Hypersensitivity reactions to carbamazepine: Characterization of the specificity, phenotype, and cytokine profile of drug-specific T cell clones

Molecular Pharmacology

Volumn 63, Issue 3, 2003, Pages 732-741

  Naisbitt, Dean J ^a   Britschgi, M ^b   Wong, G ^a   Farrell, J ^a   Depta, J P H ^b   Chadwick, D W ^a   Pichler, W J ^b   Pirmohamed, M ^a   Park, B K ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b UNIVERSITY OF BERN   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; CARBAMAZEPINE; CARBANILAMIDE; CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; DRUG METABOLITE; GAMMA INTERFERON; HLA ANTIBODY; HLA ANTIGEN CLASS 2; LAMOTRIGINE; PHENYTOIN; T LYMPHOCYTE RECEPTOR;

ANTIGEN PRESENTING CELL; ANTIGEN RECOGNITION; ARTICLE; CLINICAL ARTICLE; CLONE; CONTROLLED STUDY; CROSS REACTION; CYTOKINE RELEASE; DRUG CYTOTOXICITY; DRUG HYPERSENSITIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; EOSINOPHILIA; FEMALE; FEVER; HUMAN; HUMAN CELL; LIVER DYSFUNCTION; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; LYMPHOCYTE TRANSFORMATION TEST; MALE; PHENOTYPE; PRIORITY JOURNAL; RASH; SKIN ALLERGY; SYMPTOMATOLOGY; T LYMPHOCYTE;

ADULT; AGED; CARBAMAZEPINE; CELL CULTURE TECHNIQUES; CELL DIVISION; CROSS REACTIONS; CYTOKINES; DRUG HYPERSENSITIVITY; FEMALE; HUMANS; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; PHENOTYPE; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES;

EID: 0344951264     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.63.3.732     Document Type: Article

References (39)

