Analysis of pyridyloxobutyl DNA adducts in F344 rats chronically treated with (R)- and (S)-N′-nitrosonornicotine

Chemical Research in Toxicology

Volumn 20, Issue 2, 2007, Pages 246-256

  Lao, Yanbin ^a   Yu, Nanxiong ^a   Kassie, Fekadu ^a   Villalta, Peter W ^a   Hecht, Stephen S ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7 [4 (3 PYRIDYL) 4 OXBUT 1 YL]GUANINE; CYTOCHROME P450 2A; CYTOCHROME P450 2A3; NITROSONORNICOTINE; O 2 [4 (3 PYRIDYL) 4 OXOBUT 1 YL]CYTOSINE; O 2 [4 (3 PYRIDYL) 4 OXOBUT 1 YL]THMIDINE; O 6 [4 (3 PYRIDYL) 4 OXOBUT 1 YL] 2' DEOXYGUANOSINE; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARCINOGENICITY; CHEMICAL STRUCTURE; CONTROLLED STUDY; DNA ADDUCT; DNA ISOLATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; METABOLISM; NONHUMAN; RAT; TOXICOKINETICS;

ADMINISTRATION, ORAL; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DNA ADDUCTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ESOPHAGUS; LIVER; LUNG; LUNG NEOPLASMS; MALE; MOLECULAR STRUCTURE; NITROSAMINES; PYRIDINES; RATS; RATS, INBRED F344; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STEREOISOMERISM; TIME FACTORS;

RATTUS;

EID: 33947150540     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx060208j     Document Type: Article

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