Toxic liver injuries - A current view on pathogenesis. part I;Toksyczne uszkodzenie wątroby - współczesny pogląd na etiopatogenezę. część I

Medycyna Pracy

Volumn 62, Issue 1, 2011, Pages 47-55

  Bak, Marek ^a   Czerniak, Maciej ^a   Kicińska Krogulska, Magda ^a   Michowicz, Aleksandra ^b   Krakowiak, Anna ^a  

^a NOFER INSTITUTE OF OCCUPATIONAL MEDICINE   (Poland)

^b MEDICAL UNIVERSITY OF LODZ   (Poland)

Author keywords

Chemicals; Exposure to drugs; Liver; Pathogenesis; Toxic injury

Indexed keywords

XENOBIOTIC AGENT;

CHEMICALLY INDUCED DISORDER; DRUG EFFECT; FATTY LIVER; HUMAN; LIVER; LIVER MICROSOME; LIVER MITOCHONDRION; METABOLISM; OCCUPATIONAL DISEASE; OCCUPATIONAL EXPOSURE; REVIEW; RISK FACTOR; TOXIC HEPATITIS;

DRUG-INDUCED LIVER INJURY; FATTY LIVER; HUMANS; LIVER; MICROSOMES, LIVER; MITOCHONDRIA, LIVER; OCCUPATIONAL DISEASES; OCCUPATIONAL EXPOSURE; RISK FACTORS; XENOBIOTICS;

EID: 79953842015     PISSN: 04655893     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (73)

