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Volumn 51, Issue 1, 2011, Pages 106-116

Regulation and roles of PI3Kβ, a major actor in platelet signaling and functions

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Indexed keywords


EID: 79954545891     PISSN: 00652571     EISSN: None     Source Type: Book Series    
DOI: 10.1016/j.advenzreg.2010.09.011     Document Type: Review
Times cited : (64)

References (68)
  • 1
    • 70350389400 scopus 로고    scopus 로고
    • Dominant role of the p110beta isoform of PI3K over p110alpha in energy homeostasis regulation by POMC and AgRP neurons
    • Al-Qassab H., Smith M.A., Irvine E.E., Guillermet-Guibert J., Claret M., Choudhury A.I., et al. Dominant role of the p110beta isoform of PI3K over p110alpha in energy homeostasis regulation by POMC and AgRP neurons. Cell Metab 2009, 10:343-354.
    • (2009) Cell Metab , vol.10 , pp. 343-354
    • Al-Qassab, H.1    Smith, M.A.2    Irvine, E.E.3    Guillermet-Guibert, J.4    Claret, M.5    Choudhury, A.I.6
  • 2
    • 0036185944 scopus 로고    scopus 로고
    • Early embryonic lethality in mice deficient in the p110beta catalytic subunit of PI 3-kinase
    • Bi L., Okabe I., Bernard D.J., Nussbaum R.L. Early embryonic lethality in mice deficient in the p110beta catalytic subunit of PI 3-kinase. Mamm Genome 2002, 13:169-172.
    • (2002) Mamm Genome , vol.13 , pp. 169-172
    • Bi, L.1    Okabe, I.2    Bernard, D.J.3    Nussbaum, R.L.4
  • 3
    • 34548643512 scopus 로고    scopus 로고
    • Phosphoinositide phosphatases in a network of signalling reactions
    • Blero D., Payrastre B., Schurmans S., Erneux C. Phosphoinositide phosphatases in a network of signalling reactions. Pflugers Arch 2007, 455:31-44.
    • (2007) Pflugers Arch , vol.455 , pp. 31-44
    • Blero, D.1    Payrastre, B.2    Schurmans, S.3    Erneux, C.4
  • 4
    • 70349251723 scopus 로고    scopus 로고
    • Genetic evidence for a predominant role of PI3K{beta} catalytic activity in ITAM- and integrin-mediated signaling in platelets
    • Canobbio I., Stefanini L., Cipolla L., Ciraolo E., Gruppi C., Balduini C., et al. Genetic evidence for a predominant role of PI3K{beta} catalytic activity in ITAM- and integrin-mediated signaling in platelets. Blood 2009, 114:2193-2196.
    • (2009) Blood , vol.114 , pp. 2193-2196
    • Canobbio, I.1    Stefanini, L.2    Cipolla, L.3    Ciraolo, E.4    Gruppi, C.5    Balduini, C.6
  • 5
    • 0037205048 scopus 로고    scopus 로고
    • The phosphoinositide 3-kinase pathway
    • Cantley L.C. The phosphoinositide 3-kinase pathway. Science 2002, 296:1655-1657.
    • (2002) Science , vol.296 , pp. 1655-1657
    • Cantley, L.C.1
  • 7
    • 55649084906 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development
    • ra3
    • Ciraolo E., Iezzi M., Marone R., Marengo S., Curcio C., Costa C., et al. Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development. Sci Signal 2008, 1. ra3.
    • (2008) Sci Signal , vol.1
    • Ciraolo, E.1    Iezzi, M.2    Marone, R.3    Marengo, S.4    Curcio, C.5    Costa, C.6
  • 8
    • 77649101891 scopus 로고    scopus 로고
    • Essential role of the p110beta subunit of phosphoinositide 3-OH kinase in male fertility
    • Ciraolo E., Morello F., Hobbs R.M., Wolf F., Marone R., Iezzi M., et al. Essential role of the p110beta subunit of phosphoinositide 3-OH kinase in male fertility. Mol Biol Cell 2010, 21:704-711.
