Guanine nucleotides inhibit NMDA and kainate-induced neurotoxicity in cultured rat hippocampal and neocortical neurons

Neurochemistry International

Volumn 45, Issue 1, 2004, Pages 95-101

  Morciano, M ^a   Ortinau, S ^a   Zimmermann, Herbert ^a  

^a GOETHE UNIVERSITY   (Germany)

Author keywords

Cerebral cortex; Guanine nucleotides; Hippocampus; Kainate; Neurotoxicity; NMDA

Indexed keywords

GUANINE NUCLEOTIDE; GUANOSINE DIPHOSPHATE; GUANOSINE PHOSPHATE; GUANOSINE TRIPHOSPHATE; KAINIC ACID; N METHYL DEXTRO ASPARTIC ACID; NEUROPROTECTIVE AGENT;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; BRAIN NERVE CELL; CONTROLLED STUDY; CULTURE MEDIUM; DRUG EFFECT; DRUG HYDROLYSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; HIPPOCAMPUS; NEOCORTEX; NERVE CELL CULTURE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; GUANINE NUCLEOTIDES; HIPPOCAMPUS; KAINIC ACID; N-METHYLASPARTATE; NEOCORTEX; NEURONS; RATS; RATS, WISTAR;

EID: 1842636771     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuint.2003.11.017     Document Type: Article

References (43)

