Quinolinic acid promotes seizures and decreases glutamate uptake in young rats: Reversal by orally administered guanosine

Brain Research

Volumn 1018, Issue 1, 2004, Pages 48-54

  Oliveira, Diogo Losch De ^a   Horn, Joel Felipe ^a   Rodrigues, Juliana Moura ^a   Frizzo, Marcos E S ^a   Moriguchi, Emílio ^b   Souza, Diogo Onofre ^a   Wofchuk, Susana ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b PONTIFICAL CATHOLIC UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Anticonvulsant; Cortical slice; Disorders of the nervous system; Epilepsy: anti convulsant drugs; Excitotoxicity; Glutamate uptake; Guanosine; Seizure

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; ANTICONVULSIVE AGENT; DIZOCILPINE; GLUTAMIC ACID; GUANOSINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PHENOBARBITAL; PICROTOXIN; QUINOLINIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; BRAIN CORTEX; BRAIN SLICE; CONTROLLED STUDY; DRUG EFFECT; FEMALE; MALE; NEUROTRANSMITTER UPTAKE; NONHUMAN; PRIORITY JOURNAL; RAT; SEIZURE; TREATMENT OUTCOME;

ADMINISTRATION, ORAL; AGING; ANIMALS; ANIMALS, NEWBORN; ANTICONVULSANTS; BRAIN; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; DRUG INTERACTIONS; EPILEPSY; EXCITATORY AMINO ACID ANTAGONISTS; FEMALE; GABA ANTAGONISTS; GLUTAMIC ACID; GUANOSINE; INJECTIONS, INTRAVENTRICULAR; MALE; NEURONS; PHENOBARBITAL; PICROTOXIN; QUINOLINIC ACID; RATS; RATS, WISTAR;

EID: 3242669826     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2004.05.033     Document Type: Article

References (54)

