Mutant frequencies and mutation spectra of dimethylnitrosamine (DMN) at the lacI and cII loci in the livers of Big Blue® transgenic mice

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 452, Issue 2, 2000, Pages 197-210

  Shane, B S ^a   Smith Dunn, D L ^a   De Boer, J G ^b   Glickman, B W ^b   Cunningham, M L ^c  

^a LOUISIANA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF VICTORIA   (Canada)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

cII assay; Big Blue transgenic mice; Dimethylnitrosamine; lacI assay

Indexed keywords

DIMETHYLNITROSAMINE; GENE PRODUCT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASE PAIRING; CONTROLLED STUDY; GENE LOCUS; GENE MUTATION; GENOTOXICITY; MALE; MOUSE; MUTATION RATE; NONHUMAN; PRIORITY JOURNAL; SPONTANEOUS MUTATION; TRANSGENIC MOUSE;

ANIMAL; BACTERIAL PROTEINS; BASE SEQUENCE; DIMETHYLNITROSAMINE; DNA PRIMERS; LIVER; MALE; MICE; MICE, TRANSGENIC; MUTAGENS; MUTATION; REPRESSOR PROTEINS; SUPPORT, U.S. GOV'T, P.H.S.; TRANSCRIPTION FACTORS;

EID: 0034683670     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(00)00081-6     Document Type: Article

References (66)

