-
1
-
-
0034718204
-
Structure of tau protein and assembly into paired helical filaments
-
P. Friedhoff, M. von Bergen, E.M. Mandelkow and E. Mandelkow, Structure of tau protein and assembly into paired helical filaments, Biochim. Biophys. Acta 1502 (2000), 122-132.
-
(2000)
Biochim. Biophys. Acta
, vol.1502
, pp. 122-132
-
-
Friedhoff, P.1
Von Bergen, M.2
Mandelkow, E.M.3
Mandelkow, E.4
-
2
-
-
0037135111
-
The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
-
J. Hardy and D.J. Selkoe, The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics, Science 297 (2002), 353-356.
-
(2002)
Science
, vol.297
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
3
-
-
1442264828
-
Take five-BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation
-
C. Haass, Take five-BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation, EMBO J. 23 (2004), 483-488.
-
(2004)
EMBO J.
, vol.23
, pp. 483-488
-
-
Haass, C.1
-
4
-
-
16044373524
-
Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and AβPP mutations linked to familial Alzheimer's disease
-
D. Scheuner, C. Eckman, M. Jensen, X. Song, M. Citron, N. Suzuki, T.D. Bird, J. Hardy, M. Hutton, W. Kukull, E. Larson, E. Levy-Lahad, M. Viitanen, E. Peskind, P. Poorkaj, G. Schellenberg, R. Tanzi, W. Wasco, L. Lannfelt, D. Selkoe and S. Younkin, Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and AβPP mutations linked to familial Alzheimer's disease, Nat. Med. 2 (1996), 864-870.
-
(1996)
Nat. Med.
, vol.2
, pp. 864-870
-
-
Scheuner, D.1
Eckman, C.2
Jensen, M.3
Song, X.4
Citron, M.5
Suzuki, N.6
Bird, T.D.7
Hardy, J.8
Hutton, M.9
Kukull, W.10
Larson, E.11
Levy-Lahad, E.12
Viitanen, M.13
Peskind, E.14
Poorkaj, P.15
Schellenberg, G.16
Tanzi, R.17
Wasco, W.18
Lannfelt, L.19
Selkoe, D.20
Younkin, S.21
more..
-
5
-
-
0026745610
-
Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production
-
M. Citron, T. Oltersdorf, C. Haass, L. McConlogue, A.Y. Hung, P. Seubert, C. Vigo-Pelfrey, I. Lieberburg and D.J. Selkoe, Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production, Nature 360 (1992), 672-674.
-
(1992)
Nature
, vol.360
, pp. 672-674
-
-
Citron, M.1
Oltersdorf, T.2
Haass, C.3
McConlogue, L.4
Hung, A.Y.5
Seubert, P.6
Vigo-Pelfrey, C.7
Lieberburg, I.8
Selkoe, D.J.9
-
6
-
-
0028246308
-
Mutations associated with a locus for familial Alzheimer's disease result in alternative processing of amyloid beta-protein precursor
-
C. Haass, A.Y. Hung, D.J. Selkoe and D.B. Teplow, Mutations associated with a locus for familial Alzheimer's disease result in alternative processing of amyloid beta-protein precursor, J. Biol. Chem, 269 (1994), 17741-17748.
-
(1994)
J. Biol. Chem
, vol.269
, pp. 17741-17748
-
-
Haass, C.1
Hung, A.Y.2
Selkoe, D.J.3
Teplow, D.B.4
-
7
-
-
1342344129
-
Clinical, pathological, and biochemical spectrum of Alzheimer disease associated with PS-1 mutations
-
A. Lleo, O. Berezovska, J.H. Growdon and B.T. Hyman, Clinical, pathological, and biochemical spectrum of Alzheimer disease associated with PS-1 mutations, Am. J. Geriatr. Psychiatry 12 (2004), 146-156.
-
(2004)
Am. J. Geriatr. Psychiatry
, vol.12
, pp. 146-156
-
-
Lleo, A.1
Berezovska, O.2
Growdon, J.H.3
Hyman, B.T.4
-
9
-
-
0035808361
-
Tau filament formation in transgenic mice expressing P301L tau
-
J. Gotz, F. Chen, R. Barmettler and R.M. Nitsch, Tau filament formation in transgenic mice expressing P301L tau, J. Biol. Chem. 276 (2001), 529-534.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 529-534
-
-
Gotz, J.1
Chen, F.2
Barmettler, R.3
Nitsch, R.M.4
-
10
-
-
0027477946
-
Do defects in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases?
-
M.F. Beal, B.T. Hyman and W. Koroshetz, Do defects in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases?, Trends Neurosci. 16 (1993), 125-131.
-
(1993)
Trends Neurosci.
, vol.16
, pp. 125-131
-
-
Beal, M.F.1
Hyman, B.T.2
Koroshetz, W.3
-
11
-
-
0034237719
-
Energetics in the pathogenesis of neurodegenerative diseases
-
M.F. Beal, Energetics in the pathogenesis of neurodegenerative diseases, Trends Neurosci. 23 (2000), 298-304.
-
(2000)
Trends Neurosci.
, vol.23
, pp. 298-304
-
-
Beal, M.F.1
-
12
-
-
0033653771
-
Brain glucose and energy metabolism abnormalities in sporadic Alzheimer disease. Causes and consequences: An update
-
S. Hoyer, Brain glucose and energy metabolism abnormalities in sporadic Alzheimer disease. Causes and consequences: an update, Exp. Gerontol. 35 (2000), 1363-1372.
-
(2000)
Exp. Gerontol.
, vol.35
, pp. 1363-1372
-
-
Hoyer, S.1
-
13
-
-
0036592758
-
The role of the metabolic lesion in Alzheimer's disease
-
J.P. Blass, G.E. Gibson and S. Hoyer, The role of the metabolic lesion in Alzheimer's disease, J. Alzheimers. Dis. 4 (2002), 225-232.
