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Volumn 2010, Issue , 2010, Pages

Formation, repair, and genotoxic properties of bulky DNA adducts formed from tobacco-specific nitrosamines

Author keywords

[No Author keywords available]

Indexed keywords

4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANONE; 4 HYDROXY 1 [3 PYRIDYL] 1 BUTANONE; 6 O ALKYLGUANINE DNA ALKYLTRANSFERASE; 7 [4 (3 PYIDYL) 4 OXOBUT 1 YL] 2' DEOXYGUANOSINE; DEOXYGUANOSINE; NITROSAMINE; NITROSONORNICOTINE; O 2 [4 (3 PYRIDYL) 4 OXOBUT 1 YL] 2' DEOXYCYTOSINE; O 2 [4 (3 PYRIDYL) 4 OXOBUT 1 YL] 2' DEOXYTHYMIDINE; O 6 [4 (3 PYRIDYL) 4 OXOBUT 1 YL] 2' DEOXYGUANOSINE; UNCLASSIFIED DRUG; XRCC1 PROTEIN;

EID: 79955122770     PISSN: 20900201     EISSN: 2090021X     Source Type: Journal    
DOI: 10.4061/2010/284935     Document Type: Review
Times cited : (36)

References (104)
  • 1
    • 0141852509 scopus 로고    scopus 로고
    • International Agency for Research on Cancer, 83rd Lyon, France IARC
    • International Agency for Research on Cancer, Tobacco Smoke and Involuntary Smoking 2004 83rd Lyon, France IARC
    • (2004) Tobacco Smoke and Involuntary Smoking
  • 2
    • 84957940642 scopus 로고    scopus 로고
    • Fact Sheet 297. 2009
    • World Health Organization, Cancer. Fact Sheet No. 297. 2009 http://www.who.int/mediacentre/factsheets/fs297/en/print.html
    • Cancer
  • 4
    • 5444239783 scopus 로고    scopus 로고
    • Environmental and chemical carcinogenesis
    • DOI 10.1016/j.semcancer.2004.06.010, PII S1044579X04000537
    • Wogan G. N., Hecht S. S., Felton J. S., Conney A. H., Loeb L. A., Environmental and chemical carcinogenesis. Seminars in Cancer Biology 2004 14 6 473 486 2-s2.0-5444239783 10.1016/j.semcancer.2004.06.010 (Pubitemid 39360995)
    • (2004) Seminars in Cancer Biology , vol.14 , Issue.6 , pp. 473-486
    • Wogan, G.N.1    Hecht, S.S.2    Felton, J.S.3    Conney, A.H.4    Loeb, L.A.5
  • 6
    • 0033591845 scopus 로고    scopus 로고
    • Tobacco smoke carcinogens and lung cancer
    • Hecht S. S., Tobacco smoke carcinogens and lung cancer. Journal of the National Cancer Institute 1999 91 14 1194 1210 2-s2.0-0033591845 (Pubitemid 29357186)
    • (1999) Journal of the National Cancer Institute , vol.91 , Issue.14 , pp. 1194-1210
    • Hecht, S.S.1
  • 7
    • 0023898409 scopus 로고
    • Tobacco-specific nitrosamines, an important group of carcinogens in tobacco and tobacco smoke
    • 2-s2.0-0023898409
    • Hecht S. S., Hoffmann D., Tobacco-specific nitrosamines, an important group of carcinogens in tobacco and tobacco smoke. Carcinogenesis 1988 9 6 875 884 2-s2.0-0023898409
    • (1988) Carcinogenesis , vol.9 , Issue.6 , pp. 875-884
    • Hecht, S.S.1    Hoffmann, D.2
  • 8
    • 0031831381 scopus 로고    scopus 로고
    • Biochemistry, biology, and carcinogenicity of tobacco-specific N- nitrosamines
    • DOI 10.1021/tx980005y
    • Hecht S. S., Biochemistry, biology, and carcinogenicity of tobacco-specific N -nitrosamines. Chemical Research in Toxicology 1998 11 6 559 603 2-s2.0-0031831381 10.1021/tx980005y (Pubitemid 28285583)
    • (1998) Chemical Research in Toxicology , vol.11 , Issue.6 , pp. 559-603
    • Hecht, S.S.1
  • 9
    • 0018889232 scopus 로고
    • Comparative carcinogenicity in F344 rats of the tobacco-specific nitrosamines, N'-nitrosonornicotine and 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl) 1-butanone
    • Hecht S. S., Chen C. B., Ohmori T., Hoffmann D., Comparative carcinogenicity in F344 rats of the tobacco-specific nitrosamines, N′ -nitrosonornicotine and 4-(N -methyl- N -nitrosamino)-1-(3-pyridyl)-1-butanone. Cancer Research 1980 40 2 298 302 2-s2.0-0018889232 (Pubitemid 10140152)
    • (1980) Cancer Research , vol.40 , Issue.2 , pp. 298-302
    • Hecht, S.S.1    Chen, C.B.2    Ohmori, T.3    Hoffmann, D.4
  • 10
    • 0024262907 scopus 로고
    • Induction of lung and exocrine pancreas tumors in F344 rats by tobacco-specific and Areca-derived N-nitrosamines
    • Rivenson A., Hoffmann D., Prokopczyk B., Amin S., Hecht S. S., Induction of lung and exocrine pancreas tumors in F344 rats by tobacco-specific and areca-derived N -nitrosamines. Cancer Research 1988 48 23 6912 6917 2-s2.0-0024262907 (Pubitemid 19012226)
    • (1988) Cancer Research , vol.48 , Issue.23 , pp. 6912-6917
    • Rivenson, A.1    Hoffmann, D.2    Prokopczyk, B.3    Amin, S.4    Hecht, S.S.5
  • 11
    • 0024350057 scopus 로고
    • Rapid single-dose model for lung tumor induction in A/J mice by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and the effect of diet
    • Hecht S. S., Morse M. A., Amin S., Stoner G. D., Jordan K. G., Choi C.-I., Chung F.-L., Rapid single-dose model for lung tumor induction in A/J mice by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and the effect of diet. Carcinogenesis 1989 10 10 1901 1904 2-s2.0-0024350057 (Pubitemid 19244867)
    • (1989) Carcinogenesis , vol.10 , Issue.10 , pp. 1901-1904
    • Hecht, S.S.1    Morse, M.A.2    Amin, S.3    Stoner, G.D.4    Jordan, K.G.5    Choi, C.-I.6    Chung, F.-L.7
  • 12
    • 25644461068 scopus 로고    scopus 로고
    • International lung cancer trends by histologic type: Male:female differences diminishing and adenocarcinoma rates rising
    • DOI 10.1002/ijc.21183
    • Devesa S. S., Bray F., Vizcaino A. P., Parkin D. M., International lung cancer trends by histologic type: male:female differences diminishing and adenocarcinoma rates rising. International Journal of Cancer 2005 117 2 294 299 2-s2.0-25644461068 10.1002/ijc.21183 (Pubitemid 41379403)
    • (2005) International Journal of Cancer , vol.117 , Issue.2 , pp. 294-299
    • Devesa, S.S.1    Bray, F.2    Vizcaino, A.P.3    Parkin, D.M.4
  • 13
    • 34247202217 scopus 로고    scopus 로고
    • Declining incidence rate of lung adenocarcinoma in the United States
    • DOI 10.1378/chest.06-1695
    • Chen F., Bina W. F., Cole P., Declining incidence rate of lung adenocarcinoma in the United States. Chest 2007 131 4 1000 1005 2-s2.0-34247202217 10.1378/chest.06-1695 (Pubitemid 46608699)
    • (2007) Chest , vol.131 , Issue.4 , pp. 1000-1005
    • Chen, F.1    Bina, W.F.2    Cole, P.3
  • 15
    • 0027488025 scopus 로고
    • Cigarette smoking and adenocarcinoma of the lung: The relevance of nicotine-derived N-nitrosamines
    • Hoffmann D., Rivenson A., Murphy S. E., Chung F.-L., Amin S., Hecht S. S., Cigarette smoking and adenocarcinoma of the lung: the relevance of nicotine-derived N -nitrosamines. Journal of Smoking-Related Disorders 1993 4 3 165 189 2-s2.0-0027488025 (Pubitemid 23344039)
    • (1993) Journal of Smoking-Related Disorders , vol.4 , Issue.3 , pp. 165-189
    • Hoffmann, D.1    Rivenson, A.2    Murphy, S.E.3    Chung, F.-L.4    Amin, S.5    Hecht, S.S.6
  • 16
    • 0027988016 scopus 로고
    • Smoking and lung cancer: Scientific challenges and opportunities
    • Wynder E. L., Hoffmann D., Smoking and lung cancer: scientific challenges and opportunities. Cancer Research 1994 54 20 5284 5295 2-s2.0-0027988016 (Pubitemid 24336015)
    • (1994) Cancer Research , vol.54 , Issue.20 , pp. 5284-5295
    • Wynder, E.L.1    Hoffmann, D.2
  • 17
    • 0027380766 scopus 로고
    • A tobacco-specific lung carcinogen in the urine of men exposed to cigarette smoke
    • DOI 10.1056/NEJM199311183292105