1. Stieger B., O'Neill B., Meier P.J.: ATP-dependent bilesalt transport in canalicular rat liver plasma-membrane vesicles. Biochem. J. 1992;284:67-74
2. Higuchi H., Gores G.J.: Bile acid regulation of hepatic physiology: IV. Bile acids and death receptors. Am. J. Physiol. Gastrointest. Liver Physiol. 2003;284: G734-G738
3. Xia X., Francis H., Glaser S., Alpini G., LeSage G.: Bile acid interactions with cholangiocytes. World J. Gastroenterol. 2006;12:3553-3563
4. Geier A., Kim S.K., Gerloff T., Dietrich C.G., Lammert F., Karpen S.J. i wsp.: Hepatobiliary organic anion transporters are differentially regulated in acute toxic liver injury induced by carbon tetrachloride. J. Hepatol. 2002;37:198-205
5. Green R.M., Whiting J.F., Rosenbluth A.B., Beier D., Gollan J.L.: Interleukin-6 inhibits hepatocyte taurocholate uptake and sodium-potassium-adenosinetriphosphatase activity. Am. J. Physiol. 1994;267: G1094-G1100
6. Whiting J.F., Green R.M., Rosenbluth A.B., Gollan J.L.: Tumor necrosis factor-alpha decreases hepatocyte bile salt uptake and mediates endotoxin-induced cholestasis. Hepatology 1995;22:1273-1278
7. Denson L.A., Auld K.L., Schiek D.S., McClure M.H., Mangelsdorf D.J., Karpen S.J.: Interleukin-1beta suppresses retinoid transactivation of two hepatic transporter genes involved in bile formation. J. Biol. Chem. 2000;275:8835-8843
8. Zollner G., Fickert P., Zenz R., Fuchsbichler A., Stumptner C., Kenner L. i wsp.: Hepatobiliary transporter expression in percutaneous liver biopsies of patients with cholestatic liver diseases. Hepatology 2001;33: 633-646
9. Kim N.D., Moon J.O., Slitt A.L., Copple B.L.: Early growth response factor-1 is critical for cholestatic liver injury. Toxicol. Sci. 2006;90:586-595
10. Kudo A., Kashiwagi S., Kajimura M., Yoshimura Y., Uchida K., Arii S. i wsp.: Kupffer cells alter organic anion transport through multidrug resistance protein 2 in the post-cold ischemic rat liver. Hepatology 2004;39:1099-1109
11. Tanaka Y., Chen C., Maher J.M., Klaassen C.D.: Kupffer cell-mediated downregulation of hepatic transporter expression in rat hepatic ischemia-reperfusion. Transplantation 2006;82:258-266
12. Kobayashi T., Hirano K., Yamamoto T., Hasegawa G., Hatakeyama K., Suematsu M. i wsp.: The protective role of Kupffer cells in the ischemia-reperfused rat liver. Arch. Histol. Cytol. 2002;65:251-261
13. Yamamoto Y., Moore R., Hess H.A., Guo G.L., Gonzalez F.J., Korach K.S. i wsp.: Estrogen receptor alpha mediates 17alphaethynylestradiol causing hepatotoxicity. J. Biol. Chem. 2006;281:16625-16631
14. Schreiber A.J., Simon F.R.: Estrogen-induced cholestasis: clues to pathogenesis and treatment. Hepatology 1983;3:607-813
15. Lee J.M., Trauner M., Soroka C.J., Stieger B., Meier P.J., Boyer J.L.: Expression of the bile salt export pump is maintained after chronic cholestasis in the rat. Gastroenterology 2000;118:163-172
16. Simon F.R., Fortune J., Iwahashi M., Gartung C., Wolkoff A., Sutherland E.: Ethinyl estradiol cholestasis involves alterations in expression of liver sinusoidal transporters. Am. J. Physiol. 1996;271:G1043-G1052
17. Byrne J.A., Strautnieks S.S., Mieli-Vergani G., Higgins C.F., Linton K.J., Thompson R.J.: The human bile salt export pump: characterization of substrate specificity and identification of inhibitors. Gastroenterology 2002;123:1649-1658
18. Francis G.A., Fayard E., Picard F., Auwerx J.: Nuclear receptors and the control of metabolism. Annu. Rev. Physiol. 2003;65:261-311
19. Guo G.L., Lambert G., Negishi M., Ward J.M., Brewer H.B. Jun., Kliewer S.A. i wsp.: Complementary roles of farnesoid X receptor, pregnane X receptor and constitutive androstane receptor in protection against bile acid toxicity. J. Biol. Chem. 2003;278:45062-45071
20. Karpen S.J.: Nuclear receptor regulation of hepatic function. J. Hepatol. 2002;36:832-850
21. Xie W., Radominska-Pandya A., Shi Y., Simon C.M., Nelson M.C., Ong E.S. i wsp.: An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids. Proc. Natl. Acad. Sci. USA 2001;98:3375-3380
22. Forman B.M., Goode E., Chen J., Oro A.E., Bradley D.J., Perlmann T. i wsp.: Identification of a nuclear receptor that is activated by farnesol metabolites. Cell 1995;81:687-693
23. Ananthanarayanan M., Balasubramanian N., Makishima M., Mangelsdorf D.J., Suchy F.J.: Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor. J. Biol. Chem. 2001;276:28857-28865
24. Sinal C.J., Tohkin M., Miyata M., Ward J.M., Lambert G., Gonzalez F.J.: Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis. Cell 2000;102:731-744
25. Fiorucci S., Clerici C., Antonelli E., Orlandi S., Goodwin B., Sadeghpour B.M. i wsp.: Protective effects of 6-ethyl chenodeoxycholic acid, a farnesoid X receptor ligand, in estrogen-induced cholestasis. J. Pharmacol. Exp. Ther. 2005;313:604-612