-
(2002)
J. Alzheimers. Dis.
, vol.4
, pp. 225-232
-
-
Blass, J.P.1
Gibson, G.E.2
Hoyer, S.3
-
14
-
-
0028948660
-
Distribution of brain cytochrome oxidase activity in various neurodegenerative diseases
-
P. Chagnon, C. Betard, Y. Robitaille, A. Cholette and D. Gauvreau, Distribution of brain cytochrome oxidase activity in various neurodegenerative diseases, Neuroreport 6 (1995), 711-715.
-
(1995)
Neuroreport
, vol.6
, pp. 711-715
-
-
Chagnon, P.1
Betard, C.2
Robitaille, Y.3
Cholette, A.4
Gauvreau, D.5
-
15
-
-
0028236018
-
Electron transport chain defects in Alzheimer's disease brain
-
W.D. Parker, Jr., J. Parks, C.M. Filley and B.K. Kleinschmidt-DeMasters, Electron transport chain defects in Alzheimer's disease brain, Neurology 44 (1994), 1090-1096.
-
(1994)
Neurology
, vol.44
, pp. 1090-1096
-
-
Parker Jr., W.D.1
Parks, J.2
Filley, C.M.3
Kleinschmidt-DeMasters, B.K.4
-
16
-
-
0026408619
-
Cytochrome oxidase deficiency in Alzheimer's disease
-
W.D. Parker, Jr., Cytochrome oxidase deficiency in Alzheimer's disease, Ann. N. Y. Acad. Sci. 640 (1991), 59-64.
-
(1991)
Ann. N. Y. Acad. Sci.
, vol.640
, pp. 59-64
-
-
Parker Jr., W.D.1
-
17
-
-
0034612075
-
A selective defect of cytochrome c oxidase is present in brain of Alzheimer disease patients
-
I. Maurer, S. Zierz and H.J. Moller, A selective defect of cytochrome c oxidase is present in brain of Alzheimer disease patients, Neurobiol. Aging 21 (2000), 455-462.
-
(2000)
Neurobiol. Aging
, vol.21
, pp. 455-462
-
-
Maurer, I.1
Zierz, S.2
Moller, H.J.3
-
18
-
-
0036408915
-
The role of cytochrome c oxidase deficient hippocampal neurones in Alzheimer's disease
-
D.A. Cottrell, G.M. Borthwick, M.A. Johnson, P.G. Ince and D.M. Turnbull, The role of cytochrome c oxidase deficient hippocampal neurones in Alzheimer's disease, Neuropathol. Appl. Neurobiol. 28 (2002), 390-396.
-
(2002)
Neuropathol. Appl. Neurobiol.
, vol.28
, pp. 390-396
-
-
Cottrell, D.A.1
Borthwick, G.M.2
Johnson, M.A.3
Ince, P.G.4
Turnbull, D.M.5
-
19
-
-
18244390483
-
Mitochondrial abnormalities in Alzheimer brain: Mechanistic implications
-
P. Bubber, V. Haroutunian, G. Fisch, J.P. Blass and G.E. Gibson, Mitochondrial abnormalities in Alzheimer brain: mechanistic implications, Ann. Neurol. 57 (2005), 695-703.
-
(2005)
Ann. Neurol.
, vol.57
, pp. 695-703
-
-
Bubber, P.1
Haroutunian, V.2
Fisch, G.3
Blass, J.P.4
Gibson, G.E.5
-
20
-
-
0035341254
-
Mitochondrial abnormalities in Alzheimer's disease
-
K. Hirai, G. Aliev, A. Nunomura, H. Fujioka, R.L. Russell, C.S. Atwood, A.B. Johnson, Y. Kress, H.V. Vinters, M. Tabaton, S. Shimohama, A.D. Cash, S.L. Siedlak, P.L. Harris, P.K. Jones, R.B. Petersen, G. Perry and M.A. Smith, Mitochondrial abnormalities in Alzheimer's disease, J. Neurosci. 21 (2001), 3017-3023.
-
(2001)
J. Neurosci.
, vol.21
, pp. 3017-3023
-
-
Hirai, K.1
Aliev, G.2
Nunomura, A.3
Fujioka, H.4
Russell, R.L.5
Atwood, C.S.6
Johnson, A.B.7
Kress, Y.8
Vinters, H.V.9
Tabaton, M.10
Shimohama, S.11
Cash, A.D.12
Siedlak, S.L.13
Harris, P.L.14
Jones, P.K.15
Petersen, R.B.16
Perry, G.17
Smith, M.A.18
-
21
-
-
11144353586
-
ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease
-
J.W. Lustbader, M. Cirilli, C. Lin, H.W. Xu, K. Takuma, N. Wang, C. Caspersen, X. Chen, S. Pollak, M. Chaney, F. Trinchese, S. Liu, F. Gunn-Moore, L.F. Lue, D.G. Walker, P. Kuppusamy, Z.L. Zewier, O. Arancio, D. Stern, S.S. Yan and H. Wu, ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease, Science 304 (2004), 448-452.
-
(2004)
Science
, vol.304
, pp. 448-452
-
-
Lustbader, J.W.1
Cirilli, M.2
Lin, C.3
Xu, H.W.4
Takuma, K.5
Wang, N.6
Caspersen, C.7
Chen, X.8
Pollak, S.9
Chaney, M.10
Trinchese, F.11
Liu, S.12
Gunn-Moore, F.13
Lue, L.F.14
Walker, D.G.15
Kuppusamy, P.16
Zewier, Z.L.17
Arancio, O.18
Stern, D.19
Yan, S.S.20
Wu, H.21
more..
-
22
-
-
1542284022
-
Intra- and extracellular Abeta and PHF in clinically evaluated cases of Alzheimer's disease
-
P. Fernandez-Vizarra, A.P. Fernandez, S. Castro-Blanco, J. Serrano, M.L. Bentura, R. Martinez-Murillo, A. Martinez and J. Rodrigo, Intra- and extracellular Abeta and PHF in clinically evaluated cases of Alzheimer's disease, Histol. Histopathol. 19 (2004), 823-844.