    • Hecht S. S., Carmella S. G., Murphy S. E., Akerkar S., Brunnemann K. D., Hoffmann D., A tobacco-specific lung carcinogen in the urine of men exposed to cigarette smoke. New England Journal of Medicine 1993 329 21 1543 1546 2-s2.0-0027380766 10.1056/NEJM199311183292105 (Pubitemid 23332440)
    • (1993) New England Journal of Medicine , vol.329 , Issue.21 , pp. 1543-1546
    • Hecht, S.S.1    Carmella, S.G.2    Murphy, S.E.3    Akerkar, S.4    Brunnemann, K.D.5    Hoffmann, D.6
  • 18
    • 0031948080 scopus 로고    scopus 로고
    • A metabolite of the tobacco-specific lung carcinogen 4- (methylnitrosamino)-1-(3-pyridyl)-1-butanone in the urine of hospital workers exposed to environmental tobacco smoke
    • Parsons W. D., Carmella S. G., Akerkar S., Bonilla L. E., Hecht S. S., A metabolite of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3- pyridyl)-1-butanone in the urine of hospital workers exposed to environmental tobacco smoke. Cancer Epidemiology Biomarkers and Prevention 1998 7 3 257 260 2-s2.0-0031948080 (Pubitemid 28353938)
    • (1998) Cancer Epidemiology Biomarkers and Prevention , vol.7 , Issue.3 , pp. 257-260
    • Parsons, W.D.1    Carmella, S.G.2    Akerkar, S.3    Bonilla, L.E.4    Hecht, S.S.5
  • 20
    • 0035226983 scopus 로고    scopus 로고
    • Carcinogen biomarkers for lung or oral cancer chemoprevention trials
    • 2-s2.0-0035226983
    • Hecht S. S., Carcinogen biomarkers for lung or oral cancer chemoprevention trials. IARC Scientific Publications 2001 154 245 255 2-s2.0-0035226983
    • (2001) IARC Scientific Publications , vol.154 , pp. 245-255
    • Hecht, S.S.1
  • 21
    • 16444374852 scopus 로고    scopus 로고
    • Tobacco-specific nitrosamines and their pyridine-N-glucuronides in the urine of smokers and smokeless tobacco users
    • DOI 10.1158/1055-9965.EPI-04-0753
    • Stepanov I., Hecht S. S., Tobacco-specific nitrosamines and their pyridine-N-glucuronides in the urine of smokers and smokeless tobacco users. Cancer Epidemiology Biomarkers and Prevention 2005 14 4 885 891 2-s2.0-16444374852 10.1158/1055-9965.EPI-04-0753 (Pubitemid 40478552)
    • (2005) Cancer Epidemiology Biomarkers and Prevention , vol.14 , Issue.4 , pp. 885-891
    • Stepanov, I.1    Hecht, S.S.2
  • 22
    • 42149172331 scopus 로고    scopus 로고
    • Detection and quantitation of N-nitrosonornicotine in human toenails by liquid chromatography-electrospray ionization-tandem mass spectrometry
    • DOI 10.1158/1055-9965.EPI-07-2711
    • Stepanov I., Hecht S. S., Detection and quantitation of N′ -nitrosonornicotine in human toenails by liquid chromatography-electrospray ionization-tandem mass spectrometry. Cancer Epidemiology Biomarkers and Prevention 2008 17 4 945 948 2-s2.0-42149172331 10.1158/1055-9965.EPI-07-2711 (Pubitemid 351536427)
    • (2008) Cancer Epidemiology Biomarkers and Prevention , vol.17 , Issue.4 , pp. 945-948
    • Stepanov, I.1    Hecht, S.S.2
  • 23
    • 64049113200 scopus 로고    scopus 로고
    • Evidence for endogenous formation of N′ -nitrosonornicotine in some long-term nicotine patch users
    • 2-s2.0-64049113200 10.1093/ntr/ntn004
    • Stepanov I., Carmella S. G., Han S., Pinto A., Strasser A. A., Lerman C., Hecht S. S., Evidence for endogenous formation of N′ -nitrosonornicotine in some long-term nicotine patch users. Nicotine and Tobacco Research 2009 11 1 99 105 2-s2.0-64049113200 10.1093/ntr/ntn004
    • (2009) Nicotine and Tobacco Research , vol.11 , Issue.1 , pp. 99-105
    • Stepanov, I.1    Carmella, S.G.2    Han, S.3    Pinto, A.4    Strasser, A.A.5    Lerman, C.6    Hecht, S.S.7
  • 24
    • 63249106893 scopus 로고    scopus 로고
    • Simultaneous determination of four tobacco-specific N -nitrosamines (TSNA) in human urine
    • 2-s2.0-63249106893 10.1016/j.jchromb.2009.03.009
    • Kavvadias D., Scherer G., Urban M., Cheung F., Errington G., Shepperd J., McEwan M., Simultaneous determination of four tobacco-specific N -nitrosamines (TSNA) in human urine. Journal of Chromatography B 2009 877 11-12 1185 1192 2-s2.0-63249106893 10.1016/j.jchromb.2009.03.009
    • (2009) Journal of Chromatography B , vol.877 , Issue.11-12 , pp. 1185-1192
    • Kavvadias, D.1    Scherer, G.2    Urban, M.3    Cheung, F.4    Errington, G.5    Shepperd, J.6    McEwan, M.7
  • 25
    • 72949106216 scopus 로고    scopus 로고
    • Determination of tobacco-specific N -nitrosamines in urine of smokers and non-smokers
    • 2-s2.0-28544452853 10.3109/13547500903242883
    • Kavvadias D., Scherer G., gerhard.scherer@abf-lab.com Cheung F., Errington G., Shepperd J., McEwan M., Determination of tobacco-specific N -nitrosamines in urine of smokers and non-smokers. Biomarkers 2009 14 8 547 553 2-s2.0-28544452853 10.3109/13547500903242883
    • (2009) Biomarkers , vol.14 , Issue.8 , pp. 547-553
    • Kavvadias, D.1    Scherer, G.2    Cheung, F.3    Errington, G.4    Shepperd, J.5    McEwan, M.6
  • 26
    • 34548029142 scopus 로고    scopus 로고
    • Determination of the role of target tissue metabolism in lung carcinogenesis using conditional cytochrome P450 reductase-null mice
    • DOI 10.1158/0008-5472.CAN-07-1006
    • Weng Y., Fang C., Turesky R. J., Behr M., Kaminsky L. S., Ding X., Determination of the role of target tissue metabolism in lung carcinogenesis using conditional cytochrome P450 reductase-null mice. Cancer Research 2007 67 16 7825 7832 2-s2.0-34548029142 10.1158/0008-5472.CAN-07-1006 (Pubitemid 47281377)
    • (2007) Cancer Research , vol.67 , Issue.16 , pp. 7825-7832
    • Weng, Y.1    Fang, C.2    Turesky, R.J.3    Behr, M.4    Kaminsky, L.S.5    Ding, X.6
  • 27
    • 0022551237 scopus 로고
    • Accumulation and persistence of DNA adducts in respiratory tissue of rats following multiple administrations of the tobacco specific carcinogen 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone
    • Belinsky S. A., White C. M., Boucheron J. A., Accumulation and persistence of DNA adducts in respiratory tissue of rats following multiple administrations of the tobacco specific carcinogen 4-(N-methyl-N-nitrosamino)-1- (3-pyridyl)-1-butanone. Cancer Research 1986 46 3 1280 1284 2-s2.0-0022551237 (Pubitemid 16048268)
    • (1986) Cancer Research , vol.46 , Issue.3 , pp. 1280-1284
    • Belinsky, S.A.1    White, C.M.2    Boucheron, J.A.3
  • 28
    • 0022654007 scopus 로고
    • Comparative tumorigenicity and DNA methylation in F344 rats by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N-nitrosodimethylamine
    • Hecht S. S., Trushin N., Castonguay A., Rivenson A., Comparative tumorigenicity and DNA methylation in F344 rats by 4-(methylnitrosamino)-1-(3- pyridyl)-1-butanone and N -nitrosodimethylamine. Cancer Research 1986 46 2 498 502 2-s2.0-0022654007 (Pubitemid 16145391)
    • (1986) Cancer Research , vol.46 , Issue.2 , pp. 498-502
    • Hecht, S.S.1    Trushin, N.2    Castonguay, A.3    Rivenson, A.4
  • 29
    • 0025297169 scopus 로고
    • 6-methylguanine formation in Clara cells and induction of pulmonary neoplasia in the rat by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
    • Belinsky S. A., Foley J. F., White C. M., Anderson M. W., Maronpot R. R., Dose-response relationship between O6 -methylguanine formation in Clara cells and induction of pulmonary neoplasia in the rat by NNK. Cancer Research 1990 50 12 3772 3780 2-s2.0-0025297169 (Pubitemid 20194130)
    • (1990) Cancer Research , vol.50 , Issue.12 , pp. 3772-3780
    • Belinsky, S.A.1    Foley, J.F.2    White, C.M.3    Anderson, M.W.4    Maronpot, R.R.5
