Azetidinones as zinc-binding groups to design selective HDAC8 inhibitors

ChemMedChem

Volumn 4, Issue 12, 2009, Pages 1991-2001

  Galletti, Paola ^a   Quintavalla, Arianna ^a   Ventrici, Caterina ^a   Giannini, Giuseppe ^b   Cabri, Walter ^b   Penco, Sergio ^b   Gallo, Grazia ^b   Vincenti, Silvia ^b   Giacomini, Daria ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b Sigma Tau SpA   (Italy)

Author keywords

Azetidinones; Heterocycles; Histone deacetylase; Inhibitors; Lactams

Indexed keywords

1 (BIPHENYL 4 YLMETHYLSULFANYL)AZETIDIN 2 ONE; 2 AZETIDINONE DERIVATIVE; 2 HYDROXYMETHYL 7 PHENYLCARBAMOYLHEPT 4 ENOIC ACID METHYL ESTER; 2 HYDROXYMETHYLPENT 4 ENOIC ACID BENZYLOXYAMIDE; 3 (3 BIPHENYL 4 YLALLYL) 1 METHYLSULFANYLAZETIDIN 2 ONE; 3 (3 BIPHENYL 4 YLALLYL)AZETIDIN 2 ONE; 3 ALLYL 1 BENZYLOXYAZETIDIN 2 ONE; 3 ALLYL 1 METHYLSULFANYLAZETIDIN 2 ONE; 4 BUT 3 ENYL 1 METHYLSULFANYLAZETIDIN 2 ONE; 5 (1 METHYLSULFANYL 4 OXO AZETIDIN 2 YL)PENT 2 ENOIC ACID PHENYLAMIDE; 6 (1 BENZYLOXY 2 OXO AZETIDIN 3 YL)HEX 4 ENOIC ACID PHENYLAMIDE; 6 (1 HYDROXY 2 OXO AZETIDIN 3 YL)HEXANOIC ACID PHENYLAMIDE; 6 (1 METHYLSULFANYL 2 OXO AZETIDIN 3 YL)HEX 4 ENOIC ACID PHENYLAMIDE; 6 (2 OXO AZETIDIN 3 YL)HEX 4 ENOIC ACID PHENYLAMIDE; 6 (2 OXO AZETIDIN 3 YL)HEXANOIC ACID PHENYLAMIDE; 6 [1 (2 AMINOPHENYL) 2 OXO AZETIDIN 3 YL]HEXANOIC ACID PHENYLAMIDE; [2 (2 HYDROXYMETHYL 7 PHENYLCARBAMOYLHEPT 4 ENOYLAMINO)PHENYL]CARBAMIC ACID BENZYL ESTER; [2 [2 OXO 3 (5 PHENYLCARBAMOYLPENT 2 ENYL)AZETIDIN 1 YL]PHENYL]CARBAMIC ACID BENZYL ESTER; BETA LACTAM DERIVATIVE; HISTONE DEACETYLASE 6; HISTONE DEACETYLASE 8; HISTONE DEACETYLASE INHIBITOR; TOLUENE 4 THIOSULFONIC ACID S BIPHENYL 4 YLMETHYL ESTER; TRICHOSTATIN A; UNCLASSIFIED DRUG; ZINC BINDING PROTEIN;

ARTICLE; DRUG ACTIVITY; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENANTIOMER; ENZYMATIC ASSAY; PRIORITY JOURNAL;

AZETIDINES; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN BINDING; PROTEIN ISOFORMS; STRUCTURE-ACTIVITY RELATIONSHIP; ZINC;

EID: 73449085175     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.200900309     Document Type: Article

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