Guanosine and GMP prevent seizures induced by quinolinic acid in mice

Brain Research

Volumn 864, Issue 1, 2000, Pages 40-43

  Schmidt, André Prato ^a   Lara, Diogo Rizzato ^a   De Faria Maraschin, Jorge ^a   Da Silveira Perla, Alexandre ^a   Souza, Diogo Onofre ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Anticonvulsant; Glutamate; GMP; Guanosine; Quinolinic acid; Seizures

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR BLOCKING AGENT; 4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; ADENOSINE; DIZOCILPINE; GLUTAMATE RECEPTOR; GLUTAMIC ACID; GUANOSINE; GUANOSINE PHOSPHATE; PHENOBARBITAL; PICROTOXIN; QUINOLINIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEIZURE; SEIZURE THRESHOLD;

5'-GUANYLIC ACID; ANIMALS; ANTICONVULSANTS; CENTRAL NERVOUS SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; EPILEPSY; GABA ANTAGONISTS; GAMMA-AMINOBUTYRIC ACID; GLUTAMIC ACID; GUANOSINE; MALE; MICE; NEURONS; PICROTOXIN; QUINOLINIC ACID; RECEPTORS, GABA-A; RECEPTORS, N-METHYL-D-ASPARTATE; RECEPTORS, PURINERGIC P1; SEIZURES; TIME FACTORS;

EID: 0034607580     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(00)02106-5     Document Type: Article

References (30)