  • 30
    • 0025102844 scopus 로고
    • Dose-response study of DNA and hemoglobin adduct formation by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in F344 rats
    • Murphy S. E., Palomino A., Hecht S. S., Hoffmann D., Dose-response study of DNA and hemoglobin adduct formation by 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanone in F344 rats. Cancer Research 1990 50 17 5446 5452 2-s2.0-0025102844 (Pubitemid 20303002)
    • (1990) Cancer Research , vol.50 , Issue.17 , pp. 5446-5452
    • Murphy, S.E.1    Palomino, A.2    Hecht, S.S.3    Hoffmann, D.4
  • 31
    • 0025925258 scopus 로고
    • 6 -Methylguanine is a critical determinant of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone tumorigenesis in A/J mouse lung
    • 2-s2.0-0025925258
    • 6 -Methylguanine is a critical determinant of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone tumorigenesis in A/J mouse lung. Cancer Research 1991 51 20 5557 5564 2-s2.0-0025925258
    • (1991) Cancer Research , vol.51 , Issue.20 , pp. 5557-5564
    • Peterson, L.A.1    Hecht, S.S.2
  • 33
    • 0029665108 scopus 로고    scopus 로고
    • 6-benzylguanine incorporated site-specifically in codon 12 of the rat H-ras gene induce semi-targeted as well as targeted mutations in Rat4 cells
    • DOI 10.1093/carcin/17.4.849
    • 6 -Ethylguanine and O6 -benzylguanine incorporated site-specifically in codon 12 of the rat H- ras gene induce semi-targeted as well as targeted mutations in Rat4 cells. Carcinogenesis 1996 17 4 849 856 2-s2.0-0029665108 10.1093/carcin/17.4.849 (Pubitemid 26129702)
    • (1996) Carcinogenesis , vol.17 , Issue.4 , pp. 849-856
    • Bishop, R.E.1    Pauly, G.T.2    Moschel, R.C.3
  • 34
    • 34447314728 scopus 로고    scopus 로고
    • MGMT: Key node in the battle against genotoxicity, carcinogenicity and apoptosis induced by alkylating agents
    • DOI 10.1016/j.dnarep.2007.03.008, PII S1568786407001243
    • Kaina B., Christmann M., Naumann S., Roos W. P., MGMT: key node in the battle against genotoxicity, carcinogenicity and apoptosis induced by alkylating agents. DNA Repair 2007 6 8 1079 1099 2-s2.0-34447314728 10.1016/j.dnarep.2007. 03.008 (Pubitemid 47058389)
    • (2007) DNA Repair , vol.6 , Issue.8 , pp. 1079-1099
    • Kaina, B.1    Christmann, M.2    Naumann, S.3    Roos, W.P.4
  • 35
    • 0034028030 scopus 로고    scopus 로고
    • 6-alkylguanine by alkyltransferases
    • DOI 10.1016/S1383-5742(00)00017-X, PII S138357420000017X
    • Pegg A. E., Repair of O6 -alkylguanine by alkyltransferases. Mutation Research 2000 462 2-3 83 100 2-s2.0-0034028030 10.1016/S1383-5742(00)00017-X (Pubitemid 30190216)
    • (2000) Mutation Research - Reviews in Mutation Research , vol.462 , Issue.2-3 , pp. 83-100
    • Pegg, A.E.1
  • 36
    • 0034027358 scopus 로고    scopus 로고
    • 6-methylguanine and the cytotoxicity of methylating agents
    • DOI 10.1016/S1383-5742(00)00016-8, PII S1383574200000168
    • Bignami M., O'Driscoll M., Aquilina G., Karran P., Unmasking a killer: DNA O6 -methylguanine and the cytotoxicity of methylating agents. Mutation Research 2000 462 2-3 71 82 2-s2.0-0034027358 10.1016/S1383-5742(00)00016-8 (Pubitemid 30190215)
    • (2000) Mutation Research - Reviews in Mutation Research , vol.462 , Issue.2-3 , pp. 71-82
    • Bignami, M.1    O'Driscoll, M.2    Aquilina, G.3    Karran, P.4
  • 37
    • 0025194782 scopus 로고
    • 4-alkylthymine and the mutagenic properties of these bases
    • Swann P. F., Why do O6 -alkylguanine and O4 -alkylthymine miscode? The relationship between the structure of DNA containing O6 -alkylguanine and O4 -alkylthymine and the mutagenic properties of these bases. Mutation Research 1990 233 1-2 81 94 2-s2.0-0025194782 (Pubitemid 20379146)
    • (1990) Mutation Research , vol.233 , Issue.1-2 , pp. 81-94
    • Swann, P.F.1
  • 38
    • 0034105503 scopus 로고    scopus 로고
    • Enantiomeric composition of N'-nitrosonornicotine and N'-nitrosoanatabine in tobacco
    • Carmella S. G., McIntee E. J., Chen M., Hecht S. S., Enantiomeric composition of N′ -nitrosonornicotine and N′ -nitrosoanatabine in tobacco. Carcinogenesis 2000 21 4 839 843 2-s2.0-0034105503 (Pubitemid 30214046)
    • (2000) Carcinogenesis , vol.21 , Issue.4 , pp. 839-843
    • Carmella, S.G.1    McIntee, E.J.2    Chen, M.3    Hecht, S.S.4
  • 39
    • 0034111281 scopus 로고    scopus 로고
    • Metabolism of N'-nitrosonornicotine enantiomers by cultured rat esophagus and in vivo in rats
    • DOI 10.1021/tx990171l
    • McIntee E. J., Hecht S. S., Metabolism of N′ -nitrosonornicotine enantiomers by cultured rat esophagus and in vivo in rats. Chemical Research in Toxicology 2000 13 3 192 199 2-s2.0-0034111281 10.1021/tx990171l (Pubitemid 30169964)
    • (2000) Chemical Research in Toxicology , vol.13 , Issue.3 , pp. 192-199
    • McIntee, E.J.1    Hecht, S.S.2
  • 40
    • 33645470191 scopus 로고    scopus 로고
    • Identification of adducts formed in the reaction of 5′ -acetoxy- N′ -nitrosonornicotine with deoxyguanosine and DNA
    • 2-s2.0-33645470191 10.1021/tx050323e
    • Upadhyaya P., McIntee E. J., Villalta P. W., Hecht S. S., Identification of adducts formed in the reaction of 5′ -acetoxy- N′ -nitrosonornicotine with deoxyguanosine and DNA. Chemical Research in Toxicology 2006 19 3 426 435 2-s2.0-33645470191 10.1021/tx050323e
    • (2006) Chemical Research in Toxicology , vol.19 , Issue.3 , pp. 426-435
    • Upadhyaya, P.1    McIntee, E.J.2    Villalta, P.W.3    Hecht, S.S.4
  • 41
    • 57449110932 scopus 로고    scopus 로고
    • Identification of adducts formed in the reactions of 5′ -acetoxy- N′ -nitrosonornicotine with deoxyadenosine, thymidine, and DNA
    • 2-s2.0-57449110932 10.1021/tx8002559
    • Upadhyaya P., Hecht S. S., Identification of adducts formed in the reactions of 5′ -acetoxy- N′ -nitrosonornicotine with deoxyadenosine, thymidine, and DNA. Chemical Research in Toxicology 2008 21 11 2164 2171 2-s2.0-57449110932 10.1021/tx8002559
    • (2008) Chemical Research in Toxicology , vol.21 , Issue.11 , pp. 2164-2171
    • Upadhyaya, P.1    Hecht, S.S.2
  • 42
    • 0038025295 scopus 로고    scopus 로고
    • Identification of adducts formed by pyridyloxobutylation of deoxyguanosine and DNA by 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone, a chemically activated form of tobacco specific carcinogens
    • Wang M., Cheng G., Sturla S. J., Shi Y., McIntee E. J., Villalta P. W., Upadhyaya P., Hecht S. S., Identification of adducts formed by pyridyloxobutylation of deoxyguanosine and DNA by 4-(acetoxymethylnitrosamino)- 1-(3-pyridyl)-1-butanone, a chemically activated form of tobacco specific carcinogens. Chemical Research in Toxicology 2003 16 5 616 626 2-s2.0-0038025295 (Pubitemid 36613095)
    • (2003) Chemical Research in Toxicology , vol.16 , Issue.5 , pp. 616-626
    • Wang, M.1    Cheng, G.2    Sturla, S.J.3    Shi, Y.4    McIntee, E.J.5    Villalta, P.W.6    Upadhyaya, P.7    Hecht, S.S.8
  • 43
    • 2442654113 scopus 로고    scopus 로고
    • 2-substituted pyrimidine adducts formed in reactions of 4-(Acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone and 4-(Acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanol with DNA
    • DOI 10.1021/tx034263t