-
(2004)
Histol. Histopathol.
, vol.19
, pp. 823-844
-
-
Fernandez-Vizarra, P.1
Fernandez, A.P.2
Castro-Blanco, S.3
Serrano, J.4
Bentura, M.L.5
Martinez-Murillo, R.6
Martinez, A.7
Rodrigo, J.8
-
23
-
-
0348111546
-
Cytochrome c oxidase is decreased in Alzheimer's disease platelets
-
S.M. Cardoso, M.T. Proenca, S. Santos, I. Santana and C.R. Oliveira, Cytochrome c oxidase is decreased in Alzheimer's disease platelets, Neurobiol. Aging 25 (2004), 105-110.
-
(2004)
Neurobiol. Aging
, vol.25
, pp. 105-110
-
-
Cardoso, S.M.1
Proenca, M.T.2
Santos, S.3
Santana, I.4
Oliveira, C.R.5
-
24
-
-
0036231792
-
Cytochrome c oxidase and mitochondrial F(1)F(0)-ATPase (ATP synthase) activities in platelets and brain from patients with Alzheimer's disease
-
F. Bosetti, F. Brizzi, S. Barogi, M. Mancuso, G. Siciliano, E.A. Tendi, L. Murri, S.I. Rapoport and G. Solaini, Cytochrome c oxidase and mitochondrial F(1)F(0)-ATPase (ATP synthase) activities in platelets and brain from patients with Alzheimer's disease, Neurobiol. Aging 23 (2002), 371-376.
-
(2002)
Neurobiol. Aging
, vol.23
, pp. 371-376
-
-
Bosetti, F.1
Brizzi, F.2
Barogi, S.3
Mancuso, M.4
Siciliano, G.5
Tendi, E.A.6
Murri, L.7
Rapoport, S.I.8
Solaini, G.9
-
25
-
-
0043166643
-
Decreased platelet cytochrome c oxidase activity is accompanied by increased blood lactate concentration during exercise in patients with Alzheimer disease
-
M. Mancuso, M. Filosto, F. Bosetti, R. Ceravolo, A. Rocchi, G. Tognoni, M.L. Manca, G. Solaini, G. Siciliano and L. Murri, Decreased platelet cytochrome c oxidase activity is accompanied by increased blood lactate concentration during exercise in patients with Alzheimer disease, Exp. Neurol. 182 (2003), 421-426.
-
(2003)
Exp. Neurol.
, vol.182
, pp. 421-426
-
-
Mancuso, M.1
Filosto, M.2
Bosetti, F.3
Ceravolo, R.4
Rocchi, A.5
Tognoni, G.6
Manca, M.L.7
Solaini, G.8
Siciliano, G.9
Murri, L.10
-
26
-
-
0033866833
-
Alzheimer's disease cybrids replicate beta-amyloid abnormalities through cell death pathways
-
S.M. Khan, D.S. Cassarino, N.N. Abramova, P.M. Keeney, M.K. Borland, P.A. Trimmer, C.T. Krebs, J.C. Bennett, J.K. Parks, R.H. Swerdlow, W.D. Parker, Jr. and J.P. Bennett, Jr., Alzheimer's disease cybrids replicate beta-amyloid abnormalities through cell death pathways, Ann. Neurol. 48 (2000), 148-155.
-
(2000)
Ann. Neurol.
, vol.48
, pp. 148-155
-
-
Khan, S.M.1
Cassarino, D.S.2
Abramova, N.N.3
Keeney, P.M.4
Borland, M.K.5
Trimmer, P.A.6
Krebs, C.T.7
Bennett, J.C.8
Parks, J.K.9
Swerdlow, R.H.10
Parker Jr., W.D.11
Bennett Jr., J.P.12
-
27
-
-
1642578313
-
Mitochondrial abnormalities in cybrid cell models of sporadic Alzheimer's disease worsen with passage in culture
-
P.A. Trimmer, P.M. Keeney, M.K. Borland, F.A. Simon, J. Almeida, R.H. Swerdlow, J.P. Parks, W.D. Parker, Jr. and J.P. Bennett, Jr., Mitochondrial abnormalities in cybrid cell models of sporadic Alzheimer's disease worsen with passage in culture, Neurobiol. Dis. 15 (2004), 29-39.
-
(2004)
Neurobiol. Dis.
, vol.15
, pp. 29-39
-
-
Trimmer, P.A.1
Keeney, P.M.2
Borland, M.K.3
Simon, F.A.4
Almeida, J.5
Swerdlow, R.H.6
Parks, J.P.7
Parker Jr., W.D.8
Bennett Jr., J.P.9
-
28
-
-
3042513691
-
Mitochondria dysfunction of Alzheimer's disease cybrids enhances Abeta toxicity
-
S.M. Cardoso, I. Santana, R.H. Swerdlow and C.R. Oliveira, Mitochondria dysfunction of Alzheimer's disease cybrids enhances Abeta toxicity, J. Neurochem. 89 (2004), 1417-1426.
-
(2004)
J. Neurochem.
, vol.89
, pp. 1417-1426
-
-
Cardoso, S.M.1
Santana, I.2
Swerdlow, R.H.3
Oliveira, C.R.4
-
29
-
-
0032810909
-
Beta-Amyloid fragment 25-35 selectively decreases complex IV activity in isolated mitochondria
-
L. Canevari, J.B. Clark and T.E. Bates, beta-Amyloid fragment 25-35 selectively decreases complex IV activity in isolated mitochondria, FEBS Lett. 457 (1999), 131-134.
-
(1999)
FEBS Lett.
, vol.457
, pp. 131-134
-
-
Canevari, L.1
Clark, J.B.2
Bates, T.E.3
-
30
-
-
0036272650
-
Beta-amyloid inhibits integrated mitochondrial respiration and key enzyme activities
-
C.S. Casley, L. Canevari, J.M. Land, J.B. Clark and M.A. Sharpe, Beta-amyloid inhibits integrated mitochondrial respiration and key enzyme activities, J. Neurochem. 80 (2002), 91-100.