    • (2010) Mol Biol Cell , vol.21 , pp. 704-711
    • Ciraolo, E.1    Morello, F.2    Hobbs, R.M.3    Wolf, F.4    Marone, R.5    Iezzi, M.6
  • 9
    • 65949110376 scopus 로고    scopus 로고
    • PIK3CA and PIK3CB inhibition produce synthetic lethality when combined with estrogen deprivation in estrogen receptor-positive breast cancer
    • Crowder R.J., Phommaly C., Tao Y., Hoog J., Luo J., Perou C.M., et al. PIK3CA and PIK3CB inhibition produce synthetic lethality when combined with estrogen deprivation in estrogen receptor-positive breast cancer. Cancer Res 2009, 69:3955-3962.
    • (2009) Cancer Res , vol.69 , pp. 3955-3962
    • Crowder, R.J.1    Phommaly, C.2    Tao, Y.3    Hoog, J.4    Luo, J.5    Perou, C.M.6
  • 10
    • 33749836234 scopus 로고    scopus 로고
    • Phosphoinositides in cell regulation and membrane dynamics
    • Di Paolo G., De Camilli P. Phosphoinositides in cell regulation and membrane dynamics. Nature 2006, 443:651-657.
    • (2006) Nature , vol.443 , pp. 651-657
    • Di Paolo, G.1    De Camilli, P.2
  • 11
    • 76249092302 scopus 로고    scopus 로고
    • Isoform-specific phosphoinositide 3-kinase inhibitors exert distinct effects in solid tumors
    • Edgar K.A., Wallin J.J., Berry M., Lee L.B., Prior W.W., Sampath D., et al. Isoform-specific phosphoinositide 3-kinase inhibitors exert distinct effects in solid tumors. Cancer Res 2010, 70:1164-1172.
    • (2010) Cancer Res , vol.70 , pp. 1164-1172
    • Edgar, K.A.1    Wallin, J.J.2    Berry, M.3    Lee, L.B.4    Prior, W.W.5    Sampath, D.6
  • 12
    • 57349194139 scopus 로고    scopus 로고
    • Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers
    • Engelman J.A., Chen L., Tan X., Crosby K., Guimaraes A.R., Upadhyay R., et al. Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers. Nat Med 2008, 14:1351-1356.
    • (2008) Nat Med , vol.14 , pp. 1351-1356
    • Engelman, J.A.1    Chen, L.2    Tan, X.3    Crosby, K.4    Guimaraes, A.R.5    Upadhyay, R.6
  • 14
    • 77954710233 scopus 로고    scopus 로고
    • Role of phosphoinositide 3-kinase beta in platelet aggregation and thromboxane A2 generation mediated by Gi signalling pathways
    • Garcia A., Kim S., Bhavaraju K., Schoenwaelder S.M., Kunapuli S.P. Role of phosphoinositide 3-kinase beta in platelet aggregation and thromboxane A2 generation mediated by Gi signalling pathways. Biochem J 2010, 429:369-377.
    • (2010) Biochem J , vol.429 , pp. 369-377
    • Garcia, A.1    Kim, S.2    Bhavaraju, K.3    Schoenwaelder, S.M.4    Kunapuli, S.P.5
  • 15
    • 71749121027 scopus 로고    scopus 로고
    • Non-redundant roles of phosphoinositide 3-kinase isoforms alpha and beta in glycoprotein VI-induced platelet signaling and thrombus formation
    • Gilio K., Munnix I.C., Mangin P., Cosemans J.M., Feijge M.A., van der Meijden P.E., et al. Non-redundant roles of phosphoinositide 3-kinase isoforms alpha and beta in glycoprotein VI-induced platelet signaling and thrombus formation. J Biol Chem 2009, 284:33750-33762.