    • Hecht S. S., Villalta P. W., Sturla S. J., Cheng G., Yu N., Upadhyaya P., Wang M., Identification of O2 -substituted pyrimidine adducts formed in reactions of 4-(Acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone and 4-(Acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanol with DNA. Chemical Research in Toxicology 2004 17 5 588 597 2-s2.0-2442654113 10.1021/tx034263t (Pubitemid 38669515)
    • (2004) Chemical Research in Toxicology , vol.17 , Issue.5 , pp. 588-597
    • Hecht, S.S.1    Villalta, P.W.2    Sturla, S.J.3    Cheng, G.4    Yu, N.5    Upadhyaya, P.6    Wang, M.7
  • 44
    • 0030612110 scopus 로고    scopus 로고
    • 6-alkylguanine-DNA alkyltransferase
    • DOI 10.1021/tx9602067
    • Wang L., Spratt T. E., Liu X.-K., Hecht S. S., Pegg A. E., Peterson L. A., Pyridyloxobutyl adduct O6 -[4-oxo-4-(3-pyridyl)butyl]guanine is present in 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone-treated DNA and is a substrate for O6 -alkylguanine-DNA alkyltransferase. Chemical Research in Toxicology 1997 10 5 562 567 2-s2.0-0030612110 10.1021/tx9602067 (Pubitemid 27217213)
    • (1997) Chemical Research in Toxicology , vol.10 , Issue.5 , pp. 562-567
    • Wang, L.1    Spratt, T.E.2    Liu, X.-K.3    Hecht, S.S.4    Pegg, A.E.5    Peterson, L.A.6
  • 45
    • 0001802918 scopus 로고
    • Evidence for 4-(3-pyridyl)-4-oxobutylation of DNA in F344 rats treated with the tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanone and N'-nitrosonornicotine
    • Hecht S. S., Spratt T. E., Trushin N., Evidence for 4-(3-pyridyl)-4- oxobutylation of DNA in F344 rats treated with the tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N′ -nitrosonornicotine. Carcinogenesis 1988 9 1 161 165 2-s2.0-0001802918 (Pubitemid 18023174)
    • (1988) Carcinogenesis , vol.9 , Issue.1 , pp. 161-165
    • Hecht, S.S.1    Spratt, T.E.2    Trushin, N.3
  • 46
    • 21144433997 scopus 로고    scopus 로고
    • Mass spectrometric analysis of relative levels of pyridyloxobutylation adducts formed in the reaction of DNA with a chemically activated form of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
    • DOI 10.1021/tx050028u
    • Sturla S. J., Scott J., Lao Y., Hecht S. S., Villalta P. W., Mass spectrometric analysis of relative levels of pyridyloxobutylation adducts formed in the reaction of DNA with a chemically activated form of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Chemical Research in Toxicology 2005 18 6 1048 1055 2-s2.0-21144433997 10.1021/tx050028u (Pubitemid 40880894)
    • (2005) Chemical Research in Toxicology , vol.18 , Issue.6 , pp. 1048-1055
    • Sturla, S.J.1    Scott, J.2    Lao, Y.3    Hecht, S.S.4    Villalta, P.W.5
  • 47
    • 0035955554 scopus 로고    scopus 로고
    • Characterization and mapping of DNA damage induced by reactive metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) at nucleotide resolution in human genomic DNA
    • DOI 10.1006/jmbi.2001.4997
    • Cloutier J.-F., Drouin R., Weinfeld M., O'Connor T. R., Castonguay A., Characterization and mapping of DNA damage induced by reactive metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) at nucleotide resolution in human genomic DNA. Journal of Molecular Biology 2001 313 3 539 557 2-s2.0-0035955554 10.1006/jmbi.2001.4997 (Pubitemid 33052286)
    • (2001) Journal of Molecular Biology , vol.313 , Issue.3 , pp. 539-557
    • Cloutier, J.-F.1    Drouin, R.2    Weinfeld, M.3    O'Connor, T.R.4    Castonguay, A.5
  • 48
    • 0037386471 scopus 로고    scopus 로고
    • 6-[4-oxo-4-(3-pyridyl)butyl]guanine
    • DOI 10.1093/nar/gkg299
    • Park S., Seetharaman M., Ogdie A., Ferguson D., Tretyakova N., 3′ -Exonuclease resistance of DNA oligodeoxynucleotides containing O6 -[4-oxo-4-(3-pyridyl)butyl]guanine. Nucleic Acids Research 2003 31 7 1984 1994 2-s2.0-0037386471 10.1093/nar/gkg299 (Pubitemid 36432706)
    • (2003) Nucleic Acids Research , vol.31 , Issue.7 , pp. 1984-1994
    • Park, S.1    Seetharaman, M.2    Ogdie, A.3    Ferguson, D.4    Tretyakova, N.5
  • 49
    • 0035998269 scopus 로고    scopus 로고
    • Evidence for phosphate adducts in DNA from mice treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK)
    • DOI 10.1021/tx015542o
    • Haglund J., Henderson A. P., Golding B. T., Törnqvist M., Evidence for phosphate adducts in DNA from mice treated with 4-(N -methyl- N -nitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Chemical Research in Toxicology 2002 15 6 773 779 2-s2.0-0035998269 10.1021/tx015542o (Pubitemid 34663617)
    • (2002) Chemical Research in Toxicology , vol.15 , Issue.6 , pp. 773-779
    • Haglund, J.1    Henderson, A.P.2    Golding, B.T.3    Tornqvist, M.4
  • 50
    • 0034012012 scopus 로고    scopus 로고
    • Transalkylation of phosphotriesters using cob(I)alamin: Toward specific determination of DNA-phosphate adducts
    • DOI 10.1021/tx990135m
    • Haglund J., Rafiq A., Ehrenberg L., Golding B. T., Törnqvist M., Transalkylation of phosphotriesters using Cob(I)alamin: toward specific determination of DNA-phosphate adducts. Chemical Research in Toxicology 2000 13 4 253 256 2-s2.0-0034012012 10.1021/tx990135m (Pubitemid 30241651)
    • (2000) Chemical Research in Toxicology , vol.13 , Issue.4 , pp. 253-256
    • Haglund, J.1    Rafiq, A.2    Ehrenberg, L.3    Golding, B.T.4    Tornqvist, M.5
  • 51
    • 34548515774 scopus 로고    scopus 로고
    • Development of liquid chromatography electrospray ionization tandem mass spectrometry methods for analysis of DNA adducts of formaldehyde and their application to rats treated with N-nitrosodimethylamine or 4-(methylnitrosamino) -1-(3-pyridyl)-1-butanone
    • DOI 10.1021/tx700189c
    • Wang M., Cheng G., Villalta P. W., Hecht S. S., Development of liquid chromatography electrospray ionization tandem mass spectrometry methods for analysis of DNA adducts of formaldehyde and their application to rats treated with N-nitrosodimethylamine or 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Chemical Research in Toxicology 2007 20 8 1141 1148 2-s2.0-34548515774 10.1021/tx700189c (Pubitemid 47372993)
    • (2007) Chemical Research in Toxicology , vol.20 , Issue.8 , pp. 1141-1148
    • Wang, M.1    Cheng, G.2    Villalta, P.W.3    Hecht, S.S.4
  • 52
    • 0033535375 scopus 로고    scopus 로고
    • DNA adduct formation from tobacco-specific N-nitrosamines
    • DOI 10.1016/S0027-5107(99)00014-7, PII S0027510799000147
    • Hecht S. S., DNA adduct formation from tobacco-specific N -nitrosamines. Mutation Research 1999 424 1-2 127 142 2-s2.0-0033535375 10.1016/S0027-5107(99) 00014-7 (Pubitemid 29101614)
    • (1999) Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis , vol.424 , Issue.1-2 , pp. 127-142
    • Hecht, S.S.1
  • 53
    • 0031023711 scopus 로고    scopus 로고
    • Evidence for an important role of DNA pyridyloxobutylation in rat lung carcinogenesis by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: Effects of dose and phenethyl isothiocyanate
    • Staretz M. E., Foiles P. G., Miglietta L. M., Hecht S. S., Evidence for an important role of DNA pyridyloxobutylation in rat lung carcinogenesis by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: effects of dose and phenethyl isothiocyanate. Cancer Research 1997 57 2 259 266 2-s2.0-0031023711 (Pubitemid 27036603)
    • (1997) Cancer Research , vol.57 , Issue.2 , pp. 259-266
    • Staretz, M.E.1    Foiles, P.G.2    Miglietta, L.M.3    Hecht, S.S.4
  • 54
    • 0037256361 scopus 로고    scopus 로고