-
(2002)
J. Neurochem.
, vol.80
, pp. 91-100
-
-
Casley, C.S.1
Canevari, L.2
Land, J.M.3
Clark, J.B.4
Sharpe, M.A.5
-
31
-
-
19944433571
-
Copper-dependent inhibition of human cytochrome c oxidase by a dimeric conformer of amyloid-beta1-42
-
P.J. Crouch, R. Blake, J.A. Duce, G.D. Ciccotosto, Q.X. Li, K.J. Barnham, C.C. Curtain, R.A. Cherny, R. Cappai, T. Dyrks, C.L. Masters and I.A. Trounce, Copper-dependent inhibition of human cytochrome c oxidase by a dimeric conformer of amyloid-beta1-42, J. Neurosci. 25 (2005), 672-679.
-
(2005)
J. Neurosci.
, vol.25
, pp. 672-679
-
-
Crouch, P.J.1
Blake, R.2
Duce, J.A.3
Ciccotosto, G.D.4
Li, Q.X.5
Barnham, K.J.6
Curtain, C.C.7
Cherny, R.A.8
Cappai, R.9
Dyrks, T.10
Masters, C.L.11
Trounce, I.A.12
-
32
-
-
0037191378
-
Amyloid beta peptide induces cytochrome C release from isolated mitochondria
-
H.S. Kim, J.H. Lee, J.P. Lee, E.M. Kim, K.A. Chang, C.H. Park, S.J. Jeong, M.C. Wittendorp, J.H. Seo, S.H. Choi and Y.H. Suh, Amyloid beta peptide induces cytochrome C release from isolated mitochondria, Neuroreport 13 (2002), 1989-1993.
-
(2002)
Neuroreport
, vol.13
, pp. 1989-1993
-
-
Kim, H.S.1
Lee, J.H.2
Lee, J.P.3
Kim, E.M.4
Chang, K.A.5
Park, C.H.6
Jeong, S.J.7
Wittendorp, M.C.8
Seo, J.H.9
Choi, S.H.10
Suh, Y.H.11
-
33
-
-
26444588771
-
Gradual Alteration of Mitochondrial Structure and Function by beta-Amyloids: Importance of Membrane Viscosity Changes, Energy Deprivation, Reactive Oxygen Species Production, and Cytochrome c Release
-
A.M. Aleardi, G. Benard, O. Augereau, M. Malgat, J.C. Talbot, J.P. Mazat, T. Letellier, J. Dachary-Prigent, G.C. Solaini and R. Rossignol, Gradual Alteration of Mitochondrial Structure and Function by beta-Amyloids: Importance of Membrane Viscosity Changes, Energy Deprivation, Reactive Oxygen Species Production, and Cytochrome c Release, J. Bioenerg. Biomembr. 37 (2005), 207-225.
-
(2005)
J. Bioenerg. Biomembr.
, vol.37
, pp. 207-225
-
-
Aleardi, A.M.1
Benard, G.2
Augereau, O.3
Malgat, M.4
Talbot, J.C.5
Mazat, J.P.6
Letellier, T.7
Dachary-Prigent, J.8
Solaini, G.C.9
Rossignol, R.10
-
34
-
-
0037100213
-
Effect of amyloid beta-peptide on permeability transition pore: A comparative study
-
P.I. Moreira, M.S. Santos, A. Moreno, A.C. Rego and C. Oliveira, Effect of amyloid beta-peptide on permeability transition pore: a comparative study, J. Neurosci. Res. 69 (2002), 257-267.
-
(2002)
J. Neurosci. Res.
, vol.69
, pp. 257-267
-
-
Moreira, P.I.1
Santos, M.S.2
Moreno, A.3
Rego, A.C.4
Oliveira, C.5
-
35
-
-
0035780141
-
Amyloid beta-peptide promotes permeability transition pore in brain mitochondria
-
P.I. Moreira, M.S. Santos, A. Moreno and C. Oliveira, Amyloid beta-peptide promotes permeability transition pore in brain mitochondria, Biosci. Rep. 21 (2001), 789-800.
-
(2001)
Biosci. Rep.
, vol.21
, pp. 789-800
-
-
Moreira, P.I.1
Santos, M.S.2
Moreno, A.3
Oliveira, C.4
-
36
-
-
0036258363
-
Effect of beta-amyloid peptide fragment 25-35 on nonselective permeability of mitochondria
-
E.F. Shevtzova, E.G. Kireeva and S.O. Bachurin, Effect of beta-amyloid peptide fragment 25-35 on nonselective permeability of mitochondria, Bull. Exp. Biol. Med. 132 (2001), 1173-1176.
-
(2001)
Bull. Exp. Biol. Med.
, vol.132
, pp. 1173-1176
-
-
Shevtzova, E.F.1
Kireeva, E.G.2
Bachurin, S.O.3
-
37
-
-
0036403832
-
Beta-amyloid fragment 25-35 causes mitochondrial dysfunction in primary cortical neurons
-
C.S. Casley, J.M. Land, M.A. Sharpe, J.B. Clark, M.R. Duchen and L. Canevari, Beta-amyloid fragment 25-35 causes mitochondrial dysfunction in primary cortical neurons, Neurobiol. Dis. 10 (2002), 258-267.
-
(2002)
Neurobiol. Dis.
, vol.10
, pp. 258-267
-
-
Casley, C.S.1
Land, J.M.2
Sharpe, M.A.3
Clark, J.B.4
Duchen, M.R.5
Canevari, L.6
-
38
-
-
0036982389
-
Mitochondria in Alzheimer's disease
-
R.H. Swerdlow and S.J. Kish, Mitochondria in Alzheimer's disease, Int. Rev. Neurobiol. 53 (2002), 341-385.
-
(2002)
Int. Rev. Neurobiol.