1. Jacubczack J.L., Merlino G., French J.E., Muller W.J., Paul B., Adhya S., Garges S. Analysis of genetic instability during mammary tumor progression using a novel selection based assay for in vivo mutations in a bacteriophage λ transgene target. Proc. Natl. Acad. Sci. 93:1996;9073-9078.
2. Monroe J.J., Kort J.J., Miller J.E., Marino D.R., Skopek T.R. A comparative study of in vivo mutation assays: analysis of hprt, lacI and cII/cI as mutational targets for N-nitroso-N-methylurea and benzo[a]pyrene in Big Blue™ mice. Mutat. Res. 421:1998;121-136.
3. ® mice. Carcinogenesis. 21:2000;715-725.
4. DeMarini D.M., Shelton M.L., Bell D.A. Mutation spectra in Salmonella of complex mixtures: comparison of urban air to benzo[a]pyrene. Environ. Mol. Mutagen. 24:1994;262-275.
5. ® mice. Environ. Mol. Mutagen. 33:1999;249-256.
6. ® transgenic mice. Environ. Mol. Mutagen. 33:1999;132-143.
7. deBoer J.G., Erfle H., Walsh D., Holcroft J., Provost J.S., Rogers B., Tindall K.R., Glickman B.W. Spectrum of spontaneous mutations in liver tissue of lacI transgenic mice. Environ. Mol. Mutagen. 30:1997;273-286.
8. ® rat 2 embryonic fibroblasts. Mutagenesis. 13:1998;487-497.
9. W. Lijinsky, Chemistry and Biology of N-Nitroso Compounds, Cambridge University Press, Cambridge, UK, 1992.
10. International Agency for Research in Cancer, Monographs on the Evaluation of the Carcinogenic Risks to Humans, IARC Scientific Publications, Lyon, France, 17 (1978) pp. 125-173.
11. Magee P.N., Farber E. Toxic liver injury and carcinogenesis-methylation of rat-liver nucleic acids by dimethylnitrosamine in vitro. Biochem. J. 83:1962;106-114.
12. Hotckiss J.H. Preformed N-nitroso compounds in foods and beverages. Cancer Surv. 8:1989;295-321.
13. Hecht S.S., Hoffman D. The relevance of tobacco-specific nitrosamines to human cancer. Cancer Surv. 8:1989;273-294.
14. Poirier S., Ohshima H., de The G., Hubert A., Bourgade M.C., Bartsch H. Volatile nitrosamine levels in common foods from Tunisia, South China and Greenland: high risk areas for nasopharyngeal carcinoma (NPC). Int. J. Cancer. 39:1987;293-296.
15. Biaudet H., Mavelle T., Debry G. Mean daily intake of N-nitrosodimethylamine from foods and beverages in France in 1987-1992. Food Chem. Toxicol. 32:1994;417-421.
16. Xu G.P., Reed P.I. N-nitroso compounds in fresh gastric juice and their relation to intragastric pH and nitrite employing an improved analytical method. Carcinogenesis. 14:1993;2547-2551.
17. Marletta M.A. Mammalian synthesis of nitrite, nitrate, nitric oxide and N-nitrosating agents. Chem. Res. Toxicol. 1:1988;249-257.
18. Leaf C.D., Wishnok J.S., Tannenbaum S.R. Mechanisms of endogenous nitrosation. Cancer Surv. 8:1989;323-334.
19. Gonzalez C.A., Riboli E., Badosa J., Batiste E., Cardona T., Pita S., SanzTorrent J.M., Agudo A. Nutritional factors and gastric cancer in Spain. Am. J. Epidemiol. 139:1994;466-473.
20. Rogers M.A.M., Vaughn T.L., Davis S., Thomas D.B. Consumption of nitrate, nitrite and nitrosodimethylamine and the risk of upper aerodigestive tract cancer. Cancer Epidemiol. Biomark. Prev. 4:1995;29-36.
21. DeStefani E., Deneo-Pellegrini H., Carzoglio J.C., Ronco A., Medilaharsu M. Dietary nitrosodimethylamine and the risk of lung cancer: a case-control study from Uruguay. Cancer Epidemiol. Biomark. Prev. 4:1996;29-36.
22. Claxton L.D., Morin R.S., Hughes T.J., Lewtas J.A. Genotoxic assessment of environmental tobacco smoke using bacterial bioassays. Mutat. Res. 222:1989;81-99.
23. Matsumoto K., Iwase T., Hirono I., Nishida Y., Iwahori Y., Hori T., Asamoto M., Takasuke N., Kim D.J., Ushijima T., Nagao M., Tsuda H. Demonstration of ras and p53 gene mutations in carcinomas in the forestomach and intestine and soft tissue sarcomas induced by N-methyl-N-nitrosourea in the rat. Jpn. J. Cancer Res. 88:1997;129-136.
