Ethinyl estradiol cholestasis involves alterations in expression of liver sinusoidal transporters

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 271, Issue 6 34-6, 1996, Pages

  Simon, Francis R ^a   Fortune, John ^b   Iwahashi, Mieko ^b   Gartung, Carsten ^b   Wolkoff, Allan ^b   Sutherland, Eileen ^b  

^a UNIVERSITY OF COLORADO   (United States)

^b NONE

Author keywords

bile acids; fluidity; organic anion transporter; sodium dependent bile acid transporter; sodium potassium activated adenosinetriphosphatase

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ANION; CARRIER PROTEIN; CORN OIL; ETHINYLESTRADIOL; SODIUM; TAUROCHOLIC ACID;

ALPHA CHAIN; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANION TRANSPORT; ARTICLE; BETA CHAIN; BILE FLOW; CHOLESTASIS; CONTROLLED STUDY; ENZYME SUBUNIT; LIVER SINUSOID; MALE; MEMBRANE FLUIDITY; MEMBRANE TRANSPORT; NONHUMAN; PRIORITY JOURNAL; RAT; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0030470648     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.1996.271.6.g1043     Document Type: Article

References (35)

1. Arias, I. M. What is primary in cholestasis? In: Hepatology: A Festschrift for Hans Popper. New York: Raven, 1985, p. 281-284.
2. Berr, F., F. R. Simon, and J. Reichen. Ethinyl estradiol impairs bile salt uptake and Na-K pump function of rat hepatocytes. Am. J. Physiol. 247 (Gastrointest. Liver Physiol. 10): G437-G443, 1984.
3. Bossard, R., B. Stieger, B. O'Neill, G. Fricker, and P. J. Meier. Ethinylestradiol treatment induces multiple canalicular membrane transport alterations in rat liver. J. Clin. Invest. 91: 2714-2720, 1993.
4. Buscher, H.-P., I. Meder, S. MacNelly, and W. Gerok. Zonal changes of hepatobiliary taurocholate transport in intrahepatic cholestasis induced by 17α-ethinyl estradiol. A histoautoradiographic study in rats. Hepatology 17: 494-499, 1993.
5. Chong, P. L.-G., P. A. G. Fortes, and D. M. Jameson. Mechanisms of inhibition of (Na,K)-ATPase by hydrostatic pressure studied with fluorescent probes. J. Biol. Chem. 260: 14484-14490, 1985.
6. Davis, R. A., T. S. Elliott, G. R. Lattier, R. B. Showalter, and F. Kern, Jr. Ethinyl estradiol inhibits bile acid synthesis by direct interaction with the microsomal membrane. Biochemistry 25: 632-642, 1986.
7. Davis, R. A., and F. Kern, Jr. Effects of ethinyl estradiol and phenobarbital on bile acid synthesis and biliary bile acid and cholesterol excretion. Gastroenterology 70: 1130-1135, 1976.
8. +-ATPase and bile flow by estrogen: effects on liver surface membrane lipid structure and function. Proc. Natl. Acad. Sci. USA 75: 4130-4134, 1978.
9. Deutsch, J. C., M. M. Iwahashi, E. M. Sutherland, J. Mapoles, and F. R. Simon. Characterization of the transport of a synthetic bile salt, iodinated cholyl-glycyl-tyrosine, in isolated cultured rat hepatocytes. Hepatology 15: 917-922, 1992.
10. +/bile acid cotransporter in extrahepatic cholestasis. Gastroenterology 110: 199-209, 1996.
11. Green, R. M., and J. M. Crawford. Hepatocellular cholestasis: pathobiology and histological outcome. Sem. Liver Dis. 15: 372-388, 1995.
12. Green, R. M., J. F. Whiting, A. B. Rosenbluth, D. Beier, and J. L. Gollan. Interleukin-6 inhibits hepatocyte taurocholate uptake and sodium-potassium-adenosinetriphosphatase activity. Am. J. Physiol. 267 (Gastrointest. Liver Physiol. 30): G1094-G1100, 1994.
13. +/bile acid cotransport system. Proc. Natl. Acad. Sci. USA 88: 10629-10633, 1991.
14. Hardikar, W., M. Ananthanarayanan, and F. J. Suchy. Differential ontogenic regulation of basolateral and canalicular bile acid transport proteins in rat liver. J. Biol. Chem. 270: 20841-20846, 1995.
15. Heikel, T. A. J., and G. H. Lathe. The effect of 17α-ethinyl-substituted steroids on adenosine triphosphatases of rat liver plasma membrane. Biochem. J. 118: 187-189, 1970.
