida, N.3    Nakayama, K.I.4
  • 81
    • 0034682818 scopus 로고    scopus 로고
    • Phosphorylation at serine 10, a major phosphorylation site of p27Kip1, increases its protein stability
    • Ishida N, Kitagawa M, Hatakeyama S, Nakayama K. Phosphorylation at serine 10, a major phosphorylation site of p27Kip1, increases its protein stability. J Biol Chem 2000;275:25146-54
    • (2000) J Biol Chem , vol.275 , pp. 25146-54
    • Ishida, N.1    Kitagawa, M.2    Hatakeyama, S.3    Nakayama, K.4
  • 83
    • 0030997297 scopus 로고    scopus 로고
    • Regulation of the cyclin-dependent kinase inhibitor p27 by degradation and phosphorylation
    • Alessandrini A, Chiaur DS, Pagano M. Regulation of the cyclin-dependent kinase inhibitor p27 by degradation and phosphorylation. Leukemia 1997;11:342-5 (Pubitemid 27120981)
    • (1997) Leukemia , vol.11 , Issue.3 , pp. 342-345
    • Alessandrini, A.1    Chiaur, D.S.2    Pagano, M.3
  • 84
    • 0041696635 scopus 로고    scopus 로고
    • Focus on p27. Keeping p27Kip1 in the cytoplasm. A second front in cancer's war on p27
    • Reed SI. Focus on p27. Keeping p27Kip1 in the cytoplasm. A second front in cancer's war on p27. Cell Cycle 2002;1:389-90
    • (2002) Cell Cycle , vol.1 , pp. 389-90
    • Reed, S.I.1
  • 85
    • 1542677089 scopus 로고    scopus 로고
    • Phosphorylation of p27Kip1 at threonine 198 by p90 localization
    • Fujita N, Sato S, Tsuruo T. Phosphorylation of p27Kip1 at threonine 198 by p90 localization. J Biol Chem 2003;278:49254-60
    • (2003) J Biol Chem , vol.278 , pp. 49254-60
    • Fujita, N.1    Sato, S.2    Tsuruo, T.3
  • 87
    • 30344457896 scopus 로고    scopus 로고
    • kip1 contributing to actin organization and cortical neuronal migration
    • DOI 10.1038/ncb1338, PII N1338
    • Kawauchi T, Chihama K, Nabeshima YI, Hoshino M. Cdk5 phosphorylates and stabilizes p27Kip1 contributing to actin organization and cortical neuronal migration. Nat Cell Biol 2006;8:17-26 (Pubitemid 43064793)
    • (2006) Nature Cell Biology , vol.8 , Issue.1 , pp. 17-26
    • Kawauchi, T.1    Chihama, K.2    Nabeshima, Y.-I.3    Hoshino, M.4
  • 88
    • 77958153958 scopus 로고    scopus 로고
    • CaMKII phosphorylates serine 10 of p27 and confers apoptosis resistance to HeLa cells
    • Kajihara R, Fukushige S, Shioda N, et al. CaMKII phosphorylates serine 10 of p27 and confers apoptosis resistance to HeLa cells. Biochem Biophys Res Commun 2010;401:350-5
    • (2010) Biochem Biophys Res Commun , vol.401 , pp. 350-5
    • Kajihara, R.1    Fukushige, S.2    Shioda, N.3
  • 90
    • 0036799377 scopus 로고    scopus 로고
    • Kip1 at threonine 157 and modulation of its cellular localization
    • DOI 10.1038/nm759
    • Shin I, Yakes FM, Rojo F, et al. PKB/Akt mediates cell-cycle progression by phosphorylation of p27Kip1 at threonine 157 and modulation of its cellular localization. Nat Med 2002;8:1145-52 (Pubitemid 35175970)
    • (2002) Nature Medicine , vol.8 , Issue.10 , pp. 1145-1152
    • Shin, I.1    Yakes, F.M.2    Rojo, F.3    Shin, N.-Y.4    Bakin, A.V.5    Baselga, J.6    Arteaga, C.L.7
  • 94
    • 31544471421 scopus 로고    scopus 로고
    • Kip1 in the acute promyelocytic leukemia cell line NB4
    • DOI 10.1182/blood-2005-05-1771
    • Kardinal C, Dangers M, Kardinal A, et al. Tyrosine phosphorylation modulates binding preference to cyclin-dependent kinases and subcellular localization of p27Kip1 in the acute promyelocytic leukemia cell line NB4. Blood 2006;107:1133-40 (Pubitemid 43156315)
    • (2006) Blood , vol.107 , Issue.3 , pp. 1133-1140
