Discovery of histone deacetylase 8 selective inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 9, 2011, Pages 2601-2605

  Tang, Weiping ^a,b   Luo, Tuoping ^a   Greenberg, Edward F ^a   Bradner, James E ^a   Schreiber, Stuart L ^a  

^a BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

HDAC; HDAC8; Hydroxamic acid; Inhibitor; Macrocycle

Indexed keywords

ALDEHYDE; HISTONE DEACETYLASE 8 INHIBITOR; HISTONE DEACETYLASE INHIBITOR; HYDRAZIDE; HYDROXAMIC ACID; UNCLASSIFIED DRUG;

CONFERENCE PAPER; DRUG SCREENING; DRUG SYNTHESIS;

BIOLOGICAL ASSAY; ENZYME ACTIVATION; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; REPRESSOR PROTEINS;

EID: 79955467289     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.01.134     Document Type: Conference Paper

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