1. B.M. Baron, M.W. Dudley, D.R. McCarty, F.P. Miller, I.J. Reynolds, C.J. Schmidt, Guanine nucleotides are competitive inhibitors of N-methyl-D-aspartate at its receptor site both in vitro and in vivo, J. Pharmacol. Exp. Ther. 250 (1989) 162-169.
2. R. Ciccarelli, P. Di lorio, P. Giuliani, I. D'Alimonte, P. Ballerini, F. Caciagli, M. Rathbone, Rat cultured astrocytes release guaninebased purines in basal conditions and after hypoxia/hypoglycemia, Glia 25 (1999) 93-98.
3. M.J. During, D.D. Spencer, Adenosine: a potential mediator of seizure arrest and postictal refractoriness, Ann. Neurol. 32 (1992) 618-624.
4. T. Gudermann, T. Schorneberg, G. Schultz, Functional and structural complexity of signal transduction via G-protein-coupled receptors, Annu. Rev. Neurosci. 20 (1997) 399-427.
5. H. Hagberg, P. Andersson, J. Lacarewicz, I. Jacobson, S. Butcher, M. Sandberg, Extracellular adenosine, inosine, hypoxanthine and xanthine in relation to tissue nucleotides and purines in rat striatum during transient ischemia, J. Neurochem. 49 (1987) 227-231.
6. T.J. Haley, W.G. McCormick, Pharmacologic effects of intracerebral injection of drugs in conscious mouse, Br. J. Pharmacol. 12 (1957) 12-15.
7. M. Hallak, S.M. Irtenkauf, C.A. Janusz, D.B. Cotton, Stimulation and inhibition of N-methyl-D-aspartate receptors in rats: developing a seizure model, Am. J. Obstet. Gynecol. 169 (1993) 695-700.
8. M.P. Heyes, A.R. Wyler, O. Devinsky, J.A. Yergey, S.P. Markey, N.S. Nadi, Quinolinic acid concentrations in brain and cerebrospinal fluid of patients with intractable complex partial seizures, Epilepsia 31 (1990) 172-177.
9. A receptor pharmacology, Pharmacol. Ther. 69 (1996) 173-198.
10. R.N. Kalaria, S.I. Harik, Adenosine receptors and the nucleoside transporter in human brain vasculature, J. Cereb. Blood Flow Metab. 8 (1988) 32-39.
11. S.A. Lipton, P.A. Rosemberg, Excitatory amino acids as a final common pathway for neurologic disorders, New Engl. J. Med. 330 (1994) 613-622.
12. C. Malcon, M. Achaval, F. Komlos, W. Partata, M. Sauressig, G. Ramirez, D.O. Souza, GMP protects against quinolinic acid-induced loss of NADPH-diaphorase-positive cells in the rat striatum, Neurosci. Lett. 225 (1997) 145-148.
13. B.S. Meldrum, The role of glutamate in epilepsy and other CNS disorders, Neurology 44 (suppl 8) (1994) S14-S23.
14. P. Migani, R. Fiorini, E. Ferretti, E. Manini, S. Chimichi, G. Moneti, Role of guanine nucleotides as endogenous ligands of a kainic acid binding site population in the mammalian cerebellum, J. Neurochem. 68 (1997) 1648-1654.
15. K. Nakano, S. Takahashi, M. Mizobuchi, T. Kuroda, K. Masuda, J. Kitoh, High levels of quinolinic acid in brain of epilepsy-prone El mice, Brain Res. 619 (1993) 195-198.
16. S. Ozawa, H. Kamiya, K. Tsuzuki, Glutamate receptors in the mammalian central nervous system, Prog. Neurobiol. 54 (1998) 581-618.
17. Y. Paas, A.D. Thiéry, J.P. Changeux, F. Medevielle, V.I. Teichberg, Identification of an extracellular motif involved in the binding of guanine nucleotides by a glutamate receptor, EMBO J. 15 (1996) 1548-1556.
18. M.M. Paz, M. Ramos, G. Ramirez, D. Souza, Differential effects of guanine nucleotides on kainic acid binding and on adenylate cyclase activity in chick optic tectum, FEBS Lett. 355 (1994) 205-208.
19. A.S. Perla, J.F. Maraschin, D.O. Souza, GMP and GDP inhibit seizures induced by quinolinic acid in mice, J. Neurological Sci. Suppl. (1997) Abstract S200.
20. D.L. Price, New order from neurological disorders, Nature 299 (1999) A3-A5.
21. V. Ralevic, G. Burnstock, Receptors for purines and pyrimidines, Pharmacol. Rev. 50 (1998) 413-492.
22. M.P. Rathbone, P.J. Middlemiss, J.W. Gysbergs, C. Andrew, M.A.R. Herman, J.K. Reed, R. Ciccarelli, P. Di Iorio, F. Caciagli, Trophic effects of purines in neurons and glial cells, Prog. Neurobiol. 59 (1999) 663-690.
23. A. Regner, R.E. Crestana, J.P.J. Silveira, G. Friedman, I. Chemale, D. Souza, Guanine nucleotides are present in human CSF, NeuroReport 8 (1997) 3771-3774.
24. A. Regner, G. Ramírez, A. Belló-Klein, D. Souza, Effects of guanine nucleotides on glutamate-induced chemiluminescence of hippocampal slices submitted to hypoxia, Neurochem. Res. 23 (1998) 519-524.
25. M.A. Rubin, A. Jurach, E.M. Costa, T.T. Lima, R.E. Jimenez-Bernal, J. Begnini, D.O. Souza, C.F. Mello, GMP reverses the facilitatory effect of glutamate on inhibitory avoidance task in rats, NeuroReport 7 (1996) 2078-2080.
26. D.O. Souza, D.R. Lara, Characterization of extracellular binding of [3H]GMP (and derivatives) to rat synaptic membranes, FASEB J 13 (1999) A1574.
27. T.W. Stone, Neuropharmacology of quinolinic and kynurenic acids, Pharmacol. Rev. 45 (1993) 310-379.
28. C.I. Tasca, L.F. Cardoso, L.H. Martini, G. Ramirez, D.O. Souza, Guanine nucleotides inhibit cAMP accumulation induced by metabotropic glutamate receptor activation, Neurochem. Res. 23 (1998) 183-188.
29. C.I. Tasca, S.T. Wofchuk, D.O. Souza, G. Ramirez, R. Rodnight, Guanine nucleotides inhibit the stimulation of GFAP phosphorylation by glutamate, NeuroReport 6 (1995) 249-252.
30. Y. Uemura, J.M. Miller, W.R. Matson, M.F. Beal, Neurochemical analysis of focal ischemia in rats, Stroke 22 (1991) 1548-1553.