    • (2009) J Biol Chem , vol.284 , pp. 33750-33762
    • Gilio, K.1    Munnix, I.C.2    Mangin, P.3    Cosemans, J.M.4    Feijge, M.A.5    van der Meijden, P.E.6
  • 16
    • 0041816451 scopus 로고    scopus 로고
    • Integrin alpha IIb beta 3-dependent calcium signals regulate platelet-fibrinogen interactions under flow. Involvement of phospholipase C gamma 2
    • Goncalves I., Hughan S.C., Schoenwaelder S.M., Yap C.L., Yuan Y., Jackson S.P. Integrin alpha IIb beta 3-dependent calcium signals regulate platelet-fibrinogen interactions under flow. Involvement of phospholipase C gamma 2. J Biol Chem 2003, 278:34812-34822.
    • (2003) J Biol Chem , vol.278 , pp. 34812-34822
    • Goncalves, I.1    Hughan, S.C.2    Schoenwaelder, S.M.3    Yap, C.L.4    Yuan, Y.5    Jackson, S.P.6
  • 17
    • 51549083000 scopus 로고    scopus 로고
    • Different roles of SHIP1 according to the cell context: the example of blood platelets
    • Gratacap M.P., Severin S., Chicanne G., Plantavid M., Payrastre B. Different roles of SHIP1 according to the cell context: the example of blood platelets. Adv Enzyme Regul 2008, 48:240-252.
    • (2008) Adv Enzyme Regul , vol.48 , pp. 240-252
    • Gratacap, M.P.1    Severin, S.2    Chicanne, G.3    Plantavid, M.4    Payrastre, B.5
  • 19
    • 46149106818 scopus 로고    scopus 로고
    • The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma
    • Guillermet-Guibert J., Bjorklof K., Salpekar A., Gonella C., Ramadani F., Bilancio A., et al. The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma. Proc Natl Acad Sci U S A 2008, 105:8292-8297.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 8292-8297
    • Guillermet-Guibert, J.1    Bjorklof, K.2    Salpekar, A.3    Gonella, C.4    Ramadani, F.5    Bilancio, A.6
  • 22
    • 51749104480 scopus 로고    scopus 로고
    • Overlapping and distinct roles for PI3K{beta} and {gamma} isoforms in S1P-induced migration of human and mouse endothelial cells
    • Heller R., Chang Q., Ehrlich G., Hsieh S.N., Schoenwaelder S.M., Kuhlencordt P.J., et al. Overlapping and distinct roles for PI3K{beta} and {gamma} isoforms in S1P-induced migration of human and mouse endothelial cells. Cardiovasc Res 2008, 80:96-105.
    • (2008) Cardiovasc Res , vol.80 , pp. 96-105
    • Heller, R.1    Chang, Q.2    Ehrlich, G.3    Hsieh, S.N.4    Schoenwaelder, S.M.5    Kuhlencordt, P.J.6
  • 27
    • 63749106157 scopus 로고    scopus 로고
    • Should individual PI3 kinase isoforms be targeted in cancer?
    • Jia S., Roberts T.M., Zhao J.J. Should individual PI3 kinase isoforms be targeted in cancer?. Curr Opin Cell Biol 2009, 21:199-208.
    • (2009) Curr Opin Cell Biol , vol.21 , pp. 199-208
    • Jia, S.1    Roberts, T.M.2    Zhao, J.J.3
  • 28
    • 77952048131 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase pathway activation in phosphate and tensin homolog (PTEN)-deficient prostate cancer cells is independent of receptor tyrosine kinases and mediated by the p110beta and p110delta catalytic subunits
    • Jiang X., Chen S., Asara J.M., Balk S.P. Phosphoinositide 3-kinase pathway activation in phosphate and tensin homolog (PTEN)-deficient prostate cancer cells is independent of receptor tyrosine kinases and mediated by the p110beta and p110delta catalytic subunits. J Biol Chem 2010, 285:14980-14989.