1. Adamec E., Yang F., Cole G.M., Nixon R.A. Multi-label immunocytochemistry for the evaluation of nature of cell death in experimental models of neurodegeneration. Brain Res. Protocols. 7:2001;193-202.
2. Aleu J., Barat A., Burgos J.S., Solsona C., Marsal J., Ramírez G. Guanine nucleotides, including GMP, antagonize kainate responses in Xenopus oocytes injected with chick cerebellar membranes. J. Neurochem. 72:1999;2170-2176.
3. 3H ]cyano-7-nitroquinoxaline-2,3-dione binding in goldfish brain J. Neurochem. 61:1993;1685-1691.
4. Baron M.D., Dudley M.W., McCarthy D.R., Miller F.P., Reynolds I.J., Schmidt C.J. Guanine nucleotides are competitive inhibitors of N-methyl-D-aspartate and its receptor site both in vitro and in vivo. J. Pharmacol. Exp. Ther. 250:1989;162-169.
5. Bigge C.F. Ionotropic glutamate receptors. Curr. Opin. Chem. Biol. 3:1999;441-447.
6. Bodin P., Burnstock G. Purinergic signalling: ATP release. Neurochem. Res. 26:2001;959-969.
7. Brecht S., Gelderblom M., Srinivasan A., Mielke K., Dityateva G., Herdegen T. Caspase-3 activation and DNA fragmentation in primary hippocampal neurons following glutamate excitotoxicity. Mol. Brain Res. 94:2001;25-34.
8. Brewer G.J., Torricelli J.R., Evege E.K., Price P.J. Optimized survival of hippocampal neurons in B27-supplemented Neurobasal™, a new serum-free medium combination. J. Neurosci. Res. 35:1993;567-576.
9. Brooke S.M., Bliss T.M., Franklin L.R., Sapolsky R.M. Quantification of neuron survival in monolayer cultures using an enzyme-linked immunoabsorbent assay approach, rather that by cell counting. Neurosci. Lett. 267:1999;21-24.
10. Budson A.E., Jackson P.S., Lipton S.A. GDPβS antagonizes whole cell current responses to excitatory amino acids. Brain Res. 548:1991;346-348.
11. Burgos J.S., Barat A., Souza D.O., Ramírez G. Guanine nucleotides protect against kainate toxicity in an ex vivo chick retinal preparation. FEBS Lett. 430:1998;176-180.
12. Burgos J.S., Aleu J., Barat A., Solsona C., Marsal J., Ramírez G. Kainate-triggered currents in Xenopus oocytes injected with chick retinal membrane fragments: effect of guanine nucleotides. Invest. Ophthalmol. Vis. Sci. 44:2003;3124-3129.
13. 3H] APB) to L-glutamate-sensitive sites on rat brain membranes Biochem. Pharmacol. 35:1986;991-994.
14. Ciccarelli R., Di Iorio P., Giuliani P., D'Alimonte I., Ballerini P., Caciagli F., Rathbone M.P. Rat cultured astrocytes release guanine-based purines in basal conditions and after hypoxia/hypoglycemia. Glia. 25:1999;93-98.
15. Cunha R.A. Regulation of the ecto-nucleotidase pathway in rat hippocampal nerve terminals. Neurochem. Res. 26:2001;979-991.
16. Dev K.K., Roberts P.J., Henley J.M. Characterization of the interaction between guanyl nucleotides and AMPA receptors in rat brain. Neuropharmacology. 35:1996;1583-1593.
17. Dingledine R., Borges K., Bowie D., Traynelis S.F. The glutamate receptor ion channels. Pharmacol. Rev. 51:1999;7-61.
18. Gorodinsky A., Paas Y., Teichberg V.I. A ligand binding study of the interactions of guanine nucleotides with non-NMDA receptors. Neurochem. Int. 23:1993;285-291.
19. 3H]TCP binding to the NMDA receptor complex Eur. J. Pharmacol. 188:1990;43-49.
20. Kemp J.A., McKernan R.M. NMDA receptor pathways as drug targets. Nat. Neurosci. 5:2002;1039-1042.
21. Lerma J., Paternain A.V., Rodríguez-Moreno A., López García J.C. Molecular physiology of kainate receptors. Physiol. Rev. 81:2001;971-998.
22. Malcon C., Achaval M., Komlus S., Partata W., Sauressig M., Ramírez G., Souza D.O. GMP protects against quinolinic acid-induced loss of NADPH diaphorase-positive cells in the rat striatum. Nuerosci. Lett. 225:1997;145-148.
23. Migani P., Fiorini R., Ferretti E., Manani E., Chimichi S., Moneti G. Role of guanine nucleotides as endogenous ligands of a kainic acid binding site population in the mammalian cerebellum. J. Neurochem. 68:1997;1648-1654.
24. Monahan J.B., Hood W.F., Michel J., Compton R.P. Effects of guanine nucleotides on N-methyl-D-aspartate receptor-ligand interactions. Mol. Pharmacol. 34:1988;111-116.
25. Oliveira I.J.L., Molz S., Souza D.O., Tasca C.I. Neuroprotective effect of GMP in hippocampal slices submitted to an in vitro model of ischemia. Cell. Mol. Neurobiol. 22:2002;335-344.
26. Ortinau S., Laube B., Zimmermann H. ATP inhibits NMDA receptors after heterologous expression and in cultured hippocampal neurons, and attenuates NMDA-mediated neurotoxicity. J. Neurosci. 23:2003;4996-5003.
27. Paas Y., Devillers-Thiéry A., Changeux J.-P., Medeville F., Teichberg V.I. Identification of an extracellular motif involved in the binding of guanine nucleotides by a glutamate receptor. EMBO J. 15:1996;1548-1556.
28. Pintor J., Kowalewski H.J., Torres M., Miras-Portugal M.T., Zimmermann H. Synaptic vesicle storage of diadenosine polyphosphates in the Torpedo electric organ. Neurosci. Res. Commun. 10:1992;9-15.
29. Poulopoulou C., Nowak L.M. Extracellular 3′,5′ cyclic guanosine monophosphate inhibits kainate-acivated responses in cultured mouse cerebellar neurons. J. Pharmacol. Exp. Ther. 286:1998;99-109.
30. Ralevic V., Burnstock G. Receptors for purines and pyrimidines. Pharmacol. Rev. 50:1998;413-492.
31. 3H]PppNHp to extracellular membrane receptors in chick cerebellum: possible involvement of kainic acid receptors FEBS Lett. 406:1997;114-118.
32. Regner A., Crestana R.E., Silveira J.P.J., Friedman G., Chemale I., Souza D. Guanine nucleotides are present in human CSF. Neuroreport. 8:1997;3771-3774.
33. Regner A., Ramírez G., Belló-Klein A., Souza D. Effect of guanine-nucleotides on glutamate-induced chemoluminescence in rat hippocampal slices submitted to hypoxia. Neurochem. Res. 23:1998;519-524.
34. Schmidt A.P., Lara D.R., Maraschin J.F., Perla A.S., Souza D.O. Guanosine and GMP prevent seizures induced by quinolinic acid in mice. Brain Res. 864:2000;40-43.
35. Souza D.O., Ramírez G. Effect of guanine nucleotides on kainic acid binding and on adenylate cyclase in chick optic tectum and cerebellum. J. Mol. Neurosci. 3:1991;39-45.
36. Vollmayer P., Koch M., Braun N., Heine P., Servos J., Israr E., Kegel B., Zimmermann H. Multiple ecto-nucleotidases in PC12 cells: identification and cellular distribution after heterologous expression. J. Neurochem. 78:2001;1019-1028.
37. Wagner J.A., Carlson S.S., Kelly R.B. Chemical and physical characterization of cholinergic synaptic vesicles. Biochemistry. 17:1978;1199-1206.
38. Williams K. Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: selectivity and mechanisms at recombinant heteromeric receptors. Mol. Pharmacol. 44:1993;851-859.
39. Yoneda Y., Ogita K., Suzuki T., Enomoto R., Ping Z.P. Competitive inhibition of NMDA-mediated responses by guanine nucleotides in brain synaptic membranes treated with Triton X-100. Neurosci. Res. 9:1990;114-125.
40. Zimmermann H. Signalling via ATP in the nervous system. Trends Neurosci. 17:1994;420-426.
41. Zimmermann H. Biochemistry, localization and functional roles of ecto-nucleotidases in the nervous system. Prog. Neurobiol. 49:1996;589-618.
42. Zimmermann, H., 2001. Ecto-nucleotidases. In: Abbracchio, M.P., Williams, M. (Eds.), Handbook of Experimental Pharmacology. Purinergic and Pyrimidergic Signalling. Springer Verlag, Heidelberg, pp. 209-250.
43. Zimmermann H., Braun N. Ecto-nucleotidases: molecular structures, catalytic properties, and functional roles in the nervous system. Prog. Brain Res. 120:1999;371-385.