Comparative levels of O6-methylguanine, pyridyloxobutyl-, and pyridylhydroxybutyl-DNA adducts in lung and liver of rats treated chronically with the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanone

Drug Metabolism and Disposition

Volumn 37, Issue 6, 2009, Pages 1147-1151

  Upadhyaya, Pramod ^a   Lindgren, Bruce R ^a   Hecht, Stephen S ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 O [4 (3 PYRIDYL) 4 OXOBUT 1 YL]THYMIDINE; 4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANONE; 6 O METHYLGUANINE; CIGARETTE SMOKE; DNA; THYMIDINE DERIVATIVE; UNCLASSIFIED DRUG; 4-(N-METHYL-N-NITROSAMINO)-1-(3-PYRIDYL)-1-BUTANONE; CARCINOGEN; DRUG DERIVATIVE; GUANINE; NITROSAMINE; O (6) METHYLGUANINE; O-(6)-METHYLGUANINE;

ANIMAL TISSUE; ARTICLE; CHEMICAL CARCINOGENESIS; CIGARETTE SMOKING; CONTROLLED STUDY; DNA ADDUCT; ELECTROSPRAY MASS SPECTROMETRY; LIVER; LUNG; NONHUMAN; PRIORITY JOURNAL; RAT; TANDEM MASS SPECTROMETRY; TOXICOKINETICS; ANIMAL; CHEMICALLY INDUCED DISORDER; CHEMISTRY; DRUG EFFECT; FISCHER 344 RAT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LUNG TUMOR; METABOLISM; TOBACCO;

NICOTIANA TABACUM; RATTUS;

ANIMALS; CARCINOGENS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DNA ADDUCTS; GUANINE; LIVER; LUNG; LUNG NEOPLASMS; NITROSAMINES; RATS; RATS, INBRED F344; TOBACCO;

EID: 66649088331     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.109.027078     Document Type: Article

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