Phosphorylation of p27Kip1 regulates assembly and activation of cyclin D1-Cdk4

Molecular and Cellular Biology

Volumn 28, Issue 20, 2008, Pages 6462-6472

  Larrea, Michelle D ^a   Liang, Jiyong ^b,c   Da Silva, Thiago ^a   Hong, Feng ^a   Shao, Shan H ^b   Han, Kathy ^b   Dumont, D ^b   Slingerland, Joyce M ^a  

^a UNIVERSITY OF MIAMI   (United States)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABELSON KINASE; CYCLIN D1; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE INHIBITOR 1B; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN TYROSINE KINASE; RECOMBINANT PROTEIN; CDK2 PROTEIN, HUMAN; CDK4 PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE 2; PHOSPHOTYROSINE; PROTEIN KINASE INHIBITOR; THREONINE;

ALLELE; ARTICLE; COMPLEX FORMATION; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; MUTANT; NEOPLASM; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN PHOSPHORYLATION; AMINO ACID SUBSTITUTION; CATALYSIS; CELL CYCLE G1 PHASE; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; PHOSPHORYLATION; PROTEIN BINDING; TUMOR CELL LINE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; AMINO ACID SUBSTITUTION; CATALYSIS; CELL LINE, TUMOR; CYCLIN D1; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASE INHIBITOR P27; ENZYME ACTIVATION; G1 PHASE; HUMANS; PHOSPHORYLATION; PHOSPHOTYROSINE; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; THREONINE;

EID: 53549126089     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.02300-07     Document Type: Article

References (64)