    • Kardinal, C.1    Dangers, M.2    Kardinal, A.3    Koch, A.4    Brandt, D.T.5    Tamura, T.6    Welte, K.7
  • 95
    • 41149150219 scopus 로고    scopus 로고
    • The Cdk inhibitor p27 in human cancer: Prognostic potential and relevance to anticancer therapy
    • DOI 10.1038/nrc2347, PII NRC2347
    • Chu IM, Hengst L, Slingerland JM. The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy. Nat Rev Cancer 2008;8:253-67 (Pubitemid 351430863)
    • (2008) Nature Reviews Cancer , vol.8 , Issue.4 , pp. 253-267
    • Chu, I.M.1    Hengst, L.2    Slingerland, J.M.3
  • 96
    • 0031048236 scopus 로고
    • Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas
    • Loda M, Cukor B, Tam SW, et al. Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas. Nat Med 1977;3:231-4
    • (1977) Nat Med , vol.3 , pp. 231-4
    • Loda, M.1    Cukor, B.2    Tam, S.W.3
  • 97
    • 0033558373 scopus 로고    scopus 로고
    • Loss of p27(Kip1) expression independently predicts poor prognosis for patients with resectable pancreatic adenocarcinoma
    • DOI 10.1002/(SICI)1097-0142(19990315)85:6<1250::AID-CNCR6>3.0.CO;2- #
    • Lu CD, Morita S, Ishibashi T, et al. Loss of p27Kip1 expression independently predicts poor prognosis for patients with resectable pancreatic adenocarcinoma. Cancer 1999;85:1250-60 (Pubitemid 29125077)
    • (1999) Cancer , vol.85 , Issue.6 , pp. 1250-1260
    • Lu, C.-D.1    Morita, S.2    Ishibashi, T.3    Hara, H.4    Isozaki, H.5    Tanigawa, N.6
  • 99
    • 0037083674 scopus 로고    scopus 로고
    • Kip1 is associated with tumor size and poor prognosis in patients with renal cell carcinoma
    • DOI 10.1002/cncr.10338
    • Migita T, Oda Y, Naito S, Tsuneyoshi M. Low expression of p27Kip1 is associated with tumor size and poor prognosis in patients with renal cell carcinoma. Cancer 2002;94:973-9 (Pubitemid 34150851)
    • (2002) Cancer , vol.94 , Issue.4 , pp. 973-979
    • Migita, T.1    Oda, Y.2    Naito, S.3    Tsuneyoshi, M.4
  • 100
    • 34548268220 scopus 로고    scopus 로고
    • Kip1 by miRNA 221/222 in glioblastoma
    • Gillies JK, Lorimer IA. Regulation of p27Kip1 by miRNA 221/222 in glioblastoma. Cell Cycle 2007;6:2005-9 (Pubitemid 47327888)
    • (2007) Cell Cycle , vol.6 , Issue.16 , pp. 2005-2009
    • Gillies, J.K.1    Lorimer, I.A.J.2
  • 102
    • 41149141967 scopus 로고    scopus 로고
    • Oncogenic properties and prognostic implications of the ubiquitin ligase Skp2 in cancer
    • DOI 10.1002/cncr.23317
    • Hershko DD. Oncogenic properties and prognostic implications of the ubiquitin ligase Skp2 in cancer. Cancer 2008;112:1415-24 (Pubitemid 351441154)
    • (2008) Cancer , vol.112 , Issue.7 , pp. 1415-1424
    • Hershko, D.D.1
  • 103
    • 34347360771 scopus 로고    scopus 로고
    • 1 transition
    • DOI 10.1128/MCB.00862-06
    • Susaki E, Nakayama K, Nakayama KI. Cyclin D2 translocates p27 out of the nucleus and promotes its degradation at the G0-G1 transition. Mol Cell Biol 2007;27:4626-40 (Pubitemid 47016118)
    • (2007) Molecular and Cellular Biology , vol.27 , Issue.13 , pp. 4626-4640
    • Susaki, E.1    Nakayama, K.2    Nakayama, K.I.3
  • 104
    • 79952251697 scopus 로고    scopus 로고
    • Phosphorylated p27Kip1 on Thr157 is an important prognosis in human hepatocellular carcinoma in vivo and in vitro
    • published online 28 Janury 2010, doi: 10.1007/s12032-009-9408-4
    • He S, Lu M, Xue W, et al. Phosphorylated p27Kip1 on Thr157 is an important prognosis in human hepatocellular carcinoma in vivo and in vitro. Med Oncol 2010: published online 28 Janury 2010, doi: 10.1007/s12032-009-9408-4
    • (2010) Med Oncol