    • 6-[4-Oxo-4-(3-pyridyl)butyl] guanine, is detected in tissues from 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanone-treated A/J mice
    • DOI 10.1021/tx025585k
    • Thomson N. M., Kenney P. M., Peterson L. A., The pyridyloxobutyl DNA adduct, O6 -[4-oxo-4-(3-pyridyl)butyl]guanine, is detected in tissues from 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-treated A/J mice. Chemical Research in Toxicology 2003 16 1 1 6 2-s2.0-0037256361 10.1021/tx025585k (Pubitemid 36139404)
    • (2003) Chemical Research in Toxicology , vol.16 , Issue.1 , pp. 1-6
    • Thomson, N.M.1    Kenney, P.M.2    Peterson, L.A.3
  • 55
    • 10844279953 scopus 로고    scopus 로고
    • 6-[4-oxo-4-(3-pyridyl)butyl]-2-deoxyguanosine
    • DOI 10.1021/tx0498298
    • Thomson N. M., Mijal R. S., Ziegel R., Fleischer N. L., Pegg A. E., Tretyakova N. Y., Peterson L. A., Development of a quantitative liquid chromatography/electrospray mass spectrometric assay for a mutagenic tobacco specific nitrosamine-derived DNA adduct, O6 -[4-oxo-4-(3-pyridyl)butyl]- 2′ -deoxyguanosine. Chemical Research in Toxicology 2004 17 12 1600 1606 2-s2.0-10844279953 10.1021/tx0498298 (Pubitemid 39665551)
    • (2004) Chemical Research in Toxicology , vol.17 , Issue.12 , pp. 1600-1606
    • Thomson, N.M.1    Mijal, R.S.2    Ziegel, R.3    Fleischer, N.L.4    Pegg, A.E.5    Tretyakova, N.Y.6    Peterson, L.A.7
  • 56
    • 33744483513 scopus 로고    scopus 로고
    • Quantitation of pyridyloxobutyl DNA adducts of tobacco-specific nitrosamines in rat tissue DNA by high-performance liquid chromatography- electrospray ionization-tandem mass spectrometry
    • DOI 10.1021/tx050351x
    • Lao Y., Villalta P. W., Sturla S. J., Wang M., Hecht S. S., Quantitation of pyridyloxobutyl DNA adducts of tobacco-specific nitrosamines in rat tissue DNA by high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry. Chemical Research in Toxicology 2006 19 5 674 682 2-s2.0-33744483513 10.1021/tx050351x (Pubitemid 43800984)
    • (2006) Chemical Research in Toxicology , vol.19 , Issue.5 , pp. 674-682
    • Lao, Y.1    Villalta, P.W.2    Sturla, S.J.3    Wang, M.4    Hecht, S.S.5
  • 57
    • 33947166345 scopus 로고    scopus 로고
    • Formation and accumulation of pyridyloxobutyl DNA adducts in F344 rats chronically treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol
    • DOI 10.1021/tx060207r
    • Lao Y., Yu N., Kassie F., Villalta P. W., Hecht S. S., Formation and accumulation of pyridyloxobutyl DNA adducts in F344 rats chronically treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol. Chemical Research in Toxicology 2007 20 2 235 245 2-s2.0-33947166345 10.1021/tx060207r (Pubitemid 46408860)
    • (2007) Chemical Research in Toxicology , vol.20 , Issue.2 , pp. 235-245
    • Lao, Y.1    Yu, N.2    Kassie, F.3    Villalta, P.W.4    Hecht, S.S.5
  • 58
    • 66649088331 scopus 로고    scopus 로고
    • Comparative levels of O6 -methylguanine, pyridyloxobutyl-, and pyridylhydroxybutyl-DNA adducts in lung and liver of rats treated chronically with the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanone
    • 2-s2.0-66649088331 10.1124/dmd.109.027078
    • Upadhyaya P., Lindgren B. R., Hecht S. S., Comparative levels of O6 -methylguanine, pyridyloxobutyl-, and pyridylhydroxybutyl-DNA adducts in lung and liver of rats treated chronically with the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanone. Drug Metabolism and Disposition 2009 37 6 1147 1151 2-s2.0-66649088331 10.1124/dmd.109.027078
    • (2009) Drug Metabolism and Disposition , vol.37 , Issue.6 , pp. 1147-1151
    • Upadhyaya, P.1    Lindgren, B.R.2    Hecht, S.S.3
  • 59
    • 67649921189 scopus 로고    scopus 로고
    • Analysis of pyridyloxobutyl and pyridylhydroxybutyl DNA adducts in extrahepatic tissues of F344 rats treated chronically with 4-(methylnitrosamino) -1-(3-pyridyl)-1-butanone and enantiomers of 4-(methylnitrosamino)-1-(3-pyridyl) -1-butanol
    • 2-s2.0-67649921189 10.1021/tx900015d
    • Zhang S., Wang M., Villalta P. W., Lindgren B. R., Upadhyaya P., Lao Y., Hecht S. S., Analysis of pyridyloxobutyl and pyridylhydroxybutyl DNA adducts in extrahepatic tissues of F344 rats treated chronically with 4-(methylnitrosamino) -1-(3-pyridyl)-1-butanone and enantiomers of 4-(methylnitrosamino)-1-(3-pyridyl) -1-butanol. Chemical Research in Toxicology 2009 22 5 926 936 2-s2.0-67649921189 10.1021/tx900015d
    • (2009) Chemical Research in Toxicology , vol.22 , Issue.5 , pp. 926-936
    • Zhang, S.1    Wang, M.2    Villalta, P.W.3    Lindgren, B.R.4    Upadhyaya, P.5    Lao, Y.6    Hecht, S.S.7
  • 60
    • 33947150540 scopus 로고    scopus 로고
    • Analysis of pyridyloxobutyl DNA adducts in F344 rats chronically treated with (R)- and (S)-N-nitrosonornicotine
    • DOI 10.1021/tx060208j
    • Lao Y., Yu N., Kassie F., Villalta P. W., Hecht S. S., Analysis of pyridyloxobutyl DNA adducts in F344 rats chronically treated with (R)- and (S)- N′ -nitrosonornicotine. Chemical Research in Toxicology 2007 20 2 246 256 2-s2.0-33947150540 10.1021/tx060208j (Pubitemid 46408861)
    • (2007) Chemical Research in Toxicology , vol.20 , Issue.2 , pp. 246-256
    • Lao, Y.1    Yu, N.2    Kassie, F.3    Villalta, P.W.4    Hecht, S.S.5
  • 61
    • 67649964709 scopus 로고    scopus 로고
    • Quantitation of pyridyloxobutyl DNA adducts in nasal and oral mucosa of rats treated chronically with enantiomers of N′ -nitrosonornicotine
    • 2-s2.0-67649964709 10.1021/tx900040j
    • Zhang S., Wang M., Villalta P. W., Lindgren B. R., Lao Y., Hecht S. S., Quantitation of pyridyloxobutyl DNA adducts in nasal and oral mucosa of rats treated chronically with enantiomers of N′ -nitrosonornicotine. Chemical Research in Toxicology 2009 22 5 949 956 2-s2.0-67649964709 10.1021/tx900040j
    • (2009) Chemical Research in Toxicology , vol.22 , Issue.5 , pp. 949-956
    • Zhang, S.1    Wang, M.2    Villalta, P.W.3    Lindgren, B.R.4    Lao, Y.5    Hecht, S.S.6
  • 62
    • 33947331376 scopus 로고    scopus 로고
    • Mass spectrometric analysis of 4-hydroxy-1-(3-pyridyl)-1-butanone- releasing DNA adducts in human lung
    • DOI 10.1016/j.tox.2007.01.016, PII S0300483X07000406
    • Hölzle D., Schlöbe D., Tricker A. R., Richter E., Mass spectrometric analysis of 4-hydroxy-1-(3-pyridyl)-1-butanone-releasing DNA adducts in human lung. Toxicology 2007 232 3 277 285 2-s2.0-33947331376 10.1016/j.tox.2007.01.016 (Pubitemid 46441620)
    • (2007) Toxicology , vol.232 , Issue.3 , pp. 277-285
    • Holzle, D.1    Schlobe, D.2    Tricker, A.R.3    Richter, E.4
  • 63
    • 39249085060 scopus 로고    scopus 로고
    • 4-Hydroxy-1-(3-pyridyl)-1-butanone-releasing DNA adducts in lung, lower esophagus and cardia of sudden death victims
    • 2-s2.0-39249085060 10.1016/j.tox.2007.12.021
    • Schlöbe D., Hölzle D., Hatz D., von Meyer L., Tricker A. R., Richter E., 4-Hydroxy-1-(3-pyridyl)-1-butanone-releasing DNA adducts in lung, lower esophagus and cardia of sudden death victims. Toxicology 2008 245 1-2 154 161 2-s2.0-39249085060 10.1016/j.tox.2007.12.021
    • (2008) Toxicology , vol.245 , Issue.1-2 , pp. 154-161
    • Schlöbe, D.1    Hölzle, D.2    Hatz, D.3    Von Meyer, L.4    Tricker, A.R.5    Richter, E.6
  • 64
    • 0034599723 scopus 로고    scopus 로고
    • Active and alkylated human AGT structures: A novel zinc site, inhibitor and extrahelical base binding
