The hunchback and its neighbours: Proline as an environmental modulator

Trends in Biochemical Sciences

Volumn 26, Issue 11, 2001, Pages 679-684

  Reiersen, Herald ^a   Rees, Anthony R ^b  

^a Affitech AS   (Norway)

^b UNIVERSITY OF BATH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GLOBULAR PROTEIN; LIGAND; MUSCLE PROTEIN; PRION PROTEIN; PROLINE; PROTEIN;

GENETIC ENGINEERING; HUMAN; LIGAND BINDING; NONHUMAN; PH; PRION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN MODIFICATION; PROTEIN STABILITY; PROTEIN STRUCTURE; REVIEW; TEMPERATURE;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; ENVIRONMENT; GENETIC ENGINEERING; HUMANS; MODELS, MOLECULAR; PEPTIDES; PRIONS; PROTEIN CONFORMATION;

EID: 0035499604     PISSN: 09680004     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0004(01)01957-0     Document Type: Review

References (56)

1. 2 increases the internal proline level and improves NaCl tolerance when produced in Escherichia coli
2. Metabolic implications of stress-induced proline accumulation in plants
3. Proline inhibits aggregation during protein refolding
4. Low temperature cycled PCR protocol for Klenow fragment of DNA polymerase I in the presence of proline
5. Prolines and amyloidogenicity in fragments of the Alzheimer's peptide β/A4
6. Transproteomic evidence of a loop-deletion mechanism for enhancing protein thermostability
7. α-Helical, but not β-sheet, propensity of proline is determined by peptide environment
8. C-H-O hydrogen bond involving proline residues in α-helices
9. Hinges, swivels and switches: The role of proline in signalling via transmembrane α-helices
10. 2 adrenergic receptor
11. Conformational properties of polypeptide chains
12. An examination of the steric effects of 5-tert-butylproline on the conformation of polyproline and the cooperative nature of type II to type I helical interconversion
13. Left-handed polyproline II helices commonly occur in globular proteins
14. Molecular dynamics simulations of polypeptide conformations in water: A comparison of α, β, and poly(pro)II conformations
15. Converging on proline: The mechanism of WW domain peptide recognition
16. The importance of being proline: The interaction of proline-rich motifs in signaling proteins with their cognate domains
17. Exploiting the basis of proline recognition by SH3 and WW domains: Design of N-substituted inhibitors
18. The structure and function of proline-rich regions in proteins
19. Function of WW domains as phosphoserine- or phosphothreonine-binding modules
20. Functions of WW domains in the nucleus
21. Translating cell biology into therapeutic advances in Alzheimer's disease
22. Hyperphosphorylation induces structural modification of tau-protein
23. Hyperphosphorylation induces self-assembly of τ into tangles of paired helical filaments/straight filaments
24. The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein
25. Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filament
26. Phosphorylated tau can promote tubulin assembly
27. Pathologic conformations of prion proteins
28. Chicken prion tandem repeats form a stable, protease-resistant domain
29. Prion protein selectively binds copper(II) ions
30. Copper binding to the prion protein: Structural implications of four identical cooperative binding sites
31. Analysis of 27 mammalian and 9 avian PrPs reveals high conservation of flexible regions of the prion protein
32. Metal-dependent α-helix formation promoted by the glycine-rich octapeptide region of prion protein
33. Prion protein binds copper within the physiological concentration range
34. 2+ binding sites in the C-terminal domain of the murine prion protein: A pulse EPR and ENDOR study
35. Location and properties of metal-binding sites on the human prion protein
36. 2+ binding sites in the N-terminal domain of the prion protein by EPR and CD spectroscopy
37. Normal prion protein has an activity like that of superoxide dismutase
38. Copper binding to octarepeat peptides of the prion protein monitored by mass spectrometry
39. Post-translational hydroxylation at the N-terminus of the prion protein reveals presence of PPII structure in vivo
40. Is polyproline II helix the killer conformation? A Raman optical activity study of the amyloidogenic prefibrillar intermediate of human lysozyme
41. Mammalian prion proteins
42. Copper-catalyzed oxidation of the recombinant SHa(29-231) prion protein
43. Copper converts the cellular prion protein into a protease-resistant species that is distinct from the scrapie isoform
44. Membrane environment alters the conformational structure of the recombinant human prion protein
45. Binding of disease-associated prion protein to plasminogen
46. Signal transduction through prion protein
47. The prion protein has DNA strand transfer properties similar to retroviral nucleocapsid protein
48. Molecular machines: How motion and other functions of living organisms can result from reversible chemical changes
49. Short elastin-like peptides exhibit the same temperature induced structural transitions as elastin polymers: Implications for protein engineering
50. Purification of recombinant proteins by fusion with thermally-responsive polypeptides
51. An engineered minidomain containing an elastin turn exhibits a reversible temperature-induced IgG binding
52. MOLSCRIPT: A program to produce both detailed and schematic plots of protein structures
53. Two binding orientations for peptides to the Src SH3 domain: Development of a general model for SH3-ligand interactions
54. 1H NMR
55. A molecular dynamics investigation of the elastomeric restoring force in elastin
56. NMR structure of the bovine prion protein