26. Rizzo G., Renga B., Mencarelli A., Pellicciari R., Fiorucci S.: Role of FXR in regulating bile acid homeostasis and relevance for human diseases. Curr. Drug Targets Immune Endocr. Metabol. Disord. 2005;5:289-303
27. Liu Y., Binz J., Numerick M.J., Dennis S., Luo G., Desai B. i wsp.: Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis. J. Clin. Invest. 2003;112:1678-1687
28. Kossor D.C., Goldstein R.S., Ngo W., DeNicola D.B., Leonard T.B., Dulik D.M. I wsp.: Biliary epithelial cell proliferation following alphanaphthylisothiocyanate (ANIT) treatment: relationship to bile duct obstruction. Fundam. Appl. Toxicol. 1995;26:51-62
29. Fickert P., Fuchsbichler A., Marschall H.U., Wagner M., Zollner G., Krause R. I wsp.: Lithocholic acid feeding induces segmental bile duct obstruction and destructive cholangitis in mice. Am. J. Pathol. 2006;168: 410-422
30. Hines J.E., Johnson S.J., Burt A.D.: In vivo responses of macrophages and perisinusoidal cells to cholestatic liver injury. Am. J. Pathol. 1993;142:511-518
31. Tang L., Tanaka Y., Marumo F., Sato C.: Phenotypic change in portal fibroblasts in biliary fibrosis. Liver 1994;14:76-82
32. Tuchweber B., Desmouliere A., Bochaton-Piallat M.L., Rubbia-Brandt L., Gabbiani G.: Proliferation and phenotypic modulation of portal fibroblasts in the early stages of cholestatic fibrosis in the rat. Lab. Invest. 1996;74:265-278
33. Pessayre D., Berson A., Fromenty B., Mansouri A.: Mitochondria in steatohepatitis. Semin. Liver. Dis. 2001; 21:57-69
34. Kim J.S., Qian T., Lemasters J.J.: Mitochondrial permeability transition in the switch from necrotic to apoptotic cell death in ischemic rat hepatocytes. Gastroenterology 2003;124:494-503
35. Ramm G.A., Ruddell R.G.: Hepatotoxicity of iron overload: mechanisms of iron-induced hepatic fibrogenesis. Semin. Liver. Dis. 2005;25:433-449
36. Yang Y.L., Li J.P., Xu X.P., Dou K.F., Yue S.Q., Li K.Z.: Protective effects of tumor necrosis factor alpha antibody and ulinastatin on liver ischemic reperfusion in rats. World J. Gastroenterol. 2004;10:3161-3164
37. Mansouri A., Gaou I., Fromenty B., Berson A., Lettéron P., Degott C. I wsp.: Premature oxidative aging of hepatic mitochondrial DNA in Wilson's disease. Gastroenterology 1997;113:599-605
38. Mansouri A., Gaou I., De Kerguenec C., Amsellem S., Haouzi D., Berson A. I wsp.: An alcoholic binge causes massive degradation of hepatic mitochondrial DNA in mice. Gastroenterology 1999;117:181-190
39. Sanyal A.J., Campbell-Sargent C., Mirshahi F., Rizzo W.B., Contos M.J., Sterling R.K. I wsp.: Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities. Gastroenterology 2001;120:1183-1192
40. Fromenty B., Pessayre D.: Inhibition of mitochondrial beta-oxidation as a mechanism of hepatotoxicity. Pharmacol. Ther. 1995;67:101-154
41. Nehra V., Angulo P., Buchman A.L., Lindor K.D.: Nutritional and metabolic considerations in the etiology of nonalcoholic steatohepatitis. Dig. Dis. Sci. 2001;46: 2347-2352
42. Martins D.L., Cury-Boaventura M.F., Giannocco G., Nunes M.T., Curi R.: Comparative toxicity of fatty acids on a macrophage cell line (J774). Clin. Sci. (London) 2006;111:307-317
43. Fernandez-Checa J.C., Kaplowitz N.: Hepatic mitochondrial glutathione: transport and role in disease and toxicity. Toxicol. Appl. Pharmacol. 2005;204:263-273
44. Feldstein A.E., Canbay A., Angulo P., Taniai M., Burgart L.J., Lindor K.D. I wsp.: Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis. Gastroenterology 2003;125: 437-443
45. Ribeiro P.S., Cortez-Pinto H., Sola S., Castro R.E., Ramalho R.M., Baptista A. I wsp.: Hepatocyte apoptosis, expression of death receptors, and activation of NF--kappaB in the liver of nonalcoholic and alcoholic steatohepatitis patients. Am. J. Gastroenterol. 2004;99: 1708-1717
46. Feldstein A.E., Werneburg N.W., Canbay A., Guicciardi M.E., Bronk S.F., Rydzewski R. I wsp.: Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway. Hepatology 2004;40:185-194
47. Malhi H., Bronk S.F., Werneburg N.W., Gores G.J.: Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis. J. Biol. Chem. 2006;281:12093-12101
48. Farrell J., Naisbitt D.J., Drummond N.S., Depta J.P., Vilar F.J., Pirmohamed M. I wsp.: Characterization of sulfamethoxazole and sulfamethoxazole metabolite-specific T-cell responses in animals and humans. J. Pharmacol. Exp. Ther. 2003;306:229-237
49. Gruchalla R.S., Sullivan T.J.: Detection of human IgE to sulfamethoxazole by skin testing with sulfamethoxazoyl-poly-l-tyrosine. J. Allergy Clin. Immunol. 1991;88: 784-792