    • Daniels D. S., Mol C. D., Arvai A. S., Kanugula S., Pegg A. E., Tainer J. A., Active and alkylated human AGT structures: a novel zinc site, inhibitor and extrahelical base binding. EMBO Journal 2000 19 7 1719 1730 2-s2.0-0034599723 (Pubitemid 30182178)
    • (2000) EMBO Journal , vol.19 , Issue.7 , pp. 1719-1730
    • Daniels, D.S.1    Mol, C.D.2    Arvai, A.S.3    Kanugula, S.4    Pegg, A.E.5    Tainer, J.A.6
  • 65
    • 0036262190 scopus 로고    scopus 로고
    • 6-alkylguanine-DNA alkyltransferase
    • Xu-Welliver M., Pegg A. E., Degradation of the alkylated form of the DNA repair protein, O6 -alkylguanine-DNA alkyltransferase. Carcinogenesis 2002 23 5 823 830 2-s2.0-0036262190 (Pubitemid 34567522)
    • (2002) Carcinogenesis , vol.23 , Issue.5 , pp. 823-830
    • Xu-Welliver, M.1    Pegg, A.E.2
  • 67
    • 68949107651 scopus 로고    scopus 로고
    • The influence of repair pathways on the cytotoxicity and mutagenicity induced by the pyridyloxobutylation pathway of tobacco-specific nitrosamines
    • 2-s2.0-68949107651 10.1021/tx9001572
    • Li L., Perdigao J., Pegg A. E., Lao Y., Hecht S. S., Lindgren B. R., Reardon J. T., Sancar A., Wattenberg E. V., Peterson L. A., The influence of repair pathways on the cytotoxicity and mutagenicity induced by the pyridyloxobutylation pathway of tobacco-specific nitrosamines. Chemical Research in Toxicology 2009 22 8 1464 1472 2-s2.0-68949107651 10.1021/tx9001572
    • (2009) Chemical Research in Toxicology , vol.22 , Issue.8 , pp. 1464-1472
    • Li, L.1    Perdigao, J.2    Pegg, A.E.3    Lao, Y.4    Hecht, S.S.5    Lindgren, B.R.6    Reardon, J.T.7    Sancar, A.8    Wattenberg, E.V.9    Peterson, L.A.10
  • 68
    • 1342324026 scopus 로고    scopus 로고
    • DNA glycosylase recognition and catalysis
    • DOI 10.1016/j.sbi.2004.01.003
    • Fromme J. C., Banerjee A., Verdine G. L., DNA glycosylase recognition and catalysis. Current Opinion in Structural Biology 2004 14 1 43 49 2-s2.0-1342324026 10.1016/j.sbi.2004.01.003 (Pubitemid 38249591)
    • (2004) Current Opinion in Structural Biology , vol.14 , Issue.1 , pp. 43-49
    • Fromme, J.C.1    Banerjee, A.2    Verdine, G.L.3
  • 69
    • 0942268168 scopus 로고    scopus 로고
    • The base excision repair: Mechanisms and its relevance for cancer susceptibility
    • DOI 10.1016/j.biochi.2003.11.003
    • Fortini P., Pascucci B., Parlanti E., D'Errico M., Simonelli V., Dogliotti E., The base excision repair: mechanisms and its relevance for cancer susceptibility. Biochimie 2003 85 11 1053 1071 2-s2.0-0942268168 10.1016/j.biochi.2003.11.003 (Pubitemid 38142361)
    • (2003) Biochimie , vol.85 , Issue.11 , pp. 1053-1071
    • Fortini, P.1    Pascucci, B.2    Parlanti, E.3    D'Errico, M.4    Simonelli, V.5    Dogliotti, E.6
  • 70
    • 33845726097 scopus 로고    scopus 로고
    • Methylating agents and DNA repair responses: Methylated bases and sources of strand breaks
    • DOI 10.1021/tx060164e
    • Wyatt M. D., Pittman D. L., Methylating agents and DNA repair responses: methylated bases and sources of strand breaks. Chemical Research in Toxicology 2006 19 12 1580 1594 2-s2.0-33845726097 10.1021/tx060164e (Pubitemid 44975121)
    • (2006) Chemical Research in Toxicology , vol.19 , Issue.12 , pp. 1580-1594
    • Wyatt, M.D.1    Pittman, D.L.2
  • 71
    • 0028172493 scopus 로고
    • Detection of O6 -butyl- and O6 -(4-hydroxybutyl)guanine in urothelial and hepatic DNA of rats given the bladder carcinogen N -nitrosobutyl(4- hydroxybutyl)amine
    • 2-s2.0-0028172493
    • Airoldi L., Magagnotti C., Bonfanti M., Chiappetta L., Lolli M., Medana C., De Gregorio G., Fanelli R., Detection of O6 -butyl- and O6 -(4-hydroxybutyl)guanine in urothelial and hepatic DNA of rats given the bladder carcinogen N -nitrosobutyl(4-hydroxybutyl)amine. Carcinogenesis 1994 15 10 2297 2301 2-s2.0-0028172493
    • (1994) Carcinogenesis , vol.15 , Issue.10 , pp. 2297-2301
    • Airoldi, L.1    Magagnotti, C.2    Bonfanti, M.3    Chiappetta, L.4    Lolli, M.5    Medana, C.6    De Gregorio, G.7    Fanelli, R.8
  • 72
    • 33747371617 scopus 로고    scopus 로고
    • Formamidopyrimidine adducts are detected using the comet assay in human cells treated with reactive metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)- 1-butanone (NNK)
    • 2-s2.0-33747371617 10.1016/j.mrfmmm.2006.04.005
    • Lacoste S., Castonguay A., Drouin R., Formamidopyrimidine adducts are detected using the comet assay in human cells treated with reactive metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Mutation Research 2006 600 1-2 138 149 2-s2.0-33747371617 10.1016/j.mrfmmm.2006.04.005
    • (2006) Mutation Research , vol.600 , Issue.1-2 , pp. 138-149
    • Lacoste, S.1    Castonguay, A.2    Drouin, R.3
  • 73
    • 15944381621 scopus 로고    scopus 로고
    • Protein-protein interactions and posttranslational modifications in mammalian base excision repair
    • DOI 10.1016/j.freeradbiomed.2005.01.012
    • Fan J., Wilson D. M. III, Protein-protein interactions and posttranslational modifications in mammalian base excision repair. Free Radical Biology and Medicine 2005 38 9 1121 1138 2-s2.0-15944381621 10.1016/j. freeradbiomed.2005.01.012 (Pubitemid 40445529)
    • (2005) Free Radical Biology and Medicine , vol.38 , Issue.9 , pp. 1121-1138
    • Fan, J.1    Wilson III, D.M.2
  • 74
    • 0032716382 scopus 로고    scopus 로고
    • Nucleotide excision repair: From E. coli to man
    • 2-s2.0-0032716382 10.1016/S0300-9084(99)80034-0
    • Petit C., Sancar A., Nucleotide excision repair: from E. coli to man. Biochimie 1999 81 1-2 15 25 2-s2.0-0032716382 10.1016/S0300-9084(99)80034-0
    • (1999) Biochimie , vol.81 , Issue.1-2 , pp. 15-25
    • Petit, C.1    Sancar, A.2
  • 75
    • 3943107573 scopus 로고    scopus 로고
    • Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints
    • DOI 10.1146/annurev.biochem.73.011303.073723
    • Sancar A., Lindsey-Boltz L. A., Ünsal-Kamaz K., Linn S., Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annual Review of Biochemistry 2004 73 39 85 2-s2.0-3943107573 10.1146/annurev.biochem.73. 011303.073723 (Pubitemid 39050363)
    • (2004) Annual Review of Biochemistry , vol.73 , pp. 39-85
    • Sancar, A.1    Lindsey-Boltz, L.A.2    Unsal-Kacmaz, K.3    Linn, S.4
  • 76
    • 38149049320 scopus 로고    scopus 로고
    • Repair of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA pyridyloxobutylation by nucleotide excision repair
    • 2-s2.0-38149049320 10.1016/j.canlet.2007.10.015
    • Brown P. J., Bedard L. L., Massey T. E., Repair of 4-(methylnitrosamino)- 1-(3-pyridyl)-1-butanone-induced DNA pyridyloxobutylation by nucleotide excision repair. Cancer Letters 2008 260 1-2 48 55 2-s2.0-38149049320 10.1016/j.canlet.2007.10.015
    • (2008) Cancer Letters , vol.260 , Issue.1-2 , pp. 48-55
    • Brown, P.J.1    Bedard, L.L.2    Massey, T.E.3
  • 77
    • 0020394578 scopus 로고
    • Hypersensitivity to mutation and sister-chromatid-exchange induction in CHO cell mutants defective in incising DNA containing UV lesions
    • DOI 10.1007/BF01543017
    • Thompson L. H., Brookman K. W., Dillehay L. E., Hypersensitivity to mutation and sister-chromatid-exchange induction in CHO cell mutants defective in incising DNA containing UV lesions. Somatic Cell Genetics 1982 8 6 759 773 2-s2.0-0020394578 (Pubitemid 13167399)
    • (1982) Somatic Cell Genetics , vol.8 , Issue.6 , pp. 759-773
