Analysis of pyridyloxobutyl and pyridylhydroxybutyl DNA adducts in extrahepatic tissues of F344 rats treated chronically with 4-(methylnitrosamino) -1-(3-pyridyl)-1-butanone and enantiomers of 4-(methylnitrosamino)-1-(3-pyridyl) -1-butanol

Chemical Research in Toxicology

Volumn 22, Issue 5, 2009, Pages 926-936

  Zhang, Siyi ^a   Wang, Mingyao ^a   Villalta, Peter W ^a   Lindgren, Bruce R ^a   Upadhyaya, Pramod ^a   Lao, Yanbin ^a,b   Hecht, Stephen S ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANOL; 4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANONE; 7 [4 (3 PYRIDYL) 4 HYDROXYBUT 1 YL]GUANINE; 7 [4 (3 PYRIDYL) 4 OXOBUT 1 YL]GUANINE; BUTYLATE; CYTOCHROME P450; O 2 [4 (3 PYRIDYL) 4 HYDROXYBUT 1 YL]THYMIDINE; O 2 [4 (3 PYRIDYL) 4 OXOBUT 1 YL]THYMIDINE; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA ADDUCT; ENANTIOMER; FISCHER 344 RAT; LIVER; MALE; MOUTH MUCOSA; NONHUMAN; OLFACTORY EPITHELIUM; RAT; RESPIRATORY TRACT MUCOSA;

ADMINISTRATION, ORAL; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DNA ADDUCTS; MALE; NITROSAMINES; ORGAN SPECIFICITY; PYRIDINES; RATS; RATS, INBRED F344; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STEREOISOMERISM;

NICOTIANA TABACUM; RATTUS;

EID: 67649921189     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx900015d     Document Type: Article

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