    • He, S.1    Lu, M.2    Xue, W.3
  • 105
    • 58849158826 scopus 로고    scopus 로고
    • Cytoplasmic sequestration of p27 via AKT phosphorylation in renal cell carcinoma
    • Kim J, Jonasch E, Alexander A, et al. Cytoplasmic sequestration of p27 via AKT phosphorylation in renal cell carcinoma. Clin Cancer Res 2009;15:81-90
    • (2009) Clin Cancer Res , vol.15 , pp. 81-90
    • Kim, J.1    Jonasch, E.2    Alexander, A.3
  • 108
    • 77958614328 scopus 로고    scopus 로고
    • P27kip1 Expression in non-small cell lung cancer is not an independent prognostic factor
    • Sion-Vardy N, Freedman J, Lazarov I, et al. p27kip1 Expression in non-small cell lung cancer is not an independent prognostic factor. Anticancer Res 2010;30:3699-704
    • (2010) Anticancer Res , vol.30 , pp. 3699-704
    • Sion-Vardy, N.1    Freedman, J.2    Lazarov, I.3
  • 109
    • 2342618936 scopus 로고    scopus 로고
    • Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression
    • Liang J, Slingerland JM. Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression. Cell Cycle 2003;2:339-45
    • (2003) Cell Cycle , vol.2 , pp. 339-45
    • Liang, J.1    Slingerland, J.M.2
  • 112
    • 68149172804 scopus 로고    scopus 로고
    • Discrimination of multiple primary lung cancers from intrapulmonary metastasis based on the expression of four cancer-related proteins
    • Ono K, Sugio K, Uramoto H, et al. Discrimination of multiple primary lung cancers from intrapulmonary metastasis based on the expression of four cancer-related proteins. Cancer 2009;115:3489-500
    • (2009) Cancer , vol.115 , pp. 3489-500
    • Ono, K.1    Sugio, K.2    Uramoto, H.3
  • 113
    • 63449140852 scopus 로고    scopus 로고
    • P27Kip1 in stage III colon cancer: Implications for outcome following adjuvant chemotherapy in cancer and leukemia group B protocol 89803
    • Bertagnolli MM, Warren RS, Niedzwiecki D, et al. p27Kip1 in stage III colon cancer: implications for outcome following adjuvant chemotherapy in cancer and leukemia group B protocol 89803. Clin Cancer Res 2009;15:2116-22
    • (2009) Clin Cancer Res , vol.15 , pp. 2116-22
    • Bertagnolli, M.M.1    Warren, R.S.2    Niedzwiecki, D.3
  • 114
    • 70349443672 scopus 로고    scopus 로고
    • Interaction of molecular markers and physical activity on mortality in patients with colon cancer
    • Meyerhardt JA, Ogino S, Kirkner GJ, et al. Interaction of molecular markers and physical activity on mortality in patients with colon cancer. Clin Cancer Res 2009;15:5931-6
    • (2009) Clin Cancer Res , vol.15 , pp. 5931-6
    • Meyerhardt, J.A.1    Ogino, S.2    Kirkner, G.J.3
  • 117
    • 58549087351 scopus 로고    scopus 로고
    • Expression of p21waf1/cip1, p27kip1, p63 and androgen receptor in low and high gleason score prostate cancer
    • Romics I, Banfi G, Szekely E, et al. Expression of p21waf1/cip1, p27kip1, p63 and androgen receptor in low and high gleason score prostate cancer. Pathol Oncol Res 2008;14:307-11
    • (2008) Pathol Oncol Res , vol.14 , pp. 307-11
    • Romics, I.1    Banfi, G.2    Szekely, E.3
  • 119
    • 77956042544 scopus 로고    scopus 로고
    • SRC: A century of science brought to the clinic
    • Aleshin A, Finn RS. SRC: a century of science brought to the clinic. Neoplasia 2010;12:599-607
    • (2010) Neoplasia , vol.12 , pp. 599-607
    • Aleshin, A.1    Finn, R.S.2
  • 120
    • 66149160364 scopus 로고    scopus 로고
    • Combined Src and aromatase inhibition impairs human breast cancer growth in vivo and bypass pathways are activated in AZD0530-resistant tumors
