Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells

EMBO Reports

Volumn 8, Issue 11, 2007, Pages 1052-1060

  Höck, Julia ^a   Weinmann, Lasse ^a   Ender, Christine ^a   Rüdel, Sabine ^a   Kremmer, Elisabeth ^b   Raabe, Monika ^c   Urlaub, Henning ^c   Meister, Gunter ^a  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ARGONAUTE 2 PROTEIN; ARGONAUTE PROTEIN; ARGONAUTE PROTEIN 1; MESSENGER RNA; MICRORNA; RIBONUCLEASE; RIBONUCLEOPROTEIN; RNA BINDING MOTIF PROTEIN 4; RNA BINDING PROTEIN; RNA INDUCED SILENCING COMPLEX; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; GENE CONTROL; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN ISOLATION; PROTEIN RNA BINDING; PROTEOMICS; RNA INTERFERENCE; RNA METABOLISM;

CARBOXYPEPTIDASES; CELL LINE; EUKARYOTIC INITIATION FACTOR-2; EUKARYOTIC INITIATION FACTORS; GENE SILENCING; GENES, REPORTER; HUMANS; MACROMOLECULAR SUBSTANCES; MICRORNAS; PROTEOME; PROTO-ONCOGENE PROTEINS; RAS PROTEINS; RIBONUCLEASE III; RIBONUCLEOPROTEINS; RNA, MESSENGER; RNA-BINDING PROTEINS;

EID: 35748932681     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/sj.embor.7401088     Document Type: Article

References (28)

1. Behm-Ansmant I, Rehwinkel J, Doerks T, Stark A, Bork P, Izaurralde E (2006) mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes. Genes Dev 20: 1885-1898
2. Beitzinger M, Peters L, Zhu JY, Kremmer E, Meister G (2007) Identification of human microRNA targets from isolated Argonaute protein complexes. RNA Biol 4: E1-e9
3. Chu CY, Rana TM (2006) Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54. PLoS Biol 4 e210
4. Eulalio A, Behm-Ansmant I, Izaurralde E (2007a) P bodies: At the crossroads of post-transcriptional pathways. Nat Rev Mol Cell Biol 8: 9-22
5. Eulalio, A, Behm-Ansmant I, Schweizer D, Izaurralde E (2007b),P-body formation is a consequence, not the cause, of RNA-mediated gene silencing. Mol Cell Biol 27: 3970-3981
6. Filipowicz W, Jaskiewicz L, Kolb FA, Pillai RS (2005) Post-transcriptional gene silencing by siRNAs and miRNAs. Curr Opin Struct Biol 15: 331-341
7. Gregory RI, Yan KP, Amuthan G, Chendrimada T, Doratotaj B, Cooch N, Shiekhattar R (2004) The Microprocessor complex mediates the genesis of microRNAs. Nature 432: 235-240
8. Gregory RI, Chenerimada TP, Cooch N, Shiekhattar R (2005) Human RISC couples microRNA biogenesis and posttranscriptional gene silencing Cell 123: 631-640
9. Johnson SM, Grosshans H, Shingara J, Byrom M, Jarvis R, Cheng A, Labourier E, Reiner KL, Brown D, Slack FJ (2005) RAS is regulated by the let-7 microRNA family. Cell 120: 635-647
10. Kim J, Krichevsky A, Graid Y, Hayes GD, Kosik KS, Church GM; Ruvkun G (2004) Identification of many microRNAs that copurify with polyribosomes in mammalian neurons. Pro Natl Acad Sci USA 101: 360-365
11. Kiriakidou M, Tan GS, Lamprinaki S, De Planell-Saguer M, Nelson PT, Mourelatos Z (2007) An mRNA m(7)G cap binding-like motif within human ago2 represses translation. Cell 129: 1141-1151
12. Liu J, Carmell MA, Rivas FV, Marsden CG, Thomson JM, Song JJ, Hammond SM, Joshua-Tor L, Hannon-GJ (2004) Argonaute2 is the catalytic engine of mammalian RNAi. Science 305: 1437-1441
13. Lia J, Valencia-Sanchez MA, Hannon GJ, Parker R (2005) MicroRNA-dependent localizatiorr of targeted mRNAs to mammalian P-bodies. Nat Cell Biol 7: 719-723
14. Maroney PA, Yu Y, Fisher J, Nilsen TW (2006) Evidence that microRNAs are associated with translating messenger RNAs in human cells. Nat Struct Mol Biol 13: 1102-1107
15. Mayr C, Hemann MT, Bartel DP(2007) Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation. Science 315: 1576-1579
16. Meister G, Tuschl T (2004) Mechanisms of gene silencing by double-stranded RNA. Nature 431: 343-349
17. Meister G, Landthaler M, Patkaniowska A, Dorsett Y, Teng G, Tuschl T (2004) Human argonaute2 mediates RNA cleavage targeted by miRNAs, and SiRNAs. Mol Cell 15: 185-197
18. Meister G, Landthaler M, Peters L, Chen PY, Urlaub H, Luhrmann,R, Tuschl T (2005) Identification of novel argonaute-associated proteins. Curr Biol 15: 2149-2155
19. Mourelatos Z, Dostie J, Paushkin S, Sharma A, Charroux B, Abel L, Rappsilber J, Mann M, Dreyfuss G (2002) miRNPs: A novel class of ribonucleoproteins containing numerous microRNAs. Genes Dev 16 720-728
20. Nelson PT, Hatzigeorgiou AG, Mourelatos Z (2004) miRNP:mRNA association in polyribosomes in a human neuronal cell line. RNA 10: 387-394
21. Nottrott S, Simard MJ, Richter JD (2006) Human let-7a miRNA blocks protein production on actively translating polyribosomes, Nat Struct Mol Biol 13: 1108-1114
22. Parker JS, Barford D (2006) Argonaute: A scaffold for the function of short regulatory RNAs. Trends Biochem Sci 31: 622-630
23. Peters L, Meister G (2007) Argonaute proteins: Mediators of RNA silencing. Mol Cell 26: 611-623
24. Pillai RS, Bhattacharyya SN, Artus CG, Zoller T, Cougot N, Basyuk E, Bertrand E, Filipowicz W (2005) Inhibition of translational initiation by let-7 MicroRNA in human cells. Science 309: 1573-1576
25. Pillai RS, Bhattacharyya SN, Filipowicz W (2007) Repression of protein synthesis by miRNAs: How many mechanisms? Trends Cell Biol 17 118-126
26. Robb GB, Rana TM (2007) RNA helicase a interacts with RISC in human cells and functions in RISC loading. Mol Cell 26: 523-537
27. Wu L, Fan J, Belasco JG (2006) MicroRNAs direct rapid deadenylation of mRNA. Proc Natl Acad Sci USA 103: 4034-4039
28. Zamore PD, Haley B (2005) Ribo-gnome: The big world of small RNAs. Science 309: 1519-1524