Guanosine enhances glutamate uptake in brain cortical slices at normal and excitotoxic conditions

Cellular and Molecular Neurobiology

Volumn 22, Issue 3, 2002, Pages 353-363

  Dos Santos Frizzo, Marcos Emílio ^a   Lara, Diogo Rizzato ^b   Prokopiuk, Alexandre De Souza ^a   Vargas, Carmen Regla ^c   Salbego, Christianne Gazzana ^a   Wajner, Moacir ^a   Souza, Diogo Onofre ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b PONTIFICAL CATHOLIC UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^c HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

Author keywords

Excitotoxicity; Glutamate; Hypoglycemia; Hypoxia; Neuroprotection; Taurine

Indexed keywords

GLUCOSE; GLUTAMIC ACID; GUANOSINE; OXYGEN; PROPIDIUM IODIDE; TAURINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN HYPOXIA; BRAIN ISCHEMIA; BRAIN SLICE; CONTROLLED STUDY; GLUCOSE BRAIN LEVEL; MALE; NEUROPROTECTION; NEUROTOXICITY; NEUROTRANSMITTER UPTAKE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; RAT;

ANIMALS; CELL DEATH; CEREBRAL CORTEX; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; GLUTAMIC ACID; GUANOSINE; HYPOXIA-ISCHEMIA, BRAIN; MALE; NEURONS; NEUROPROTECTIVE AGENTS; NEUROTOXINS; RATS; RATS, WISTAR; SYNAPSES; TAURINE;

ANIMALIA;

EID: 0036625248     PISSN: 02724340     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1020728203682     Document Type: Article

References (37)