1. Austin J.K., Dunn D.W. Progressive behavioral changes in children with epilepsy. Prog. Brain Res. 135:2002;419-427
2. Baron B.M., Dudley M.W., McCarty D.R., Miller F.P., Reynolds I.J., Schmidt C.J. Guanine nucleotides are competitive inhibitors of N-methyl-D-aspartate at its receptor site both in vitro and in vivo. J. Pharmacol. Exp. Ther. 250:1989;162-169
3. Bittigau P., Sifringer M., Ikonomidou C. Antiepileptic drugs and apoptosis in the developing brain. Ann. N.Y. Acad. Sci. 993:2003;103-114
4. Blanc E.M., Keller J.N., Fernandez S., Mattson M.P. 4-Hydroxynonenal, a lipid peroxidation product, impairs glutamate transport in cortical astrocytes. Glia. 22:1998;149-160
5. Bradford H.F. Glutamate, GABA and epilepsy. Prog. Neurobiol. 47:1995;477-511
6. Burgos J.S., Barat A., Souza D.O., Ramirez G. Guanine nucleotides protect against kainate toxicity in an ex vivo chick retinal preparation. FEBS Lett. 430:1998;176-180
7. Chapman A.G. Glutamate and epilepsy. J. Nutr. 130:2000;1043S-1045S
8. Ciccarelli R., Ballerini P., Sabatino G., Rathbone M.P., D'Onofrio M., Caciagli F., DiIorio P. Involvement of astrocytes in purine-mediated reparative processes in the brain. Int. J. Dev. Neurosci. 19:2001;395-414
9. Cowan L.D. The epidemiology of the epilepsies in children. Ment. Retard. Dev. Disabil. Res. Rev. 8:2002;171-181
10. Danbolt N.C. Glutamate uptake. Prog. Neurobiol. 65:2001;1-105
11. Eastman C.L., Urbanska E.M., Chapman A.G., Schwarcz R. Differential expression of the astrocytic enzymes 3-hydroxyanthranilic acid oxygenase, kynurenine aminotransferase and glutamine synthetase in seizure-prone and non-epileptic mice. Epilepsy Res. 18:1994;185-194
12. Folbergrova J., Haugvicova R., Mares P. Attenuation of seizures induced by homocysteic acid in immature rats by metabotropic glutamate group II and group III receptor agonists. Brain Res. 908:2001;120-129
13. Frizzo M.E., Lara D.R., Dahm K.C., Prokopiuk A.S., Swanson R.A., Souza D.O. Activation of glutamate uptake by guanosine in primary astrocyte cultures. NeuroReport. 12:2001;879-881
14. Frizzo M.E., Lara D.R., Prokopiuk A.S., Vargas C.R., Salbego C.G., Wajner M., Souza D.O. Guanosine enhances glutamate uptake in brain cortical slices at normal and excitotoxic conditions. Cell. Mol. Neurobiol. 22:2002;353-363
15. Grunewald R. Childhood seizures and their consequences for the hippocampus. Brain. 125:2002;1935-1936
16. Gudermann T., Schoneberg T., Schultz G. Functional and structural complexity of signal transduction via G-protein-coupled receptors. Annu. Rev. Neurosci. 20:1997;399-427
17. Heyes M.P., Wyler A.R., Devinsky O., Yergey J.A., Markey S.P., Nadi N.S. Quinolinic acid concentrations in brain and cerebrospinal fluid of patients with intractable complex partial seizures. Epilepsia. 31:1990;172-177
18. Ingram E.M., Wiseman J.W., Tessler S., Emson P.C. Reduction of glial glutamate transporters in the parietal cortex and hippocampus of the EL mouse. J. Neurochem. 79:2001;564-575
19. Izquierdo I., Medina J.H. Memory formation: the sequence of biochemical events in the hippocampus and its connection to activity in other brain structures. Neurobiol. Learn. Mem. 68:1997;285-316
20. Kalaria R.N., Harik S.I. Adenosine receptors and the nucleoside transporter in human brain vasculature. J. Cereb. Blood Flow Metab. 8:1988;32-39
21. Lapin I.P., Prakhie I.B., Kiseleva I.P. Antagonism of seizures induced by the administration of the endogenous convulsant quinolinic acid into rat brain ventricles. J. Neural Transm. 65:1986;177-185
22. Lara D.R., Schmidt A.P., Frizzo M.E., Burgos J.S., Ramirez G., Souza D.O. Effect of orally administered guanosine on seizures and death induced by glutamatergic agents. Brain Res. 912:2001;176-180
23. Malcon C., Achaval M., Komlos F., Partata W., Sauressig M., Ramirez G., Souza D.O. GMP protects against quinolinic acid-induced loss of NADPH-diaphorase-positive cells in the rat striatum. Neurosci. Lett. 225:1997;145-148
24. Maragakis N.J., Rothstein J.D. Glutamate transporters in neurologic disease. Arch. Neurol. 58:2001;365-370
25. Maragakis N.J., Rothstein J.D. Glutamate transporters: animal models to neurologic disease. Neurobiol. Dis. 15:2004;461-473
26. Meldrum B.S. The role of glutamate in epilepsy and other CNS disorders. Neurology. 44:1994;S14-S23
27. Meldrum B.S. Concept of activity-induced cell death in epilepsy: historical and contemporary perspectives. Prog. Brain Res. 135:2002;3-11
28. Mena F.V., Baab P.J., Zielke C.L., Zielke H.R. In vivo glutamine hydrolysis in the formation of extracellular glutamate in the injured rat brain. J. Neurosci. Res. 60:2000;632-641
29. Nakano K., Takahashi S., Mizobuchi M., Kuroda T., Masuda K., Kitoh J. High levels of quinolinic acid in brain of epilepsy-prone E1 mice. Brain Res. 619:1993;195-198
30. Obrenovitch T.P., Urenjak J. Altered glutamatergic transmission in neurological disorders: from high extracellular glutamate to excessive synaptic efficacy. Prog. Neurobiol. 51:1997;39-87
