Guanosine is neuroprotective against oxygen/glucose deprivation in hippocampal slices via large conductance Ca2+-activated K+ channels, phosphatidilinositol-3 kinase/protein kinase B pathway activation and glutamate uptake

Neuroscience

Volumn 183, Issue , 2011, Pages 212-220

  Dal Cim, T ^a   Martins, W C ^a   Santos, A R S ^a   Tasca, C I ^a  

^a FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

Author keywords

Akt phosphorylation; BK activation; Glutamate uptake; Guanosine; Hippocampal slices; Oxygen glucose deprivation

Indexed keywords

APAMIN; GLIBENCLAMIDE; GLUTAMIC ACID; GUANOSINE; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; WORTMANNIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DISEASE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; HIPPOCAMPUS; MALE; NEUROPROTECTION; NEUROTRANSMISSION; NONHUMAN; OXYGEN GLUCOSE DEPRIVATION; OXYGENATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; RAT;

ANIMALS; ANOXIA; CELL SURVIVAL; DRUG INTERACTIONS; ENZYME ACTIVATION; ENZYME INHIBITORS; GLUCOSE; GLUTAMIC ACID; GUANOSINE; HIPPOCAMPUS; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MALE; NEUROPROTECTIVE AGENTS; PHOSPHATIDYLINOSITOL 3-KINASES; POTASSIUM CHANNEL BLOCKERS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; STATISTICS, NONPARAMETRIC; TRITIUM;

EID: 79955585812     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2011.03.022     Document Type: Article

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