    • (2010) J Biol Chem , vol.285 , pp. 14980-14989
    • Jiang, X.1    Chen, S.2    Asara, J.M.3    Balk, S.P.4
  • 29
    • 31944448780 scopus 로고    scopus 로고
    • Oncogenic transformation induced by the p110beta, -gamma, and -delta isoforms of class I phosphoinositide 3-kinase
    • Kang S., Denley A., Vanhaesebroeck B., Vogt P.K. Oncogenic transformation induced by the p110beta, -gamma, and -delta isoforms of class I phosphoinositide 3-kinase. Proc Natl Acad Sci U S A 2006, 103:1289-1294.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 1289-1294
    • Kang, S.1    Denley, A.2    Vanhaesebroeck, B.3    Vogt, P.K.4
  • 30
    • 1942425169 scopus 로고    scopus 로고
    • Signaling through GP Ib-IX-V activates alpha IIb beta 3 independently of other receptors
    • Kasirer-Friede A., Cozzi M.R., Mazzucato M., De Marco L., Ruggeri Z.M., Shattil S.J. Signaling through GP Ib-IX-V activates alpha IIb beta 3 independently of other receptors. Blood 2004, 103:3403-3411.
    • (2004) Blood , vol.103 , pp. 3403-3411
    • Kasirer-Friede, A.1    Cozzi, M.R.2    Mazzucato, M.3    De Marco, L.4    Ruggeri, Z.M.5    Shattil, S.J.6
  • 31
    • 1042301420 scopus 로고    scopus 로고
    • Akt activation in platelets depends on Gi signaling pathways
    • Kim S., Jin J., Kunapuli S.P. Akt activation in platelets depends on Gi signaling pathways. J Biol Chem 2004, 279:4186-4195.
    • (2004) J Biol Chem , vol.279 , pp. 4186-4195
    • Kim, S.1    Jin, J.2    Kunapuli, S.P.3
  • 32
    • 71749111351 scopus 로고    scopus 로고
    • Role of phosphoinositide 3-kinase beta in glycoprotein VI-mediated Akt activation in platelets
    • Kim S., Mangin P., Dangelmaier C., Lillian R., Jackson S.P., Daniel J.L., et al. Role of phosphoinositide 3-kinase beta in glycoprotein VI-mediated Akt activation in platelets. J Biol Chem 2009, 284:33763-33772.
    • (2009) J Biol Chem , vol.284 , pp. 33763-33772
    • Kim, S.1    Mangin, P.2    Dangelmaier, C.3    Lillian, R.4    Jackson, S.P.5    Daniel, J.L.6
  • 33
    • 33646383684 scopus 로고    scopus 로고
    • A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling
    • Knight Z.A., Gonzalez B., Feldman M.E., Zunder E.R., Goldenberg D.D., Williams O., et al. A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell 2006, 125:733-747.
    • (2006) Cell , vol.125 , pp. 733-747
    • Knight, Z.A.1    Gonzalez, B.2    Feldman, M.E.3    Zunder, E.R.4    Goldenberg, D.D.5    Williams, O.6
  • 34
    • 0029050557 scopus 로고
    • Phosphoinositide 3-kinase inhibition spares actin assembly in activating platelets but reverses platelet aggregation
    • Kovacsovics T.J., Bachelot C., Toker A., Vlahos C.J., Duckworth B., Cantley L.C., et al. Phosphoinositide 3-kinase inhibition spares actin assembly in activating platelets but reverses platelet aggregation. J Biol Chem 1995, 270:11358-11366.
    • (1995) J Biol Chem , vol.270 , pp. 11358-11366
    • Kovacsovics, T.J.1    Bachelot, C.2    Toker, A.3    Vlahos, C.J.4    Duckworth, B.5    Cantley, L.C.6
  • 35
    • 29644446699 scopus 로고    scopus 로고
    • Specific role for p85/p110beta in GTP-binding-protein-mediated activation of Akt
    • Kubo H., Hazeki K., Takasuga S., Hazeki O. Specific role for p85/p110beta in GTP-binding-protein-mediated activation of Akt. Biochem J 2005, 392:607-614.
    • (2005) Biochem J , vol.392 , pp. 607-614
    • Kubo, H.1    Hazeki, K.2    Takasuga, S.3    Hazeki, O.4
  • 36
    • 0034912213 scopus 로고    scopus 로고
    • Association of phosphatidylinositol 3-kinase composed of p110beta-catalytic and p85-regulatory subunits with the small GTPase Rab5
    • Kurosu H., Katada T. Association of phosphatidylinositol 3-kinase composed of p110beta-catalytic and p85-regulatory subunits with the small GTPase Rab5. J Biochem 2001, 130:73-78.