31. Ozawa S., Kamiya H., Tsuzuki K. Glutamate receptors in the mammalian central nervous system. Prog. Neurobiol. 54:1998;581-618
32. Painter M.J., Scher M.S., Stein A.D., Armatti S., Wang Z., Gardiner J.C., Paneth N., Minnigh B., Alvin J. Phenobarbital compared with phenytoin for the treatment of neonatal seizures. N. Engl. J. Med. 341:1999;485-489
33. Patil S.D., Unadkat J.D. Sodium-dependent nucleoside transport in the human intestinal brush-border membrane. Am. J. Physiol. 272:1997;G1314-G1320
34. Pellock J.M. Drug treatment in children. Engel J. Jr., Pedley T.A. Epilepsy: A Comprehensive Textbook. vol. 2:1997;1205-1210 Lippincot-Raven, Philadelphia
35. Peterson G.L. A simplification of the protein assay method of Lowry et al. which is more generally applicable. Anal. Biochem. 83:1977;346-356
36. Porciuncula L.O., Vinade L., Wofchuk S., Souza D.O. Guanine based purines inhibit [(3)H]glutamate and [(3)H]AMPA binding at postsynaptic densities from cerebral cortex of rats. Brain Res. 928:2002;106-112
37. Rathbone M.P., Middlemiss P.J., Gysbers J.W., Andrew C., Herman M.A., Reed J.K., Ciccarelli R., Di Iorio P., Caciagli F. Trophic effects of purines in neurons and glial cells. Prog. Neurobiol. 59:1999;663-690
38. Rodriguez-Martinez E., Camacho A., Maldonado P.D., Pedraza-Chaverri J., Santamaria D., Galvan-Arzate S., Santamaria A. Effect of quinolinic acid on endogenous antioxidants in rat corpus striatum. Brain Res. 858:2000;436-439
39. Rossato J.I., Zeni G., Mello C.F., Rubin M.A., Rocha J.B. Ebselen blocks the quinolinic acid-induced production of thiobarbituric acid reactive species but does not prevent the behavioral alterations produced by intra-striatal quinolinic acid administration in the rat. Neurosci. Lett. 318:2002;137-140
40. Rothstein J.D., Dykes-Hoberg M., Pardo C.A., Bristol L.A., Jin L., Kuncl R.W., Kanai Y., Hediger M.A., Wang Y., Schielke J.P., Welty D.F. Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate. Neuron. 16:1996;675-686
41. Rubin M.A., Jurach A., Costa Junior E.M., Lima T.T., Jimenez-Bernal R.E., Begnini J., Souza D.O., de Mello C.F. GMP reverses the facilitatory effect of glutamate on inhibitory avoidance task in rats. NeuroReport. 7:1996;2078-2080
42. Schmidt A.P., Lara D.R., de Faria M.J., da Silveira P.A., Onofre S.D. Guanosine and GMP prevent seizures induced by quinolinic acid in mice. Brain Res. 864:2000;40-43
43. Segovia G., Porras A., Del Arco A., Mora F. Glutamatergic neurotransmission in aging: a critical perspective. Mech. Ageing Dev. 122:2001;1-29
44. Stone T.W. Kynurenines in the CNS: from endogenous obscurity to therapeutic importance. Prog. Neurobiol. 64:2001;185-218
45. Swann J.W. Recent experimental studies of the effects of seizures on brain development. Prog. Brain Res. 135:2002;391-393
46. Tanaka K., Watase K., Manabe T., Yamada K., Watanabe M., Takahashi K., Iwama H., Nishikawa T., Ichihara N., Kikuchi T., Okuyama S., Kawashima N., Hori S., Takimoto M., Wada K. Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1. Science. 276:1997;1699-1702
47. Tasca C.I., Cardoso L.F., Martini L.H., Ramirez G., Souza D.O. Guanine nucleotides inhibit cAMP accumulation induced by metabotropic glutamate receptor activation. Neurochem. Res. 23:1998;183-188
48. Tavares R.G., Tasca C.I., Santos C.E., Wajner M., Souza D.O., Dutra-Filho C.S. Quinolinic acid inhibits glutamate uptake into synaptic vesicles from rat brain. NeuroReport. 11:2000;249-253
49. Tavares R.G., Tasca C.I., Santos C.E., Alves L.B., Porciuncula L.O., Emanuelli T., Souza D.O. Quinolinic acid stimulates synaptosomal glutamate release and inhibits glutamate uptake into astrocytes. Neurochem. Int. 40:2002;621-627
50. Trotti D., Danbolt N.C., Volterra A. Glutamate transporters are oxidant-vulnerable: a molecular link between oxidative and excitotoxic neurodegeneration? Trends Pharmacol. Sci. 19:1998;328-334
51. Ueda Y., Doi T., Tokumaru J., Yokoyama H., Nakajima A., Mitsuyama Y., Ohya-Nishiguchi H., Kamada H., Willmore L.J. Collapse of extracellular glutamate regulation during epileptogenesis: down-regulation and functional failure of glutamate transporter function in rats with chronic seizures induced by kainic acid. J. Neurochem. 76:2001;892-900
52. Velisek L., Mares P. Age-dependent anticonvulsant action of clonazepam in the N-methyl-D-aspartate model of seizures. Pharmacol. Biochem. Behav. 52:1995;291-296
53. Vezzani A., Ungerstedt U., French E.D., Schwarcz R. In vivo brain dialysis of amino acids and simultaneous EEG measurements following intrahippocampal quinolinic acid injection: evidence for a dissociation between neurochemical changes and seizures. J. Neurochem. 45:1985;335-344
54. Vinadé E.R., Schmidt A.P., Frizzo M.E.S., Izquierdo I., Elisabetsky E. Chronically administered guanosine is anticonvulsant, amnesic and anxiolytic in mice. Brain Res. 977:2003;97-102