24. Chang K.W., Lin S.C., Koos S., Pather K., Solt D. p53 and Ha ras mutations in chemically-induced hamster buccal pouch carcinomas. Carcinogenesis. 17:1996;595-600.
25. Wang D., Weghorst C.M., Calvert R.J., Stoner G.D. Mutation in the p53 tumor suppressor gene in rat esophageal papillomas induced by N-nitrosomethylbenzylamine. Carcinogenesis. 17:1996;625-630.
26. Belinsky S.A., Devereux T.R., Anderson M.W. Role of DNA methylation in the activation of proto-oncogenes and the induction of pulmonary neoplasia by nitrosamines. Mutat. Res. 233:1990;105-116.
27. Maltzman T.H., Mueller B.A., Schroeder J., Rutledge J.C., Patterson K., Preston-Martin S., Faustman E.M. Ras oncogene mutations in childhood brain tumors. Cancer Epidemiol. Biomark. Prev. 6:1997;239-243.
28. Hsieh L.L., Hsieh J.T., Wang L.Y., Fang C.Y., Chang S.H., Chen T.C. P53 mutations in gastric cancers from Taiwan. Cancer Lett. 100:1996;107-113.
29. Liang Y.Y., Esteve A., Martel-Planche G., Takahashi S., Lu S.H., Montesano R., Hollstein M. P53 mutations in esophageal tumors from high-incidence areas of China. Int. J. Cancer. 61:1995;611-614.
30. Warren W., Biggs P.J., el-Baz M., Ghoneim M.A., Stratton M.R., Venitt S. Mutations in the p53 gene in schistosomal bladder cancer: a study of 92 tumors from Egyptian patients and a comparison between mutational spectra from schistosomal and non-schistosomal urothelial tumours. Carcinogenesis. 16:1995;1181-1189.
31. ® transgenic mice. Carcinogenesis. 20:1999;1315-1321.
32. ® transgenic animals. Environ. Mol. Mutagen. 28:1997;393-396.
33. Adams W.T., Skopek T.R. Statistical test for the comparison of samples from mutational spectra. J. Mol. Biol. 194:1987;391-396.
34. Gollapudi B.B., Jackson K.M., Stott W.T. Hepatic lacI and cII mutation in transgenic (λLIZ) rats treated with dimethylnitrosamine. Mutat. Res. 419:1998;131-135.
35. Nouso K., Thorgeirsson S.S., Battula N. Stable expression of human cytochrome P450IIE1 in mammalian cells: metabolic activation of nitrosodimethylamine and formation of adducts with cellular DNA. Cancer Res. 52:1992;1796-1800.
36. Yoo J.S., Ishizaki H., Yang C.S. Roles of cytochrome P450 IIE1 in the dealkylation and denitrosation of N-nitrosodimethylamine and N-nitrosodiethylamine in rat liver microsomes. Carcinogenesis. 11:1990;2239-2243.
37. 5. Arch. Biochem. Biophys. 248:1986;158-165.
38. Singer B. Sites in nucleic acids reacting with alkylating agents of differing carcinogenicity or mutagenicity. J. Toxicol. Environ. Hlth. 2:1977;1279-1295.
39. Beranek D.T. Distribution of methyl and ethyl adducts following alkylation with monofunctional alkylating agents. Mutat. Res. 231:1990;11-30.
40. Takeshita M., Eisenberg W. Mechanism of mutation on DNA templates containing synthetic abasic sites: study with a double strand vector. Nucleic Acid Res. 22:1994;1897-1902.
41. 6-methylguanine built into a unique site in a viral genome. Proc. Natl Acad. Sci. USA. 81:1984;6271-6275.
42. 6-methylguanine in DNA-the crucial role of the conformation of the phosphodiester bond. Biochemistry. 33:1994;5335-5346.
43. 6-substituted guanines in double-stranded or gapped plasmids. Biochemistry. 34:1995;8924-8930.
44. 6-methylguanine in the human Ha-ras oncogene in E.coli and in vitro. Nucleic Acid Res. 22:1994;3846-3853.
45. Jansen J.G., Mohn G.R., Vrieling H., van Teijlingen C.M., Lohman P.H., van Zeeland A.A. Molecular analysis of hprt gene mutations in skin fibroblasts of rats exposed in vivo to N-methyl-N-nitrosourea or N-ethyl-N-nitrosourea. Cancer Res. 54:1994;2478-2485.
46. Horsfall M.J., Zeilmaker M.J., Mohn G.R., Glickman B.W. Mutational specificities of environmental carcinogens in the lac I gene of Escherichia coli, II. A host-mediated approach to N-nitroso-N,N-dimethylamine and endogenous mutagenesis in vivo. Mol. Carcinogenesis. 2:1989;107-115.
