Crystal structure and function of a DARPin neutralizing inhibitor of lactococcal phage TP901-1. Comparison of DARPin and camelid VHH binding mode

Journal of Biological Chemistry

Volumn 284, Issue 44, 2009, Pages 30718-30726

  Veesler, David ^a   Dreier, Birgit ^b   Blangy, Stéphanie ^a   Lichière, Julie ^a   Tremblay, Denise ^c   Moineau, Sylvain ^c   Spinelli, Silvia ^a   Tegoni, Mariella ^a   Plückthun, Andreas ^b   Campanacci, Valérie ^a   Cambillau, Christian ^a  

^a AIX MARSEILLE UNIVERSITY   (France)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c UNIVERSITÉ LAVAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANKYRIN; BASEPLATE; BINDING MODES; COCRYSTALLIZATION; COMBINATORIAL LIBRARY; HIGH SPECIFICITY; LACTOCOCCUS LACTIS; MULTI-PROTEIN COMPLEX; MULTIPLE CRYSTALS; NANOMOLAR RANGE; PHAGE INFECTION; PROOF OF CONCEPT; PROTEIN COMPLEXES; RECEPTOR-BINDING PROTEINS; RIBOSOME DISPLAY; SPECIFIC BINDING; VIRAL INFECTIONS;

BINDING ENERGY; PROTEINS; STOICHIOMETRY;

CRYSTAL STRUCTURE;

ANKYRIN; PROTEIN DARPIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DNA LIBRARY; LACTOCOCCUS LACTIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; RECEPTOR BINDING; SEQUENCE ANALYSIS; STOICHIOMETRY; STRUCTURE ANALYSIS;

ANKYRIN REPEAT; ANTIVIRAL AGENTS; BACTERIOPHAGES; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; LACTOCOCCUS LACTIS; MULTIPROTEIN COMPLEXES; PEPTIDE LIBRARY; PROTEIN CONFORMATION; PROTEIN ENGINEERING; RECEPTORS, VIRUS; VIRAL PROTEINS; VIRUS DISEASES;

CAMELIDAE; LACTOCOCCUS LACTIS;

EID: 71049152941     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.037812     Document Type: Article

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