, vol.53
, pp. 341-385
-
-
Swerdlow, R.H.1
Kish, S.J.2
-
39
-
-
0032904412
-
An evaluation of the role of mitochondria in neurodegenerative diseases: Mitochondrial mutations and oxidative pathology, protective nuclear responses, and cell death in neurodegeneration
-
D.S. Cassarino and J.P. Bennett, Jr., An evaluation of the role of mitochondria in neurodegenerative diseases: mitochondrial mutations and oxidative pathology, protective nuclear responses, and cell death in neurodegeneration, Brain Res. Brain Res. Rev. 29 (1999), 1-25.
-
(1999)
Brain Res. Brain Res. Rev.
, vol.29
, pp. 1-25
-
-
Cassarino, D.S.1
Bennett Jr., J.P.2
-
40
-
-
0032104130
-
Mitochondrial function impairment induced by amyloid beta-peptide on PC12 cells
-
C. Pereira, M.S. Santos and C. Oliveira, Mitochondrial function impairment induced by amyloid beta-peptide on PC12 cells, Neuroreport 9 (1998), 1749-1755.
-
(1998)
Neuroreport
, vol.9
, pp. 1749-1755
-
-
Pereira, C.1
Santos, M.S.2
Oliveira, C.3
-
41
-
-
0033022771
-
Involvement of oxidative stress on the impairment of energy metabolism induced by A beta peptides on PC12 cells: Protection by antioxidants
-
C. Pereira, M.S. Santos and C. Oliveira, Involvement of oxidative stress on the impairment of energy metabolism induced by A beta peptides on PC12 cells: protection by antioxidants, Neurobiol. Dis. 6 (1999), 209-219.
-
(1999)
Neurobiol. Dis.
, vol.6
, pp. 209-219
-
-
Pereira, C.1
Santos, M.S.2
Oliveira, C.3
-
42
-
-
1642499152
-
Beta-amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase
-
A.Y. Abramov, L. Canevari and M.R. Duchen, Beta-amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase, J. Neurosci. 24 (2004), 565-575.
-
(2004)
J. Neurosci.
, vol.24
, pp. 565-575
-
-
Abramov, A.Y.1
Canevari, L.2
Duchen, M.R.3
-
43
-
-
0042847291
-
Neurotoxic mechanisms caused by the Alzheimer's disease-linked Swedish amyloid precursor protein mutation: Oxidative stress, caspases, and the JNK pathway
-
C.A. Marques, U. Keil, A. Bonert, B. Steiner, C. Haass, W.E. Muller and A. Eckert, Neurotoxic mechanisms caused by the Alzheimer's disease-linked Swedish amyloid precursor protein mutation: oxidative stress, caspases, and the JNK pathway, J. Biol. Chem. 278 (2003), 28294-28302.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 28294-28302
-
-
Marques, C.A.1
Keil, U.2
Bonert, A.3
Steiner, B.4
Haass, C.5
Muller, W.E.6
Eckert, A.7
-
44
-
-
9644272489
-
Amyloid beta-induced changes in nitric oxide production and mitochondrial activity lead to apoptosis
-
U. Keil, A. Bonert, C.A. Marques, I. Scherping, J. Weyermann, J.B. Strosznajder, F. Muller-Spahn, C. Haass, C. Czech, L. Pradier, W.E. Muller and A. Eckert, Amyloid beta-induced changes in nitric oxide production and mitochondrial activity lead to apoptosis, J. Biol. Chem. 279 (2004), 50310-50320.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 50310-50320
-
-
Keil, U.1
Bonert, A.2
Marques, C.A.3
Scherping, I.4
Weyermann, J.5
Strosznajder, J.B.6
Muller-Spahn, F.7
Haass, C.8
Czech, C.9
Pradier, L.10
Muller, W.E.11
Eckert, A.12
-
45
-
-
0033580077
-
Mitochondrial abnormalities in neuroectodermal cells stably expressing human amyloid precursor protein (hAβPP751)
-
S.M. Grant, S.L. Shankar, R.M. Chalmers-Redman, W.G. Tatton, M. Szyf and A.C. Cuello, Mitochondrial abnormalities in neuroectodermal cells stably expressing human amyloid precursor protein (hAβPP751), Neuroreport 10 (1999), 41-46.
-
(1999)
Neuroreport
, vol.10
, pp. 41-46
-
-
Grant, S.M.1
Shankar, S.L.2
Chalmers-Redman, R.M.3
Tatton, W.G.4
Szyf, M.5
Cuello, A.C.6
-
46
-
-
0037437192
-
Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells
-
H.K. Anandatheerthavarada, G. Biswas, M.A. Robin and N.G. Avadhani, Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells, J. Cell Biol. 161 (2003), 41-54.
-
(2003)
J. Cell Biol.
, vol.161
, pp. 41-54
-
-
Anandatheerthavarada, H.K.1
Biswas, G.2
Robin, M.A.3
Avadhani, N.G.4
-
47
-
-
0031587787
-
Elevated amyloid beta protein(1-40) level induces CREB phosphorylation at serine-133 via p44/42 MAP kinase (Erk1/2)-dependent pathway in rat pheochromocytoma PC12 cells
-
N. Sato, K. Kamino, K. Tateishi, T. Satoh, Y. Nishiwaki, A. Yoshiiwa, T. Miki and T. Ogihara, Elevated amyloid beta protein(1-40) level induces CREB phosphorylation at serine-133 via p44/42 MAP kinase (Erk1/2)-dependent pathway in rat pheochromocytoma PC12 cells, Biochem. Biophys. Res. Commun. 232 (1997), 637-642.
-
(1997)
Biochem. Biophys. Res. Commun.