1. Britschgi M, Steiner UC, Schmid S, Depta JP, Senti G, Bircher A, Burkhart C, Yawalkar N, and Pichler WJ (2001) T-cell involvement in drug-induced acute generalized exanthematous pustulosis. J Clin Investig 107:1433-1441.
2. Brown KL, Henderson DC, Nadel S, Tanveer A, and Booy R (1999) Carbamazepine hypersensitivity and the use of lymphocyte proliferation responses. Dev Med Child Neurol 41:267-269.
3. 51Cr-labelled allogenic target cells in vitro: inhibition by isoantibody and by drugs. Immunology 14:181-196.
4. Csetenyi J, Baker KM, Frigerio A, and Morselli PL (1973) Iminostilbene - a metabolite of carbamazepine isolated from rat urine. J Pharm Pharmacol 25:340-341.
5. Dearman RJ, Basketter DA, and Kimber I (1996a) Characterization of chemical allergens as a function of divergent cytokine secretion profiles induced in mice. Toxicol Appl Pharmacol 138:308-316.
6. Dearman RJ, Moussavi A, Kemeny DM, and Kimber I (1996b) Contribution of CD4+ and CD8+ T lymphocytes to the cytokine secretion patterns induced in mice during sensitization to contact and respiratory chemical allergens. Immunology 89:502-510.
7. Diamond DJ, Szalay P, Symer D, Hao P, Shin HS, Dintzis RZ, Dintzis HM, Reinherz EL, and Siliciano RF (1991) Major histocompatibility complex independent T cell receptor-antigen interaction: functional analysis using fluorescein derivatives. J Exp Med 174:229-241.
8. Friedmann PS, Strickland I, Pirmohamed M, and Park BK (1994) Investigation of mechanisms in toxic epidermal necrolysis induced by carbamazepine. Arch Dermatol 130:598-604.
9. Hari Y, Frutig-Schnyder K, Hurni M, Yawalkar N, Zanni MP, Schnyder B, Kappeler A, von Greyerz S, Braathen LR, and Pichler WJ (2001) T cell involvement in cutaneous drug eruptions. Clin Exp Allergy 31:1398-1408.
10. Hertl M, Jugert F, and Merk HF (1995) CD8+ dermal T cells from a sulphamethoxazole-induced bullous exanthem proliferate in response to drug-modified liver microsomes. Br J Dermatol 132:215-220.
11. Ju C and Uetrecht JP (1999) Detection of 2-hydroxyiminostilbene in the urine of patients taking carbamazepine and its oxidation to a reactive iminoquinone intermediate. J Pharmacol Exp Ther 288:51-56.
12. Koga T, Kubota Y, and Nakayama J (2000) Interferon-gamma production in the peripheral lymphocytes of a patient with carbamazepine hypersensitivity syndrome. Acta Derm Venereol 80:73.
13. Leeder JS (1998) Mechanisms of idiosyncratic hypersensitivity reactions to antiepileptic drugs. Epilepsia 39:S8-S16.
14. Leyva L, Torres MJ, Posadas S, Blanca M, Besso G, O'Valle F, del Moral RG, Santamaria LF, and Juarez C (2000) Anticonvulsant-induced toxic epidermal necrolysis: monitoring the immunologic response. J Allergy Clin Immunol 105:157-165.
15. Madden S, Maggs JL, and Park BK (1996) Bioactivation of carbamazepine in the rat in-vivo - evidence for the formation of reactive arene oxide(s). Drug Metab Dispos 24:469-479.
16. Maggs JL, Pirmohamed M, Kitteringham NR, and Park BK (1997) Characterization of the metabolites of carbamazepine in patient urine by liquid chromatography/mass spectrometry. Drug Metab Dispos 25:275-280.
17. Mauri-Hellweg D, Bettens F, Mauri D, Brander C, Hunziker T, and Pichler WJ (1995) Activation of drug-specific CD4+ and CD8+ T cells in individuals allergic to sulfonamides, phenytoin and carbamazepine. J Immunol 155:462-472.
18. Morita CT, Beckman EM, Bukowski JF, Tanaka Y, Band H, Bloom BR, Golan DE, and Brenner MB (1995) Direct presentation of nonpeptide prenyl pyrophosphate antigens to human gamma delta T cells. Immunity 3:495-507.
19. Nassif A, Bensussan A, Dorothee G, Mami-Chouaib F, Bachot N, Bagot M, Boumsell L, and Roujeau JC (2002) Drug specific cytotoxic T-cells in the skin lesions of a patient with toxic epidermal necrolysis. J Investig Dermatol 118:728-733.
20. Nyfeler B and Pichler WL (1997) The lymphocyte transformation test for the diagnosis of drug allergy: sensitivity and specificity. Clin Exp Allergy 27:175-181.
21. Ohta A, Sekimoto M, Sato M, Koda T, Nishimura S, Iwakura Y, Sekikawa K, and Nishimura T (2000) Indispensable role for TNF-alpha and IFN-gamma at the effector phase of liver injury mediated by Th1 cells specific to hepatitis B virus surface antigen. J Immunol 165:956-961.
22. Park BK, Pirmohamed M, and Kitteringham NR (1998) Role of drug disposition in drug hypersensitivity: a chemical, molecular and clinical perspective. Chem Res Toxicol 9:969-988.
23. Pichler WJ, Yawalker N, Britschgi M, Depta J, Strasse I, Schmid S, Kuechle P, and Naisbitt D (2002) Cellular and molecular pathophysiology of cutaneous drug reactions. Am J Clin Dermatol 3:229-238.
24. Pichler WJ, Zanni M, von Greyerz S, Schnyder B, Mauri-Hellweg D, and Wendland T (1997) High IL-5 production by human drug-specific T cell clones. Int Arch Allergy Immunol 113:177-180.
25. Pirmohamed M, Lin K, Chadwick D, and Park BK (2001) TNF-alpha promoter region gene polymorphisms in carbamazepine-hypersensitive patients, Neurology 56:890-896.
26. Riley RJ, Kitteringham NR, and Park BK (1989) Structural requirements for bioactivation of anticonvulsants to cytotoxic metabolites in vitro. Br J Clin Pharmacol 28:482-487.
27. Schnyder B, Frutig K, Mauri-Hellweg D, Limat A, Yawalkar N, and Pichler WJ (1998) T-cell-mediated cytotoxicity against keratinocytes in sulfamethoxazole-induced skin reaction. Clin Exp Allergy 28:1412-1417.
28. Schnyder B, Mauri-Hellweg D, Zanni M, Bettens F, and Pichler WJ (1997) Direct, MHC-dependent presentation of the drug sulfamethoxazole to human alphabeta T cell clones. J Clin Investig 100:136-141.
29. Tennis P and Stern RS (1997) Risk of serious cutaneous disorders after initiation of use of phenytoin, carbamazepine, or sodium valproate: a record linkage study. Neurology 49:542-546.
30. Tomson T, Tybring G, Bertilsson L, Ekbom K, and Rane A (1980) Carbamazepine therapy in trigeminal neuralgia: clinical effects in relation to plasma concentration. Arch Neurol 37:699-703.
31. Villada G, Roujeau JC, Clerici T, Bourgault I, and Revuz J (1992) Immunopathology of toxic epidermal necrolysis. Arch Dermatol 128:50-53.
32. Vitorrio CC and Muglia JJ (1995) Anticonvulsant hypersensitivity syndrome. Arch Intern Med 155:2285-2290.
33. + T cell clones. Int Immunol 13:877-885.
34. von Greyerz S, Zanni MP, Frutig K, Schnyder B, Burkhart C, and Pichler WJ (1999) Interaction of sulfonamide derivatives with the TCR of sulfamethoxazole-specific human alpha beta+ T cell clones. J Immunol 162:595-602.
35. Yawalkar N, Hari Y, Frutig K, Egli F, Wendland T, Braathen LR, and Pichler WJ (2000a) T cells isolated from positive epicutaneous test reactions to amoxicillin and ceftriaxone are drug specific and cytotoxic. J Investig Dermatol 115:647-652.
36. Yawalkar N, Shrikhande M, Hari Y, Nievergelt H, Braathen LR, and Pichler WJ (2000b) Evidence for a role for IL-5 and eotaxin in activating and recruiting eosinophils in drug-induced cutaneous eruptions. J Allergy Clin Immunol 106:1171-1176.
37. Zakrzewska JM and Ivanyi L (1988) In vitro lymphocyte proliferation by carbamazepine, carbamazepine-10, 11-epoxide and oxcarbazepine in the diagnosis of drug-induced hypersensitivity. J Allergy Clin Immunol 82:110-115.
38. Zanni MP, Mauri-Hellweg D, Brander C, Wendland T, Schnyder B, Frei E, von Greyerz S, Bircher A, and Pichler WJ (1997) Characterization of lidocaine-specific T cells. J Immunol 158:1139-1148.
39. Zanni MP, von Greyerz S, Schnyder B, Brander KA, Frutig K, Hari Y, Valitutti S, and Pichler WJ (1998) HLA-restricted, processing- and metabolism-independent pathway of drug recognition by human alpha beta T lymphocytes. J Clin Investig 102:1591-1598.