Conversion of scFv peptide-binding specificity for crystal chaperone development

Protein Engineering, Design and Selection

Volumn 24, Issue 5, 2011, Pages 419-428

  Pai, Jennifer C ^a   Culver, Jeffrey A ^b   Drury, Jason E ^b   Motani, Rakesh S ^c   Lieberman, Raquel L ^b   Maynard, Jennifer A ^a  

^a The University of Texas at Austin   (United States)

^b GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

Author keywords

antibody; binding affinity; co crystallization; protein complex; protein engineering

Indexed keywords

ANTIBODY FRAGMENT; ANTIBODY LIBRARY; BINDING AFFINITIES; BINDING SPECIFICITIES; BINDING SURFACE; BIOCHEMICAL CHARACTERISTICS; COCRYSTALLIZATION; CRYSTALLIZATION CONDITIONS; GEL FILTRATION; HIGH QUALITY; INTERNAL LOOPS; MEMBRANE PROTEINS; MODEL PROTEINS; NANOMOLAR AFFINITY; PEPTIDE-BINDING; PHAGE DISPLAY; PROTEIN COMPLEX; PROTEIN CRYSTAL; PROTEIN ENGINEERING; PROTEIN EXPRESSIONS; RANDOM MUTAGENESIS; RESOLUTION STRUCTURE; SEQUENCE IDENTITY; SINGLE-CHAIN ANTIBODIES; SPACE GROUPS; STRUCTURE DETERMINATION; SUB-MICROMOLAR AFFINITY;

AMINO ACIDS; ANTIBODIES; BINDING ENERGY; BIOCHEMICAL ENGINEERING; BIOLOGICAL MEMBRANES; CRYSTALLIZATION; GENETIC ENGINEERING; PEPTIDES; X RAY CRYSTALLOGRAPHY;

CRYSTAL STRUCTURE;

CHAPERONE; EPITOPE; HEXAHISTIDINE; HEXAPEPTIDE; MALTOSE BINDING PROTEIN; PEPTIDE LIBRARY; POLYHISTIDINE TAG; RECOMBINANT ANTIBODY; RECOMBINANT SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; SCAFFOLD PROTEIN; UNCLASSIFIED DRUG;

ANTIBODY COMBINING SITE; ANTIBODY ENGINEERING; ANTIBODY SPECIFICITY; ARTICLE; BACTERIAL GENOME; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; ENZYME LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI; GEL FILTRATION; IMMUNOPRECIPITATION; MUTAGENESIS; NONHUMAN; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN PURIFICATION;

AMINO ACID SEQUENCE; ANTIBODY SPECIFICITY; COMPLEMENTARITY DETERMINING REGIONS; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; EPITOPES; HISTIDINE; HUMANS; MODELS, MOLECULAR; MOLECULAR CHAPERONES; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES; PEPTIDE LIBRARY; PEPTIDES; PROTEIN CONFORMATION; PROTEIN ENGINEERING; SINGLE-CHAIN ANTIBODIES;

EID: 79955374721     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzq120     Document Type: Article

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