, vol.232
, pp. 637-642
-
-
Sato, N.1
Kamino, K.2
Tateishi, K.3
Satoh, T.4
Nishiwaki, Y.5
Yoshiiwa, A.6
Miki, T.7
Ogihara, T.8
-
48
-
-
0033916814
-
Inducible nitric oxide synthase (iNOS) expression upregulates p21 and inhibits vascular smooth muscle cell proliferation through p42/44 mitogen-activated protein kinase activation and independent of p53 and cyclic guanosine monophosphate
-
M.R. Kibbe, J. Li, S. Nie, S.C. Watkins, A. Lizonova, I. Kovesdi, R.L. Simmons, T.R. Billiar and E. Tzeng, Inducible nitric oxide synthase (iNOS) expression upregulates p21 and inhibits vascular smooth muscle cell proliferation through p42/44 mitogen-activated protein kinase activation and independent of p53 and cyclic guanosine monophosphate, J. Vasc. Surg. 31 (2000), 1214-1228.
-
(2000)
J. Vasc. Surg.
, vol.31
, pp. 1214-1228
-
-
Kibbe, M.R.1
Li, J.2
Nie, S.3
Watkins, S.C.4
Lizonova, A.5
Kovesdi, I.6
Simmons, R.L.7
Billiar, T.R.8
Tzeng, E.9
-
49
-
-
3342880690
-
A role for heme in Alzheimer's disease: Heme binds amyloid beta and has altered metabolism
-
H. Atamna and W.H. Frey, A role for heme in Alzheimer's disease: heme binds amyloid beta and has altered metabolism, Proc. Natl. Acad. Sci. USA 101 (2004), 11153-11158.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 11153-11158
-
-
Atamna, H.1
Frey, W.H.2
-
50
-
-
0037069320
-
Heme deficiency may be a factor in the mitochondrial and neuronal decay of aging
-
H. Atamna, D.W. Killilea, A.N. Killilea and B.N. Ames, Heme deficiency may be a factor in the mitochondrial and neuronal decay of aging, Proc. Natl. Acad. Sci. USA 99 (2002), 14807-14812.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 14807-14812
-
-
Atamna, H.1
Killilea, D.W.2
Killilea, A.N.3
Ames, B.N.4
-
51
-
-
0035930604
-
Heme deficiency selectively interrupts assembly of mitochondrial complex IV in human fibroblasts: Revelance to aging
-
H. Atamna, J. Liu and B.N. Ames, Heme deficiency selectively interrupts assembly of mitochondrial complex IV in human fibroblasts: revelance to aging, J. Biol. Chem. 276 (2001), 48410-48416.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 48410-48416
-
-
Atamna, H.1
Liu, J.2
Ames, B.N.3
-
52
-
-
0037013327
-
Intracellular amyloid-beta 1-42, but not extracellular soluble amyloid- beta peptides, induces neuronal apoptosis
-
P. Kienlen-Campard, S. Miolet, B. Tasiaux and J.N. Octave, Intracellular amyloid-beta 1-42, but not extracellular soluble amyloid- beta peptides, induces neuronal apoptosis, J. Biol. Chem. 277 (2002), 15666-15670.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 15666-15670
-
-
Kienlen-Campard, P.1
Miolet, S.2
Tasiaux, B.3
Octave, J.N.4
-
53
-
-
14644442872
-
Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice
-
L.M. Billings, S. Oddo, K.N. Green, J.L. McGaugh and F.M. LaFerla, Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice, Neuron 45 (2005), 675-688.
-
(2005)
Neuron
, vol.45
, pp. 675-688
-
-
Billings, L.M.1
Oddo, S.2
Green, K.N.3
McGaugh, J.L.4
LaFerla, F.M.5
-
54
-
-
16644379264
-
Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function
-
J.P. Cleary, D.M. Walsh, J.J. Hofmeister, G.M. Shankar, M.A. Kuskowski, D.J. Selkoe and K.H. Ashe, Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function, Nat. Neurosci. 8 (2005), 79-84.
-
(2005)
Nat. Neurosci.
, vol.8
, pp. 79-84
-
-
Cleary, J.P.1
Walsh, D.M.2
Hofmeister, J.J.3
Shankar, G.M.4
Kuskowski, M.A.5
Selkoe, D.J.6
Ashe, K.H.7
-
55
-
-
0034718232
-
Oxidative stress in Alzheimer's disease
-
M.A. Smith, C.A. Rottkamp, A. Nunomura, A.K. Raina and G. Perry, Oxidative stress in Alzheimer's disease, Biochim. Biophys. Acta 1502 (2000), 139-144.
-
(2000)
Biochim. Biophys. Acta
, vol.1502
, pp. 139-144
-
-
Smith, M.A.1
Rottkamp, C.A.2
Nunomura, A.3
Raina, A.K.4
Perry, G.5
-
56
-
-
0034923434
-
Oxidative damage is the earliest event in Alzheimer disease
-
A. Nunomura, G. Perry, G. Aliev, K. Hirai, A. Takeda, E.K. Balraj, P.K. Jones, H. Ghanbari, T. Wataya, S. Shimohama, S. Chiba, C.S. Atwood, R.B. Petersen and M.A. Smith, Oxidative damage is the earliest event in Alzheimer disease, J. Neuropathol. Exp. Neurol. 60 (2001), 759-767.
-
(2001)
J. Neuropathol. Exp. Neurol.
, vol.60
, pp. 759-767
-
-
Nunomura, A.1
Perry, G.2
Aliev, G.3
Hirai, K.4
Takeda, A.5
Balraj, E.K.6
Jones, P.K.7
Ghanbari, H.8
Wataya, T.9
Shimohama, S.10
Chiba, S.11
Atwood, C.S.12
Petersen, R.B.13
Smith, M.A.14
-
57
-
-
0030915855
-
Oxidative stress hypothesis in Alzheimer's disease
-
W.R. Markesbery, Oxidative stress hypothesis in Alzheimer's disease, Free Radic. Biol. Med. 23 (1997), 134-147.
-
(1997)
Free Radic. Biol. Med.