    • Chen Y, Guggisberg N, Jorda M, et al. Combined Src and aromatase inhibition impairs human breast cancer growth in vivo and bypass pathways are activated in AZD0530-resistant tumors. Clinical Cancer Res 2009;15:3396-405
    • (2009) Clinical Cancer Res , vol.15 , pp. 3396-405
    • Chen, Y.1    Guggisberg, N.2    Jorda, M.3
  • 122
    • 55349141070 scopus 로고    scopus 로고
    • Imatinib mesylate induces quiescence in gastrointestinal stromal tumor cells through the CDH1-SKP2-p27Kip1 signaling axis
    • Liu Y, Perdreau SA, Chatterjee P, et al. Imatinib mesylate induces quiescence in gastrointestinal stromal tumor cells through the CDH1-SKP2-p27Kip1 signaling axis. Cancer Res 2008;68:9015-23
    • (2008) Cancer Res , vol.68 , pp. 9015-23
    • Liu, Y.1    Perdreau, S.A.2    Chatterjee, P.3
  • 124
    • 66049111715 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors as novel anticancer therapeutics
    • Walkinshaw DR, Yang XJ. Histone deacetylase inhibitors as novel anticancer therapeutics. Curr Oncol 2008;15:237-43
    • (2008) Curr Oncol , vol.15 , pp. 237-43
    • Walkinshaw, D.R.1    Yang, X.J.2
  • 125
    • 10044280340 scopus 로고    scopus 로고
    • 1 arrest in fibroblasts
    • DOI 10.1002/jcp.20094
    • Chen JS, Faller DV. Histone deacetylase inhibition-mediated post-translational elevation of p27KIP1 protein levels is required for G1 arrest in fibroblasts. J Cell Physiol 2005;202:87-99 (Pubitemid 39603365)
    • (2005) Journal of Cellular Physiology , vol.202 , Issue.1 , pp. 87-99
    • Chen, J.S.1    Faller, D.V.2
  • 126
    • 0034610545 scopus 로고    scopus 로고
    • P27(Kip1) accumulation is associated with retinoic-induced neuroblastoma differentiation: Evidence of a decreased proteasome-dependent degradation
    • Borriello A, Della Pietra V, Criscuolo M, et al. p27Kip1 accumulation is associated with retinoic-induced neuroblastoma differentiation: evidence of a decreased proteasome-dependent degradation. Oncogene 2000;19:51-60 (Pubitemid 30066350)
    • (2000) Oncogene , vol.19 , Issue.1 , pp. 51-60
    • Borriello, A.1    Della Pietra, V.2    Criscuolo, M.3    Oliva, A.4    Tonini, G.P.5    Iolascon, A.6    Zappia, V.7    Della Ragione, F.8
  • 127
    • 33646248087 scopus 로고    scopus 로고
    • Retinoic acid induces p27Kip1 nuclear accumulation by modulating its phosphorylation
    • Borriello A, Cucciolla V, Criscuolo M, et al. Retinoic acid induces p27Kip1 nuclear accumulation by modulating its phosphorylation. Cancer Res 2006;66:4240-8
    • (2006) Cancer Res , vol.66 , pp. 4240-8
    • Borriello, A.1    Cucciolla, V.2    Criscuolo, M.3
  • 129
    • 41549133200 scopus 로고    scopus 로고
    • Proteasome inhibitors in cancer therapy: Lessons from the first decade
    • DOI 10.1158/1078-0432.CCR-07-2218
    • Orlowski RZ, Kuhn DJ. Proteasome inhibitors in cancer therapy: lessons from the first decade. Clin Cancer Res 2008;14:1649-57 (Pubitemid 351469448)
    • (2008) Clinical Cancer Research , vol.14 , Issue.6 , pp. 1649-1657
    • Orlowski, R.Z.1    Kuhn, D.J.2
  • 130
    • 60249101252 scopus 로고    scopus 로고
    • Bortezomib arrests the proliferation of hepatocellular carcinoma cells HepG2 and JHH6 by differentially affecting E2F1, p21 and p27 levels
    • Baiz D, Pozzato G, Dapas B, et al. Bortezomib arrests the proliferation of hepatocellular carcinoma cells HepG2 and JHH6 by differentially affecting E2F1, p21 and p27 levels. Biochimie 2009;91:373-82
    • (2009) Biochimie , vol.91 , pp. 373-82
    • Baiz, D.1    Pozzato, G.2    Dapas, B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.