1. cip1. Mol. Cell. Biol. 20:8748-8757.
2. Cip1 are not required for the formation of active D cyclin-cdk4 complexes. Mol. Cell. Biol. 23:7285-7290.
3. Bates, S, D. Parry, L. Bonetta, K. Vousden, C. Dickson, and G. Peters. 1994. Absence of cyclin D/cdk complexes in cells lacking functional retinoblastoma protein. Oncogene 9:1633-1640.
4. Besson, A., M. Gurian-West, X. Chen, K. S. Kelly-Spratt, C. J. Kemp, and J. M. Roberts. 2006. A pathway in quiescent cells that controls p27Kipl stability, subcellular localization, and tumor suppression. Genes Dev. 20:47-64.
5. Besson, A., M. Gurian-West, A. Schmidt, A Hall, and J. M. Roberts. 2004. p27Kip1 modulates cell migration through the regulation of RhoA activation. Genes Dev. 18:862-876.
6. Blagosklonny, M. V., and A. B. Pardee. 2002. The restriction point of the cell cycle. Cell Cycle 1:103-110.
7. Kip1 and regulates cell cycle progression. EMBO J. 21: 3390-3401.
8. Cariou, S., J. C. Donovan, W. M. Flanagan, A. Milic, N. Bhattacharya, and J. M. Slingerland. 2000. Down-regulation of p21WAFl/CIPl or p27Kipl abrogates antiestrogen-mediated cell cycle arrest in human breast cancer cells. Proc. Natl. Acad. Sci. USA 97:9042-9046.
9. KIp1 CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts. EMBO J. 18:1571-1583.
10. Chu, I., J. Sun, A. Arnaout, H. Kahn, W. Hanna, S. Narod, P. Sun, C. K Tan, L. Hengst, and J. Slingerland. 2007. p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2. Cell 128:281-294.
11. Chu, I. M., L. Hengst, and J. M. Slingerland. 2008. The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy. Nat. Rev. Cancer 8:253-267.
12. 1 arrest. Mol. Cell. Biol. 22:2993-3002.
13. Cornil, I., D. Theodorescu, S. Man, M. Herlyn, J. Jambrosic, and B. Kerbel. 1991. Fibroblast cell interactions with human melanoma cells affect tumor cell growth as a function of tumor progression. Proc. Natl. Acad. Sci. USA 88:6028-6032.
14. 0 by Mirk/dyrk1B kinase. J. Biol. Chem. 279:22498-22504.
15. KiP1 tumor suppressor functions as a cytoplasmic metastatic oncogene in melanoma. Cancer Res. 67:9238-9243.
16. Diehl, J. A., F. Zindy, and C. J. Sherr. 1997. Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway. Genes Dev. 11:957-972.
17. Dufner, A., and G. Thomas. 1999. Ribosomal S6 kinase signaling and the control of translation. Exp. Cell Res. 253:100-109.
18. Florenes, V. A., N. Bhattacharya, M. R. Bani, Y. Ben-David, R. S. Kerbel, and J. M. Slingerland. 1996. TGF-beta mediated G1 arrest in a human melanoma cell line lacking p15INK4B: evidence for cooperation between p21Cip1/WAF1 and p27Kip1. Oncogene 13:2447-2457.
19. Fujita, N., S. Sato, K. Katayama, and T. Tsuruo. 2002. Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization. J. Biol. Chem. 277:28706-28713.
20. Kip1 at threonine 198 by p90 ribosomal protein S6 kinases promotes its binding to 14-3-3 and cytoplasmic localization. J. Biol. Chem. 278:49254-49260.
21. Kip1 are directly regulated by oncogenic tyrosine kinases. Cell 128:269-280.
22. 1 transition mediated by a Skp2-independent ubiquitination pathway. J. Biol. Chem. 276:48937-48943.
23. Herlyn, M. 1990. Human melanoma: development and progression. Cancer Metastasis Rev. 9:101-112.
24. Hong, F., M. D. Larrea, C. Doughty, D. J. Kwiatkowski, R. Squillace, and J. M. Slingerland. 2008. mTOR-raptor binds and activates SGK1 to regulate p27 phosphorylation. Mol. Cell 30:701-711.
25. Kip1, increases its protein stability. J. Biol. Chem. 275:25146-25154.
26. Kip1 controls its cyclin D-cdk4 inhibitory activity. Mol. Cell. Biol. 28:498-510.
27. 1 phase. Nat. Cell Biol. 6:1229-1235.
28. Kardinal, C., M. Dangers, A. Kardinal, A. Koch, D. T. Brandt, T. Tamura, and K. Welte. 2006. Tyrosine phosphorylation modulates binding preference to cyclin-dependent kinases and subcellular localization of p27Kipl in the acute promyelocytic leukemia cell line NB4. Blood 107:1133-1140.
29. Koff, A., M. Ohtsuki, K Polyak, J. M. Roberts, and J. Massague. 1993. Negative regulation of G1 in mammalian cells: inhibition of cyclin E-dependent kinase by TGF-beta. Science 260:536-539.
30. Kossatz, U., J. Vervoorts, I. Nickeleit, H. A. Sundberg, J. S. C. Arthur, M. P. Manns, and N. P. Malek. 2006. C-terminal phosphorylation controls the stability and function of p27kip1. EMBO J. 25:5159-5170.
31. Kotake, Y, K. Nakayama, N. Ishida, and K. I. Nakayama. 2005. Role of serine 10 phosphorylation in p27 stabilization revealed by analysis of p27 knock-in mice harboring a serine 10 mutation. I. Biol. Chem. 280:1095-1102.
32. LaBaer, J., M. D. Garrett, L. F. Stevenson, J. M. Slingerland, C. Sandhu, H. S. Chou, A. Fattaey, and E. Harlow. 1997. New functional activities for the p21 family of CDK inhibitors. Genes Dev. 11:847-862.