, vol.23
, pp. 134-147
-
-
Markesbery, W.R.1
-
58
-
-
0035871971
-
Elevated vulnerability to oxidative stress-induced cell death and activation of caspase-3 by the Swedish amyloid precursor protein mutation
-
A. Eckert, B. Steiner, C. Marques, S. Leutz, H. Romig, C. Haass and W.E. Muller, Elevated vulnerability to oxidative stress-induced cell death and activation of caspase-3 by the Swedish amyloid precursor protein mutation, J. Neurosci. Res. 64 (2001), 183-192.
-
(2001)
J. Neurosci. Res.
, vol.64
, pp. 183-192
-
-
Eckert, A.1
Steiner, B.2
Marques, C.3
Leutz, S.4
Romig, H.5
Haass, C.6
Muller, W.E.7
-
59
-
-
0036014113
-
Reduction of trophic support enhances apoptosis in PC12 cells expressing Alzheimer's AβPP mutation and sensitizes cells to staurosporine-induced cell death
-
S. Leutz, B. Steiner, C.A. Marques, C. Haass, W.E. Muller and A. Eckert, Reduction of trophic support enhances apoptosis in PC12 cells expressing Alzheimer's AβPP mutation and sensitizes cells to staurosporine-induced cell death, J. Mol. Neurosci. 18 (2002), 189-201.
-
(2002)
J. Mol. Neurosci.
, vol.18
, pp. 189-201
-
-
Leutz, S.1
Steiner, B.2
Marques, C.A.3
Haass, C.4
Muller, W.E.5
Eckert, A.6
-
60
-
-
0344826476
-
Time sequence of maturation of dystrophic neurites associated with Abeta deposits in AβPP/PS1 transgenic mice
-
V. Blanchard, S. Moussaoui, C. Czech, N. Touchet, B. Bonici, M. Planche, T. Canton, I. Jedidi, M. Gohin, O. Wirths, T.A. Bayer, D. Langui, C. Duyckaerts, G. Tremp and L. Pradier, Time sequence of maturation of dystrophic neurites associated with Abeta deposits in AβPP/PS1 transgenic mice, Exp. Neurol. 184 (2003), 247-263.
-
(2003)
Exp. Neurol.
, vol.184
, pp. 247-263
-
-
Blanchard, V.1
Moussaoui, S.2
Czech, C.3
Touchet, N.4
Bonici, B.5
Planche, M.6
Canton, T.7
Jedidi, I.8
Gohin, M.9
Wirths, O.10
Bayer, T.A.11
Langui, D.12
Duyckaerts, C.13
Tremp, G.14
Pradier, L.15
-
61
-
-
19944373389
-
Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria
-
C.A. Hansson, S. Frykman, M.R. Farmery, L.O. Tjernberg, C. Nilsberth, S.E. Pursglove, A. Ito, B. Winblad, R.F. Cowburn, J. Thyberg and M. Ankarcrona, Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria, J. Biol. Chem. 279 (2004), 51654-51660.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 51654-51660
-
-
Hansson, C.A.1
Frykman, S.2
Farmery, M.R.3
Tjernberg, L.O.4
Nilsberth, C.5
Pursglove, S.E.6
Ito, A.7
Winblad, B.8
Cowburn, R.F.9
Thyberg, J.10
Ankarcrona, M.11
-
62
-
-
11844272073
-
Impaired Cu/Zn-SOD activity contributes to increased oxidative damage in AβPP transgenic mice
-
K. Schuessel, S. Schafer, T.A. Bayer, C. Czech, L. Pradier, F. Muller-Spahn, W.E. Muller and A. Eckert, Impaired Cu/Zn-SOD activity contributes to increased oxidative damage in AβPP transgenic mice, Neurobioi. Dis. 18 (2005), 89-99.
-
(2005)
Neurobioi. Dis.
, vol.18
, pp. 89-99
-
-
Schuessel, K.1
Schafer, S.2
Bayer, T.A.3
Czech, C.4
Pradier, L.5
Muller-Spahn, F.6
Muller, W.E.7
Eckert, A.8
-
63
-
-
0142219833
-
A role of P301L tau mutant in anti-apoptotic gene expression, cell cycle and apoptosis
-
Z. Zhao, L. Ho, J. Suh, W. Qin, H. Pyo, P. Pompl, H. Ksiezak-Reding and G.M. Pasinetti, A role of P301L tau mutant in anti-apoptotic gene expression, cell cycle and apoptosis, Mol. Cell Neurosci. 24 (2003), 367-379.
-
(2003)
Mol. Cell Neurosci.
, vol.24
, pp. 367-379
-
-
Zhao, Z.1
Ho, L.2
Suh, J.3
Qin, W.4
Pyo, H.5
Pompl, P.6
Ksiezak-Reding, H.7
Pasinetti, G.M.8
-
64
-
-
33644851265
-
Inducible expression of tau repeat domain in cell models of tauopathy: Aggregation is toxic to cells but can be reversed by inhibitor drugs
-
I. Khlistunova, J. Biernat, Y. Wang, M. Pickhardt, M. von Bergen, Z. Gazova, E. Mandelkow and E.M. Mandelkow, Inducible expression of tau repeat domain in cell models of tauopathy: Aggregation is toxic to cells but can be reversed by inhibitor drugs, J. Biol. Chem. 281 (2006), 1205-1214.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 1205-1214
-
-
Khlistunova, I.1
Biernat, J.2
Wang, Y.3
Pickhardt, M.4
Von Bergen, M.5
Gazova, Z.6
Mandelkow, E.7
Mandelkow, E.M.8
-
65
-
-
21244486781
-
Proteomic and functional analyses reveal a mitochondrial dysfunction in P301L tau transgenic mice
-
D.C. David, S. Hauptmann, I. Scherping, K. Schuessel, U. Keil, P. Rizzu, R. Ravid, S. Drose, U. Brandt, W.E. Muller, A. Eckert and J. Gotz, Proteomic and functional analyses reveal a mitochondrial dysfunction in P301L tau transgenic mice, J. Biol. Chem. 280 (2005), 23802-23814.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 23802-23814
-
-
David, D.C.1
Hauptmann, S.2
Scherping, I.3
Schuessel, K.4
Keil, U.5
Rizzu, P.6
Ravid, R.7
Drose, S.8
Brandt, U.9
Muller, W.E.10
Eckert, A.11
Gotz, J.12
-
66
-
-
0035029341
-
Alzheimer's disease-like alterations in peripheral cells from presenilin-1 transgenic mice
-
A. Eckert, K. Schindowski, S. Leutner, C. Luckhaus, N. Touchet, C. Czech and W.E. Muller, Alzheimer's disease-like alterations in peripheral cells from presenilin-1 transgenic mice, Neurobiol. Dis. 8 (2001), 331-342.