    • (2001) J Biochem , vol.130 , pp. 73-78
    • Kurosu, H.1    Katada, T.2
  • 37
    • 77954641960 scopus 로고    scopus 로고
    • A constitutively activated form of the p110beta isoform of PI3-kinase induces prostatic intraepithelial neoplasia in mice
    • Lee S.H., Poulogiannis G., Pyne S., Jia S., Zou L., Signoretti S., et al. A constitutively activated form of the p110beta isoform of PI3-kinase induces prostatic intraepithelial neoplasia in mice. Proc Natl Acad Sci U S A 2010, 107:11002-11007.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 11002-11007
    • Lee, S.H.1    Poulogiannis, G.2    Pyne, S.3    Jia, S.4    Zou, L.5    Signoretti, S.6
  • 38
    • 0038281249 scopus 로고    scopus 로고
    • Phosphoinositide recognition domains
    • Lemmon M.A. Phosphoinositide recognition domains. Traffic 2003, 4:201-213.
    • (2003) Traffic , vol.4 , pp. 201-213
    • Lemmon, M.A.1
  • 39
    • 31544436597 scopus 로고    scopus 로고
    • Sequential activation of p38 and ERK pathways by cGMP-dependent protein kinase leading to activation of the platelet integrin alphaIIb beta3
    • Li Z., Zhang G., Feil R., Han J., Du X. Sequential activation of p38 and ERK pathways by cGMP-dependent protein kinase leading to activation of the platelet integrin alphaIIb beta3. Blood 2006, 107:965-972.
    • (2006) Blood , vol.107 , pp. 965-972
    • Li, Z.1    Zhang, G.2    Feil, R.3    Han, J.4    Du, X.5
  • 40
    • 0032828890 scopus 로고    scopus 로고
    • Roles of non-catalytic subunits in gbetagamma-induced activation of class I phosphoinositide 3-kinase isoforms beta and gamma
    • Maier U., Babich A., Nurnberg B. Roles of non-catalytic subunits in gbetagamma-induced activation of class I phosphoinositide 3-kinase isoforms beta and gamma. J Biol Chem 1999, 274:29311-29317.
    • (1999) J Biol Chem , vol.274 , pp. 29311-29317
    • Maier, U.1    Babich, A.2    Nurnberg, B.3
  • 41
    • 42149140646 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinases p110alpha and p110beta regulate cell cycle entry, exhibiting distinct activation kinetics in G1 phase
    • Marques M., Kumar A., Cortes I., Gonzalez-Garcia A., Hernandez C., Moreno-Ortiz M.C., et al. Phosphoinositide 3-kinases p110alpha and p110beta regulate cell cycle entry, exhibiting distinct activation kinetics in G1 phase. Mol Cell Biol 2008, 28:2803-2814.
    • (2008) Mol Cell Biol , vol.28 , pp. 2803-2814
    • Marques, M.1    Kumar, A.2    Cortes, I.3    Gonzalez-Garcia, A.4    Hernandez, C.5    Moreno-Ortiz, M.C.6
  • 42
    • 77950423041 scopus 로고    scopus 로고
    • Deletion of the p110beta isoform of phosphoinositide 3-kinase in platelets reveals its central role in Akt activation and thrombus formation in vitro and in vivo
    • Martin V., Guillermet-Guibert J., Chicanne G., Cabou C., Jandrot-Perrus M., Plantavid M., et al. Deletion of the p110beta isoform of phosphoinositide 3-kinase in platelets reveals its central role in Akt activation and thrombus formation in vitro and in vivo. Blood 2010, 115:2008-2013.