47. Jiao J., Glickman B.W., Anderson M.W., Zielinska M. Mutational specificity of N-nitrosodimethylamine: comparison between in vivo and in vitro assays. Mutat. Res. 301:1993;27-31.
48. Souliotis V., van Delft J.H.M., Steenwinkel M.S.T., Baan R.A., Kyrtopoulos S.A. DNA adducts, mutant frequencies and mutation spectra in λlacZ transgenic mice treated with N-nitrosodimethylamine. Carcinogenesis. 19:1998;731-739.
49. Nelson M.A., Wymer J., Clements N. Jr. Detection of K-ras mutations in non-neoplastic lung tissue and lung cancers. Cancer Lett. 103:1996;115-121.
50. Dobo K.L., Eastmond D.A., Grosovsky A.J. Sequence specific mutations induced by N-nirosodimethylamine at two marker loci in metabolically competent human lymphoblastoid cells. Carcinogenesis. 19:1998;755-764.
51. Nivard M.J., Pastink A., Vogel E.W. Mutational spectra induced under distinct excision repair conditions by three methylating agents N-methyl-N-nitrosourea, N-methyl-N′-nitro-N-nitrosoguanidine and N-nitrosodimethylamine in postmeiotic male germ cells of Drosophila. Mutat. Res. 352:1996;97-115.
52. 6-methylguanine-DNA methyltransferase (MGMT) cDNA in Chinese hamster cells: the role of MGMT in protection against the genotoxic effects of alkylating agents. Carcinogenesis. 12:1991;1857-1867.
53. Maher V.M., Domoradzki J., Battacharyya N.P., Tsujimura T., Corner R.C., McCormick J.J. Alkylation damage, DNA repair and mutagenesis in human cells. Mutat. Res. 233:1990;235-245.
54. 6-methylguanine and A:C and G:T mismatches cause asymmetric structural defects in DNA that are affected by DNA sequence. Biochemistry. 29:1990;5012-5018.
55. 6-methylguanine by mismatch correction in human cell extracts. Curr. Biol. 6:1996;1528-1531.
56. 6-methylguanine in DNA inhibits DNA replication and stimulates DNA repair synthesis in vitro. Ann. NY Acad Sci. 726:1994;340-342.
57. Guttenplan J.B. Effects of cytosol on mutagenesis induced by N-nitrosodimethylamine, N-nitrosomethylurea and alpha-acetoxy-N-nitrosodimethylamine in different strains of Salmonella: evidence for different ultimate mutagens from N-nitrosodimethylamine. Carcinogenesis. 14:1993;1013-1019.
58. Josephy P.D., Lord H.L., Snieckus V.A. Dimethylnitrosamine genotoxicity: does N-acetyltransferase activity play a role? Carcinogenesis. 15:1994;479-482.
59. Graves R.J., Callander R.D., Green T. The role of formaldehyde and S-chloromethylglutathione in the bacterial mutagenicity of methylene chloride. Mutat. Res. 320:1994;235-243.
60. Shaham J., Bomstein Y., Meltzer A., Kaufman Z., Palma E., Ribak J. DNA-protein crosslinks, a biomarker of exposure to formaldehyde: in vitro and in vivo studies. Carcinogenesis. 17:1996;121-125.
61. Ma T.H., Harris M.M. Review of the genotoxcity of formaldehyde. Mutat. Res. 196:1988;37-59.
62. Lieber H.L., Benforado K., Crosby R.M., Simpson D., Skopek T.R. Formaldehyde-induced and spontaneous alterations in human hprt DNA sequence and mRNA expression. Mutat. Res. 226:1989;31-37.
63. Crosby R.M., Richardson K.K., Craft T.R., Benforado K.B., Lieber H.L., Skopek T.R. Molecular analysis of formaldehyde-induced mutations in human lymphoblasts. Environ. Mol. Mutagen. 12:1988;155-166.
64. Dillon D., Combes R., Zeiger E. The effectiveness of Salmonella strains TA100, TA102 and TA104 for detecting mutagenicity of some aldehydes and peroxides. Mutagenesis. 13:1998;19-26.
65. de Boer J.G., Mirsalis J.C., Glickman B.W. The mutational spectrum of dimethylnitrosamine in the liver of three and six week old lacI transgenic mice. Environ Mol. Mutagen. 34:1999;80-83.
66. Yang J.L., Lin J.G., Hu M.C., Wu C.W. Mutagenicity and mutational spectrum of N-methyl-N-nitro-N-nitrosoguanidine in the hprt gene in G1-S and late S-phase of diploid human fibroblasts. Cancer Res. 53:1993;2865-2873.