-
(2001)
Neurobiol. Dis.
, vol.8
, pp. 331-342
-
-
Eckert, A.1
Schindowski, K.2
Leutner, S.3
Luckhaus, C.4
Touchet, N.5
Czech, C.6
Muller, W.E.7
-
67
-
-
33644653041
-
Aging sensitizes towards ROS formation and lipid peroxidation in PS1M146L transgenic mice
-
K. Schuessel, C. Frey, C. Jourdan, U. Keil, C. C. Weber, F. Müller-Spahn, W.E. Müller and A. Eckert, Aging sensitizes towards ROS formation and lipid peroxidation in PS1M146L transgenic mice, Free Radic. Biol. Med. 40 (2006), 850-862.
-
(2006)
Free Radic. Biol. Med.
, vol.40
, pp. 850-862
-
-
Schuessel, K.1
Frey, C.2
Jourdan, C.3
Keil, U.4
Weber, C.C.5
Müller-Spahn, F.6
Müller, W.E.7
Eckert, A.8
-
68
-
-
0141960033
-
Beta-Amyloid induces paired helical filament-like tau filaments in tissue culture
-
A. Ferrari, F. Hoerndli, T. Baechi, R.M. Nitsch and J. Gotz, beta-Amyloid induces paired helical filament-like tau filaments in tissue culture, J. Biol. Chem. 278 (2003), 40162-40168.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 40162-40168
-
-
Ferrari, A.1
Hoerndli, F.2
Baechi, T.3
Nitsch, R.M.4
Gotz, J.5
-
69
-
-
0035943436
-
Formation of neurofibrillary tangles in P3011 tau transgenic mice induced by Abeta 42 fibrils
-
J. Gotz, F. Chen, J. van Dorpe and R.M. Nitsch, Formation of neurofibrillary tangles in P3011 tau transgenic mice induced by Abeta 42 fibrils, Science 293 (2001), 1491-1495.
-
(2001)
Science
, vol.293
, pp. 1491-1495
-
-
Gotz, J.1
Chen, F.2
Van Dorpe, J.3
Nitsch, R.M.4
-
70
-
-
17944382037
-
Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and AβPP
-
J. Lewis, D.W. Dickson, W.L. Lin, L. Chisholm, A. Corral, G. Jones, S.H. Yen, N. Sahara, L. Skipper, D. Yager, C. Eckman, J. Hardy, M. Hutton and E. McGowan, Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and AβPP, Science 293 (2001), 1487-1491.
-
(2001)
Science
, vol.293
, pp. 1487-1491
-
-
Lewis, J.1
Dickson, D.W.2
Lin, W.L.3
Chisholm, L.4
Corral, A.5
Jones, G.6
Yen, S.H.7
Sahara, N.8
Skipper, L.9
Yager, D.10
Eckman, C.11
Hardy, J.12
Hutton, M.13
McGowan, E.14
-
71
-
-
0042697305
-
Triple-transgenic model of Alzheimer's disease with plaques and tangles: Intracellular Abeta and synaptic dysfunction
-
S. Oddo, A. Caccamo, J.D. Shepherd, M.P. Murphy, T.E. Golde, R. Kayed, R. Metherate, M.P. Mattson, Y. Akbari and F.M. LaFerla, Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction, Neuron 39 (2003), 409-421.
-
(2003)
Neuron
, vol.39
, pp. 409-421
-
-
Oddo, S.1
Caccamo, A.2
Shepherd, J.D.3
Murphy, M.P.4
Golde, T.E.5
Kayed, R.6
Metherate, R.7
Mattson, M.P.8
Akbari, Y.9
LaFerla, F.M.10
-
72
-
-
4043167747
-
Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome
-
S. Oddo, L. Billings, J.P. Kesslak, D.H. Cribbs and F.M. LaFerla, Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome, Neuron 43 (2004), 321-332.
-
(2004)
Neuron
, vol.43
, pp. 321-332
-
-
Oddo, S.1
Billings, L.2
Kesslak, J.P.3
Cribbs, D.H.4
LaFerla, F.M.5
-
73
-
-
33144487701
-
Temporal Profile of Amyloid-beta (Abeta) Oligomerization in an in Vivo Model of Alzheimer Disease: A link between Abeta and tau pathology
-
S. Oddo, A. Caccamo, L. Tran, M.P. Lambert, C.G. Glabe, W.L. Klein and F.M. LaFerla, Temporal Profile of Amyloid-beta (Abeta) Oligomerization in an in Vivo Model of Alzheimer Disease: A link between Abeta And tau pathology, J. Biol. Chem. 281 (2006), 1599-1604.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 1599-1604
-
-
Oddo, S.1
Caccamo, A.2
Tran, L.3
Lambert, M.P.4
Glabe, C.G.5
Klein, W.L.6
LaFerla, F.M.7
-
74
-
-
33744974998
-
Mitochondrial dysfunction in sporadic and genetic Alzheimer's disease
-
in press
-
S. Hauptmann, U. Keil, I. Scherping, A. Bonert, A. Eckert and W.E. Müller, Mitochondrial dysfunction in sporadic and genetic Alzheimer's disease, Exp. Gerontol (2006), in press.
-
(2006)
Exp. Gerontol
-
-
Hauptmann, S.1
Keil, U.2
Scherping, I.3
Bonert, A.4
Eckert, A.5
Müller, W.E.6
|