    • (2010) Blood , vol.115 , pp. 2008-2013
    • Martin, V.1    Guillermet-Guibert, J.2    Chicanne, G.3    Cabou, C.4    Jandrot-Perrus, M.5    Plantavid, M.6
  • 43
    • 3543010757 scopus 로고    scopus 로고
    • SHIP1 and Lyn kinase negatively regulate integrin alpha IIb beta 3 signaling in platelets
    • Maxwell M.J., Yuan Y., Anderson K.E., Hibbs M.L., Salem H.H., Jackson S.P. SHIP1 and Lyn kinase negatively regulate integrin alpha IIb beta 3 signaling in platelets. J Biol Chem 2004, 279:32196-32204.
    • (2004) J Biol Chem , vol.279 , pp. 32196-32204
    • Maxwell, M.J.1    Yuan, Y.2    Anderson, K.E.3    Hibbs, M.L.4    Salem, H.H.5    Jackson, S.P.6
  • 44
    • 59849125052 scopus 로고    scopus 로고
    • Mutations in phosphoinositide metabolizing enzymes and human disease
    • McCrea H.J., De Camilli P. Mutations in phosphoinositide metabolizing enzymes and human disease. Physiology (Bethesda) 2009, 24:8-16.
    • (2009) Physiology (Bethesda) , vol.24 , pp. 8-16
    • McCrea, H.J.1    De Camilli, P.2
  • 45
    • 0034661839 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase forms a complex with platelet membrane glycoprotein Ib-IX-V complex and 14-3-3zeta
    • Munday A.D., Berndt M.C., Mitchell C.A. Phosphoinositide 3-kinase forms a complex with platelet membrane glycoprotein Ib-IX-V complex and 14-3-3zeta. Blood 2000, 96:577-584.
    • (2000) Blood , vol.96 , pp. 577-584
    • Munday, A.D.1    Berndt, M.C.2    Mitchell, C.A.3
  • 47
    • 0033567185 scopus 로고    scopus 로고
    • A collagen-related peptide regulates phospholipase Cgamma2 via phosphatidylinositol 3-kinase in human platelets
    • Pasquet J.M., Bobe R., Gross B., Gratacap M.P., Tomlinson M.G., Payrastre B., et al. A collagen-related peptide regulates phospholipase Cgamma2 via phosphatidylinositol 3-kinase in human platelets. Biochem J 1999, 342(Pt 1):171-177.
    • (1999) Biochem J , vol.342 , Issue.PART 1 , pp. 171-177
    • Pasquet, J.M.1    Bobe, R.2    Gross, B.3    Gratacap, M.P.4    Tomlinson, M.G.5    Payrastre, B.6
  • 50
    • 34948891046 scopus 로고    scopus 로고
    • Roles of the C-terminal tyrosine residues of LAT in GPVI-induced platelet activation: insights into the mechanism of PLC gamma 2 activation
    • Ragab A., Severin S., Gratacap M.P., Aguado E., Malissen M., Jandrot-Perrus M., et al. Roles of the C-terminal tyrosine residues of LAT in GPVI-induced platelet activation: insights into the mechanism of PLC gamma 2 activation. Blood 2007, 110:2466-2474.
    • (2007) Blood , vol.110 , pp. 2466-2474
    • Ragab, A.1    Severin, S.2    Gratacap, M.P.3    Aguado, E.4    Malissen, M.5    Jandrot-Perrus, M.6
  • 51
    • 0033605718 scopus 로고    scopus 로고
    • The role of phosphoinositide 3-kinase lipid products in cell function
    • Rameh L.E., Cantley L.C. The role of phosphoinositide 3-kinase lipid products in cell function. J Biol Chem 1999, 274:8347-8350.
    • (1999) J Biol Chem , vol.274 , pp. 8347-8350
    • Rameh, L.E.1    Cantley, L.C.2
  • 53
    • 77953027360 scopus 로고    scopus 로고
    • The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
    • Sasaki J., Kofuji S., Itoh R., Momiyama T., Takayama K., Murakami H., et al. The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death. Nature 2010, 465:497-501.