    • Thompson, L.H.1    Brookman, K.W.2    Dillehay, L.E.3
  • 79
    • 0024063562 scopus 로고
    • In vivo effect of DNA repair on the transition frequency produced from a single O6 -methyl-or O6 -n-butyl-guanine in a T:G base pair
    • 2-s2.0-0024063562 10.1007/BF00339598
    • Chambers R. W., Sledziewska-Gojska E., Hirani-Hojatti S., In vivo effect of DNA repair on the transition frequency produced from a single O6 -methyl-or O6 -n-butyl-guanine in a T:G base pair. Molecular & General Genetics 1988 213 2-3 325 331 2-s2.0-0024063562 10.1007/BF00339598
    • (1988) Molecular & General Genetics , vol.213 , Issue.2-3 , pp. 325-331
    • Chambers, R.W.1    Sledziewska-Gojska, E.2    Hirani-Hojatti, S.3
  • 80
    • 0032945635 scopus 로고    scopus 로고
    • Nucleotide excision repair modulates the cytotoxic and mutagenic effects of N-n-butyl-N-nitrosourea in cultured mammalian cells as well as in mouse splenocytes in vivo
    • DOI 10.1093/mutage/14.3.317
    • Bol S. A. M., van Steeg H., van Oostrom C. T. H. M., Tates A. D., Vrieling H., De Groot A. J. L., Mullenders L. H. F., Van Zeeland A. A., Jansen J. G., Nucleotide excision repair modulates the cytotoxic and mutagenic effects of N -butyl- N -nitrosourea in cultured mammalian cells as well as in mouse splenocytes in vivo. Mutagenesis 1999 14 3 317 322 2-s2.0-0032945635 10.1093/mutage/14.3.317 (Pubitemid 29219016)
    • (1999) Mutagenesis , vol.14 , Issue.3 , pp. 317-322
    • Bol, S.A.M.1    Van Steeg, H.2    Van Oostrom, C.Th.M.3    Tates, A.D.4    Vrieling, H.5    De Groot, A.J.L.6    Mullenders, L.H.F.7    Van Zeeland, A.A.8    Jansen, J.G.9
  • 81
    • 0023004256 scopus 로고
    • A comparison of cell survival, mutation and persistence of putative promutagenic lesions in Chinese hamster cells exposed to BNU or MNU
    • 2-s2.0-0023004256
    • Boyle J. M., Saffhill R., Margison G. P., Fox M., A comparison of cell survival, mutation and persistence of putative promutagenic lesions in Chinese hamster cells exposed to BNU or MNU. Carcinogenesis 1986 7 12 1981 1985 2-s2.0-0023004256
    • (1986) Carcinogenesis , vol.7 , Issue.12 , pp. 1981-1985
    • Boyle, J.M.1    Saffhill, R.2    Margison, G.P.3    Fox, M.4
  • 82
    • 0022989738 scopus 로고
    • Evidence for the excision repair of O6 -n-butyldeoxyguanosine in human cells
    • 2-s2.0-0022989738
    • Boyle J. M., Margison G. P., Saffhill R., Evidence for the excision repair of O6 -n-butyldeoxyguanosine in human cells. Carcinogenesis 1986 7 12 1987 1990 2-s2.0-0022989738
    • (1986) Carcinogenesis , vol.7 , Issue.12 , pp. 1987-1990
    • Boyle, J.M.1    Margison, G.P.2    Saffhill, R.3
  • 84
    • 0033513097 scopus 로고    scopus 로고
    • Mismatch repair processing of carcinogen-DNA adducts triggers apoptosis
    • Wu J., Gu L., Wang H., Geacintov N. E., Li G.-M., Mismatch repair processing of carcinogen-DNA adducts triggers apoptosis. Molecular and Cellular Biology 1999 19 12 8292 8301 2-s2.0-0033513097 (Pubitemid 30414023)
    • (1999) Molecular and Cellular Biology , vol.19 , Issue.12 , pp. 8292-8301
    • Wu, J.1    Gu, L.2    Wang, H.3    Geacintov, N.E.4    Li, G.-M.5
  • 85
    • 0242331221 scopus 로고    scopus 로고
    • Mechanisms of human DNA repair: An update
    • DOI 10.1016/S0300-483X(03)00287-7
    • Christmann M., Tomicic M. T., Roos W. P., Kaina B., Mechanisms of human DNA repair: an update. Toxicology 2003 193 1-2 3 34 2-s2.0-0242331221 10.1016/S0300-483X(03)00287-7 (Pubitemid 37340141)
    • (2003) Toxicology , vol.193 , Issue.1-2 , pp. 3-34
    • Christmann, M.1    Tomicic, M.T.2    Roos, W.P.3    Kaina, B.4
  • 86
    • 0035902108 scopus 로고    scopus 로고
    • Genome maintenance mechanisms for preventing cancer
    • DOI 10.1038/35077232
    • Hoeijmakers J. H. J., Genome maintenance mechanisms for preventing cancer. Nature 2001 411 6835 366 374 2-s2.0-0035902108 10.1038/35077232 (Pubitemid 32467046)
    • (2001) Nature , vol.411 , Issue.6835 , pp. 366-374
    • Hoeijmakers, J.H.J.1
  • 87
    • 27144560291 scopus 로고    scopus 로고
    • 6-pyridyloxobutylguanine adducts contribute to the mutagenic properties of pyridyloxobutylating agents
    • DOI 10.1021/tx050139t
    • 6 -pyridyloxobutylguanine adducts contribute to the mutagenic properties of pyridyloxobutylating agents. Chemical Research in Toxicology 2005 18 10 1619 1625 2-s2.0-27144560291 10.1021/tx050139t (Pubitemid 41504483)
    • (2005) Chemical Research in Toxicology , vol.18 , Issue.10 , pp. 1619-1625
    • Mijal, R.S.1    Loktionova, N.A.2    Vu, C.C.3    Pegg, A.E.4    Peterson, L.A.5
  • 88
    • 41949114939 scopus 로고    scopus 로고
    • Mgmt deficiency alters the in vivo mutational spectrum of tissues exposed to the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)
    • DOI 10.1093/carcin/bgn030
    • Sandercock L. E., Hahn J. N., Li L., Luchman H., Giesbrecht J. L., Peterson L. A., Jirik F. R., Mgmt deficiency alters the in vivo mutational spectrum of tissues exposed to the tobacco carcinogen 4-(methylnitrosamino)-1- (3-pyridyl)-1-butanone (NNK). Carcinogenesis 2008 29 4 866 874 2-s2.0-41949114939 10.1093/carcin/bgn030 (Pubitemid 351505884)
    • (2008) Carcinogenesis , vol.29 , Issue.4 , pp. 866-874
    • Sandercock, L.E.1    Hahn, J.N.2    Li, L.3    Luchman, H.4    Giesbrecht, J.L.5    Peterson, L.A.6    Jirik, F.R.7
  • 89
    • 0035422061 scopus 로고    scopus 로고
    • Interactions between methylating and pyridyloxobutylating agents in A/J mouse lungs: Implications for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone- induced lung tumorigenesis
    • Peterson L. A., Thomson N. M., Crankshaw D. L., Donaldson E. E., Kenney P. J., Interactions between methylating and pyridyloxobutylating agents in A/J mouse lungs: implications for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone- induced lung tumorigenesis. Cancer Research 2001 61 15 5757 5763 2-s2.0-0035422061 (Pubitemid 32769091)
    • (2001) Cancer Research , vol.61 , Issue.15 , pp. 5757-5763
    • Peterson, L.A.1    Thomson, N.M.2    Crankshaw, D.L.3    Donaldson, E.E.4    Kenney, P.J.5
  • 90
    • 63549086512 scopus 로고    scopus 로고
    • In vivo treatment with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces organ-specific alterations in in vitro repair of DNA pyridyloxobutylation
    • 2-s2.0-63549086512 10.1016/j.mrfmmm.2008.12.008
    • Brown P. J., Massey T. E., In vivo treatment with 4-(methylnitrosamino)- 1-(3-pyridyl)-1-butanone (NNK) induces organ-specific alterations in in vitro repair of DNA pyridyloxobutylation. Mutation Research 2009 663 1-2 15 21 2-s2.0-63549086512 10.1016/j.mrfmmm.2008.12.008
    • (2009) Mutation Research , vol.663 , Issue.1-2 , pp. 15-21
    • Brown, P.J.1    Massey, T.E.2
  • 91
    • 0020954912 scopus 로고
    • Effects of -deuterium substitution on the mutagenicity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)
    • Hecht S. S., Lin D., Castonguay A., Effects of α -deuterium substitution on the mutagenicity of 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanone (NNK). Carcinogenesis 1983 4 3 305 310 2-s2.0-0020954912 (Pubitemid 13091947)
    • (1983) Carcinogenesis , vol.4 , Issue.3 , pp. 305-310
    • Hecht, S.S.1    Lin, D.2    Castonguay, A.3
  • 92
    • 0026532087 scopus 로고
    • Analysis of mutagenic activity and ability to induce replication of polyoma DNA sequences by different model metabolites of the carcinogenic tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