33. Laiho, M., J. A. DeCaprio, J. W. Ludlow, D. M. Livingston, and J. Massague. 1990. Growth inhibition by TGF-beta linked to suppression of retinoblastoma protein phosphorylation. Cell 62:175-185.
34. Lee, S., and D. M. Hellman. 2004. Cytoplasmic p21Cip1 is involved in Ras-induced inhibition of the ROCK/LIMK/cofilin pathway. J. Biol. Chem. 279:1885-1891.
35. Li, Y, D. Dowbenko, and L. A. Lasky. 2002. AKT/PKB phosphorylation of p21Cip/WAF1 enhances protein stability of p21Cip/WAF1 and promotes cell survival. J. Biol. Chem. 277:11352-11361.
36. kip1 phosphorylation mediating the decision to enter autophagy or apoptosis. Nat. Cell Biol. 9:218-224.
37. Liang, J., and J. M. Slingerland. 2003. Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression. Cell Cycle 2:339-345.
38. Liang, J., J. Zubovitz, T. Petrocelli, R Kotchetkov, M. K. Connor, K Han, J. H. Lee, S. Ciarallo, C. Catzavelos, R. Beniston, E. Franssen, and J. M. Slingerland. 2002. PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest. Nat. Med. 8:1153-1160.
39. Malumbres, M., and M. Barbacid. 2005. Mammalian cyclin-dependent kinases. Trends Biochem. Sci. 30:630-641.
40. Matsushime, H., D. E. Quelle, S. A. Shurtleff, M. Shibuya, C. J. Sherr, and J. Y. Kato. 1994. D-type cyclin-dependent kinase activity in mammalian cells. Mol. Cell. Biol. 14:2066-2076.
41. kip1 C-terminal scatter domain mediates Rac-dependent cell migration independent of cell cycle arrest functions. Mol. Cell. Biol. 23:216-228.
42. kip1 in breast cancer. Cell Cycle 3:1074-1080.
43. Muise-Helmericks, R C., H. L. Grimes, A. Bellacosa, S. E. Malstrom, P. N. Tsichlis, and N. Rosen. 1998. Cyclin D expression is controlled post-transcriptionally via a phosphatidylinositol 3-krnase/Akt-dependent pathway. J. Biol. Chem. 273:29864-29872.
44. kip1 within a conserved but non-canonical region. Cell Div. 1:11.
45. Kip1 induces cell migration. Nat. Med. 4:1449-1452.
46. Parry, D., S. Bates, D. J. Mann, and G. Peters. 1995. Lack of cyclin D-Cdk complexes in Rb-negative cells correlates with high levels of p16INK4/MTS1 tumour suppressor gene product. EMBO J. 14:503-511.
47. Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest. Genes Dev. 8:9-22.
48. Polyak, K, M. H. Lee, H. Erdjument-Bromage, A. Koff, J. Roberts, P. Tempst, and J. Massagué. 1994. Cloning of p27KIP1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell 78:59-66.
49. Rodier, G., A. Montagnoli, L. Di Marcotullio, P. Coulombe, G. F. Draetta, M. Pagano, and S. Meloche. 2001. p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis. EMBO J. 20:6672-6682.
50. Cip1 regulates PCNA binding and proliferation of endothelial cells. Mol. Cell. Biol. 21:5644-5657.
51. QINK4B-cdk4 complexes, and inhibits cyclin D1-cdk4 association in human mammary epithelial cells. Mol. Cell. Biol. 17:2458-2467.
52. Sheaff, R. J., M. Groudine, M. Gordon, J. M. Roberts, and B. E. Clurman. 1997. Cyclin E-CDK2 is a regulator of p27Kip1. Genes Dev. 11:1464-1478.
53. Sherr, C. J. 2000. The Pezcoller Lecture: cancer cell cycles revisited. Cancer Res. 60 6:3689-3695.
54. Sherr, C. J., and J. M. Roberts. 1999. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev. 13:1501-1512.
55. Kip1 at threonine 157 and modulation of its cellular localization. Nat. Med. 8:1145-1152.
56. Slingerland, J., and M. Pagano. 2000. Regulation of the cdk inhibitor p27 and its deregulation in cancer. J. Cell. Physiol. 183:10-17.
57. Slingerland, J. M., L. Hengst, C. H. Pan, D. Alexander, M. R. Stampfer, and S. I. Reed. 1994. A novel inhibitor of cyclin-Cdk activity detected in transforming growth factor β-arrested epithelial cells. Mol. Cell. Biol. 14:3683-3694.
58. Stampfer, M. 1985. Isolation and growth of human mammary epithelial cells. J. Tissue Cult. Methods 9:107-115.
59. Kip1 by PKB/Akt- media ted phosphorylation in breast cancer. Nat. Med. 8:1136-1144.
60. Vlach, J., S. Hennecke, and B. Amati. 1997. Phosphorylation- dependent degradation of the cyclin-dependent kinase inhibitor p27. EMBO J. 16:5334-5344.
61. Kip1 inhibits cancer cell motility, survival, and tumorigenicity. Cancer Res. 66:2162-2172.
62. Yakes, F. M., W. Chinratanalab, C. A. Ritter, W. King, S. Seelig, and C. L. Arteaga. 2002. Herceptin-induced inhibition of phosphatidylinositol-3 kinase and Akt Is required for antibody-mediated effects on p27, cyclin D1, and antitumor action. Cancer Res. 62:4132-4141.
63. Zhang, H., G. Hannon, and D. Beach. 1994. p21-containing cyclin kinases exist in both active and inactive states. Genes Dev. 8:1750-1758.
64. Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells. Nat. Cell Biol. 3:245-252.