    • (2010) Nature , vol.465 , pp. 497-501
    • Sasaki, J.1    Kofuji, S.2    Itoh, R.3    Momiyama, T.4    Takayama, K.5    Murakami, H.6
  • 55
    • 77449106039 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase p110 beta regulates integrin alpha IIb beta 3 avidity and the cellular transmission of contractile forces
    • Schoenwaelder S.M., Ono A., Nesbitt W.S., Lim J., Jarman K., Jackson S.P. Phosphoinositide 3-kinase p110 beta regulates integrin alpha IIb beta 3 avidity and the cellular transmission of contractile forces. J Biol Chem 2010, 285:2886-2896.
    • (2010) J Biol Chem , vol.285 , pp. 2886-2896
    • Schoenwaelder, S.M.1    Ono, A.2    Nesbitt, W.S.3    Lim, J.4    Jarman, K.5    Jackson, S.P.6
  • 56
    • 33745219660 scopus 로고    scopus 로고
    • A phosphoinositide 3-kinase-AKT-nitric oxide-cGMP signaling pathway in stimulating platelet secretion and aggregation
    • Stojanovic A., Marjanovic J.A., Brovkovych V.M., Peng X., Hay N., Skidgel R.A., et al. A phosphoinositide 3-kinase-AKT-nitric oxide-cGMP signaling pathway in stimulating platelet secretion and aggregation. J Biol Chem 2006, 281:16333-16339.
    • (2006) J Biol Chem , vol.281 , pp. 16333-16339
    • Stojanovic, A.1    Marjanovic, J.A.2    Brovkovych, V.M.3    Peng, X.4    Hay, N.5    Skidgel, R.A.6
  • 57
    • 0030611707 scopus 로고    scopus 로고
    • Purification and characterization of Gbetagamma-responsive phosphoinositide 3-kinases from pig platelet cytosol
    • Tang X., Downes C.P. Purification and characterization of Gbetagamma-responsive phosphoinositide 3-kinases from pig platelet cytosol. J Biol Chem 1997, 272:14193-14199.
    • (1997) J Biol Chem , vol.272 , pp. 14193-14199
    • Tang, X.1    Downes, C.P.2
  • 58
    • 0036280038 scopus 로고    scopus 로고
    • Phosphoinositides and signal transduction
    • Toker A. Phosphoinositides and signal transduction. Cell Mol Life Sci 2002, 59:761-779.
    • (2002) Cell Mol Life Sci , vol.59 , pp. 761-779
    • Toker, A.1
  • 59
    • 51349100763 scopus 로고    scopus 로고
    • A chemical screen in diverse breast cancer cell lines reveals genetic enhancers and suppressors of sensitivity to PI3K isoform-selective inhibition
    • Torbett N.E., Luna-Moran A., Knight Z.A., Houk A., Moasser M., Weiss W., et al. A chemical screen in diverse breast cancer cell lines reveals genetic enhancers and suppressors of sensitivity to PI3K isoform-selective inhibition. Biochem J 2008, 415:97-110.
    • (2008) Biochem J , vol.415 , pp. 97-110
    • Torbett, N.E.1    Luna-Moran, A.2    Knight, Z.A.3    Houk, A.4    Moasser, M.5    Weiss, W.6
  • 60
    • 13044263119 scopus 로고    scopus 로고
    • A key role of adenosine diphosphate in the irreversible platelet aggregation induced by the PAR1-activating peptide through the late activation of phosphoinositide 3-kinase
    • Trumel C., Payrastre B., Plantavid M., Hechler B., Viala C., Presek P., et al. A key role of adenosine diphosphate in the irreversible platelet aggregation induced by the PAR1-activating peptide through the late activation of phosphoinositide 3-kinase. Blood 1999, 94:4156-4165.
    • (1999) Blood , vol.94 , pp. 4156-4165
    • Trumel, C.1    Payrastre, B.2    Plantavid, M.3    Hechler, B.4    Viala, C.5    Presek, P.6
  • 61
    • 37849039177 scopus 로고    scopus 로고
    • Dual P2Y 12 receptor signaling in thrombin-stimulated platelets-involvement of phosphoinositide 3-kinase beta but not gamma isoform in Ca2+ mobilization and procoagulant activity
    • van der Meijden P.E., Schoenwaelder S.M., Feijge M.A., Cosemans J.M., Munnix I.C., Wetzker R., et al. Dual P2Y 12 receptor signaling in thrombin-stimulated platelets-involvement of phosphoinositide 3-kinase beta but not gamma isoform in Ca2+ mobilization and procoagulant activity. FEBS J 2008, 275:371-385.
