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22
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0141576939
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note
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HPLC purities were measured at 254 nm.
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23
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0141576938
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note
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In general, in automated synthesis, an operationally simpler protocol may be preferred over a more complex sequence, even at the expense of a slightly reduced yield, since it introduces less opportunity for failure of the entire synthesis. In this case, we found it advantageous to routinely repeat the sulfonylation step twice in separate reaction blocks (1 and 2, Fig. 2), prior to scavenging.
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24
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0033708289
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(a) C. Jamieson, M. S. Congreve, D. F. Emiabata-Smith and S. V. Ley, Synlett, 2000, 11, 1603;
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Congreve, M.S.2
Emiabata-Smith, D.F.3
Ley, S.V.4
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25
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0036858614
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(b) C. Jamieson, M. S. Congreve, D. F. Emiabata-Smith, S. V. Ley and J. J. Scicinski, Org. Proc. Res. Develop., 2002, 6, 823.
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Congreve, M.S.2
Emiabata-Smith, D.F.3
Ley, S.V.4
Scicinski, J.J.5
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26
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0037161861
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Pd EnCat™ This reagent is available from Avecia (www.avecia.com), cf: (a) C. Ramarao, S. V. Ley, I. M. Shirley and N. J. DeAlmeida, Chem. Commun., 2002, 1132;
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Ramarao, C.1
Ley, S.V.2
Shirley, I.M.3
Dealmeida, N.J.4
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27
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0037161724
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(b) S. V. Ley, C. Ramarao, R. S. Gordon, A. B. Holmes, A. G. Morrison, I. F. McConvey, I. M. Shirley, S. C. Smith and M. D. Smith, Chem. Commun., 2002, 1134.
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-
Ley, S.V.1
Ramarao, C.2
Gordon, R.S.3
Holmes, A.B.4
Morrison, A.G.5
McConvey, I.F.6
Shirley, I.M.7
Smith, S.C.8
Smith, M.D.9
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28
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0141465333
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FibreCat™ 1001: 2.71 mol% Pd was supplied by Johnson Matthey (www.chemicals.matthey.com).
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Matthey, J.1
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29
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0141576937
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A pre-production trial batch of this polymer supported reagent was kindly supplied by Argonaut Technologies Inc. (www.argotech.com).
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30
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0141688540
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note
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6) 167.9, 143.9, 143.5, 140.0, 136.9, 130.2, 129.9, 129.7, 127.1, 119.5, 118.3, 21.3.
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31
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0141688541
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note
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-1 available from Fluka (order No. 20026).
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