50. Madden S., Maggs J.L., Park B.K.: Bioactivation of carbamazepine in the rat in vivo. Evidence for the formation of reactive arene oxide(s). Drug Metab. Dispos. 1996;24:469-479
51. Naisbitt D.J., Britschgi M., Wong G., Farrell J., Depta J.P., Chadwick D.W. I wsp.: Hypersensitivity reactions to carbamazepine: characterization of the specificity, phenotype and cytokine profile of drug-specific T cell clones. Mol. Pharmacol. 2003;63:732-741
52. Park B.K., Kitteringham N.R., Maggs J.L., Pirmohamed M., Williams D.P.: The role of metabolic activation in drug-induced hepatotoxicity. Annu. Rev. Pharmacol. Toxicol. 2005;45:177-202
53. Pohl L.R.: Drug-induced allergic hepatitis. Semin. Liver Dis. 1990;10:305-315
54. Bourdi M., Chen W., Peter R.M., Martin J.L., Buters J.T., Nelson S.D. I wsp.: Human cytochrome P450 2E1 is a major autoantigen associated with halothane hepatitis. Chem. Res. Toxicol. 1996;9:1159-1166
55. Lohse A.W., Manns M., Dienes H.P., Meyer zum Buschenfelde K.H., Cohen I.R.: Experimental autoimmune hepatitis: disease induction, time course and T-cell reactivity. Hepatology 1990;11:24-30
56. Lohse A.W., Brunner S., Kyriatsoulis A., Manns M., Meyer zum Buschenfelde K.H.: Autoantibodies in experimental autoimmune hepatitis. J. Hepatol. 1992;14:48-53
57. Belloc C., Gauffre A., Andre C., Beaune P.H.: Epitope mapping of human CYP1A2 in dihydralazine-induced autoimmune hepatitis. Pharmacogenetics 1997;7: 181-186
58. Muller D., Enderle G.J., Low O., Dietze E., Krell H.: Bile ductular proliferation and altered leukotriene elimination in thioacetamide-induced fibrosis of rat liver. J. Hepatol. 1996;25:547-553
59. Poli G.: Pathogenesis of liver fibrosis: role of oxidative stress. Mol. Aspects Med. 2000;21:49-98
60. Malarkey D.E., Johnson K., Ryan L., Boorman G. Maronpot R.R.: Newinsights into functional aspects of liver morphology. Toxicol. Pathol. 2005;33:27-34
61. Smedsrod B.: Clearance function of scavenger endothelial cells. Comp. Hepatol. 2004;3(Supl. 1):S22:1-10
62. Dobbs B.R., Rogers G.W., Xing H.Y., Fraser R.: Endotoxin-induced defenestration of the hepatic sinusoidal endothelium: a factor in the pathogenesis of cirrhosis? Liver 1994;14:230-233
63. McCuskey R.S.: Sinusoidal endothelial cells as an early target for hepatic toxicants. Clin. Hemorheol. Microcirc. 2006;34:5-10
64. Mabuchi A., Mullaney I., Sheard P.W., Hessian P.A., Mallard B.L., Tawadrous M.N. I wsp.: Role of hepatic stellate cell/hepatocyte interaction and activation of hepatic stellate cells in the early phase of liver regeneration in the rat. J. Hepatol. 2004;40:910-916
65. Pinzani M., Marra F.: Cytokine receptors and signaling in hepatic stellate cells. Semin. Liver Dis. 2001;21: 397-416
66. Thakur V., Pritchard M.T., McMullen M.R., Wang Q., Nagy L.E.: Chronic ethanol feeding increases activation of NADPH oxidase by lipopolysaccharide in rat Kupffer cells: role of increased reactive oxygen in LPS-stimulated ERK1/2 activation and TNF-alpha production. J. Leukoc. Biol. 2006;79:1348-1356
67. Knittel T., Kobold D., Piscaglia F., Saile B., Neubauer K., Mehde M. I wsp.: Localization of liver myofibroblasts and hepatic stellate cells in normal and diseased rat livers: distinct roles of (myo-)fibroblast subpopulations in hepatic tissue repair. Histochem. Cell Biol. 1999;112: 387-401
68. Gressner A.M., Polzar B., Lahme B., Mannherz H.G.: Induction of rat liver parenchymal cell apoptosis by hepatic myofibroblasts via transforming growth factor beta. Hepatology 1996;23:571-581
69. Greenwel P., Dominguez-Rosales J.A., Mavi G., Rivas-Estilla A.M., Rojkind M.: Hydrogen peroxide: a link between acetaldehyde-elicited alpha1(I) collagen gene up-regulation and oxidative stress in mouse hepatic stellate cells. Hepatology 2000;31:109-116
70. Parola M., Pinzani M., Casini A., Albano E., Poli G., Gentilini A. I wsp.: Stimulation of lipid peroxidation or 4-hydroxynonenal treatment increases procollagen alpha 1(I) gene expression in human liver fat-storing cells. Biochem. Biophys. Res. Commun. 1993;194: 1044-1050
71. Fontana L., Jerez D., Rojas-Valencia L., Solis-Herruzo J.A., Greenwel P., Rojkind M.: Ethanol induces the expression of alpha 1(I) procollagen mRNA in a coculture system containing a liver stellate cell-line and freshly isolated hepatocytes. Biochim. Biophys. Acta. 1997;1362:135-144
72. Svegliati-Baroni G., Ridolfi F., di Sario A., Saccomanno S., Bendia E., Benedetti A. I wsp.: Intracellular signaling pathways involved in acetaldehyde-induced collagen and fibronectin gene expression in human hepatic stellate cells. Hepatology 2001;33:1130-1140
73. Leonarduzzi G., Arkan M.C., Basaga H., Chiarpotto E., Sevanian A., Poli G.: Lipid oxidation products in cell signaling. Free Radic. Biol. Med. 2000;28:1370-1378