    • (2008) FEBS J , vol.275 , pp. 371-385
    • van der Meijden, P.E.1    Schoenwaelder, S.M.2    Feijge, M.A.3    Cosemans, J.M.4    Munnix, I.C.5    Wetzker, R.6
  • 64
    • 66249116702 scopus 로고    scopus 로고
    • PI3K pathway activation mediates resistance to MEK inhibitors in KRAS mutant cancers
    • Wee S., Jagani Z., Xiang K.X., Loo A., Dorsch M., Yao Y.M., et al. PI3K pathway activation mediates resistance to MEK inhibitors in KRAS mutant cancers. Cancer Res 2009, 69:4286-4293.
    • (2009) Cancer Res , vol.69 , pp. 4286-4293
    • Wee, S.1    Jagani, Z.2    Xiang, K.X.3    Loo, A.4    Dorsch, M.5    Yao, Y.M.6
  • 65
    • 0038542920 scopus 로고    scopus 로고
    • Interaction between von Willebrand factor and glycoprotein Ib activates Src kinase in human platelets: role of phosphoinositide 3-kinase
    • Wu Y., Asazuma N., Satoh K., Yatomi Y., Takafuta T., Berndt M.C., et al. Interaction between von Willebrand factor and glycoprotein Ib activates Src kinase in human platelets: role of phosphoinositide 3-kinase. Blood 2003, 101:3469-3476.
    • (2003) Blood , vol.101 , pp. 3469-3476
    • Wu, Y.1    Asazuma, N.2    Satoh, K.3    Yatomi, Y.4    Takafuta, T.5    Berndt, M.C.6
  • 66
    • 0036098158 scopus 로고    scopus 로고
    • Essential role for phosphoinositide 3-kinase in shear-dependent signaling between platelet glycoprotein Ib/V/IX and integrin alpha(IIb)beta(3)
    • Yap C.L., Anderson K.E., Hughan S.C., Dopheide S.M., Salem H.H., Jackson S.P. Essential role for phosphoinositide 3-kinase in shear-dependent signaling between platelet glycoprotein Ib/V/IX and integrin alpha(IIb)beta(3). Blood 2002, 99:151-158.
    • (2002) Blood , vol.99 , pp. 151-158
    • Yap, C.L.1    Anderson, K.E.2    Hughan, S.C.3    Dopheide, S.M.4    Salem, H.H.5    Jackson, S.P.6
  • 67
    • 38349188189 scopus 로고    scopus 로고
    • The role of Akt in the signaling pathway of the glycoprotein Ib-IX induced platelet activation
    • Yin H., Stojanovic A., Hay N., Du X. The role of Akt in the signaling pathway of the glycoprotein Ib-IX induced platelet activation. Blood 2008, 111:658-665.
    • (2008) Blood , vol.111 , pp. 658-665
    • Yin, H.1    Stojanovic, A.2    Hay, N.3    Du, X.4
  • 68
    • 48649083369 scopus 로고    scopus 로고
    • Phosphoinositide 3-OH kinase p85alpha and p110beta are essential for androgen receptor transactivation and tumor progression in prostate cancers
    • Zhu Q., Youn H., Tang J., Tawfik O., Dennis K., Terranova P.F., et al. Phosphoinositide 3-OH kinase p85alpha and p110beta are essential for androgen receptor transactivation and tumor progression in prostate cancers. Oncogene 2008, 27:4569-4579.
    • (2008) Oncogene , vol.27 , pp. 4569-4579
    • Zhu, Q.1    Youn, H.2    Tang, J.3    Tawfik, O.4    Dennis, K.5    Terranova, P.F.6


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