1. Anderson, C. M., and Swanson, R. A. (2000). Astrocyte glutamate transport: Review of properties, regulation, and physiological functions. Glia 32:1-14.
2. Asai, S., Zhao, H., Yamashita, A., Jike, T., Kunimatsu, T., Nagata, T., Kohno, T., and Ishikawa, K. (1999). Nicergoline enhances glutamate re-uptake and protects against brain damage in rat global brain ischemia. Eur. J. Pharmacol. 383:267-274.
3. Boldyrev, A. A., Johnson, P., Wei, Y., Tan, Y., and Carpenter, D. O. (1999). Carnosine and taurine protect rat cerebellar granular cells from free radical damage. Neurosci. Lett. 263:169-172.
4. Ciccarelli, R., Di Iorio, P., Giuliani, P., D'Alimonte, I., Ballerini, P., Caciagli, F., and Rathbone, M. (1999). Rat cultured astrocytes release guanine-based purines in basal conditions and after hypoxia/hypoglycemia. Glia 25:93-98.
5. Danbolt, N. C. (2001). Glutamate uptake. Prog. Neurobiol. 65:1-105.
6. Dirnagl, U., Iadecola, C., and Moskowitz, M. A. (1999). Pathobiology of ischemic stroke: An integrated view. Trends Neurosci. 22:391-397.
7. Dobolyi, Á., Reichart, A., Szikra. T., Nyitrai, G., Kékesi, K. A., and Juhász, G. (2000). Sustained depolarization induces changes in the extracellular concentrations of purine and pyrimidine nucleosides in the rat thalamus. Neurochem. Int. 37:71-79.
8. Duan, S., Anderson, C. M., Stein, B. A., and Swanson, R. A. (1999). Glutamate induces rapid upregulation of astrocyte glutamate transport and cell-surface expression of GLAST. J. Neurosci. 19:10193-10200.
9. Frizzo, M. E. S., Lara, D. R., Dahm, K. C., Prokopiuk, A. S., Swanson, R. A., and Souza, D. O. (2001). Activation of glutamate uptake by guanosine in primary astrocyte cultures. Neuroreport 12:879-881.
10. Gegelashvili, G., Civenni, G., Racagni, G., Danbolt, N. C., Schousboe, I., and Schousboe, A. (1996). Glutamate receptor agonists up-regulate glutamate transporter GLAST in astrocytes. Neuroreport 8:261-265.
11. Greene, J. G., and Greenamyre, J. T. (1996). Bioenergetics and glutamate excitotoxicity. Prog. Neurobiol. 48:613-634.
12. Izquierdo, I., Medina, J. H., Vianna, M. R., Izquierdo, L. A., and Barros, D. M. (1999). Separate mechanisms for short- and long-term memory. Behav. Brain Res. 103:1-11.
13. Joseph, M. H., and Marsden, C. A. (1986). Amino acids and small peptides. In Lim, C. K. (ed.), HPLC of Small Peptides, IRL Press, Oxford, pp. 13-27.
14. Jurkowitz, M. S., Litsky, M. L., and Browning, M. J. (1998). Adenosine, inosine, and guanosine protect glial cells during glucose deprivation and mitocondrial inhibition: Correlation between protection and ATP preservation. J. Neurochem. 71:535-548.
15. Lara, D. R., Schmidt, A. P., Frizzo, M. E. S., Burgos, J. S., Ramirez, G., and Souza, D. O. (2001). Effect of orally administered guanosine on seizures and death induced by glutamatergic agents. Brain Res. 912:176-180.
16. Lee, J. M., Zipfel, G. J., and Choi, D. W. (1999). The changing landscape of ischaemic brain injury mechanisms. Nature 399:A7-A14.
17. Masliah, E., Raber, J., Alford, M., Mallory, M., Mattson, M. P., Yang, D., Wong, D., and Mucke, L. (1998). Amyloid protein precursor stimulates excitatory amino acid transport. Implications for roles in neuroprotection and pathogenesis. J. Biol. Chem. 273:12548-12554.
18. Meldrum, B. S. (2000). Glutamate as a neurotransmitter in the brain: Review of physiology and pathology. J. Nutr. 130:1007S-1015S.
19. Monahan, J. B., Hood, W. F., Michel, J., and Compton, R. P. (1988). Effects of guanine nucleotides on N-methyl-D-aspartate receptor-ligand interactions. Mol. Pharmacol. 34:111-116.
20. Munir, M., Correale, D. M., and Robinson, M. B. (2000). Substrate-induced up-regulation of Na(+)-dependent glutamate transport activity. Neurochem. Int. 37:147-162.
21. Nicholls, D. G., and Budd, S. L. (1998). Mitochondria and neuronal glutamate excitotoxicity. Biochem. Biophys. Acta 1366:97-112.
22. Nieoullon, A., Kerkerian, L., and Dusticier, N. (1983). Presynaptic dopaminergic control of high affinity glutamate uptake in the striatum. Neurosci. Lett. 43:191-196.
23. Nishizawa, Y. (2001). Glutamate release and neuronal damage in ischemia. Life Sci. 69:369-381.
24. Ozawa, S., Kamiya, H., and Tsuzuki, K. (1998). Glutamate receptors in the mammalian central nervous system. Prog. Neurobiol. 54:581-618.
25. Peterson, G. L. (1977). Review of the Folin phenol protein quantitation method of Lowry, Rosebrough, Farr and Randall. Anal. Biochem. 83:346-356.
26. Phillis, J. W., Ren, J., and O'Regan, M. H. (2000). Transporter reversal as a mechanism of glutamate release from the ischemic rat cerebral cortex: Studies with DL-threo-beta-benzyloxyaspartate. Brain Res. 880:224.
27. Rathbone, M. P., Middlemiss, P. J., Gysbers, J. W., Andrew, C., Herman, M. A. R., Reed, J. K., Ciccarelli, R., Di Iorio, P., and Caciagli, F. (1999). Tropic effects of purines in neurons and glial cells. Prog. Neurobiol. 59:663-690.
28. Sanchez-Carbente, M. R., and Massieu, L. (1999). Transient inhibition of glutamate uptake in vivo induces neurodegeneration when energy metabolism is impaired. J. Neurochem. 72:129-138.
29. Saransaari, P., and Oja, S. S. (2000). Taurine and neural cell damage. Amino Acids 19:509-526.
30. Schmidt, A. P., Lara, D. R., Maraschin, J. F., Perla, A. S., and Souza, D. O. (2000). Guanosine and GMP prevent seizures induced by quinolinic acid in mice. Brain Res. 864:40-43.
31. Segovia, G., Porras, A., Del Arco, A., and Mora, F. (2001). Glutamatergic neurotransmission in aging: A critical perspective. Mech. Ageing Dev. 122:1-29.
32. Shimada, F., Shiga, Y., Morikawa, M., Kawazura, H., Morikawa, O., Matsuoka, T., Nishizaki, T., and Saito, N. (1999). The neuroprotective agent MS-153 stimulates glutamate uptake. Eur. J. Pharmacol. 386:263-270.
33. Souza, D. O., and Ramirez, G. (1991). Effects of guanine nucleotides on kainic acid binding and on adenylate cyclase in chick optic tectum and cerebellum. J. Mol. Neurosci. 3:39-45.
34. Stover, J. F., and Unterberg, A. W. (2000). Increased cerebrospinal fluid glutamate and taurine concentrations are associated with traumatic brain edema formation in rats. Brain Res. 875:51-55.
35. Tang, X. C., Rao, M. R., Hu, G., and Wang, H. (2000). Alterations of amino acid levels from striatum, hippocampus, and cerebral cortex induced by global cerebral ischemia in gerbil. Acta Pharmacol. Sin. 21:819-823.
36. 3H]-guanosine binding sites in rat brain membranes. Br. J. Pharmacol. 135:969-976.
37. Uemura, Y., Miller, J. M., Matson, W. R., and Beal, M. F. (1991). Neurochemical analysis of focal ischemia in rats. Stroke 22:1548-1553.