16. +independent organic anion transporter. Proc. Natl. Acad. Sci. USA 91: 133-137, 1994.
17. Kast, C., B. Stieger, K. H. Winterhalter, and P. J. Meier. Hepatocellular transport of bile acids. Evidence for distinct subcellular localizations of electrogenic and ATP-dependent taurocholate transport in rat hepatocytes. J. Biol. Chem. 269: 5179-5186, 1994.
18. Keefe, K. D., B. F. Scharschmidt, N. M. Blandenship, and R. K. Ockner. Studies of relationships among bile flow, liver plasma membrane NaK-ATPase, and membrane microviscosity in the rat. J. Clin. Invest. 64: 1590-1598, 1979.
19. Kullak-Ublick, G.-A., B. Hagenbuch, B. Stieger, A. W. Wolkoff, and P. J. Meier. Functional characterization of the basolateral rat liver organic anion transporting polypeptide. Hepatology 20: 411-416, 1994.
20. Lin, S. W., and G. Guidotti. Cloning and expression of a cDNA coding for a rat liver plasma membrane ecto-ATPase. J. Biol. Chem. 264: 14408-14414, 1989.
21. Madar, Z., N. J. MacLusky, and F. Naftolin. Estrogen stimulation of 3-O-methyl-D-glucose uptake in isolated rat hepatocytes. Endocrinology 110: 330-335, 1982.
22. Margolis, R. N., M. J. Schell, S. I. Taylor, and A. L. Hubbard. Hepatocyte plasma membrane ecto-ATPase is a substrate for tyrosine kinase activity of the insulin receptor. Biochem. Biophys. Res. Commun. 166: 562-566, 1990.
23. Meier, P. J. Molecular mechanisms of hepatic bile salt transport from sinusoidal blood into bile. Am. J. Physiol. 269 (Gastrointest. Liver Physiol. 32): G801-G812, 1995.
24. Mills, P. R., P. J. Meier, D. J. Smith, N. Ballatori, J. L. Boyer, and E. R. Gordon. The effect of changes in the fluid state of rat liver plasma membrane on the transport of taurocholate. Hepatology 7: 61-66, 1987.
25. Reyes, H., and F. R. Simon. Intrahepatic cholestasis of pregnancy: an estrogen-related disease. Semin. Liver Dis. 13: 289-301, 1993.
26. Rosario, J., E. Sutherland, L. Zaccaro, and F. R. Simon. Ethinyl estradiol administration selectively alters liver sinusoidal membrane lipid fluidity and protein composition. Biochemistry 27: 3939-3946, 1988.
27. Rudling, M., G. Norstedt, H. Olivecrona, E. Reihnér, J.-Å. Gustafsson, and B. Angelin. Importance of growth hormone for the induction of hepatic low density lipoprotein receptors. Proc. Natl. Acad. Sci. USA 89: 6983-6987, 1992.
28. Shi, X., S. Bai, A. C. Ford, R. D. Burk, E. Jacquemin, B. Hagenbuch, P. J. Meier, and A. W. Wolkoff. Stable inducible expression of a functional rat liver organic anion transport protein in HeLa cells. J. Biol. Chem. 270: 25591-25595, 1995.
29. Simon, F. R., M. Gonzalez, E. Sutherland, L. Accatino, and R. A. Davis. Reversal of ethinyl estradiol-induced bile secretory failure with Triton WR-1339. J. Clin. Invest. 65: 851-860, 1980.
30. +-ATPase enzyme activity correlates with polarized β-subunit expression. Am. J. Physiol. 269 (Cell Physiol. 28): C69-C84, 1995.
31. Sippel, C. J., F. J. Suchy, M. Ananthanarayanan, and D. H. Perlmutter. The rat liver ecto-ATPase is also a canalicular bile acid transport protein. J. Biol. Chem. 268: 2083-2091, 1993.
32. +/taurocholate cotransporting polypeptide in rat liver. Gastroenterology 107: 1781-1787, 1994.
33. Storch, J., and D. Schachter. A dietary regimen alters hepatocyte plasma membrane lipid fluidity and ameliorates ethinyl estradiol cholestasis in the rat. Biochim. Biophys. Acta 798: 137-140, 1984.
34. Storch, J., and D. Schachter. Dietary induction of acyl chain desaturases alters the lipid composition and fluidity of rat hepatocyte plasma membranes. Biochemistry 23: 1165-1170, 1984.
35. +-ATPase activity depends on membrane lipid fluidity. Proc. Natl. Acad. Sci. USA 85: 8673-8677, 1988.