Design and synthesis of non-hydroxamate histone deacetylase inhibitors: Identification of a selective histone acetylating agent

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 13, 2005, Pages 4332-4342

  Suzuki, Takayoshi ^a   Matsuura, Azusa ^a   Kouketsu, Akiyasu ^a   Hisakawa, Shinya ^a   Nakagawa, Hidehiko ^a   Miyata, Naoki ^a  

^a NAGOYA CITY UNIVERSITY   (Japan)

Author keywords

Histone deacetylase inhibitor; Non hydroxamate

Indexed keywords

(5 PHENYLCARBAMOYLPENTYLCARBOMOYL)PHOSPHONIC ACID; (5 PHENYLCARBAMOYLPENTYLCARBOMOYL)PHOSPHONIC ACID DIETHYL ESTER; 5 (6 PHENYLCARBAMOYLHEXANE 1 SULFINYL)PENTANOIC ACID; 5 (6 PHENYLCARBAMOYLHEXANE 1 SULFONYL)PENTANOIC ACID; 6 (2 1H TETRAZOL 5 YLACETYLAMINO)HEXANOIC ACID PHENYLAMIDE; 6 (3 OXOBUTYRYLAMINO)HEXANOIC ACID PHENYLAMIDE; 6 CHLOROMETHANESULFONYLAMINOHEXANOIC ACID PHENYLAMIDE; 7 ACETYLSULFAMOYLHEPTANOIC ACID PHENYLAMIDE; 7 METHANESULFINYLHEPTANOIC ACID PHENYLAMIDE; 7 SULFAMOYLHEPTANOIC ACID PHENYLAMIDE; [(5 PHENYLCARBAMOYLPENTYLCARBAMOYL)METHYL]PHOSPHONIC ACID DIETHYL ESTER; ALPHA TUBULIN; ANILIDE; DIMETHYL SULFOXIDE; HISTONE DEACETYLASE; HISTONE DEACETYLASE INHIBITOR; HYDROXAMIC ACID DERIVATIVE; N (5 PHENYLCARBAMOYLPENTYL)ACRYLAMIDE; N (5 PHENYLCARBAMOYLPENTYL)MALONAMIC ACID; N (5 PHENYLCARBAMOYLPENTYL)MALONAMIC ACID ETHYL ESTER; PROPINOIC ACID(5 PHENYLCARBAMOYLPENTYL)AMIDE; THIAZOLE 2 CARBOXYLIC ACID(5 PHENYLCARBAMOYLPENTYL)AMIDE; THIAZOLIDINE 2 CARBOXYLIC ACID(5 PHENYLCARBAMOYLPENTYL)AMIDE; THIOPHENE 2 CARBOXYLIC ACID(5 PHENYLCARBAMOYLPENTYL)AMIDE; UNCLASSIFIED DRUG;

ACETYLATION; ARTICLE; CELL STRAIN HCT116; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG SYNTHESIS; ENZYME ASSAY; HUMAN; HUMAN CELL;

ACETYLATION; CELL PROLIFERATION; DRUG DESIGN; ENZYME INHIBITORS; HCT116 CELLS; HISTONE DEACETYLASES; HISTONES; HUMANS; HYDROXAMIC ACIDS; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN MODULATORS;

EID: 20344391371     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.04.002     Document Type: Article

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