    • 2-s2.0-0026532087 10.1016/0165-1218(92)90250-4
    • Foiles P. G., Petersen L. A., Miglietta L. M., Ronai Z., Analysis of mutagenic activity and ability to induce replication of polyoma DNA sequences by different model metabolites of the carcinogenic tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Mutation Research 1992 279 2 91 101 2-s2.0-0026532087 10.1016/0165-1218(92)90250-4
    • (1992) Mutation Research , vol.279 , Issue.2 , pp. 91-101
    • Foiles, P.G.1    Petersen, L.A.2    Miglietta, L.M.3    Ronai, Z.4
  • 93
    • 0036174214 scopus 로고    scopus 로고
    • 6-[4-oxo-4-(3-pyridyl)butyl]guanine in Escherichia coli and human cells
    • DOI 10.1021/tx0101245
    • Pauly G. T., Peterson L. A., Moschel R. C., Mutagenesis by O6 -[4-oxo-4-(3-pyridyl)butyl]guanine in Escherichia coli and human cells. Chemical Research in Toxicology 2002 15 2 165 169 2-s2.0-0036174214 10.1021/tx0101245 (Pubitemid 34163796)
    • (2002) Chemical Research in Toxicology , vol.15 , Issue.2 , pp. 165-169
    • Pauly, G.T.1    Peterson, L.A.2    Moschel, R.C.3
  • 94
    • 0020533372 scopus 로고
    • Revised methods for the Salmonella mutagenicity test
    • Maron D. M., Ames B. N., Revised methods for the salmonella mutagenicity test. Mutation Research 1983 113 3-4 173 215 2-s2.0-0020533372 (Pubitemid 13120319)
    • (1983) Mutation Research , vol.113 , Issue.3-4 , pp. 173-215
    • Maron, D.M.1    Ames, B.N.2
  • 95
    • 0028913793 scopus 로고
    • Construction and characterization of mutants of Salmonella typhimurium deficient in DNA repair of O6 -methylguanine
    • 2-s2.0-0028913793
    • Yamada M., Sedgwick B., Sofuni T., Nohmi T., Construction and characterization of mutants of Salmonella typhimurium deficient in DNA repair of O6 -methylguanine. Journal of Bacteriology 1995 177 6 1511 1519 2-s2.0-0028913793
    • (1995) Journal of Bacteriology , vol.177 , Issue.6 , pp. 1511-1519
    • Yamada, M.1    Sedgwick, B.2    Sofuni, T.3    Nohmi, T.4
  • 96
    • 0026595075 scopus 로고
    • In vitro DNA replication implicates O2-ethyldeoxythymidine in transversion mutagenesis by ethylating agents
    • 2-s2.0-0026595075
    • Bhanot O. S., Grevatt P. C., Donahue J. M., Gabrielides C. N., Solomon J. J., In vitro DNA replication implicates O2-ethyldeoxythymidine in transversion mutagenesis by ethylating agents. Nucleic Acids Research 1992 20 3 587 594 2-s2.0-0026595075
    • (1992) Nucleic Acids Research , vol.20 , Issue.3 , pp. 587-594
    • Bhanot, O.S.1    Grevatt, P.C.2    Donahue, J.M.3    Gabrielides, C.N.4    Solomon, J.J.5
  • 97
    • 23344438775 scopus 로고    scopus 로고
    • Base excision repair intermediates are mutagenic in mammalian cells
    • DOI 10.1093/nar/gki749
    • Simonelli V., Narciso L., Dogliotti E., Fortini P., Base excision repair intermediates are mutagenic in mammalian cells. Nucleic Acids Research 2005 33 14 4404 4411 2-s2.0-23344438775 10.1093/nar/gki749 (Pubitemid 41222555)
    • (2005) Nucleic Acids Research , vol.33 , Issue.14 , pp. 4404-4411
    • Simonelli, V.1    Narciso, L.2    Dogliotti, E.3    Fortini, P.4
  • 98
    • 0027333129 scopus 로고
    • G to A transitions and G to T transversions in codon 12 of the Ki- ras oncogene isolated from mouse lung tumors induced by 4-(methylnitrosamino)-1-(3- pyridyl)-1-butanone (NNK) and related DNA methylating and pyridyloxobutylating agents
    • 2-s2.0-0027333129
    • Ronai Z. A., Gradia S., Peterson L. A., Hecht S. S., G to A transitions and G to T transversions in codon 12 of the Ki- ras oncogene isolated from mouse lung tumors induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and related DNA methylating and pyridyloxobutylating agents. Carcinogenesis 1993 14 11 2419 2422 2-s2.0-0027333129
    • (1993) Carcinogenesis , vol.14 , Issue.11 , pp. 2419-2422
    • Ronai, Z.A.1    Gradia, S.2    Peterson, L.A.3    Hecht, S.S.4
  • 99
    • 0032697598 scopus 로고    scopus 로고
    • Mutagenesis induced by oral carcinogens in lacZ mouse (Muta(TM)Mouse) tongue and other oral tissues
    • DOI 10.1093/carcin/20.11.2167
    • von Pressentin M. D. M., Kosinska W., Guttenplan J. B., Mutagenesis induced by oral carcinogens in lacZ mouse (MutaMouse) tongue and other oral tissues. Carcinogenesis 1999 20 11 2167 2170 2-s2.0-0032697598 10.1093/carcin/20.11.2167 (Pubitemid 29535320)
    • (1999) Carcinogenesis , vol.20 , Issue.11 , pp. 2167-2170
    • Von Pressentin, M.D.M.1    Kosinska, W.2    Guttenplan, J.B.3
  • 100
    • 0035133407 scopus 로고    scopus 로고
    • Mutagenesis induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanose -4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N-nitrosonornicotine in lacZ upper aerodigestive tissue and liver and inhibition by green tea
    • von Pressentin M. D. M., Chen M., Guttenplan J. B., Mutagenesis induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanose-4-(methylnitrosamino)-1-(3- pyridyl)-1-butanone and N-nitrosonornicotine in lacZ upper aerodigestive tissue and liver and inhibition by green tea. Carcinogenesis 2001 22 1 203 206 2-s2.0-0035133407 (Pubitemid 32098164)
    • (2001) Carcinogenesis , vol.22 , Issue.1 , pp. 203-206
    • Von Pressentin, M.D.M.1    Chen, M.2    Guttenplan, J.B.3
  • 101
    • 2442619404 scopus 로고    scopus 로고
    • Mutations induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in the lacZ and cII genes of Muta Mouse
    • DOI 10.1016/j.mrgentox.2004.02.010, PII S1383571804000518
    • Hashimoto K., Ohsawa K.-I., Kimura M., Mutations induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in the lacZ and cII genes of Muta Mouse. Mutation Research 2004 560 2 119 131 2-s2.0-2442619404 10.1016/j.mrgentox.2004.02.010 (Pubitemid 38638789)
    • (2004) Mutation Research - Genetic Toxicology and Environmental Mutagenesis , vol.560 , Issue.2 , pp. 119-131
    • Hashimoto, K.1    Ohsawa, K.-I.2    Kimura, M.3
  • 103
    • 0031816428 scopus 로고    scopus 로고
    • DNA adducts, mutant frequencies and mutation spectra in lacZ transgenic mice treated with N-nitrosodimethylamine
    • DOI 10.1093/carcin/19.5.731
    • Souliotis V. L., van Delft J. H. M., Steenwinkel M.-J. S. T., Baan R. A., Kyrtopoulos S. A., DNA adducts, mutant frequencies and mutation spectra in λ lacZ transgenic mice treated with N -nitrosodimethylamine. Carcinogenesis 1998 19 5 731 739 2-s2.0-0031816428 10.1093/carcin/19.5.731 (Pubitemid 28376761)
    • (1998) Carcinogenesis , vol.19 , Issue.5 , pp. 731-739
    • Souliotis, V.L.1    Van Delft, J.H.M.2    Steenwinkel, M.-J.S.T.3    Baan, R.A.4    Kyrtopoulos, S.A.5
  • 104
    • 0034683670 scopus 로고    scopus 로고
    • Mutant frequencies and mutation spectra of dimethylnitrosamine (DMN) at the lacI and cII loci in the livers of Big Blue transgenic mice
    • 2-s2.0-0034683670 10.1016/S0027-5107(00)00081-6
    • Shane B. S., Smith-Dunn D. L., de Boer J. G., Glickman B. W., Cunningham M. L., Mutant frequencies and mutation spectra of dimethylnitrosamine (DMN) at the lacI and cII loci in the livers of Big Blue transgenic mice. Mutation Research 2000 452 2 197 210 2-s2.0-0034683670 10.1016/S0027-5107(00)00081-6
    • (2000) Mutation Research , vol.452 , Issue.2 , pp. 197-210
    • Shane, B.S.1    Smith-Dunn, D.L.2    De Boer, J.G.3    Glickman, B.W.4    Cunningham, M.L.5


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